Jan Krumsiek
Postdoctoral fellow
Email me
Tel.: +49 (0) 89 3187 3641
Room: 158
Research
- Modeling of metabolic networks based on metabolomics data
- Modeling of hematopoietic stem cell differentiation
- Quantifying discrete models of biological systems
- Odefy
Journal articles
- Multiple Novel Loci Highlighting Metabolic Control of Urate Production and Excretion are Associated with Gout.
Köttgen A*, Albrecht E*, Teumer A*, Vitart V*, Krumsiek J*, the GUGC Consortium, Ciullo M, Fox C, Caulfield M, Bochud M, Gieger C
Nature Genetics, accepted
- Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma.
Ried JS, Baurecht H, Stückler F, Krumsiek J, Gieger C, Heinrich J, Kabesch M, Prehn C, Peters A, Rodriguez E, Schulz H, Strauch K, Suhre K, Wang-Sattler R, Wichmann H-, Theis FJ, Illig T, Adamski J, Weidinger S
Allergy, accepted
- Metabolomic profiles in individuals with negative affectivity and social inhibition: A population-based study of Type D personality.
Altmaier E, Emeny RT, Krumsiek J, Lacruz ME, Lukaschek K, Häfner S, Kastenmüller G, Römisch-Margl W, Prehn C, Mohney RP, Evans AM, Milburn MV, Illig T, Adamski J, Theis F, Suhre K, Ladwig K
Psychoneuroendocrinology, 2012 [ PubMed ]
- A strategy for combining minor genetic susceptibility genes to improve prediction of disease in type 1 diabetes.
Winkler C, Krumsiek J, Lempainen J, Achenbach P, Grallert H, Giannopoulou E, Bunk M, Theis FJ, Bonifacio E, Ziegler A
Genes & Immunity, 13(7):549--555, 2012 [ PubMed ]
- Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information.
Krumsiek J, Suhre K, Evans AM, Mitchell MW, Mohney RP, Milburn MV, Wägele B, Römisch-Margl W, Illig T, Adamski J, Gieger C, Theis FJ, Kastenmüller G
PLoS Genetics, 8(10):e1003005, 2012 [ PubMed ]
- Identification and Quantification of 1-Hydroxybutene-2-yl Mercapturic Acid in Human Urine by UPLC- HILIC-MS/MS as a Novel Biomarker for 1,3-Butadiene Exposure.
Sterz K, Scherer G, Krumsiek J, Theis FJ, Ecker J
Chemical Research in Toxicology, 25(8):1565-1567, 2012
- Body fat free mass is associated with the serum metabolite profile in a population-based study.
Jourdan C, Petersen A, Gieger C, Döring A, Illig T, Wang-Sattler R, Meisinger C, Peters A, Adamski J, Prehn C, Suhre K, Altmaier E, Kastenmüller G, Römisch-Margl W, Theis FJ, Krumsiek J, Wichmann H, Linseisen J
PLoS ONE, 7(6):e40009, 2012 [ PubMed ]
- On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies.
Petersen A, Krumsiek J, Wägele B, Theis FJ, Wichmann H, Gieger C, Suhre K
BMC Bioinformatics, 13(1):120, 2012 [ PubMed ]
- Bayesian Independent Component Analysis recovers pathway signatures from blood metabolomics data.
Krumsiek J, Suhre K, Illig T, Adamski J, Theis FJ
Journal of Proteome Research, 2012 [ PubMed ]
- The dynamic range of the human metabolome revealed by challenges.
Krug S*, Kastenmüller G*, Stückler F*, Rist MJ*, Skurk T*, Sailer M, Raffler J, Römisch-Margl W, Adamski J, Prehn C, Frank T, Engel K, Hofmann T, Luy B, Zimmermann R, Moritz F, Schmitt-Kopplin P, Krumsiek J, Kremer W, Huber F, Oeh U, Theis FJ, Szymczak W, Hauner H, Suhre K, Daniel H
FASEB Journal, 2012 [ PubMed ]
- Hierarchical Differentiation of Myeloid Progenitors Is Encoded in the Transcription Factor Network.
Krumsiek J*, Marr C*, Schroeder T, Theis FJ
PLoS ONE, 6(8):e22649, 2011 [ PubMed ]
- Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers.
Mittelstrass K*, Ried JS*, Yu Z*, Krumsiek J, Gieger C, Prehn C, Roemisch-Margl W, Polonikov A, Peters A, Theis FJ, Meitinger T, Kronenberg F, Weidinger S, Wichmann HE, Suhre K, Wang-Sattler R, Adamski J, Illig T
PLoS Genetics, 7(8):e1002215, 2011 [ PubMed ]
- Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data.
Krumsiek J, Suhre K, Illig T, Adamski J, Theis FJ
BMC Systems Biology, 5(1):21, 2011 [ PubMed ]
- Odefy--from discrete to continuous models.
Krumsiek J, Pölsterl S, Wittmann DM, Theis FJ
BMC Bioinformatics, 2010 [ PubMed ]
- Intronic microRNAs support their host genes by mediating synergistic and antagonistic regulatory effects.
Lutter D, Marr C, Krumsiek J, Lang EW, Theis FJ
BMC Genomics, 2010 [ PubMed ]
- Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling.
Wittmann DM, Krumsiek J, Saez-Rodriguez J, Lauffenburger DA, Klamt S, Theis FJ
BMC Systems Biology, 2009 [ PubMed ]
- Bootstrapping the interactome: unsupervised identification of protein complexes in yeast.
Friedel CC, Krumsiek J, Zimmer R
Journal of Computational Biology, 16(8):971--987, 2009 [ PubMed ]
- ProCope--protein complex prediction and evaluation.
Krumsiek J, Friedel CC, Zimmer R
Bioinformatics, 24(18):2115--2116, 2008 [ PubMed ]
- Bootstrapping the Interactome: Unsupervised Identification of Protein Complexes in Yeast.
Friedel CC, Krumsiek J, Zimmer R
RECOMB 2008, 2008
- SIMAP--structuring the network of protein similarities.
Rattei T, Tischler P, Arnold R, Hamberger F, Krebs J, Krumsiek J, Wachinger B, Stümpflen V, Mewes W
Nucleic Acids Research, 36(Database issue):D289--D292, 2008 [ PubMed ]
- Gepard: a rapid and sensitive tool for creating dotplots on genome scale.
Krumsiek J, Arnold R, Rattei T
Bioinformatics, 23(8):1026--1028, 2007 [ PubMed ]
Conference proceedings
- Efficient fluorescence image normalization for time lapse movies.
Schwarzfischer M*, Marr C*, Krumsiek J, Hoppe PS, Schroeder T, Theis FJ
ICSB 2011 workshop: Microscopic Image Analysis with Applications in Biology, 2011
- An ISA Algorithm With Unknown Group Sizes Identifies Meaningful Clusters in Metabolomics Data.
Gutch H, Krumsiek J, Theis F
EUSIPCO - European Signal Processing Conference, 2011
- Gaussian graphical modeling reveals specific lipid correlations in glioblastoma cells.
Mueller NS, Krumsiek J, Theis FJ, Böhm C, Meyer-Baese A
Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering IX, 8058(1):805819, 2011
Book chapters
- Systems Biology meets Metabolism.
Krumsiek J, Stückler F, Kastenmüller G, Theis FJ
in Genetics Meets Metabolomics, 2012
- From Discrete to Continuous Gene Regulation Models – A Tutorial Using the Odefy Toolbox.
Krumsiek J, Wittmann DM, Theis FJ
in Applications of MATLAB in Science and Engineering, 2011
* = These authors contributed equally to this work.