Publications
2011
Maier V, Jolicoeur C, Rayburn H, Takegahara N, Kumanogoh A, Kikutani H, Tessier-Lavigne M, Wurst W, Friedel RH. "Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development." Mol Cell Neurosci. 2011 Feb;46(2):419-31. Epub 2010 Nov 29.
Chertoff M, Di Paolo N, Schoeneberg A, Depino A, Ferrari C, Wurst W, Pfizenmaier K, Eisel U, Pitossi F. "Neuroprotective and neurodegenerative effects of the chronic expression of tumor necrosis factor α in the nigrostriatal dopaminergic circuit of adult mice." Exp Neurol. 2011 Feb;227(2):237-51. Epub 2010 Nov 17.
Horsch M, Seeburg PH, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Garrett L, Götz A, Hans W, Higuchi M, Hölter SM, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Schrewe A, Adamski J, Busch DH, Esposito I, Graw J, Ivandic B, Klingenspor M, Klopstock T, Mempel M, Ollert M, Schulz H, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, de Angelis MH, Beckers J. "Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice." J Biol Chem. 2011 May 27;286(21):18614-22. Epub 2011 Apr 5.
Kollias G, Papadaki P, Apparailly F, Vervoordeldonk MJ, Holmdahl R, Baumans V, Desaintes C, Di Santo J, Distler J, Garside P, Hegen M, Huizinga TW, Jüngel A, Klareskog L, McInnes I, Ragoussis I, Schett G, Hart BT, Tak PP, Toes R, van den Berg W, Wurst W, Gay S. "Animal models for arthritis: innovative tools for prevention and treatment." Ann Rheum Dis. 2011 May 30. [Epub ahead of print]
Kleinhammer A, Wurst W, Kühn R. "Constitutive and conditional RNAi transgenesis in mice." Methods. 2011 Apr;53(4):430-6. Epub 2010 Dec 22.
Rolyan H, Scheffold A, Heinrich A, Begus-Nahrmann Y, Langkopf BH, Hölter SM, Vogt-Weisenhorn DM, Liss B, Wurst W, Lie DC, Thal DR, Biber K, Rudolph KL. "Telomere shortening reduces Alzheimer's disease amyloid pathology in mice." Brain. 2011 Jun 14. [Epub ahead of print]
Wang XD, Chen Y, Wolf M, Wagner KV, Liebl C, Scharf SH, Harbich D, Mayer B, Wurst W, Holsboer F, Deussing JM, Baram TZ, Müller MB, Schmidt MV. "Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling." Neurobiol Dis. 2011 Jun;42(3):300-10. Epub 2011 Feb 3.
Piccoli, G., S. B. Condliffe, M. Bauer, F. Giesert, K. Boldt, S. De Astis, A. Meixner, H. Sarioglu, D. M. Vogt-Weisenhorn, W. Wurst, C. J. Gloeckner, M. Matteoli, C. Sala, and M. Ueffing (2011), "LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool", J Neurosci 31 (6):2225-2237.
Conrad, M. (2011) Mouse models for glutathione peroxidase 4 (GPx4). Selenium : Its Molecular Biology and Role in Human Health, Third Edition D.L. Hatfield, M. J. Berry, V.N. Gladyshev, ed, Springer, New York.
Puglisi, R., Maccari, I., Pipolo, S., Conrad, M., Mangia, F., Boitani C. (2011) The nuclear form of glutathione peroxidase 4 is associated with sperm nuclear matrix and is required for proper paternal chromatin decondensation at fertilization. J. Cell. Physiol. in press
Azimzadeh, O., Scherthan, h., Sarioglu, H., Barjaktarovic, Z., Conrad, M., Vogt, A., Calzada-Wacke, J., Neff, F., Aubele, M., Buske, C., Atkinson, M.J., Tapio S. (2011) Total body ionizing radiation causes rapid proteomic remodeling of cardiac tissue. Proteomics. in press.
Noblanc, A., Kocer, A., Chabory, E., Vernet, P., Saez, F., Cadet, R., Conrad M., Drevet, J.R. (2011) Glutathione peroxidases (Gpx) at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability. J Androl. Mar 25. [Epub ahead of print]
Mannes, A.M., Seiler, A., Bosello, V., Maiorino, M., Conrad, M.* (2011) The cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild type selenoenzyme. FASEB J. Mar 14. [Epub ahead of print]
Conrad, M.*, Sato, H. (2011) The oxidative stress-inducible cystine/glutamate antiporter, system xc-: cystine supplier and beyond. Amino Acids. Mar 16. [Epub ahead of print]
Sibbing, D.§, Pfeufer, A.§, Perisic, T.§, Mannes, A.M., Fritz-Wolf, K., Unwin, S., Sinner, M.F., Gieger, C., Gloeckner, C.J., Wichmann, E., Kremmer, E., Schäfer, Z., Walch, A., Hinterseer, M., Näbauer, M., Kääb, S., Kastrati, A., Schömig, A., Meitinger, T., Bornkamm, G.W.§ *, Conrad, M.§ *, von Beckerath, N.§ * (2011) Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy. Eur Heart J. 32:1121-1133.
Massie A., Schallier A., Kim S.W., Fernando R., Kobayashi S., Beck H., De Bundel D., Vermoesen K., Bannai S., Smolders I., Conrad M., Plesnila N., Sato H., Michotte Y. (2011) Dopaminergic neurons of system xc--deficient mice are highly protected against 6-hydroxydopamine-induced toxicity. FASEB J. 25:1359-1369.
Tobaben, S., Hoehn, M., Seiler, A., Conrad, M., Plesnila, N., and Culmsee C. (2011) Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons. Cell Death Differ. 18:282-292.
Fischer, T., Faus-Kessler, T., Welzl, G., Simeone, A., Wurst, W. and Prakash, N. (2011). Fgf15-mediated control of neurogenic and proneural gene expression regulates dorsal midbrain neurogenesis. Dev. Biol., 350: 496-510.
Hölter SM, Glasl L. High throughput phenotyping. In: Dunnett SB, Lane E (eds) Animal models of movement disorders. Humana Press (2011) in press
Expression of the Splicing Factor Gene SFRS10 is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis. Jussi Pihlajamäki, Carles Lerin, Paula Itkonen, Tanner Boes, Thomas Floss, Joshua Schroeder, Farrell Dearie, Sarah Crunkhorn, Furkan Burak, Josep C. Jimenez-Chillaron, Tiina Kuulasmaa, Pekka Miettinen, Peter J. Park, Imad Nasser, Zhenwen Zhao, Zhaiyi Zhang, Yan Xu, Wolfgang Wurst, Hongmei Ren, Andrew J. Morris, Stefan Stamm, Allison B. Goldfine, Markku Laakso, Mary Elizabeth Patti. Cell metabolism 2011; accepted.
Musashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice Luisa de Andrés-Aguayo, Florencio Varas, Eric M. Kallin, José F. Infante, Wolfgang Wurst, Thomas Floss, and Thomas Graf. Blood. 2011 May 25.
Frank Schnütgen, Franziska Ehrmann, Ina Poser, Nina C. Hubner, Jens Hansen, Thomas Floss, Wolfgang Wurst, Anthony Hyman, Matthias Mann, and Harald von Melchner (2011) Use of public gene trap resources for high throughput proteome analysis Nature Methods, 8(2):103-104.
2010
Zhang J, Giesert F, Kloos K, Vogt Weisenhorn DM, Aigner L, Wurst W, Couillard-Despres S. "A powerful transgenic tool for fate mapping and functional analysis of newly generated neurons." BMC Neurosci. 2010 Dec 31;11:158.
Mandal, P.K., Schneider, M., Kölle, P., Kuhlencordt, P.K., Förster, H., Beck, H., Bornkamm, G.W., and Conrad, M.* (2010) Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacological glutathione deprivation. Cancer Res. 70:9505-9514.
Conrad, M.* § , Sandin, A., Förster, H., Seiler, A., Frijhoff, J., Dagnell, M., Bornkamm, G.W., Rådmark, O., Hooft van Huijsduijnen, R., Aspenström, P., Böhmer, F., and Östman, A.* § (2010) 12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases. Proc. Natl. Acad. Sci. U S A. 107:15774-15779.
Mandal, P.K., Seiler, A., Perisic, T., Kölle, P., Banjac Canak, A., Förster, H., Weiss, N., Kremmer, E., Lieberman, M.W., Bannai, S., Kuhlencordt, P., Sato, H., Bornkamm, G.W., and Conrad, M.* (2010) System XC- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency. J. Biol. Chem. 285, 22244-22253.
Illner, D., Zinner, R., Handtke, V., Rouquette, J., Strickfaden, H., Lanctot, C., Conrad, M., Seiler, A., Imhof, A., Cremer, T., and Cremer, M. (2010) Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin. Exp. Cell Res. 316, 1662-1680.
Schneider, M., Wortmann, M., Mandal, P.K., Arpornchayanon, W., Jannasch, K., Alves, F., Strieth, S., Conrad, M.* §, and Beck, H.* § (2010) Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity. Neoplasia 12, 254-263.
Wirth, E.K., Conrad, M., Winterer, J., Wozny, C., Carlson, B.A., Roth, S., Schmitz, D., Bornkamm, G.W., Coppola, V., Tessarollo, L., Schomburg, L., Köhrle, J., Hatfield, D.L., and Schweizer, U. (2010) Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration. FASEB J. 24, 844-852.
Conrad, M.*, and Schweizer U. (2010) Unveiling the Molecular Mechanisms Behind Selenium-Related Diseases Through Knockout Mouse Studies. Antiox. Redox Signal. 12, 851-865.
Bouman L, Schlierf A, Lutz AK, Shan J, Deinlein A, Kast J, Galehdar Z, Palmisano V, Patenge N, Berg D, Gasser T, Augustin R, Trümbach D, Irrcher I, Park DS, Wurst W, Kilberg MS, Tatzelt J, Winklhofer KF. (2010) Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ. [Epub ahead of print]
Haupt C, Kloos K, Faus-Kessler T, Huber AB (2010) Semaphorin 3A-Neuropilin-1 signaling regulates peripheral axon fasciculation and pathfinding but not developmental cell death patterns. Eur J Neurosci. 31(7):1164-72.
Chapouton P, Skupien P, Hesl B, Coolen M, Moore JC, Madelaine R, Kremmer E, Faus-Kessler T, Blader P, Lawson ND, Bally-Cuif L. (2010) Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells. J Neurosci. 30(23):7961-74.
Stübner S., Faus-Kessler Th., Fischer Th., Wurst. W., Prakash N. (2010). Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect. Developmental Dynamics 239/1:246-260
Trümbach D*, Graf C*, Pütz B, Kühne C, Panhuysen M, Weber P, Holsboer F, Wurst W, Welzl G, Deussing JM (2010) Deducing corticotropin-releasing hormone receptor type 1 signaling networks from gene expression data by usage of genetic algorithms and graphical Gaussian models.BMC Systems Biology 4, 159.
Schmidt MV, Trümbach D, Weber P, Wagner K, Scharf SH, Liebl C, Datson N, Namendorf C, Gerlach T, Kühne C, Uhr M, Deussing JM, Wurst W, Binder EB, Holsboer F, Müller MB. (2010) Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus. J Neurosci 30(50), 16949-58.
Kinzel D, Boldt K, Davis EE, Burtscher I, Trümbach D, Diplas B, Attié-Bitach T, Wurst W, Katsanis N, Ueffing M, Lickert H. (2010) Pitchfork regulates primary cilia disassembly and left-right asymmetry. Dev. Cell. 19(1), 66-77.
Tsolakidou A, Czibere L, Pütz B, Trümbach D, Panhuysen M, Deussing JM, Wurst W, Sillaber I, Landgraf R, Holsboer F, Rein T. (2010) Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein. BMC Genomics. 11:546.
Ringwald, M., Iyer, V., Mason, JC., Stone, KR., Tadepally, HD., Kadin, JA., Bult, CJ., Eppig, JT., Oakley, DJ., Briois, S., Stupka, E., Maselli, V., Smedley, D, Liu, S., Hansen, J., Baldock, R., Hicks, GG, Skarnes, WC. (2010) The IKMC web portal: a central point of entry to data and resources from the International Knockout Mouse Consortium. Nucleic Acid Res. 39, D849-D855.
Glasl, L., K. Kloos, F. Giesert, A. Roethig, B. di Benedetto, R. Kühn, J. Zhang, U. Haven, J. Zerle, A. Hofmann, K. F. Winklhofer, S.M. Hoelter, D.M. Vogt Weisenhorn, and W. Wurst (2010), "Pink1-deficiency in mice recapitulates symptoms of the early phase of Parkinson´s Disease", J Neurosci submitted.
Aron, L., P. Klein, T. T. Pham, E. R. Kramer, W. Wurst, and R. Klein (2010), "Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons", PLoS Biol 8 (4):e1000349.
Di Salvio, M., Di Giovannantonio, L. G., Acampora, D., Prosperi, R., Omodei, D., Prakash, N., Wurst, W., and Simeone, A. (2010). Otx2 controls neuron subtype identity in the ventral tegmental area and antagonizes vulnerability to the Parkinsonian toxin MPTP by suppressing Dopamine transporter. Nat. Neurosci. 13: 1481-1488.
Meyer M, de Angelis MH, Wurst W, Kühn R. (2010). Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proc Natl Acad Sci USA, 107, 15022-15026.
Hölter SM, Cryan JF. Phenotyping of Behavioural Characteristics. In: Encyclopedia of Psychopharmacology, Ian P. Stolerman (ed.), Springer-Verlag (2010); DOI 10.1007/978-3-540-68706-1
Deussing JM, Breu J, Kühne C, Kallnik M, Bunck M, Glasl L, Yen YC, Vogl AM, Gailus-Durner V, Fuchs H, Hölter SM, Wotjak CT, Landgraf R, Hrabe de Angelis M, Holsboer F, Wurst W. (2010) Urocortin 3 modulates social discrimination abilities via corticotrophin-releasing hormone receptor 2. J Neurosci 30(27):9103-9116
Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schulz C, Rozman J, Hoeller D, Qiu CH, Londono MB, Jedlicka P, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, Hrabé de Angelis M, Dikic I. (2010) CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J 29(14):2421-2432
Phenotypic annotation of the mouse X chromosome. Cox BJ, Vollmer M, Tamplin O, Lu M, Biechele S, Gertsenstein M, van Campenhout C, Floss T, Kühn R, Wurst W, Lickert H, Rossant J.Genome Res. 2010 Aug;20(8):1154-64.
Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps. Schebelle L, Wolf C, Stribl C, Javaheri T, Schnütgen F, Ettinger A, Ivics Z, Hansen J, Ruiz P, von Melchner H, Wurst W, Floss T.Nucleic Acids Res. 2010 May;38(9):e106.
DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments.Pham TT, Giesert F, Röthig A, Floss T, Kallnik M, Weindl K, Hölter SM, Ahting U, Prokisch H, Becker L, Klopstock T, Hrabé de Angelis M, Beyer K, Görner K, Kahle PJ, Vogt Weisenhorn DM, Wurst W. Genes Brain Behav. 2010 Apr;9(3):305-17.
2009
González Carvajal, B., Mack, B., Conrad, M., and Gires, O. (2009) EpCAM is a marker of murine embryonic stem cells. Stem Cells 27, 1782-1791.
Schneider, M., Förster, H., Boersma, A., Seiler, A., Wehnes, H., Sinowatz F., Neumüller, C., Deutsch, M.J., Walch A., Hrabé de Angelis, M., Wurst, W., Ursini, F., Roveri, A., Maleszewski, M., Maiorino, M., and Conrad, M.* (2009) Mitochondrial glutathione peroxidase 4 disruption causes male infertility. FASEB J. 23, 3233-3242.
Conrad, M. (2009) Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4. Biochim. Biophys. Acta. 1790, 1575-1585.
Welzl, G., Hense, B. (2009). Statistische Bewertungsverfahren im biologischen Kontext. Teil III: Hauptkomponentenanlyse. DGL-Mitteilungen I: 67-81.
Jagasia R, Steib K, Englberger E, Herold S, Faus-Kessler T, Saxe M, Gage FH, Song H-J, Lie DC (2009). GABA-CREB signalling regulates survival and maturation of newborn neurons in the adult hippocampus. The Journal of Neuroscience 29:7966-7977
Obradovic D, Zanca C, Vogl A, Trümbach D, Deussing J, Condorelli G, Rein T. (2009) Vitamin D(3) signalling in the brain enhances the function of Phosphoprotein Enriched in Astrocytes - 15 KDa (PEA-15). J Cell Mol Med, 13 (9b), 3315 – 3328.
Wittmann DM, Blöchl F, Trümbach D, Wurst W, Prakash N, Theis FJ. (2009) Spatial analysis of expression patterns predicts genetic interactions at the mid-hindbrain boundary. PLoS Comput Biol. 5(11):e1000569.
Lutz, A. K., N. Exner, M. E. Fett, J. S. Schlehe, K. Kloos, K. Laemmermann, B. Brunner, A. Kurz-Drexler, F. Vogel, A. S. Reichert, L. Bouman, D. Vogt-Weisenhorn, W. Wurst, J. Tatzelt, C. Haass, and K. F. Winklhofer (2009), "Loss of parkin or PINK1 function increases DRP1-dependent mitochondrial fragmentation", J Biol Chem. 284 (34): 22938-51
Morais, V. A., P. Verstreken, A. Roethig, J. Smet, A. Snellinx, M. Vanbrabant, D. Haddad, C. Frezza, W. Mandemakers, D. Vogt-Weisenhorn, R. Van Coster, W. Wurst, L. Scorrano, and B. De Strooper (2009), "Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function", EMBO Mol Med 1 (2):99-111.
Prakash, N., Puelles, E., Freude, K., Trümbach, D., Omodei, D., Di Salvio, M., Sussel, L., Ericson, J., Sander, M., Simeone, A. and Wurst, W. (2009). Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development 136: 2545-2555.
Wurst, W. and Prakash, N. (2009). Genetic control of meso-diencephalic dopaminergic neuron development in rodents. In: Dopamine Handbook. Eds: Iversen, L. et al. Oxford University Press, Oxford, UK. pp. 141-159.
The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice. Carlson BA, Schweizer U, Perella C, Shrimali RK, Feigenbaum L, Shen L, Speransky S, Floss T, Jeong SJ, Watts J, Hoffmann V, Combs GF, Gladyshev VN, Hatfield DL.Biochem J. 2009 Feb 15;418(1):61-71.
Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import. Ahting U, Floss T, Uez N, Schneider-Lohmar I, Becker L, Kling E, Iuso A, Bender A, de Angelis MH, Gailus-Durner V, Fuchs H, Meitinger T, Wurst W, Prokisch H, Klopstock T.Biochim Biophys Acta. 2009 May;1787(5):371-6.
Periphilin is strongly expressed in the murine nervous system and is indispensable for murine development. Soehn AS, Pham TT, Schaeferhoff K, Floss T, Weisenhorn DM, Wurst W, Bonin M, Riess O.Genesis. 2009 Oct;47(10):697-707.
Katharine J Webb, William HJ Norton, Dietrich Trümbach, Annemarie H Meijer, Jovica Ninkovic, Stefanie Topp, Daniel Heck, Carsten Marr, Wolfgang Wurst, Fabian J Theis, Herman P Spaink and Laure Bally-Cuif (2009), Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine, Genome Biology 2009, 10:R81.
Claudia Liebl, Markus Panhuysen, Benno Pütz, Dietrich Trümbach, Wolfgang Wurst, Jan M. Deussing, Marianne B. Mueller and Mathias V. Schmidt (2009). "Gene expression profiling following maternal deprivation: Involvement of the brain renin-angiotensin system." Front Mol Neurosci.;2:1. Epub 2009 May 14.
Benedetto, B. D., B. Wefers, W. Wurst and R. Kuhn (2009). "Local Knockdown of ERK2 in the Adult Mouse Brain Via Adeno-Associated Virus-Mediated RNA Interference." Mol Biotechnol 41(3): 263-9.
Di Benedetto, B., M. Kallnik, D. M. Weisenhorn, W. A. Falls, W. Wurst and S. M. Holter (2009). "Activation of ERK/MAPK in the lateral amygdala of the mouse is required for acquisition of a fear-potentiated startle response." Neuropsychopharmacology 34(2): 356-66.
Feil, R., S. M. Hölter, K. Weindl, W. Wurst, S. Langmesser, A. Gerling, S. Feil and U. Albrecht (2009). "cGMP-dependent protein kinase I, the circadian clock, sleep and learning." Communicative & Integrative Biology 2(4): 1-4
Fuchs, H., V. Gailus-Durner, T. Adler, J. A. Pimentel, L. Becker, I. Bolle, M. Brielmeier, J. Calzada-Wack, C. Dalke, N. Ehrhardt, N. Fasnacht, B. Ferwagner, U. Frischmann, W. Hans, S. M. Holter, G. Holzlwimmer, M. Horsch, A. Javaheri, M. Kallnik, E. Kling, C. Lengger, H. Maier, I. Mossbrugger, C. Morth, B. Naton, U. Noth, B. Pasche, C. Prehn, G. Przemeck, O. Puk, I. Racz, B. Rathkolb, J. Rozman, K. Schable, R. Schreiner, A. Schrewe, C. Sina, R. Steinkamp, F. Thiele, M. Willershauser, R. Zeh, J. Adamski, D. H. Busch, J. Beckers, H. Behrendt, H. Daniel, I. Esposito, J. Favor, J. Graw, G. Heldmaier, H. Hofler, B. Ivandic, H. Katus, M. Klingenspor, T. Klopstock, A. Lengeling, M. Mempel, W. Muller, S. Neschen, M. Ollert, L. Quintanilla-Martinez, P. Rosenstiel, J. Schmidt, S. Schreiber, K. Schughart, H. Schulz, E. Wolf, W. Wurst, A. Zimmer and M. Hrabe de Angelis (2009). "The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models." Curr Pharm Biotechnol 10(2): 236-43.
Gailus-Durner, V., H. Fuchs, T. Adler, A. Aguilar Pimentel, L. Becker, I. Bolle, J. Calzada-Wack, C. Dalke, N. Ehrhardt, B. Ferwagner, W. Hans, S. M. Holter, G. Holzlwimmer, M. Horsch, A. Javaheri, M. Kallnik, E. Kling, C. Lengger, C. Morth, I. Mossbrugger, B. Naton, C. Prehn, O. Puk, B. Rathkolb, J. Rozman, A. Schrewe, F. Thiele, J. Adamski, B. Aigner, H. Behrendt, D. H. Busch, J. Favor, J. Graw, G. Heldmaier, B. Ivandic, H. Katus, M. Klingenspor, T. K. Elisabeth Kremmer, M. Ollert, L. Quintanilla-Martinez, H. Schulz, E. Wolf, W. Wurst and M. H. de Angelis (2009). "Systemic First-Line Phenotyping." Methods Mol Biol 530: 1-47.
Hitz, C., P. Steuber-Buchberger, S. Delic, W. Wurst and R. Kuhn (2009). "Generation of shRNA Transgenic Mice." Methods Mol Biol 530: 1-29.
Kala, K., M. Haugas, K. Lillevali, J. Guimera, W. Wurst, M. Salminen and J. Partanen (2009). "Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons."
Kamprath, K., W. Plendl, G. Marsicano, J. M. Deussing, W. Wurst, B. Lutz and C. T. Wotjak (2009). "Endocannabinoids mediate acute fear adaptation via glutamatergic neurons independently of corticotropin-releasing hormone signaling." Genes Brain Behav 8(2): 203-11.
Kuhn, R. and W. Wurst (2009). "Overview on mouse mutagenesis." Methods Mol Biol 530: 1-12.
Prinzen, C., D. Trümbach, W. Wurst, K. Endres, R. Postina and F. Fahrenholz (2009). "Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice." BMC Genomics 10: 66.
Silberstein, S., A. M. Vogl, J. J. Bonfiglio, W. Wurst, F. Holsboer, E. Arzt, J. M. Deussing and D. Refojo (2009). "Immunology, signal transduction, and behavior in hypothalamic-pituitary-adrenal axis-related genetic mouse models." Ann N Y Acad Sci 1153: 120-30.
Waak, J., S. S. Weber, A. Waldenmaier, K. Gorner, M. Alunni-Fabbroni, H. Schell, D. Vogt-Weisenhorn, T. T. Pham, V. Reumers, V. Baekelandt, W. Wurst and P. J. Kahle (2009). "Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1." FASEB
2008
Ahting, U., T. Floss, N. Uez, I. Schneider-Lohmar, L. Becker, E. Kling, A. Iuso, A. Bender, M. H. de Angelis, V. Gailus-Durner, H. Fuchs, T. Meitinger, W. Wurst, H. Prokisch and T. Klopstock (2008). "Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import." Biochim Biophys Acta.
Andersson, E. R., N. Prakash, L. Cajanek, E. Minina, V. Bryja, L. Bryjova, T. P. Yamaguchi, A. C. Hall, W. Wurst and E. Arenas (2008). "Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo." PLoS ONE 3(10): e3517
Bender, A., J. Beckers, I. Schneider, S. M. Holter, T. Haack, T. Ruthsatz, D. M. Vogt-Weisenhorn, L. Becker, J. Genius, D. Rujescu, M. Irmler, T. Mijalski, M. Mader, L. Quintanilla-Martinez, H. Fuchs, V. Gailus-Durner, M. H. de Angelis, W. Wurst, J. Schmidt and T. Klopstock (2008). "Creatine improves health and survival of mice." Neurobiol Aging 29(9): 1404-11.
Bohm, J., A. Buck, W. Borozdin, A. U. Mannan, U. Matysiak-Scholze, I. Adham, W. Schulz-Schaeffer, T. Floss, W. Wurst, J. Kohlhase and F. Barrionuevo (2008). "Sall1, sall2, and sall4 are required for neural tube closure in mice." Am J Pathol 173(5): 1455-63.
Carlson, B. A., U. Schweizer, C. Perella, R. K. Shrimali, L. Feigenbaum, L. Shen, S. Speransky, T. Floss, S. J. Jeong, J. Watts, V. Hoffmann, G. F. Combs Jr, V. N. Gladyshev and D. L. Hatfield (2008). "The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice." Biochem J.
Chu, Y., N. Senghaas, R. W. Koster, W. Wurst and R. Kuhn (2008). "Novel caspase-suicide proteins for tamoxifen-inducible apoptosis." Genesis 46(10): 530-6.
Delic, S., S. Streif, J. M. Deussing, P. Weber, M. Ueffing, S. M. Holter, W. Wurst and R. Kuhn (2008). "Genetic Mouse Models for Behavioral Analysis through Transgenic RNAi Technology." Genes Brain Behav.
Floss, T. and F. Schnutgen (2008). "Conditional gene trapping using the FLEx system." Methods Mol Biol 435: 127-38.
Ganguly, K., J. Favor, A. Neuhauser-Klaus, R. Sandulache, O. Puk, J. Beckers, M. Horsch, S. Schadler, D. Vogt Weisenhorn, W. Wurst and J. Graw (2008). "Novel allele of crybb2 in the mouse and its expression in the brain." Invest Ophthalmol Vis Sci 49(4): 1533-41.
Hanstein, R., A. Lu, W. Wurst, F. Holsboer, J. M. Deussing, A. B. Clement and C. Behl (2008). "Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress." Neuroscience 156(3): 712-21.
Hoelter, S. M., C. Dalke, M. Kallnik, L. Becker, M. Horsch, A. Schrewe, J. Favor, T. Klopstock, J. Beckers, B. Ivandic, V. Gailus-Durner, H. Fuchs, M. Hrabe de Angelis, J. Graw and W. Wurst (2008). ""Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?" Front Biosci 13: 5810-23.
Klafke, R., W. Wurst and N. Prakash (2008). "Genetic control of rodent midbrain dopaminergic neuron development in the light of human disease." Pharmacopsychiatry 41 Suppl 1: S44-50.
Kronsbein, H. C., A. M. Jastorff, G. Maccarrone, G. Stalla, W. Wurst, F. Holsboer, C. W. Turck and J. M. Deussing (2008). "CRHR1-dependent effects on protein expression and posttranslational modification in AtT-20 cells." Mol Cell Endocrinol 292(1-2): 1-10.
Lu, A., M. A. Steiner, N. Whittle, A. M. Vogl, S. M. Walser, M. Ableitner, D. Refojo, M. Ekker, J. L. Rubenstein, G. K. Stalla, N. Singewald, F. Holsboer, C. T. Wotjak, W. Wurst and J. M. Deussing (2008). "Conditional CRH overexpressing mice: an animal model for stress-elicited pathologies and treatments that target the central CRH system." Mol Psychiatry 13(11): 989.
Lu, A., M. A. Steiner, N. Whittle, A. M. Vogl, S. M. Walser, M. Ableitner, D. Refojo, M. Ekker, J. L. Rubenstein, G. K. Stalla, N. Singewald, F. Holsboer, C. T. Wotjak, W. Wurst and J. M. Deussing (2008). "Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior." Mol Psychiatry 13(11): 1028-42.
Mandillo, S., V. Tucci, S. M. Holter, H. Meziane, M. A. Banchaabouchi, M. Kallnik, H. V. Lad, P. M. Nolan, A. M. Ouagazzal, E. L. Coghill, K. Gale, E. Golini, S. Jacquot, W. Krezel, A. Parker, F. Riet, I. Schneider, D. Marazziti, J. Auwerx, S. D. Brown, P. Chambon, N. Rosenthal, G. Tocchini-Valentini and W. Wurst (2008). "Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study." Physiol Genomics 34(3): 243-55.
Omodei, D., D. Acampora, P. Mancuso, N. Prakash, L. G. Di Giovannantonio, W. Wurst and A. Simeone (2008). "Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon." Development 135(20): 3459-70.
Risbrough, V. B., M. A. Geyer, R. L. Hauger, S. Coste, M. Stenzel-Poore, W. Wurst and F. Holsboer (2008). "CRF(1) and CRF(2) Receptors are Required for Potentiated Startle to Contextual but not Discrete Cues." Neuropsychopharmacology.
Schmidt, S., V. Gawlik, S. M. Holter, R. Augustin, A. Scheepers, M. Behrens, W. Wurst, V. Gailus-Durner, H. Fuchs, M. Hrabe de Angelis, R. Kluge, H. G. Joost and A. Schurmann (2008). "Deletion of glucose transporter GLUT8 in mice increases locomotor activity." Behav Genet 38(4): 396-406.
Schnutgen, F., J. Hansen, S. De-Zolt, C. Horn, M. Lutz, T. Floss, W. Wurst, P. R. Noppinger and H. von Melchner (2008). "Enhanced gene trapping in mouse embryonic stem cells." Nucleic Acids Res 36(20): e133.
Seiler, A., M. Schneider, H. Forster, S. Roth, E. K. Wirth, C. Culmsee, N. Plesnila, E. Kremmer, O. Radmark, W. Wurst, G. W. Bornkamm, U. Schweizer and M. Conrad (2008). "Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death." Cell Metab 8(3): 237-48.
Soker, T., C. Dalke, O. Puk, T. Floss, L. Becker, I. Bolle, J. Favor, W. Hans, S. M. Hoelter, M. Horsch, M. Kallnik, E. Kling, C. Morth, A. Schrewe, C. Stigloher, S. Topp, V. Gailus-Durner, B. Naton, J. Beckers, H. Fuchs, B. Ivandic, T. Klopstock, H. Schulz, E. Wolf, W. Wurst, L. Bally-Cuif, M. Hrabe de Angelis and J. Graw (2008). "Pleiotropic effects in Eya3 knockout mice." BMC Dev Biol 8(1): 118.
Steuber-Buchberger, P., W. Wurst and R. Kuhn (2008). "Simultaneous Cre-mediated conditional knockdown of two genes in mice." Genesis 46(3): 144-51.
Tripathi, P. P., L. G. Di Giovannantonio, A. Viegi, W. Wurst, A. Simeone and Y. Bozzi (2008). "Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice." J Neurosci 28(37): 9271-6.
Tsolakidou, A., D. Trümbach, M. Panhuysen, B. Putz, J. Deussing, W. Wurst, I. Sillaber, F. Holsboer and T. Rein (2008). "Acute stress regulation of neuroplasticity genes in mouse hippocampus CA3 area--possible novel signalling pathways." Mol Cell Neurosci 38(3): 444-52.
Uez, N., H. Lickert, J. Kohlhase, M. H. de Angelis, R. Kuhn, W. Wurst and T. Floss (2008). "Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo." Genesis 46(9): 463-77.
2007
Conrad, M.*, Schneider, M., Seiler, A., and Bornkamm G.W. (2007) The physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals. Biol. Chem. 388, 1019-1025.
Geisberger, R., Kiermayer, C., Homig, C., Conrad, M., Schmidt, J., Zimber-Strobl, U., and Brielmeier, M. (2007) Conditional knockout of thioredoxin reductase 2 in CD4- and CD19 Cre mice does not impair B and T helper cell development and function. Biol. Chem. 388, 1083-1090.
Bentz K, Molcanyi M, Riess P, Elbers A, Pohl E, Sachinidis A, Hescheler J, Neugebauer E and Schafer U. 2007.
Embryonic Stem Cells Produce Neurotrophins in Response to Cerebral Tissue Extract: Cell Line-Dependent Differences
J Neurosci Res. 85, 5:1057-64
Blak AA, Naserke T, Saarimaki-Vire J, Peltopuro P, Giraldo-Velasquez M, Vogt Weisenhorn DM, Prakash N, Sendtner M, Partanen J and Wurst W. (2007)
Fgfr2 and Fgfr3 Are Not Required for Patterning and Maintenance of the Midbrain and Anterior Hindbrain.
Dev Biol. 303, 231-243.
Collins FS, Finnell RH, Rossant J and Wurst W. 2007.
A New Partner for the International Knockout Mouse Consortium.
Cell. 129, 2:235
Collins FS, Rossant J and Wurst W. (2007)
A Mouse for All Reasons.
Cell. 128, 1:9-13
Deussing JM, Kuhne C, Putz B, Panhuysen M, Breu J, Stenzel-Poore MP, Holsboer F and Wurst W. 2007.
Expression Profiling Identifies the Crh/Crh-R1 System as a Modulator of Neurovascular Gene Activity.
J Cereb Blood Flow Metab. 27, 8:1476-95
Deussing JM and Wurst W. 2007.
Amygdala and Neocortex: Common Origins and Shared Mechanisms.
Nat Neurosci. 10, 9:1081-1082
Di Benedetto B, Hitz C, Holter SM, Kuhn R, Vogt Weisenhorn DM and Wurst W. (2007)
Differential Mrna Distribution of Components of the Erk/Mapk Signalling Cascade in the Adult Mouse Brain.
J Comp Neurol. 500, 3:542-56
Fischer T., Guimera J., Wurst W., Prakash N. (2007).
Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.
Neuroscience 147(3):693-711.
Floss T. and Schütgen F. (2007).
Conditional Gene Trapping Using the FLEx System.
Methods in Molecular Biology 2007.
Friedel RH, Seisenberger C, Kaloff C and Wurst W. 2007. Eucomm the European Conditional Mouse Mutagenesis Program. Brief Funct Genomic Proteomic. 6, 3:180-5
Gorner K, Holtorf E, Waak J, Pham TT, Vogt-Weisenhorn DM, Wurst W, Haass C and Kahle PJ. 2007.
Structural Determinants of the C-Terminal Helix-Kink-Helix Motif Essential for Protein Stability and Survival Promoting Activity of Dj-1.
J Biol Chem. 282, 18:13680-91
Hitz C, Wurst W and Kuhn R. 2007.
Conditional Brain-Specific Knockdown of Mapk Using Cre/Loxp Regulated Rna Interference.
Nucleic Acids Res. 35, 12:e90
Horn C., Hansen J., Schnutgen F., Seisenberger C., Floss T., Irgang M., De-Zolt S., Wurst W., von Melchner H., Noppinger (2007).
Splinkerette PCR for more efficient characterization of gene trap events.
Nat Genet. 2007 Aug;39(8):933-4.
Kallnik M, Elvert R, Ehrhardt N, Kissling D, Mahabir E, Welzl G, Faus-Kessler T, Hrabe de Angelis M, Wurst W, Schmidt J, Hölter SM. (2007)
Impact of IVC housing on emotionality and fear learning in male C3HeB/FeJ and C57BL/6J mice.
Mamm Genome 18(3):173-186
Konstantinova I, Nikolova G, Ohara-Imaizumi M, Meda P, Kucera T, Zarbalis K, Wurst W, Nagamatsu S and Lammert E. 2007.
Epha-Ephrin-a-Mediated Beta Cell Communication Regulates Insulin Secretion from Pancreatic Islets.
Cell. 129, 2:359-70
Kühn R. and Wurst W. (2007)
Genetisch Veränderte Tiere.
In Handbuch Der Psychopharmakotherapie, F. Holsboer, G. Gründer and O. Benkert, (eds.).
Berlin: Springer.
Kühn R, Streif S and Wurst W. (2007)
Rna Interference in Mice.
Handb Exp Pharmacol. 178:149-76
Molcanyi M, Riess P, Bentz K, Maegele M, Hescheler J, Schafke B, Trapp T, Neugebauer E, Klug N and Schafer U. 2007.
Trauma-Associated Inflammatory Response Impairs Embryonic Stem Cell Survival and Integration after Implantation into Injured Rat Brain.
J Neurotrauma. 24, 4:625-37
Prakash N., Wurst W. (2007).
A Wnt signal regulates stem cell fate and differentiation in vivo.
Neurodegener. Dis. 4(4):333-338.
Riess P, Molcanyi M, Bentz K, Maegele M, Simanski C, Carlitscheck C, Schneider A, Hescheler J, Bouillon B, Schafer U and Neugebauer E. (2007)
Embryonic Stem Cell Transplantation after Experimental Traumatic Brain Injury Dramatically Improves Neurological Outcome, but May Cause Tumors.
J Neurotrauma. 24, 1:216-25
Saarimäki-Vire J., Peltopuro P., Lahti L., Naserke T., Blak A. A., Vogt Weisenhorn D. M., Yu K., Ornitz D. M., Wurst W., Partanen J. (2007).
Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain.
J Neurosci. 27(32):8581-8592.
Schierloh A, Deussing J, Wurst W, Zieglgansberger W and Rammes G. 2007
Corticotropin-Releasing Factor (Crf) Receptor Type 1-Dependent Modulation of Synaptic Plasticity.
Neurosci Lett. 416, 1:82-6
Schmidt MV, Oitzl M, Steenbergen P, Lachize S, Wurst W, Muller MB, de Kloet ER and Meijer OC. 2007.
Ontogeny of Steroid Receptor Coactivators in the Hippocampus and Their Role in Regulating Postnatal Hpa Axis Function.
Brain Res. 1174:1-6
Tiedemann HB, Schneltzer E, Zeiser S, Rubio-Aliaga I, Wurst W, Beckers J, Przemeck GK and Hrabe de Angelis M. 2007.
Cell-Based Simulation of Dynamic Expression Patterns in the Presomitic Mesoderm.
J Theor Biol. 248, 1:120-9
Trivedi C.M., Luo Y., Yin Z., Zhang M., Zhu W., Wang T., Floss T., Goettlicher M., Noppinger P.R., Wurst W., Ferrari V.A., Abrams C.S., Gruber PJ., Epstein J.A. (2007).
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.
Nat Med. 2007 Mar;13(3):324-31.
Vauti F, Goller T, Beine R, Becker L, Klopstock T, Holter SM, Wurst W, Fuchs H, Gailus-Durner V, de Angelis MH and Arnold HH. 2007. The Mouse Trm1-Like Gene Is Expressed in Neural Tissues and Plays a Role in Motor Coordination and Exploratory Behaviour. Gene. 389, 2:174-85
Zhao Y, Kwan KM, Mailloux CM, Lee WK, Grinberg A, Wurst W, Behringer RR and Westphal H. 2007.
Lim-Homeodomain Proteins Lhx1 and Lhx5, and Their Cofactor Ldb1, Control Purkinje Cell Differentiation in the Developing Cerebellum.
Proc Natl Acad Sci U S A. 104, 32:13182-6
Zimmermann S., Kiefer F., Prudenziati M., Spiller C., Hansen J., Floss T., Wurst W., Minucci S., Gottlicher M. (2007).
Reduced Body Size and Decreased Intestinal Tumor Rates in HDAC2-Mutant Mice.
Cancer Res. 2007 Oct 1;67(19):9047-54.
2006
Conrad, M.*, Brielmeier, M., and Bornkamm, G. W. (2006) Mitochondrial and Cytosolic Thioredoxin Reductase Knockout Mice. Selenium : Its Molecular Biology and Role in Human Health, Second Edition D.L. Hatfield, M. J. Berry, V.N. Gladyshev, ed, Springer, New York.
Kiermayer, C., Conrad, M., Schneider, M., Schmidt, J., and Brielmeier, M. (2006) Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate. Genesis 45, 11-16.
Schneider, M., Vogt-Weissenhorn, D., Bornkamm, G. W., Brielmeier, M., Conrad, M.* (2006) Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidase. Gene Expr. Patterns 6, 489-494.
Barrantes Idel B, Montero-Pedrazuela A, Guadano-Ferraz A, Obregon MJ, Martinez de Mena R, Gailus-Durner V, Fuchs H, Franz TJ, Kalaydjiev S, Klempt M, Holter S, Rathkolb B, Reinhard C, Morreale de Escobar G, Bernal J, Busch DH, Wurst W, Wolf E, Schulz H, Shtrom S, Greiner E, Hrabe de Angelis M, Westphal H and Niehrs C. (2006)
Generation and Characterization of Dickkopf3 Mutant Mice.
Mol Cell Biol. 26, 6:2317-26
Beekman C, Nichane M, De Clercq S, Maetens M, Floss T, Wurst W, Bellefroid E and Marine JC. (2006)
Evolutionarily Conserved Role of Nucleostemin: Controlling Proliferation of Stem/Progenitor Cells During Early Vertebrate Development.
Mol Cell Biol. 26, 24:9291-301
Bentz K, Molcanyi M, Hess S, Schneider A, Hescheler J, Neugebauer E and Schaefer U. (2006)
Neural Differentiation of Embryonic Stem Cells Is Induced by Signalling from Non-Neural Niche Cells.
Cell Physiol Biochem. 18, 4-5:275-86
Borgkvist A, Puelles E, Carta M, Acampora D, Ang SL, Wurst W, Goiny M, Fisone G, Simeone A and Usiello A. (2006)
Altered Dopaminergic Innervation and Amphetamine Response in Adult Otx2 Conditional Mutant Mice.
Mol Cell Neurosci. 31, 2:293-302
De-Zolt S, Schnutgen F, Seisenberger C, Hansen J, Hollatz M, Floss T, Ruiz P, Wurst W and von Melchner H. (2006)
High-Throughput Trapping of Secretory Pathway Genes in Mouse Embryonic Stem Cells.
Nucleic Acids Res. 34, 3:e25
Galy B, Holter SM, Klopstock T, Ferring D, Becker L, Kaden S, Wurst W, Grone HJ and Hentze MW. (2006)
Iron Homeostasis in the Brain: Complete Iron Regulatory Protein 2 Deficiency without Symptomatic Neurodegeneration in the Mouse.
Nat Genet. 38, 9:967-9
Grad I, McKee TA, Ludwig SM, Hoyle GW, Ruiz P, Wurst W, Floss T, Miller CA, 3rd and Picard D. (2006)
The Hsp90 Cochaperone P23 Is Essential for Perinatal Survival.
Mol Cell Biol. 26, 23:8976-83
Guimera J, Vogt Weisenhorn D, Echevarria D, Martinez S and Wurst W. (2006b)
Molecular Characterization, Structure and Developmental Expression of Megane Bhlh Factor.
Gene. 377:65-76
Guimera J, Weisenhorn DV and Wurst W. (2006a)
Megane/Heslike Is Required for Normal Gabaergic Differentiation in the Mouse Superior Colliculus.
Development. 133, 19:3847-57
Hansen, J. (2006) Wissenschaftliche Datenbanken in der Genomforschung. BIOspektrum 12 (4), 387-389.
Jukkola T, Lahti L, Naserke T, Wurst W and Partanen J. (2006)
Fgf Regulated Gene-Expression and Neuronal Differentiation in the Developing Midbrain-Hindbrain Region.
Dev Biol. 297, 1:141-57
Mori T, Tanaka K, Buffo A, Wurst W, Kuhn R and Gotz M (2006)
Inducible Gene Deletion in Astroglia and Radial Glia - a Valuable Tool for Functional and Lineage Analysis.
Glia. 54, 1:21-34
Nguyen NK, Keck ME, Hetzenauer A, Thoeringer CK, Wurst W, Deussing JM, Holsboer F, Muller MB and Singewald N. (2006)
Conditional Crf Receptor 1 Knockout Mice Show Altered Neuronal Activation Pattern to Mild Anxiogenic Challenge.
Psychopharmacology (Berl). 188, 3:374-85
Nord, A.S., Chang, P.J., Conklin, B.R., Cox, A.V., Harper, C.A., Hicks, G.G., Huang, C.C., Johns, S.J., Kawamoto, M., Liu, S., Meng, E.C., Morris, J.H., Rossant, J., Ruiz, P., Skarnes, W.C., Soriano, P., Stanford, W.L., Stryke, D., von Melchner, H., Wurst, W., Yamamura, K., Young, S.G., Babbitt, P.C., and Ferrin, T.E. (2006)
The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse.
Nucleic Acids Res. 34 (Database issue), D 642-648.
Plath N, Ohana O, Dammermann B, Errington ML, Schmitz D, Gross C, Mao X, Engelsberg A, Mahlke C, Welzl H, Kobalz U, Stawrakakis A, Fernandez E, Waltereit R, Bick-Sander A, Therstappen E, Cooke SF, Blanquet V, Wurst W, Salmen B, Bosl MR, Lipp HP, Grant SG, Bliss TV, Wolfer DP and Kuhl D. (2006)
Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories.
Neuron. 52, 3:437-44
Poet M, Kornak U, Schweizer M, Zdebik AA, Scheel O, Hoelter S, Wurst W, Schmitt A, Fuhrmann JC, Planells-Cases R, Mole SE, Hubner CA and Jentsch TJ. (2006)
Lysosomal Storage Disease Upon Disruption of the Neuronal Chloride Transport Protein Clc-6.
Proc Natl Acad Sci U S A. 103, 37:13854-9
Prakash, N., Brodski, C., Naserke, T., Puelles, E., Gogoi, R., Hall, A., Panhuysen, M., Echevarria, D., Sussel, L., Vogt Weisenhorn, D.M., Martínez, S., Arenas, E., Simeone, A. and Wurst W. (2006)
A Wnt1-regulated genetic network controls the identity and fate of midbrain dopaminergic progenitors in vivo.
Development133, 89-98.
Prakash, N., Wurst, W. (2006a)
Genetic Networks Controlling the Development of Midbrain Dopaminergic Neurons.
J Physiol. 575, Pt 2:403-10
Prakash, N., Wurst, W. (2006b)
Development of dopaminergic neurons in the mammalian brain.
Cell. Mol. Life Sci. 63, 187-206.
Schmidt MV, Deussing JM, Oitzl MS, Ohl F, Levine S, Wurst W, Holsboer F, Muller MB and de Kloet ER. (2006)
Differential Disinhibition of the Neonatal Hypothalamic- Pituitary-Adrenal Axis in Brain-Specific Crh Receptor 1-Knockout Mice.
Eur J Neurosci. 24, 8:2291-8
Schneider M, Vogt Weisenhorn DM, Seiler A, Bornkamm GW, Brielmeier M and Conrad M. (2006)
Embryonic Expression Profile of Phospholipid Hydroperoxide Glutathione Peroxidase.
Gene Expr Patterns. 6, 5:489-94
2005
Chapman R. D., Conrad, M., Eick D. (2005) Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferation. Mol. Cell. Biol. 25, 7665-7674.
Conrad, M.*, Moreno, S. G., Sinowatz, F.,Ursini, F., Kölle, S., Roveri, A., Brielmeier, M., Wurst, W., Maiorino, M., and Bornkamm, G. W. (2005) The nuclear form of PHGPx is a protein thiol peroxidase contributing to sperm chromatin stability. Mol. Cell. Biol. 25, 7637-7644.
Jakupoglu, C., Przemeck, G. K. H., Schneider, M., Moreno, S. G., Mayr, N., Hatzopoulos, A. K., Hrabé de Angelis, M., Wurst, W., Bornkamm, G. W., Brielmeier, M., and Conrad, M.* (2005) Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development. Mol. Cell. Biol. 25, 1980-1988.
Blak, A.A., Naserke, T., Vogt-Weisenhorn, D.M., Prakash, N., Partanen, J., and Wurst, W. (2005)
Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse.
Dev. Dyn. 233, 1023-1030.
Borgkvist A, Puelles E, Carta M, Acampora D, Ang SL, Wurst W, Goiny M, Fisone G, Simeone A and Usiello A. (2005)
Altered Dopaminergic Innervation and Amphetamine Response in Adult Otx2 Conditional Mutant Mice.
Mol Cell Neurosci.
Brown, S.D., Chambon, P., de Angelis, M.H., Eumorphia Consortium (including Wurst, W., Hölter, S.M., Kallnik, M. and Vogt Weisenhorn, D.) (2005)
EMPReSS: standardized phenotype screens for functional annotation of the mouse genome.
Nat. Genet. 37, 1155.
Conrad, M., Moreno, S.G., Sinowatz, F., Ursini, F., Kolle, S., Roveri, A., Brielmeier, M., Wurst, W., Maiorino, M., and Bornkamm, G.W. (2005)
The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability.
Mol. Cell. Biol. 25, 7637-7644.
Deussing, J.M., and Wurst, W. (2005)
Dissecting the genetic effect of the CRH system on anxiety and stress-related behaviour.
C. R. Biol. 328, 199-212.
Gailus-Durner, V., Fuchs, H., Becker, L., Bolle, I., Brielmeier, M., Calzada-Wack, J., Elvert, R., Ehrhardt, N., Dalke, C., Franz, T.J., Grundner-Culemann, E., Hammelbacher, S., Hölter, S.M., Holzlwimmer, G., Horsch, M.,Javaheri, A., Kalaydjiev, S.V., Klempt, M., Kling, E., Kunder, S., Lengger, C., Lisse, T., Mijalski, T., Naton, B., Pedersen, V., Prehn, C., Przemeck, G., Racz, I., Reinhard, C., Reitmeir, P., Schneider, I., Schrewe, A., Steinkamp,R., Zybill, C., Adamski, J., Beckers, J., Behrendt, H., Favor, J., Graw, J., Heldmaier, G., Hofler, H., Ivandic, B., Katus, H., Kirchhof, P., Klingenspor, M., Klopstock, T., Lengeling, A., Müller, W., Ohl, F., Ollert, M., Quintanilla-Martinez, L., Schmidt, J., Schulz, H., Wolf, E., Wurst, W., Zimmer, A., Busch, D.H., and de Angelis, M.H. (2005)
Introducing the German Mouse Clinic: open access platform for standardized phenotyping.
Nat. Methods 2, 403-404.
Hitz C., Vogt-Weisenhorn, D.V., Ruiz P., Wurst W. and Floss T. (2005):
Progressive Loss of the Spongiotrophoblast Layer of Birc6/Bruce Mutants Results in Embryonic Lethality.
Genesis 42:91-103.
Hölter, SM, Kallnik, M, Wurst, W, Marsicano, G, Lutz, B, and Wotjak, CT (2005)
Cannabinoid CB1 receptor is dispensable for memory extinction in an appetitively-motivated learning task.
Eur. J. Pharmacol. 510, 69-74.
Jakupoglu, C., Przemeck, G.K., Schneider, M., Moreno, S.G., Mayr, N., Hatzopoulos, A.K., de Angelis, M.H., Wurst, W., Bornkamm, G.W., Brielmeier, M., and Conrad, M. (2005)
Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development.
Mol. Cell. Biol. 25, 1980-1988.
Kühn R and Wurst W. (2005)
Mouse Mutagenesis and Gene Function.
In Encyclopedia of Genomics, Proteomics and Bioinformatics, Michael J. Dunn, Lynn B. Jorde, Peter F. R. Little and S. Subramaniam, (eds.). Chichester: John Wiley and Sons Ltd.
Refojo, D., Echenique, C., Müller, M.B., Reul, J.M., Deussing, J.M., Wurst, W., Sillaber, I., Paez-Pereda, M., Holsboer, F., and Arzt, E. (2005)
Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas.
Proc. Natl. Acad. Sci. USA 102, 6183-6188.
Santti, H., Mikkonen, L., Anand, A., Hirvonen-Santti, S., Toppari, J., Panhuysen, M., Vauti, F., Perera, M., Corte, G., Wurst, W.,Jänne, O.A., and Palvimo, J.J. (2005)
Disruption of the murine PIASx gene results in reduced testis weight.
J. Mol. Endocrinol. 34, 645-654.
Schnütgen, F., De-Zolt, S., Van Sloun, P., Hollatz, M., Floss, T., Hansen, J., Altschmied, J., Seisenberger, C., Ghyselinck, N.B., Ruiz, P., Chambon, P., Wurst, W., and von Melchner, H, (2005)
Genomewide production of multipurpose alleles for the functional analysis of the mouse genome.
Proc. Natl. Acad. Sci. USA 102, 7221-7226.
Trokovic, R., Jukkola, T., Saarimaki, J., Peltopuro, P., Naserke, T., Vogt Weisenhorn, D.M., Trokovic, N., Wurst, W., and Partanen, J. (2005)
Fgfr1-dependent boundary cells between developing mid- and hindbrain.
Dev. Biol. 278, 428-439.
Wurst, W. (2005)
Mouse geneticists need European strategy too.
Nature 433, 13.
2004
Conrad, M.* §, Jakupoglu, C.§, Moreno, S. G., Lippl, S., Banjac, A., Schneider, M., Beck, H., Hatzopoulos, A. K., Just, U., Sinowatz, F., et al. (2004) Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol. Cell. Biol. 24, 9414-9423.
Andræ J, Afink GB, Zhang X-Q, Wurst W and Nistér M. (2004)
Forced expression of platelet-derived growth factor B in the mouse cerebellar primordium changes cell migration during midline fusion and causes cerebellar ectopia.
Mol. Cell. Neurosci. 26:308-321.
Austin, C.P., Battey, J.F., Bradley, A., Bucan, M., Capecchi, M., Collins, F.S., Dove, W.F., Duyk, G., Dymecki, S., Eppig, J.T., Grieder, F.B., Heintz, N., Hicks, G., Insel, T.R., Joyner, A., Koller, B.H., Lloyd, K.C., Magnuson, T., Moore, M.W., Nagy, A., Pollock, J.D., Roses, A.D., Sands, A.T., Seed, B., Skarnes, W.C., Snoddy, J., Soriano, P., Stewart, D.J., Stewart, F., Stillman, B., Varmus, H., Varticovski, L., Verma, I.M., Vogt, T.F., von Melchner, H., Witkowski, J., Woychik, R.P., Wurst, W., Yancopoulos, G.D., Young, S.G., and Zambrowicz, B. (2004).
The knockout mouse project.
Nat. Genet. 36, 921-924.
Auwerx, J., Avner, P., Baldock, R., Ballabio, A., Balling, R., Barbacid, M., Berns, A., Bradley, A., Brown, S., Carmeliet, P., Chambon, P., Cox, R., Davidson, D., Davies, K., Duboule, D., Forejt, J., Granucci, F., Hastie, N., de Angelis, M.H., Jackson, I., Kioussis, D., Kollias, G., Lathrop, M., Lendahl, U., Malumbres, M., von Melchner, H., Müller, W., Partanen, J., Ricciardi-Castagnoli, P., Rigby, P., Rosen, B., Rosenthal, N., Skarnes, B., Stewart, A.F., Thornton, J., Tocchini-Valentini, G., Wagner, E., Wahli, W., and Wurst, W. (2004).
The European dimension for the mouse genome mutagenesis program.
Nat. Genet. 36, 925-927 (Corrigendum (2004) Nat. Genet. 36, 1238).
Bolz J, Uziel D, Muhlfriedel S, Gullmar A, Peuckert C, Zarbalis K, Wurst W, Torii M and Levitt P. (2004)
Multiple roles of ephrins during the formation of thalamocortical projections: maps and more.
J. Neurobiol. 59:82-94.
Chen Y, Bender RA, Brunson KL, Pomper JK, Grigoriadis DE, Wurst W, Baram TZ. (2004)
Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus.
Proc Natl Acad Sci U S A. 101(44):15782-7.
Conrad M, Jakupoglu C, Moreno SG, Lippl S, Banjac A, Schneider M, Beck H, Hatzopoulos AK, Just U, Sinowatz F, Schmahl W, Chien KR, Wurst W, Bornkamm GW, Brielmeier M (2004)
Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function.
Mol Cell Biol. 24(21):9414-23.
Ihalmo P, Rinta-Valkama J, Mai P, Astrom E, Palmen T, Pham TT, Floss T, Holthofer H. (2004)
Molecular cloning and characterization of an endogenous antisense transcript of Nphs1.
Genomics. 2004 Jun;83(6):1134-40.
Istvanffy R, Vogt Weisenhorn DM, Floss T, Wurst W. (2004)
Expression of neurochondrin in the developing and adult mouse brain.
Dev Genes Evol. 2004 Apr;214(4):206-9.
Koli, K., Wempe, F., Sterner-Kock, A., Kantola, A., Komor, M., Hofmann, W. K., von Melchner, H., and Keski-Oja, J. (2004).
Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung.
J Cell Biol 167, 123-133.
Luckow B, Joergensen J, Chilla S, Li JP, Henger A, Kiss E, Wieczorek G, Roth L, Hartmann N, Hoffmann R, Kretzler M, Nelson PJ, Perez de Lema G, Maier H, Wurst W, Balling R, Pfeffer K, Grone HJ, Schlondorff D, Zerwes HG. (2004)
Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice.
Eur J Immunol. 34(9):2568-78.
Martinat C, Shendelman S, Jonason A, Leete T, Beal MF, Yang L, Floss T, Abeliovich A. (2004)
Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary parkinsonism.
PLoS Biol. 2004 Nov;2(11):e327.
Ming Kwan K, Li AG, Wang X-J, Wurst W and Behringer RR. (2004)
Essential roles of BMPR-IA signaling in differentiation and growth of hair follicles and in skin tumorigenesis.
Genesis 39:10-25.
Müller MB, Wurst W. (2004)
Getting closer to affective disorders: the role of CRH receptor systems.
Trends Mol Med. 10(8):409-15.
Panhuysen M, Vogt-Weisenhorn DM, Blanquet V, Brodski C, Heinzmann U, Beisker W and Wurst W. (2004)
Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region.
Mol. Cell. Neurosci. 26:101-111.
Prakash N, Wurst W. (2004)
Specification of midbrain territory.
Cell Tissue Res. 318(1):5-14.
Puelles E, Annino A, Tuorto F, Usiello A, Acampora D, Czerny T, Brodski C, Ang S-L, Wurst W and Simeone A. (2004)
Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain.
Development 131:2037-2048.
Rubio-Aliaga I, Boll M, Vogt-Weisenhorn DM, Foltz M, Kottra G, Daniel H (2004)
The proton/amino acid cotransporter PAT2 is expressed in neurons with a different subcellular localization than its paralog PAT1.
J. Biol. Chem. 279, 2754-2760.
Skarnes WC, von Melchner H, Wurst W, Hicks G, Nord AS, Cox T, Young SG, Ruiz P, Soriano P, Tessier-Lavigne M, Conklin BR, Stanford WL, Rossant J (2004)
A public gene trap resource for mouse functional genomics.
Nat Genet. 2004 Jun;36(6):543-4.
2003
Moreno, S. G., Laux, G., Brielmeier, M., Bornkamm, G. W., and Conrad, M.* (2003) Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx). Biol. Chem. 384, 635-643.
Conrad, M.*, Brielmeier, M., Wurst, W., and Bornkamm, G. W. (2003) Optimized vector for conditional gene targeting in mouse embryonic stem cells. Biotechniques 34, 1136-1138, 1140.
Brodski C, Weisenhorn DM, Signore M, Sillaber I, Oesterheld M, Broccoli V, Acampora D, Simeone A, Wurst W. (2003)
Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer.
J Neurosci. 2003 May 15;23(10):4199-207.
Chi CL, Martinez S, Wurst W, Martin GR. (2003)
The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum.
Development. 2003 Jun;130(12):2633-44
Conrad M, Brielmeier M, Wurst W and Bornkamm GW. 2003.
Optimized Vector for Conditional Gene Targeting in Mouse Embryonic Stem Cells.
Biotechniques. 34, 6:1136-8, 1140
Corradi, A., Croci, L., Broccoli, V., Zecchini, S., Previtali, S., Wurst, W., Amadio, S., Maggi, R., Quattrini, A., Consalez, GG. (2003)
Hypogonadotropic hypogonadism and peripheral neuropathy in Ebf2-null mice.
Development 130, 401-410
Hansen J, Floss T, Van Sloun P, Fuchtbauer EM, Vauti F, Arnold HH, Schnutgen F, Wurst W, von Melchner H, Ruiz P. (2003)
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22. Epub 2003 Aug 06
Louvi A, Alexandre P, Metin C, Wurst W, Wassef M.(2003)
The isthmic neuroepithelium is essential for cerebellar midline fusion.
Development. 2003 Nov;130(22):5319-30. Epub 2003 Sep 24
Muller MB, Zimmermann S, Sillaber I, Hagemeyer TP, Deussing JM, Timpl P, Kormann MS, Droste SK, Kuhn R, Reul JM, Holsboer F, Wurst W. (2003)
Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.
Nat Neurosci. 2003 Oct;6(10):1100-7. Epub 2003 Sep 14
Puelles E, Acampora D, Lacroix E, Signore M, Annino A, Tuorto F, Filosa S, Corte G, Wurst W, Ang SL, Simeone A. (2003)
Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.
Nat Neurosci. 2003 May;6(5):453-60
Schmidt M, Oitzl MS, Muller MB, Ohl F, Wurst W, Holsboer F, Levine S and De Kloet ER. 2003.
Regulation of the Developing Hypothalamic-Pituitary-Adrenal Axis in Corticotropin Releasing Hormone Receptor 1-Deficient Mice.
Neuroscience. 119, 2:589-95
Schnutgen F, Doerflinger N, Calleja C, Wendling O, Chambon P and Ghyselinck NB. 2003.
A Directional Strategy for Monitoring Cre-Mediated Recombination at the Cellular Level in the Mouse.
Nat Biotechnol. 21, 5:562-5
Stevens SL, Shaw TE, Dykhuizen E, Lessov NS, Hill JK, Wurst W and Stenzel-Poore MP. 2003.
Reduced Cerebral Injury in Crh-R1 Deficient Mice after Focal Ischemia: A Potential Link to Microglia and Atrocytes That Express Crh-R1.
J Cereb Blood Flow Metab. 23, 10:1151-9
Trokovic R, Trokovic N, Hernesniemi S, Pirvola U, Vogt Weisenhorn DM, Rossant J, McMahon AP, Wurst W, Partanen J. (2003)
FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals.
EMBO J. 2003 Apr 15;22(8):1811-23
2002
Floss, T., Uez, N., Frey,S. and Wurst, W. (2002)
Genotyping gene trap mutant mice by real time PCR.
Technical Tips Online (Trends in Genetics) TO: 2593.
Floss T, Wurst W. (2002).
Functional genomics by gene-trapping in embryonic stem cells.
Methods Mol Biol. 2002;185:347-79.
Floss T., Wurst W., v.Melchner H., v. Sloun, P., Schnütgen F., Füchtbauer E.M., Arnold H.H., Vauti F., Ruiz P. und Hansen, J. (2002)
Gene in der Falle: Mutagenese des Mausgenoms.
Biospektrum 1/2002: 84-90.
Landgrebe, J., Welzl,G., Metz, T., van Gaalen, M.M., Ropers, H., and Wurst, W., Holsboer F. (2002)
Molecular Characterisation of Antidepressant Effects in the Mouse Brain using Gene Expression Profiling.
Journal of Psychiatric Research, 36:119-129.
Landgrebe, J., Wurst, W. and Welzl, G. (2002)
Permutation validated principal components analysis of microarray data,
Genome Biology, Vol. 3, 19.1-19.11.
Peñalva, R.G., Flachskamm, C., Zimmermann, S., Wurst, W., Holsboer, F., Reul, J.M.H.M. and Lindhorst, A.C.E. (2002)
Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: An in vivo microdialysis study in mutant mice,
Neuroscience, Vol.109: 253-266.
Pfaar, H., von Holst, A., Vogt-Weisenhorn, D.M., Brodski, C., Guimera, J. and Wurst, W. (2002)
mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons, Development Genes and Evolution,
Dev Genes Evol 212:43-46 .
Rantanen M, Palmen T, Patari A, Ahola H, Lehtonen S, Astrom E, Floss T, Vauti F, Wurst W, Ruiz P, Kerjaschki D, Holthofer H. (2002).
Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions.
J Am Soc Nephrol. 2002 Jun;13(6):1586-94.
Rantanen, M., Palmen,T., Patari, A., Ahola, H., Lehtonen, S., Astrom, E., Floss, T., Vauti, F., Wurst ,W., Ruiz, P., Kerjaschki, D., Holthofer, H. (2002)
A gene-trap mutation in the mouse nephrin gene. A model for studying mechanisms of the kidney glomerular filtration barrier.
J Am Soc Nephrol 2002;13(6):1586-94 .
Sillaber, I., Rammes G., Zimmermann, S., Mahal, B., Zieglgänsberger, W., Wurst, W., Holsboer, F., and Spanagel R. (2002)
Enhanced and delayed stress-induced alcohol drinking in mice lacking a functional CRH-R1 receptor.
Science, 296,931-933
Timmer W, Leclerc V, Birraux G, Neuhauser M, Hatzelmann A, Bethke T and Wurst W. 2002.
The New Phosphodiesterase 4 Inhibitor Roflumilast Is Efficacious in Exercise-Induced Asthma and Leads to Suppression of Lps-Stimulated Tnf-Alpha Ex Vivo.
J Clin Pharmacol. 42, 3:297-303
Uziel, D, Muhlfriedel, S, Zarbalis, K, Wurst, W, Levitt, P, Bolz, J (2002)
Miswiring of limbic thalamocortical projections in the absence of ephrin-A5.
J Neurosci. 22, 9352-7
2001
Pfeifer, H., Conrad, M., Roethlein, D., Kyriakopoulos, A., Brielmeier, M., Bornkamm, G. W., and Behne, D. (2001) Identification of a specific sperm nuclei selenoenzyme necessary for protamine thiol cross-linking during sperm maturation. FASEB J. 15, 1236-1238.
Brielmeier, M., Bechet, J. M., Suppmann, S., Conrad, M., Laux, G., and Bornkamm, G. W. (2001) Cloning of phospholipid hydroperoxide glutathione peroxidase (PHGPx) as an anti-apoptotic and growth promoting gene of Burkitt lymphoma cells. Biofactors 14, 179-190.
Cahana, A., Escamez, T., Nowakowski, R.S., Hayes, N.L., Giacobini, M., von Holst, A., Shmueli, O., Sapir, T., McConnell, S., Wurst, W., Martinez, S. and Reiner, O. (2001)
LIS1 Homodimerization and brain development.
PNAS, vol. 98, 11 (6429-6434).
Floss T. and Wurst, W. (2001).
Functional genomics by gene-trapping in embryonic stem cells. Methods in Molecular Biology: Embryonic Stem Cells. Ed. Kursad Turksen.
Humana Press Vol. 185: 347-380.
Knöll, B., Zarbalis, K., Dulac, C., Wurst, W. and Drescher, U. (2001)
A role for the EphA family in the topographic targeting of vomeronasal axons.
Development, 2001 128 (6): 895-906.
Müller, M.B., Preil, J., Renner, U., Zimmermann, S., Kresse A.E., Stalla, G.K., Keck, M.E., Holsboer, F., and Wurst, W. (2001)
Expression of CRHR1 and CRHR2 in mouse pituitary and adrenal gland: implications for HPA system regulation.
Endocrinology; 142: 4150-5153
Nadeau, J.H., Balling, R., Barsh, G., Beier, D., Brown, S.D., Bucan, M., Camper, S., Carlson, G., Copeland, N., Eppig, J., Fletcher, C., Frankel, W.N., Ganten, D., Goldowitz D., Goodnow, C., Guenet, J.L., Hicks, G, de Angelis, M.H., Jackson, I, Jacob H.J., Jenkins, N, Johnson, D, Justice, M., Kay, S., Kingsley, D., Lehrach,, H., Magnuson T., Meisler, M, Poustka, A, Rinchik, E.M., Rossant J., Russell L.B., Schimenti J., Shiroishi, T., Skarnes, W.C., Soriano, P., Stanford, W., Takahashi, J.S., Wurst, W., Zimmer, A.; (2001)
Sequence interpretation. Functional annotation of mouse genome sequences.
Science 2001 Feb 16;291(5507):1251-5
Preil, J., Müller, M.B., Gesing, A., Reul, J.M.H.M., Sillaber, I., van Gaalen, M.M., Landgrebe, J., Holsboer, F., Stenzel-Poore, M. and Wurst, W. (2001)
Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for corticotropin-releasing hormone receptors 1 and 2.
Endocrinology; 142, 4946-4955
Simon, H.H., Saueressig, H., Wurst, W., Goulding, M.D., O'Leary, D.D. (2001)
Fate of midbrain dopaminergic neurons controlled by the engrailed genes,
Journal of Neuroscience 21, 3126-3134
Vetter, K. and Wurst, W. (2001)
Expression of a novel gene "mbFZb" in distinct regions of t he developing nervous system and the adult brain.
Mech. Dev., 100, 123-125
Wurst, W. and Bally-Cuif, L. (2001)
Neural plate patterning: upstream and downstream of the isthmic organizer.
Nature Reviews Neuroscience, 2, 99-108
2000
Bally-Cuif L, Goutel C, Wassef M, Wurst W, Rosa F (2000)
Coregulation of anterior and posterior mesendodermal development by a hairy-related transcriptional repressor.
Genes Dev 14: 1664-1677.
Chen Y, Brunson K, Müller MB, Cariaga W, Baram TZ (2000)
Immunocytochemical distribution of corticotropin-releasing hormone type-1 (CRF1)-like immunoreactivity in the mouse brain: light microscopy analysis using an antibody directed against the C-terminus. J Comp Neurol 420: 305-323.
Kimmel RA, Turnbull DH, Blanquet V, Wurst W, Loomis CA and Joyner AL (2000)
Two lineage boundaries coordinate vertebrate apical ectodermal ridge formation.
Genes and Development 14: 1377-1389.
Mainguy G, Montesinos ML, Lesaffre B, Zevnik B, Karasawa M, Wurst W, Prochiantz A, Volovitch M (2000)
An induction gene trap for identifying a homeoprotein-regulated locus.
Nature Biotechnology 18, 746-749.
Müller MB, Keck ME, Zimmermann S, Holsboer F and Wurst W (2000)
Disruption of feeding behavior in corticotropin releasing hormone type-1 receptor (CRHR1) deficient mice is dependent on glucocorticoids.
NeuroReport 11: 1963-1966.
Müller MB, Landgraf R, Preil J, Zimmermann S, Sillaber I, Kresse AE, Keck ME, Holsboer F and Wurst W (2000)
Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids.
Endocrinology 141: 4262-4269.
Wiles M, Vauti F, Otte J, Füchtbauer A, Füchtbauer EM, Ruiz P, Metz T, Arnold HH, Lehrach H, von Melchner H, Wurst W (2000)
Establishment of a gene trap sequence tag (GTST) library to generate mutant mice from embryonic stem (ES) cells.
Nature Genetics 24, 13-14.
Wurst W, Gossler A (2000)
Gene trapping strategies in ES cells. In: A.L. Joyner (ed.) Gene targeting: A practical approach
Oxford University Press Inc., New York, 207-251.
Zarbalis K, Wurst W (2000)
Expression domains of murine ephrin-A5 in the pituitary and hypothalamus.
Mech Dev 93: 165-168.
< 2000
Broccoli V, Boncinelli E, Wurst W (1999)
The caudal limit of Otx2 expression positions the isthmic organiser and encodes caudal mesencephalic fate.
Nature 401, 164-168.
Mainguy G, Ernø H, Montesinos ML, Lesaffre B, Wurst W, Volovitch M, Prochiantz A (1999)
Regulation of Epidermal Bullous Pemphigoid Antigen 1 (BPAG1e) synthesis by homeoprotein transcription factors.
J Invest Dermatol. 113(4):643-650.
Hulander M, Wurst W, Carlsson P, Enerbäck S (1998)
The winged helix transcription factor Fkh10 is required for normal development of the inner ear.
Nature Genetics 20, 374-76
Sam M, Wurst W, Klüppel M, Jin O, Heng H, Bernstein A (1998)
Aquarius, a novel gene isolated by gene trapping with an RNA-dependent RNA polymerase motif.
Developmental Dynamics 212, 304-317.
Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JMHM, Stalla GK, Blanquet V, Steckler T, Holsboer F, Wurst W (1998)
Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1.
Nature Genetics 19:162-166.
Favor J, Sandulache R, Neuhäuser-Klaus A, Pretsch W, Chatterjee B, Senft E, Wurst W, Blanquet V, Grimes P, Spörle R, Schughart K (1996)
The mouse Pax21Neu mutation is identical to a human PAX2 mutation in a family with renal-colomboma syndrome and results in developmental defects of the brain, ear, eye and kidney.
PNAS 93:13870-13875.
Sam M, Wurst W, Forrester L, Vauti F, Heng H, Bernstein A (1996)
A novel family of repetitive sequences in the mouse genome responsive to retinoic acid.
Mammalian genome 10:741-748.
Forrester L, Nagy A, Stevenson L, Bernstein A, Joyner AL, Wurst W (1996)
An induction gene trap screen in ES cells: Identification of genes that respond to retinoic acid in vitro.
Proc Natl Acad Sci USA 93:1677-1682.
Loomis CA, Harris E, Michaud J, Wurst W, Hanks M, Joyner AL (1996)
The mouse Engrailed-1gene and ventral limb patterning.
Nature 382: 360-363.
Hanks M, Wurst W, Anson-Cartwright L, Auerbach A, Joyner AL (1995)
Rescue of the En-1 mutant phenotype by replacement of En-1 with En- 2.
Science 269:679-682.
Wurst W, Rossant J, Prideaux V, Kownacka M, Joyner AL, Hill DP, Guillemot F, Gasca S, Cado D, Auerbach A et al. (1995)
A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice.
Genetics 139:889-899.
Millen K, Wurst W, Herrup K, Joyner AL (1994)
Two targeted mutations in En-2 cause an ambryonic defect in patterning the cerebellum.
Development 120:695-706.
Wurst W, Auerbach A, Joyner AL (1994)
Multiple developmental defects in Engrailed-1 mutant mice: An early mid-hindbrain deletion and patterning defects in forelimbs and sternum.
Development 120: 2065-2075.
Klein R, Smeyne R, Wurst W, Long LK, Auerbach BA, Joyner AL, Barbacid M (1993)
Targeted disruption of the trkB neurothrophin receptor gene results in nervous system lesions and neonatal death.
Cell 75:113-122.