Diabetes

Successfully fighting diabetes – new therapies, effective prevention

Approaches to and successes in diabetes research

Using an integrative research approach, the Helmholtz Diabetes Center and its partners within Helmholtz Zentrum München contribute to new approaches in diagnosis, therapy and prevention of diabetes mellitus.

Basis

Projects

     

  • Effects of nutrition on metabolism
  •  

  • Role of mitochondria in the pathogenesis and disease course of diabetes
  •  

  • Relationships between arteriosclerosis, liver, kidney, thyroid gland and diabetes development
  •  

  • Genetic determination of different subtypes of diabetes
  •  

  • Association between diabetes risk and gender
  •  

  • Central nervous control of systems metabolism
  •  

Successes

     

  • Elucidation of the functions of genes
  •  

  • Relationship of smoking and diabetes
  •  

  • Relationship of birth weight and diabetes
  •  

  • Genetic causes identified for disturbances in the lipid metabolism
  •  

New Approaches to Therapy

Projects 

     

  • Specific nutritional forms for diabetes intervention
  •  

  • Possibilities of regeneration of beta cells and approaches to stem cell therapy
  •  

  • Vaccination study for type 1 diabetes
  •  

  • Polypharmacy for treatment of diabetes and obesity
  •  

Successes

  • Immunotherapy for type 1 diabetes

New Diagnostic Methods

Projects

     

  • Measurement of risk factors for diabetes in the exhaled air
  •  

  • Early diagnosis through metabolites in the blood
  •  

Successes

  • New markers for early detection of type 1 diabetes mellitus

New Prevention Strategies

Projects

     

  • Influence of lifestyle factors such as nutrition, exercise etc. on the course of disease
  •  

  • Nutritional intervention in carriers of risk gene variants
  •  

  • Changes in gene expression depending on diabetes status and genetic profile
  •  

Successes

     

  • Genetic risk factors identified for type 1 and type 2 diabetes
  •  

  • Vitamin D may reduce diabetes risk
  •  

Health Care Research

Projects

     

  • Benefit analysis of disease management programs
  •  

  • Diabetes and social imbalances
  •  

  • Influence of mental state/depression on the course of disease
  •  

Erfolge

  • Benefit of disease management programs is confirmed