Institute of Diabetes Research

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Type 1 Diabetes Cohorts

Type 1 diabetes is one of the most common chronic disease in childhood and adolescence and its incidence is increasing worlwide. The development of type 1 diabetes is preceded by autoantibodies against pancreatic islet beta-cell antigens and these autoantibodies often appear years prior to diabetes onset. The aetiology of type 1 diabetes is still unknown. The incidence of type 1 diabetes is increasing by 3–5% per year with peak incidence periods in childhood and adolescence.

In the light of the rising incidence of type 1 diabetes a main research area of the Institute of Diabetes Research is to determine the natural history of autoimmune diabetes and identify the genetic and environmental determinants of autoimmunity. This will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay, or reverse type 1 diabetes.

Therefore we are conducting  several Birth Cohort Studies (BABYDIAB, BABYDIET, TEDDY) with a prospective intensive follow-up from birth of up to 4000 at risk children (family history and/or genetic susceptibility) and a Puberty Cohort Study with a prospective follow-up of 1500 at risk children from age 6 to 18 years (TeenDiab).

Contact person: Dr. Christiane Winkler
Phone: +49-(0)89 / 3187 - 3745