Publications:
Rolyan H, Scheffold A, Begus-Nahrmann Y, Heinrich A, Liss B Langkopf BH, Hölter SM, Vogt Weissenhorn DM, Wurst W, Lie DC, Thal DR, Biber K, Rudolph KL. Telomere shortening reduces Alzheimer’s disease amyloid pathology in mice. Brain, in press
Karalay O, Doberauer K, Vadodaria KC, Knobloch M, Berti L, Miquelajauregui A, Schwark M, Jagasia R, Taketo MM, Tarabykin V, Lie DC, Jessberger S Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A, 2011, 108:5807-5812.
Herold S, Jagasia R, Merz K, Wassmer K, Lie DC. CREB signalling regulates early survival, neuronal gene expression and morphological development in adult subventrivular zone neurogenesis. Mol Cell Neurosci, 2011, 46:79-88.
Beckervordersandforth R, Tripathi P, Ninkovic J, Bayam E, Lepier A, Stempfhuber B, Kirchhoff F, Hirrlinger J, Haslinger A, Lie DC, Beckers J, Yoder B, Irmler M, Gotz M In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells. Cell Stem Cell, 2010, 7:744-758.
Ehm O, Göritz C, Covic M, Karaca E, Schaeffner I, Schwarz T, Kempkes B, Kremmer E, Pfrieger FW, Espinosa L, Bigas A, Giachino C, Taylor V, Frisén J, Lie DC. RBPJ-dependent signalling regulates Sox2 expression and is essential for longterm maintenance of radial glia like stem cells in the adult hippocampus. J Neurosci, 2010, 30:13794-13807.
Mira H, Andreu Z, Suh H, Lie DC, Jessberger S, Consiglio A, San Emeterio J, Hortigüela R, Marqués-Torrejón MA, Nakashima K, Colak D, Götz M, Fariñas I and Gage FH. Signalling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. Cell Stem Cell, 2010, Jul 2;7(1):78-89
Jagasia R, Steib K, Englberger E, Herold S, Faus-Kessler T, Saxe M, Gage FH, Song H, Lie DC. GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. J Neurosci. 2009, 29(25):7966-77
Haslinger A, Schwarz TJ, Covic M, Lie DC. Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis. Eur J Neurosci. 2009, 29(11):2103-14
Kuwabara T, Muotri A, Warashin M, Lie DC, Nakashima K, Hsieh J, Moore L, Asashima M and Gage FH. Wnt-mediated activation of NeuroD1 and retroelements during adult neurogenesis. Nat Neurosci. 2009, 12(9):1097-105. Epub 2009 Aug 23.
Jessberger S, Clark RE, Broadbent NJ, Clemenson GD Jr, Consiglio A, Lie DC, Squire LR, Gage FH. Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn Mem. 2009, 16(2):147-54
Jessberger S, Aigner S, Clemenson GD Jr, Toni N, Lie DC, Karalay O, Overall R, Kempermann G, Gage FH. Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biol.2008, 6(11):e272.
Winner B, Rockenstein E, Lie DC, Aigner R, Mante M, Bogdahn U, Couillard-Depres S, Masliah E, Winkler J. Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis. Neurobiol Aging 2007, 29(6):913-25. Epub 2007 Jan 31
Jacobs S, Lie DC, DeCicco KL, Shi Y, DeLuca LM, Gage FH, Evans RM. Retinoic acid is required early during adult neurogenesis in the dentate gyrus. Proc Natl Acad Sci U S A 2006, 103:3902-3907.
Lie DC, Colamarino SA, Song HJ, Désiré L, Mira H, Consiglio A, Lein ES, Jessberger S, Lansford H, Dearie AR, Gage FH. Wnt signalling regulates adult hippocampal neurogenesis. Nature 2005;437(7063):1370-5.
Winner B, Lie DC, Rockenstein E, Aigner R, Masliah E, Kuhn HG, Winkler J. Impairment of adult neurogenesis in transgenic human alpha-synuclein mice. J Neuropathol Exp Neurol 2004, 63(11):1155-66
Shi YH, Lie DC, Taupin P, Nakashima K, Ray J, Yu RT, Gage FH, Evans RM. Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature 2004, 427: 78-83
Wurmser AE, Summers RG, Nakashima K, Toni N, D’Amour KA, Lie DC, Gage FH. Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature 2004, 430: 350-356
Dziewczapolski G, Lie DC, Ray J, Gage FH, Shults CW. Survival and differentiation of adult rat-derived neural progenitor cells transplanted to the striatum of hemiparkinsonian rats. Exp Neurol 2003, 183: 653-664
Lie DC, Dziewczapolski G, Willhoite AR, Kaspar BK, Shults CW, Gage FH. The adult substantia nigra contains progenitor cells with neurogenic potential. J Neurosci. 2002, 22(15):6639-49.
Matsuura N*, Lie DC*, Hoshimaru M, Asahi M, Hojo M, Ishizaki R, Hashimoto N, Noji S, Ohuchi H, Yoshioka H, Gage FH. Sonic hedgehog facilitates dopamine differentiation in the presence of a mesencephalic glial cell line. J Neurosci 2001 21:4326-4335. (*equal contribution)
Lie DC, Weis J. GDNF expression is increased in denervated human skeletal muscle. Neurosci Lett. 1998, 250(2):87-90.
Weis J, Schonrock LM, Zuchner SL, Lie DC, Sure U, Schul C, Stogbauer F, Ringelstein EB, Halfter H. CNTF and its receptor subunits in human gliomas. J Neurooncol 1999, 44:243-253
Weis J, Lie DC, Ragoss U, Zuchner SL, Schroder JM, Karpati G, Farruggella T, Stahl N, Yancopoulos GD, DiStefano PS. Increased expression of CNTF receptor alpha in denervated human skeletal muscle. J Neuropathol Exp Neurol 1998, 57:850-857
Reviews
Khan MA, Lie DC MicroRNA - a contributor to age-associated neural stem cell dysfunction? Aging (Albany NY), 2011, 3:182-183.
Merz K, Herold S, Lie DC CREB in adult neurogenesis--master and partner in the development of adult-born neurons? Eur J Neurosci, 2011, 33:1078-1086
Covic M, Karaca E, Lie DC. Epigenetic regulation of neurogenesis in the adult Hippocampus. Heredity, 2010 Mar 24. [Epub ahead of print]
Khan MA, Berti L. (2009). Alzheimer's disease affects progenitor cells through aberrant {beta}-catenin signaling. J Neurosci. 2009, 29(40): 12369-12371.
Winner B, Vogt-Weisenhorn DM, Lie DC, Blümcke I, Winkler J. Cellular Repair Strategies in Parkinson’s disease. Therap Adv Neurol Disord 2009, 2(1): 51-60. Michaelidis TM, Lie DC. Wnt signaling and neural stem cells: caught in the Wnt web. Cell Tissue Res 2008, 331(1):193-210
Jagasia R, Song H, Gage FH, Lie DC. New regulators in adult neurogenesis and their potential role for repair. Trends Mol Med 2006, 12:400-40
Lie DC, Song HJ, Colamarino SA, Ming GL, Gage FH. Neurogenesis in the adult brain; new strategies for central nervous system diseases. Annu Rev Pharmacol Toxicol 2004, 44: 399-421
Song HJ, Lie DC, Stevens CF, Gage FH. Reply: Familial dementia with dentate atrophy and failure of neurogenesis. Ann Neurol 2003, 53 (3):421
Book Chapters
Jagasia R, Lie DC. Hippocampal Neurogenic Niche and Regulation of Adult Neurogenesis. Buchkapitel in “Postnatal and Adult Neurogenesis”. Research Signpost. L Bonfanti (ed) (2009)
Lie DC, Gotz M. Proliferation, Fate Determination, and Migration. Buchkapitel in “Adult neurogenesis”. Cold Spring Harbor Laboratory Press. FH Gage, G Kempermann, H Song (eds). (2008)
Zhao X, Lie DC, Gage FH. Adult derived stem cells for transplantation in Parkinson’s disease. Buchkapitel in “Restorative therapies in Parkinson’s disease”. Kluwer Academic/Plenum Publishers. W Olanow and P Brundin (eds) (2006)
Lie DC, Song H, Colamarino SA, Gage FH. Harnessing endogenous stem cells for CNS repair. Buchkapitel in “Neuroscience, Molecular Medicine and the Therapeutic Transformation of Neurology”. Elsevier Press. SG Waxman (ed) (2004)