assay development and screening platform (adsp)

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Selected Publications

 

Vincendeau M, Nagel D, Brenke JK, Brack-Werner R and Hadian K
Heterogenous nuclear ribonucleoprotein Q increases protein expression from HIV-1 Rev-dependent transcripts.
Virology Journal, 2013

Müller-Rischart AK, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Peis R, Deinlein A, Schweimer C, Kuhn PH, Lichtenthaler SF, Motori E, Hrelia S, Wurst W, Trümbach D, Langer T, Krappmann D, Dittmar G, Tatzelt J and Winkelhofer KF
The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.
Molecular Cell, 2013

Nagel D, Spranger S, Vincendeau M, Grau M, Raffegerst S, Kloo B, Hlahla D, Neuenschwander M, von Kries JP, Hadian K, Dörken B, Lenz P, Lenz G, Schendel DJ and Krappmann D
Pharmacological inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.
Cancer Cell, 2012

Hadian K, Griesbach RA, Dornauer S, Wanger TM, Nagel D, Metlitzky M, Beisker W, Schmidt-Supprian M and Krappmann D
NF-kB Essential Modulator (NEMO) Interaction with Linear and Lys-63 Ubiquitin Chains Contributes to NF-kB Activation.
Journal of Chemical Biology, 2011

Hadian K and Krappmann D
Signals from the Nucleus: Activation of NF-{kappa}B by Cytosolic ATM in the DNA Damage Response.
Science Signaling, 2011

Eitelhuber AC, Warth S, Schimmack G, Düwel M, Hadian K, Demski K, Beisker W, Shinohara H, Kurosaki T, Heissmeyer V and Krappmann D
Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation.
EMBO Journal, 2011

Vincendeau M, Kramer S, Hadian K, Rothenaigner I, Bell J, Hauck SM, Bickel C, Nagel D, Kremmer E, Werner T, Leib-Mösch C, Brack-Werner R
Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).
AIDS, 2010

Rybak, A, Fuchs, H, Hadian K, Smirnova L, Wulczyn, EA, Michel G, Nitsch R, Krappmann D and Wulczyn FG
The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2.
Nature Cell Biology, 2009

Hadian K, Mäusbacher N, Nagel D, Vincendeau M, Hauck S, Ueffing M, Loyter A, Werner T, Wolff H and Brack-Werner R
Identification of an hnRNP recognition motif in the HIV-1 Rev protein.
Journal of Biological Chemistry, 2009

Wolff H, Hartl A, Eilken HM, Hadian K, Ziegler M and Brack-Werner R
Live-cell assay for simultaneous monitoring of expression and interaction of proteins.
BioTechniques, 2006

Wolff H, Hadian K, Ziegler M, Weierich C, Kramer-Hämmerle S, Kleinschmidt A, Erfle V and Brack-Werner R
Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging.
Experimental Cell Research, 2006