GMC Phenomap

Phenomap legend:
New phenotype:	New phenotype:	Additional phenotype:	Additional phenotype:	Confirmed phenotype:	Confirmed phenotype:	Subtle phenotype:	Subtle phenotype:	No phenotype:	No phenotype:	Not analyzed:		Report:	Report

Mutant line	Symbol MGI ID	Gene symbol Gene name	B e h a v i o u r	D y s m o r p h o l o g y	N e u r o l o g y	E y e	C l i n i c a l c h e m i s t r y	I m m u n o l o g y	A l l e r g y	S t e r o i d	N o c i c e p t i o n	C a r d i o v a s c u l a r	L u n g f u n c t i o n	E x p r e s s i o n	M e t a b o l i s m	P a t h o l o g y	R e p o r t
DNaseX	Dnase1l1^tm1Dkfz MGI:4430191	Dnase1l1 deoxyribonuclease 1-like 1	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: New phenotype Phenotype description: muscular/coordination deficit	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: Subtle phenotype Phenotype description:	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: No phenotype Phenotype description: no differences	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Heart, muscle analyzed. Gene regulation identified in both organs. Regulated genes in heart associated with oxygen transporter activity and nucleic acid binding; in muscle with oxireductase activity and protein metabolsm.	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: increased body weight	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
NADHo		Aifm2 apoptosis-inducing factor, mitochondrion-associated 2	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Immunology Screen Phenotype: No phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: not tested	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: No phenotype Phenotype description: no differences	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: No organs selected for expression profiling	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
NCAM	Ncam1^tm1Cgn MGI:1857222	Ncam1 neural cell adhesion molecule 1	Behavioral Screen Phenotype: Additional phenotype Phenotype description: increased exploratory activity	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: Changes in bone homeostasis and body composition (males).	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Body weight related difference	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: brain analyzed. Only two regulated genes found	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: reduced body weight, hypotherm (after fasting)	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
DKK3	Dkk3^tm1Cni MGI:3621929	Dkk3 dickkopf homolog 3 (Xenopus laevis)	Behavioral Screen Phenotype: New phenotype Phenotype description: hyperactivity	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Clinical chemistry: Subtle changes of unclear relevance. Hematology: Hypochromic, macrocytic erythrocytes, increased hematocrit	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: New phenotype Phenotype description: Increased ventilation	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: No organs selected for expression profiling	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: reduced body weight,	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
DLG3	Gnl3^{Gt(W062C05)Wrst} MGI:4123403	Gnl3 Guanine nucleotide-binding protein-like 3 - or Nucleostemin	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: No phenotype Phenotype description: No differences detected.	Immunology Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Body weight related differences	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: No organs selected for expression profiling	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
MAG	Mag^tm1Mtg MGI:2384092	Mag myelin associated glycoprotein	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: Changes in bone homeostasis and body composition in males. Hearing loss. Cramping, when hung by tail.	Neurological Screen Phenotype: New phenotype Phenotype description: tremor, abnormal gait	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hypoalgesia (males)	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: New phenotype Phenotype description: disturbances in the central respiratory control,	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: brain analyzed, no regulation detected	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
Miz1	Pias2^{Gt(pT1Betageo)1Ruiz} MGI:2678428	Pias2 protein inhibitor of activated STAT 2	Behavioral Screen Phenotype: New phenotype Phenotype description: altered social and exploratory behavior, middle ear phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: New phenotype Phenotype description: abnormal posture	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting different cellular subsets	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: New phenotype Phenotype description: reduced ventilatory drive,	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: testis analyzed, no regulation detected	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: Confirmed phenotype Phenotype description: (reduced testis weight confirmed)	Report
DMBT1	Dmbt1^tm1Janm MGI:3771872	Dmbt1 deleted in malignant brain tumors 1	Behavioral Screen Phenotype: No phenotype Phenotype description: Subtle changes males more caution	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: No phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: No phenotype Phenotype description: no differences	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: No organs selected for expression profiling	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
DEA3	Tmc1^Bth MGI:2177263	Tmc1 transmembrane channel-like gene family 1	Behavioral Screen Phenotype: Subtle phenotype Phenotype description: increased caution (males), increased angular velocity (females)	Dysmorphology, Bone and Cartilage Screen Phenotype: Confirmed phenotype Phenotype description: Deafness. Changes in body composition (females)	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Well-pronounced B cell phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: New phenotype Phenotype description: differences in breathing pattern might be related to the different activity behavior	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: No organs selected for expression profiling	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: increased body weight	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
Dll1	Dll1^tm1Gos MGI:1861919	Dll1 delta-like 1 (Drosophila)	Behavioral Screen Phenotype: New phenotype Phenotype description: hyperactivity (females)	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: Changes in bone homeostasis and body composition.	Neurological Screen Phenotype: New phenotype Phenotype description: hyperactivity	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hypoalgesia	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Body weight related difference	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Thymus, liver, spleen, brain analyzed. Differential gene expression in all organs.Regulated genes associated with transcription and transport and binding activites. Several genes are involved in developmental processes.	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: reduced body weight and body fat	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
Trm1	1190005F20Rik^{Gt(W027A02)Wrst} MGI:3702935	Trm1 tRNA methionine initiator 1	Behavioral Screen Phenotype: New phenotype Phenotype description: altered exploratory behaviour	Dysmorphology, Bone and Cartilage Screen Phenotype: Subtle phenotype Phenotype description: Bone mineral density and body weight reduced in females.	Neurological Screen Phenotype: New phenotype Phenotype description: abnormal motor coordination/ balance	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: New phenotype Phenotype description: elevated IgE levels	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: minor changes	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: brain analyzed, no gene regulation detected	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: Phenotype description: tendency of increased immunoreactivity	Report
MCHR1	Mchr1^tm1Blak MGI:3603521	Mchr1 melanin-concentrating hormone receptor 1	Behavioral Screen Phenotype: New phenotype Phenotype description: hyperactivity during daytime, specific impairment in aversive memory	Dysmorphology, Bone and Cartilage Screen Phenotype: Confirmed phenotype Phenotype description: Changes in bone homeostasis and body composition.	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: No phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: minor changes	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: brain analyzed, no gene regulation detected	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: high rasper activity, not hyperphagic	Pathology Screen Phenotype: Phenotype description: Dermatitis apostematosa	Report
Eyl	Pitx3^eyl MGI:4429408	Pitx3 paired-like homeodomain transcription factor 3	Behavioral Screen Phenotype: New phenotype Phenotype description: altered emotional behavior	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Changes in bone homeostasis and body composition (females).	Neurological Screen Phenotype: Additional phenotype Phenotype description: reduced grip strength	Eye Screen Phenotype: Confirmed phenotype Phenotype description: Severe microphthalmia	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Differences in fat metabolism and liver and/or pancreas function. Indications of effects on muscle function.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hypoalgesia	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: New phenotype Phenotype description: altered spontaneous breathing pattern with more frequent	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: Liver analyzed, no regulation detected	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: reduced body weight, hypotherm (after fasting)	Pathology Screen Phenotype: Additional phenotype Phenotype description: red. Expression of dopamine transporter 1 in the mirdbrain (confirm) Microphthalmia (females), BW reduced, increased extramedullary hematopoiesis (males)	Report
Ptdsr	Jmjd6^tm1.1Gbf MGI:3606752	Jmjd6 jumonji domain containing 6	Behavioral Screen Phenotype: New phenotype Phenotype description: reduced anxiety	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance. Hints on kidney dysfunction.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: minor changes	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Thymus, brain, liver, spleen, heart analyzed. Differential gene regulation in thymus only. Regulated genes associated with heme binding.	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: No phenotype Phenotype description: Microphthalmia (not significant)	Report
Vimentin	Vim^tm2Cba MGI:1931879	Vim vimentin	Behavioral Screen Phenotype: New phenotype Phenotype description: abnormal social behavior (males)	Dysmorphology, Bone and Cartilage Screen Phenotype: Subtle phenotype Phenotype description: Bone mineral content, body weight and fat mass reduced in females.	Neurological Screen Phenotype: Additional phenotype Phenotype description: reduced grip strength	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Uric acid and white blood cell count increased. Indications of changes in kidney function and/or electrolyte homeostasis. Glucose level reduced in females	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hypoalgesia (males), Hyperalgesia (females)	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: respiratory rate differences failed to be statistically significant., In view of the observed pulmonary infection interpretation of the results is hardly possible.	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Spleen analyzed. Regulated gene asscociated with immune response and apoptosis	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: Phenotype description: increased T-cells in the PALS, reduced GFAP expression in the cerebellum	Report
mPtpg	Nipal3^tm1Pebu MGI:4360699	Nipal3 NIPA-like domain containing 3	Behavioral Screen Phenotype: New phenotype Phenotype description: altered exploration	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance in males only.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: New phenotype Phenotype description: elevated IgE levels	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: New phenotype Phenotype description: elevated ventilation detected during rest and activity is primarily related to the higher tidal volume used by mutant males	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: Brain analyzed, no differential gene regulation	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
Cin85 exon 2	Sh3kbp1^tm1Ivdi MGI:4818424	Sh3kbp1 SH3-domain kinase binding protein 1	Behavioral Screen Phenotype: New phenotype Phenotype description: hyperactivity	Dysmorphology, Bone and Cartilage Screen Phenotype: Subtle phenotype Phenotype description: Changes in body composition in females.	Neurological Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: New phenotype Phenotype description: elevated IgE levels	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: No phenotype Phenotype description: no differences	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Brain analyzed. Regulated gene associated with distinc brain functions and neurological disorders	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: Phenotype description: absence of the corpus callosum, mice on B6 genetic background, confirmed by secondary screening	Report
pk 10681			Behavioral Screen Phenotype: Not tested Phenotype description: not tested	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: Changes in bone homeostasis and body composition	Neurological Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Only changes of unclear relevance, mostly limited to one sex. There seems to be an influence on erytropoiesis but without pathological effects.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: minor changes	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Spleen, liver analyzed. Regulated gene in spleen accociated with immune response. No gene regulation in liver.	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: reduced body weight,	Pathology Screen Phenotype: Phenotype description: enlarged marginal zone in the spleen	Report
TP53	Trp53inp1^tm1Acar MGI:3700974	Trp53inp1 transformation related protein 53 inducible nuclear protein 1	Behavioral Screen Phenotype: New phenotype Phenotype description: altered locomotion	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Eye Screen Phenotype: New phenotype Phenotype description: intraretinal microflecks, disturbances in retinal lamination	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting the cellular subsets distribution in the periphery	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Body weight related differences (females)	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Spleen, thymus analyzed. Differntial regulation in thymus. Regulated genes associated with GTPase activity and protein metabolism.	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: hypotherm (after fasting)	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
Arl4	Arl4a^tm1Asch MGI:2181269	Arl4a ADP-ribosylation factor-like 4A	Behavioral Screen Phenotype: New phenotype Phenotype description: altered arousal	Dysmorphology, Bone and Cartilage Screen Phenotype: Subtle phenotype Phenotype description: Small changes in bone mineral density and body weight in males.	Neurological Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Eye Screen Phenotype: Subtle phenotype Phenotype description: Slightly increased axial eye lengths in males	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: No phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hyperalgesia	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Hypertension	Lung Function Screen Phenotype: Not tested Phenotype description: not tested	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: No animals provided for organ collection	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: reduced body weight, hypotherm (ad libitum)	Pathology Screen Phenotype: Confirmed phenotype Phenotype description: no phenotype	Report
HST009	Slc12a1^I299F MGI:103150	Slc12a1 solute carrier family 12, member 1	Behavioral Screen Phenotype: Not tested Phenotype description: not tested	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: Changes in bone homeostasis and body composition.	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Additional phenotype Phenotype description: Impaired kidney function confirmed. Changes in electrolyte homeostasis,indications of changes in bone metabolism and increased pancreas activity, increased white blood cell count and mild erythropenic anemia.	Immunology Screen Phenotype: New phenotype Phenotype description: Well-presented immunological phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hyperalgesia (females)	Cardiovascular Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Body weight related differences	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: Kidney analyzed, no gene regulation found	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: increased body weight	Pathology Screen Phenotype: Additional phenotype Phenotype description: bilateral hydronephrosis (confirmed) ovarian cystic changes (additional)	Report
FoxP2-h	Foxp2^tm1Woen MGI:3851106	Foxp2 forkhead box P2	Behavioral Screen Phenotype: New phenotype Phenotype description: Hypoactivity, increased caution	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: New phenotype Phenotype description: hypoactivity	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: No phenotype Phenotype description: No differences detected.	Immunology Screen Phenotype: No phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: No phenotype Phenotype description: no genotype-related differences	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: Brain analyzed, no differential gene regulation	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
Glut8		Slc2a8 solute carrier family 2, (facilitated glucose transporter), member 8	Behavioral Screen Phenotype: New phenotype Phenotype description: increased emotional reactivity	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: New phenotype Phenotype description: reduced grip strength (males)	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: No phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: minor changes	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Muscle, testis, liver analyzed. Regulated genes in muscle and liver are associated with functions in fatty acid and glucose metabolism. No gene regulation in testis.	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: energy balance	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
M76C04	Nkain4^{Gt(M076C04)Vmel} MGI:4413343	Nkain4 Na+/K+ transporting ATPase interacting 4	Behavioral Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance regarding locomotion and behaviour towards the board	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: New phenotype Phenotype description: nuclear or posteriorpolar opacity	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: No phenotype Phenotype description: Finding of unclear relevance. CD44 is also expressed on activated B cells	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: No phenotype Phenotype description: no differences	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: Brain analyzed, no differential gene regulation	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: Body temperature reduced	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
Eps8	Eps8^tm1Ppdf MGI:3693626	Eps8 epidermal growth factor receptor pathway substrate 8	Behavioral Screen Phenotype: New phenotype Phenotype description: altered exploratory pattern	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Deafness.	Neurological Screen Phenotype: New phenotype Phenotype description: Hypoactivity	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Subtle changes of unclear relevance. Hyperkalemia, which might influence pulse rate.Indications of effects on energy metabolism.	Immunology Screen Phenotype: No phenotype Phenotype description: Expression of homing markers, possibly due to activation??	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hypoalgesia	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Bradycardia	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Subtitle Changes, body weight related differences	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: White fat, brown fat, liver analyzed. The significantly expressed genes are associated with functions in fatty acid metabolism, apoptosis and actin remodeling.	Energy Metabolism Screen Phenotype: Confirmed phenotype Phenotype description: impaired gastro-intestinal functions	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
Cs7			Behavioral Screen Phenotype: New phenotype Phenotype description: altered emotional behavior	Dysmorphology, Bone and Cartilage Screen Phenotype: Subtle phenotype Phenotype description: Lean mass increased (females).	Neurological Screen Phenotype: Subtle phenotype Phenotype description: muscle force	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance. Regulation of hematopoiesis might be affected.	Immunology Screen Phenotype: Subtle phenotype Phenotype description: Finding of unclear relevance.	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: slight differences between female groups, physiologically not relevant	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: No organs selected for expression profiling	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: Subtle phenotype Phenotype description: spontaneus myocardium calcification 26% of the congenic mice (not significant)	Report
Dll1 C3H	Dll1^tm1Gos MGI:1861919	Dll1 delta-like 1 (Drosophila)	Behavioral Screen Phenotype: Subtle phenotype Phenotype description: mild alterations in horizontal activity/exploration	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Changes in bone homeostasis and body composition.	Neurological Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Indication of an effect on energy metabolism and hematopoiesis.	Immunology Screen Phenotype: New phenotype Phenotype description: alterations in the memory T cell compartment. Normally, CD62L expression is high on naïve Tcells and central memory cells.	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hypoalgesia	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Hypotension (males), Bradycardia,	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Body weight related differences	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Thymus, spleen, liver and brain analysed. Several of the significantly expressed genes in liver, brain and thymus are associated with apoptosis, regulation of cell cycle, tumorigenesis, em-bryogenesis, and different neu-ronal functions.	Energy Metabolism Screen Phenotype: Confirmed phenotype Phenotype description: Body mass reduced	Pathology Screen Phenotype: No phenotype Phenotype description: (BW confirmed)	Report
C3H vis	Pde6b+ C3H.C-Pde6b+/H	Pde6b phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Behavioral Screen Phenotype: New phenotype Phenotype description: altered exploratory pattern	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: Changes in bone homeostasis and body composition (secondary effect due to clear differences in body parameters)	Neurological Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Eye Screen Phenotype: New phenotype Phenotype description: Increased axial length in C3H.Pde6b+, no b-G73wave response in C3H.Pde6b+	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Reduced percentage of CD8+ T cells and höherer percentage of granulocytes,sex: Male: Reduced percentage of CD4+ T cells, Increased IgG2b plasma level (only males)	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hypoalgesia (females)	Cardiovascular Screen Phenotype: New phenotype Phenotype description: C3H.Pde6b+ mutant mice carry a functional BalbC allele of the gene of interest, while the control C3H/HeH mice represent a natural null allele of Pde6b. Among the commonly used lab strains we find that these C3H mice with retinal degeneration exhibit relatively high values for QT interval and QTc.	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Major phenotype unlikely, mainly body weight related differences.	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Brain, heart and eye selected. Differential gene expression in all ana-lyzed organs. Genes regulated in eye are associated with retina dis-eases, corneal wound healing and apoptosis or are expressed corneal epithelium and different retina layers. Several of the significantly ex-pressed genes in heart are involved in distinct heart failure (e.g. car-diac hypertrophy or cardiomyopathy).	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: reduced body weight,	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
Eya3	Eya3^{Gt(W096D02)Wrst} MGI:3834107	Eya3 eyes absent 3 homolog (Drosophila)	Behavioral Screen Phenotype: New phenotype Phenotype description: altered exploratory pattern	Dysmorphology, Bone and Cartilage Screen Phenotype: Subtle phenotype Phenotype description: Bone mineral content, body length and body weight reduced in males.	Neurological Screen Phenotype: New phenotype Phenotype description: reduced grip strength	Eye Screen Phenotype: Subtle phenotype Phenotype description: Difference in normalised (for body length) axial eye length.	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: No phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Changes in conduction and voltage properties	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Decreased tidal volume	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: muscle, heart, brain analyzed. In muscle no differences in expression levels between mutant and control mice have been detected. Several of the significantly expressed genes in brain and heart are associated with protein synthesis, synaptic vesicle exocytosis or they are expressed in different neuronal cell types	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
TGFB1		Tgfb1 transforming growth factor, beta 1	Behavioral Screen Phenotype: New phenotype Phenotype description: Mild hyperactivity	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: Subtle phenotype Phenotype description: Potential Phenotype: a single mouse mutant with unusually high percentage of CD4+CD25+ co-expressing cells.	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: Phenotype description: no phenotype	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Minor differences only	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Liver, kidney analysed. Regulated genes in kidney associated with proteolysis, oncogenesis & cholesterol metabolism. In liver: roles in cation transport, cell structure and cell motility.	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
GSK3 beta		Gsk3b glycogen synthase kinase 3 beta	Behavioral Screen Phenotype: New phenotype Phenotype description: Reduced velocities, eventually increased anxiety	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Changes in bone homeostasis and body composition	Neurological Screen Phenotype: New phenotype Phenotype description: reduced grip strength	Eye Screen Phenotype: Subtle phenotype Phenotype description: Slightly reduced axial eye lengths	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Changes in energy metabolism related parameters indicate effects on energy balance.	Immunology Screen Phenotype: Subtle phenotype Phenotype description: sex: Male: only male: increased percentage of B cells, reduced percentage of Granulocytes, slightly increased percentage of gdT cells	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Subtle phenotype Phenotype description: Male: mutant mice have slightly decreased testosterone concentrations	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Changes in conduction properties, hypotension, bradycardia	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Body mass related differences, physiologically not relevant	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: brain, pancreas and muscle analysed. Regulated genes in brain and muscle asscociated with tumorigenesis, neuronal functions and muscle differentiation.	Energy Metabolism Screen Phenotype: Additional phenotype Phenotype description: Hypermetabolic	Pathology Screen Phenotype: New phenotype Phenotype description: vacuolization of different severity of some brain structures (particularly substancia nigra, dorsal fornix, cingulum, truncus corporis callosi) could be detected. Possible demyelinization disease	Report
FoxP2-KO	Foxp2^tm2.2Woen MGI:3851108	Foxp2 forkhead box P2	Behavioral Screen Phenotype: Additional phenotype Phenotype description: Confirmed hypoactivity, reduced neophobia	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: Confirmed phenotype Phenotype description: abnormal motor coordination/ balance also in heterozygous animals	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: Subtle phenotype Phenotype description: sex: Male: increased percentage CD62L-expressing CD8+ T cells (only males ),sex: Female: increased percentage of T cells (only females).	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: Phenotype description: no phenotype	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: No differences of phjysiological relevance	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: No organs selected for expression profiling	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: Hypermetabolic	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
C1orf37	Tg(TMEM183B)1Pbo MGI:4819559	Tmem183a transmembrane protein 183A	Behavioral Screen Phenotype: Subtle phenotype Phenotype description: mild hyperactivity	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: No phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: No phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Minor changes	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: No organs selected for expression profiling	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: No phenotype	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
T181	Gper^tm1Dgen MGI:4355679	Gper G protein-coupled estrogen receptor 1	Behavioral Screen Phenotype: Subtle phenotype Phenotype description: slightly increased anxiety	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Reduced expression in T cells, with reduced L-selectin expression.	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Hypercontractility of the left ventricle	Lung Function Screen Phenotype: No phenotype Phenotype description: no differences	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: brain, kidney, thymus analyzed. Several of the significantly regulated genes in thymus are associated with tumorigenesis and immune response. No gene regulation in brain and kidney	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
GSK3 alpha		Gsk3a glycogen synthase kinase 3 alpha	Behavioral Screen Phenotype: New phenotype Phenotype description: increased anxiety	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Changes in bone homeostasis and body composition in males	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: New phenotype Phenotype description: sex: Male: Increased axial eye length in males	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Results indicate effects on hematopoiesis resulting in macrocytosis, and changes in energy metabolism.	Immunology Screen Phenotype: New phenotype Phenotype description: sex: Female: Differences in percentage between T and B cells: (only females).	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Subtle phenotype Phenotype description: Female: mutant mice have decreased DHEA concentrations	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Hypotension, Bradycardia	Lung Function Screen Phenotype: Not tested Phenotype description: n/a	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Brain, muscle analyzed.Regulated gene in muscle are associated with blood circulation and gas exchange and protein phosphorylation. No gene regulation in brain	Energy Metabolism Screen Phenotype: Additional phenotype Phenotype description: Body mass reduced, strong response to fasting	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
Dll1-C413Y	Dll1^C413Y	Dll1 delta-like 1 (Drosophila)	Behavioral Screen Phenotype: New phenotype Phenotype description: Hyperactivity sex: female: enhanced prepulse inhibition	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Changes in bone homeostasis and body composition	Neurological Screen Phenotype: New phenotype Phenotype description: Hyperactivity	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Plasma lipid and urea values suggest changes in energy metabolism.	Immunology Screen Phenotype: New phenotype Phenotype description: sex: Male: In males we foand a reduced frequency of ICAM-1 expresssing cells and slightly higher levels of IgG2a and IgG2b	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Hypertension	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: sex: Female: Only female mice showed slight differences, physiologically not relevant	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Liver, spleen, brain and thymus analysed. Gene differentially expressed in spleen associated with cell proliferation, signaling and embryogenesis. No gene regulation found in liver, thymus, and brain.	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: Body mass reduced, hypermetabolic	Pathology Screen Phenotype: Phenotype description: no phenotype	Report
HST012	Umod^A227T MGI:102674	Umod Uromodulin	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Changes in bone homeostasis and body composition.	Neurological Screen Phenotype: Not tested Phenotype description: not tested due to limited mouse number	Eye Screen Phenotype: Not tested Phenotype description: not tested due to limited mouse number	Clinical Chemical Screen Phenotype: Additional phenotype Phenotype description: Impaired kidney function confirmed , additional effects on energy metabolism, bone metabolism and blood cell count.	Immunology Screen Phenotype: New phenotype Phenotype description: sex: (females) L-selectin (CD62L) expression on Tcells, especially CD8+, is higher (heterozygous and homozygous), sex: Male: Ly6C expression on CD8 Tcells is reduced (males).	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: New phenotype Phenotype description: sex: Female: Hyperalgesia (females)	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Increased Plasma-ANP levels	Lung Function Screen Phenotype: Not tested Phenotype description: not tested	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Kidney analysed. Significantly regulated genes in kidney are annotated with hemolytic anemia, glomerulosclerosis, hypertension, diabetes and tumorigenesis	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: Additional phenotype Phenotype description: sex: Female: (females) Ovarian cysts in females, (reduced body weight)	Report
EMP3		Emp3 epithelial membrane protein 3	Behavioral Screen Phenotype: Subtle phenotype Phenotype description: subtle alterations of unclear relevance	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: No phenotype Phenotype description: No differences detected.	Immunology Screen Phenotype: No phenotype Phenotype description: The frequency of T cells, among other subsets, differed betweent mutants and wildtypes. However, we did not see a consistent phenotype comparing two different batches of mice.	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: No phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: No phenotype Phenotype description: no genotype-related differences	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Spleen and thymus analysed. Significantly regulated genes in spleen were annotated with cell communication, apoptosis, transcription regulation or calcium mediated signaling. These data indicate molecular changes of cellular processes in which the mutated gene EMP3 might also be involved. No gene regulation found in thymus	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
Irf1		Irf1 interferon regulatory factor 1	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Results indicate effects on fat and glucose metabolism, moderate macrocytosis and reduced ALP and amylase activity in mutants.	Immunology Screen Phenotype: Confirmed phenotype Phenotype description: Described phenotype of a low freq. of CD8+ Tcells and of inverse trend in CD4+ Tcells was confirmed.	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Subtle phenotype Phenotype description: Male: mutant mice have slightly increased DHEA concentrations	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: No phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: No phenotype Phenotype description: no genotype-related differences	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in brain	Report
Setdb1		Setdb1 SET domain, bifurcated 1	Behavioral Screen Phenotype: New phenotype Phenotype description: Prepulse inhibition deficit, sex: Female: hyperactivity (females) sighted C3H	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: No phenotype Phenotype description: No significant differences detected.	Immunology Screen Phenotype: No phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: New phenotype Phenotype description: Mutant mice have low levels of IgE	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: sex: Male: Tachycardia, increased heart weight in males	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: slight differences of minor physiological relevance	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: No phenotype	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in brain and liver	Report
Aldh2		Aldh2 aldehyde dehydrogenase 2, mitochondrial	Behavioral Screen Phenotype: New phenotype Phenotype description: Sex-specific alterations in activity	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Decreased triglyceride levels and mild macrocytosis in mutant animals.	Immunology Screen Phenotype: No phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Subtle phenotype Phenotype description: Male: mutant mice have slightly decreased DHEA concentrations	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Tachycardia, increased heart weight	Lung Function Screen Phenotype: No phenotype Phenotype description: no genotype-related differences	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: Not tested Phenotype description: not tested	Pathology Screen Phenotype: New phenotype Phenotype description: beta-Gal activity: in brain, heart, liver, lung, spleen, kidney, thyroid, skin, testes, ovaries, Histology: 2 of 4 mutant males have mild testicular tubular degeneration	Report
EUCJ0019_C12		Pml promyelocytic leukemia	Behavioral Screen Phenotype: Subtle phenotype Phenotype description: subtle changes of unclear relevance	Dysmorphology, Bone and Cartilage Screen Phenotype: Not tested Phenotype description: no phenotype	Neurological Screen Phenotype: Phenotype description: Hyperactivity	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Differences compared to wildtype controls were foand concerning the freq. of CD19+/CD5+ cells, and the proportions of T cell subsets. Especially, T cells from Plm mutant mice showed a high expression of CD62L+ (CD4+ and CD8+), a high expression of CD44 (	Allergy Screen Phenotype: No phenotype Phenotype description: not tested	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: no phenotype	Lung Function Screen Phenotype: Not tested Phenotype description: not tested	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: Not tested Phenotype description: not tested	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
EPD0105_5_E01		Dusp4 dual specificity phosphatase 4	Behavioral Screen Phenotype: New phenotype Phenotype description: sex: Female: Reduced anxiety (females)	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: No phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Bradycardia	Lung Function Screen Phenotype: No phenotype Phenotype description: no genotype-related differences	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: Not tested Phenotype description: not tested	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in brain, testes and ovary	Report
EUC FP00100C08		Nos2 nitric oxide synthase 2, inducible	Behavioral Screen Phenotype: New phenotype Phenotype description: Prepulse inhibition deficit only in females	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Many mild differences of unclear relevance. Fat metabolism, kidney function and liver function and integrity might be affected.	Immunology Screen Phenotype: New phenotype Phenotype description: Nos-2 mutant mice showed a slightly higher freq. of T cells and NK cells and a lower freq. of Bcells.	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Subtle phenotype Phenotype description: Male: mutant mice have slightly increased DHEA concentrations	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: No phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: No phenotype Phenotype description: no genotype-related differences	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: Hypermetabolism	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
EPD0028_5_G01		Hdac1 Histone deacetylase 1	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: New phenotype Phenotype description: More excitation/Alertness (Tail elevation)	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Lower levels of IgM	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Bradycardia	Lung Function Screen Phenotype: No phenotype Phenotype description: differences ofphysiological minor relevance, specific TV and specific MV are comparable	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: Phenotype description: Hypermetabolism, fat mass reduced	Pathology Screen Phenotype: No phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in brain, testes and ovary	Report
EPD0051_2_D09		Plxnb2 plexin B2	Behavioral Screen Phenotype: New phenotype Phenotype description: Increased prepulse inhibition only in females	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: New phenotype Phenotype description: abnormal motor coordination/ balance	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: sex: Female: Higher freq. of B cells, lower freq. of T cells and NK cells	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: No phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: Not tested Phenotype description: not tested	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: Subtle phenotype	Pathology Screen Phenotype: No phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in brain and lung	Report
EUCJ0004_F10		Nfya nuclear transcription factor-Y alpha	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: smaller head decreased body length, body weight, and fat mass in males.	Neurological Screen Phenotype: New phenotype Phenotype description: Hind limb shaking upon tail suspension Reduced grip strength	Eye Screen Phenotype: Subtle phenotype Phenotype description: Significant difference of absolute axial eye lengths (both sexes) and normalized (for body length) eye sizes (males). Differences are of unclear relevance.	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: small effects on potassium, phosphorus, creatinine, glucose and iron >> accidental or possibly secondary to changes in muscle metabolism??	Immunology Screen Phenotype: New phenotype Phenotype description: Sex-dependent phenotype: Only in female mutants higher freq. of T cells and inverse trend in B cells and granulocytes. T cells show a higher expression of CD62L and a lower expression of Ly6C (CD8+), corresponding to a more naive phenotype.	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Decreased pulse rate, mainly in males Slightly decreased HW/TBL in combination with decreased BW and increased TBL (not significant trend to decreased HW). Probably secondary to BW differences	Lung Function Screen Phenotype: No phenotype Phenotype description: no phenotype	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: Body mass and fat mass reduced in males	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
EPD0059_3_A06		Acot13 (alt Them2) acyl-CoA thioesterase 13	Behavioral Screen Phenotype: New phenotype Phenotype description: Total center time increased in the male mutants	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: decreased body weight in males.	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Fasted mice: Tendency towards increased cholesterol values. IpGTT: only females: Decreased fasted glucose level, decreased glucose clearance	Immunology Screen Phenotype: New phenotype Phenotype description: In female mutants we found a lower proportion of CD44/Ly6C co-expressing CD8+ T cells, and a lower freq. of CD11b expressing NK cells compared to wt controls. High IgG1 in male mutants	Allergy Screen Phenotype: New phenotype Phenotype description: High IgE in male mutants	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: Not tested Phenotype description: not tested	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: VO2 reduced due to reduced body mass Body mass and fat mass decreased in males	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in brain	Report
EPD0156_1_B01	Entpd1^{tm1a(EUCOMM)Wtsi}	Entpd1 ectonucleoside triphosphate diphosphohydrolase 1	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: decreased BMD in males (probably secondary effect).	Neurological Screen Phenotype: New phenotype Phenotype description: Significantly improved rotarod performance	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Mild macrocytosis, decreased platelet count increased platelet volume Improved glucose tolerance	Immunology Screen Phenotype: New phenotype Phenotype description: Slightly reduced freq. of NK cells, but a higher proportion of CD11b expressing NK cells. Sex-dependent differences in the expression of CD44 and CD62L on T cells: Males: lower prop. of Cd62L expr. CD4+ Tcells, higher freq. of Ly6C expr. CD8+ Tcells. Females: Higher freq. of CD44++ CD8+ T cells, furthermore higher ratio of CD4:CD8	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: New phenotype Phenotype description: Decreased corticosterone levels in females	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: No phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: Not tested Phenotype description: not tested	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: Body mass and fat decreased	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in uterus and pancreas	Report
EPD0060_1_B12	Hgs^{tm1a(EUCOMM)Wtsi}	Hgs HGF-regulated tyrosine kinase substrate	Behavioral Screen Phenotype: New phenotype Phenotype description: Female mutants are moving around more	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Fed: Tendency towards increased glucose and iron level, tendency towards macrocytosis	Immunology Screen Phenotype: Subtle phenotype Phenotype description: A trend of a reduced freq. of T cells in mutants	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: No phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: Not tested Phenotype description: not tested	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: Body mass and fat mass increased in males	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in brain and liver	Report
EPD0087_1_G04	Fermt2^{tm1a(EUCOMM)Wtsi}	Fermt2 fermitin family homolog 2 (Drosophila)	Behavioral Screen Phenotype: New phenotype Phenotype description: OF: Female mutants show a small significant increase in centre time, only during the last 5 minutes of the test	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Clinical chemistry fasted mice: Moderately decreased cholesterol and HDL-cholesterol concentrations; Fed mice: Potassium, iron and Amylase activity (trend) decreased ALP activity increased in males, cholesterol decreased in mutants; Hematology: WBC, MCV (WT low?), (HCT) increased in males, same tendency in females for WBC, MCHC decreased in both sexes >> findings of unclear relevance IpGTT: Males loose more weight due to fasting than expected.	Immunology Screen Phenotype: New phenotype Phenotype description: FACS: Lower frequency in T cells and higher frequency in B cells in both, females and males. Furthermore, higher frequency of CD44-expressing T cells in males.	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: No phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: Not tested Phenotype description: not tested	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: MiniSpec NMR: decreased body mass, fat and lean content but no shift in body composition	Pathology Screen Phenotype: No phenotype Phenotype description: no phenotype	Report
EPD0155_1_D04	Myl4^{tm1a(EUCOMM)Wtsi}	Myl4 myosin, light polypeptide 4	Behavioral Screen Phenotype: New phenotype Phenotype description: OF: Increased locomotor activity in both the male and female mutants; decreased rearing in the male mutants and increased rearing in the female mutants; PPI: Decreased PPI in male and female mutants at the 69dB intensity	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: New phenotype Phenotype description: SHIRPA: hyperactivity	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Clinical chemistry: Fasted mice: Mainly/only males Cholesterol (HDL and non-HDL) decreased, NEFA increased; Fed mice: ALP and iron increased, sodium and phosphate (trend) decreased; only males: Amylase and glucose decreased; Hematology: RBC, (HCT), HGB (f) increased, MCV and MCH (m) MCHC (m) decreased: Polycytemia	Immunology Screen Phenotype: New phenotype Phenotype description: Ig: higher levels of IgA (both sexes), and IgG1 and IgM (only males)	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: No phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: Not tested Phenotype description: not tested	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in atria (heart )	Report
EPD0183_3_F08	Dlec1^{tm1a(EUCOMM)Wtsi}	Dlec1 deleted in lung and esophageal cancer 1	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: New phenotype Phenotype description: SHIRPA: less urination; Rotarod: more falling	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: No phenotype Phenotype description: no phenotype	Immunology Screen Phenotype: No phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: No phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: Not tested Phenotype description: not tested	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: Increased body weight, reduced body fat, increased lean mass	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in bronchi and ependym	Report
MTA3		Mta3 metastasis associated 3	Behavioral Screen Phenotype: New phenotype Phenotype description: OF: Significantly decreased rearing behaviour in both male and female mutants; PPI: Decreased PPI in female mutants at 67 and 73 dB and globally	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: New phenotype Phenotype description: SHIRPA: Hypoactivity, less vocalization in females	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Chlinical chemistry: Fed mice: Increased ALP activity, increased liver enzyme activities only in males; slight increase of iron level and decrease of creatinine concentration that might be accidental. Fasted mice: No clear effects, slightly decreased cholesterol in females. Hematology: Slightly decreased PLT, tendency towards increased MCV and MCHC IpGTT: Decreased fasted glucose level (mainly in females), improved glucose clearance (mainly in males)	Immunology Screen Phenotype: New phenotype Phenotype description: FACS: In both sexes, mutant mice had a higher CD4/CD8 ratio then controls. Only in female mice, this was due to a significantly higher freq. of CD8 T cells	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: New phenotype Phenotype description: corticosterone level increased in male mutants	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: No phenotype Phenotype description: no phenotype	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: higher tidal volumes in mutant males at rest; possible alteration in the regulation of breathing;	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in bladder, brain, colon, heart, lung, skin, spleen, stomach, testis, thyroid, thymus	Report
EPD0102_1_D06	Arvcf^{tm1a(EUCOMM)Wtsi}	Arvcf armadillo repeat gene deleted in velo-cardio-facial syndrome	Behavioral Screen Phenotype: New phenotype Phenotype description: OF: Increased locomotor activity and decreased rearing activity by the mutants; Significantly decreased PPI in the mutants at 67dB intensity and tendency (p=0.056) to decreased PPI in the mutant mice globally	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: New phenotype Phenotype description: SHIRPA: Hopping gait, tendency to hyperactivity; Rotarod: Reduced latencies	Eye Screen Phenotype: New phenotype Phenotype description: Funduscopy: White fundus flecks in some cases (controls and mutants); Slit lamp biomicroscopy: Lens nuclear and zonular opacity in all mutants	Clinical Chemical Screen Phenotype: No phenotype Phenotype description: no phenotype	Immunology Screen Phenotype: New phenotype Phenotype description: FACS: Frequency of B cells increased, changes in T cell subsets (CD62L, CD44)	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Decreased pulse rate mainly in males	Lung Function Screen Phenotype: Not tested Phenotype description: not tested	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: No clear difference in body mass or body composition	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in Kidney, Oviduct, Brain	Report
HEPD0073_3_C11	Wbscr16^{tm1a(EUCOMM)Hmgu}	Wbscr16 Williams-Beuren syndrome chromosome region 16 homolog (human)	Behavioral Screen Phenotype: New phenotype Phenotype description: OF: Decreased rearing in the male mutants and increased rearing in the female mutants; Decreased PPI in the male and female mutants	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: New phenotype Phenotype description: Rotarod: Mutant mice fall more often from the rod (79% vs. 56%)	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: no phenotype	Immunology Screen Phenotype: New phenotype Phenotype description: Slightly lower proportion of CD25 expressing CD4 T cells, and lower proportion of CD11b expressing NK cells in mutants	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: Subtle phenotype Phenotype description: decreased testosterone levels in male mutants	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: Phenotype description: pending	Lung Function Screen Phenotype: Not tested Phenotype description: not tested	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: no phenotype	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in brain	Report
Asxl	Asxl1^{tm1a(EUCOMM)Wtsi}	Asxl1 additional sex combs like 1 (Drosophila)	Behavioral Screen Phenotype: New phenotype Phenotype description: OF: Small increase in locomotor activity during last 5 minutes; PPI: Small increase in PPI in the mutants at the 81dB intensity	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: no phenotype	Neurological Screen Phenotype: New phenotype Phenotype description: SHIRPA: Less urination, more vocalization	Eye Screen Phenotype: New phenotype Phenotype description: Absolute and normalized axial eye lengths are significantly decreased in the mutants compared to C57BL/6NTac baseline data; Microphthalmia in two males and two females. Corneal opacity in two males and four females. Iris anomaly in one male and three females; A tendency towards reduced vision in males and females. This might be a secondary effect of the slit lamp phenotypes;	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Fasted mice: non-HDL-Cholesterol, Triglycerides, NEFA and Glycerol low; Non-fasted mice: Low ALT and AST activities (accidental?) mild increase in ALP activity and iron levels.	Immunology Screen Phenotype: No phenotype Phenotype description: no phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Decreased pressure parameters and pulse rate mainly in females; Increased absolute and normalized heart weight	Lung Function Screen Phenotype: Not tested Phenotype description: not tested	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: no organs collected	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: Slightly reduced body fat, and increased lean mass	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in Stomach, Kidney, Brain, Heart, Colon, small intestine, ovary, oviduct, uterus	Report
Cidec	Cidec^{tm1a(EUCOMM)Wtsi} MGI:4433521	Cidec cell death-inducing DFFA-like effector c	Behavioral Screen Phenotype: New phenotype Phenotype description: OF: Decreased rearing in the male mutants with the opposite effect in the female mutants; tendency to increased centre time by the male mutants with the opposite effect in the female mutants	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: DXA: decreased BMD, BMC and bone content in males; decreased body weight, fat mass and fat content; increased lean mass and lean content in males.	Neurological Screen Phenotype: No phenotype Phenotype description: no phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Fed mice: Slightly increased Calcium, TP and Albumin, Cholesterol and amylase activity (liver metabolism); IpGTT: High fasting-induced BW loss, high basal glucose level in fasted mice?	Immunology Screen Phenotype: New phenotype Phenotype description: FACS: Lower frequency of CD8 T cells, higher frequency of B cells. Sex-specific phenotype: in males lower frequency of NK and NK/CD11b+ cells	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Increased absolute (ANOVA) and normalized heart weight	Lung Function Screen Phenotype: Not tested Phenotype description: not tested	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: no organs collected	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: Clearly reduced body fat, increased lean mass, massive shift in body composition	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in adipose tissue	Report
Impad1	Impad1^{tm1a(KOMP)Wtsi} MGI:4363750	Impad1 inositol monophosphatase domain containing 1	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: DXA: increased body weight and fat mass in males.	Neurological Screen Phenotype: New phenotype Phenotype description: SHIRPA: Less tail elevation, Rotarod: Subtle improvement	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Fasted mice: Females cholesterol decreased (total, HDL and less non-HDL), tendencies: decreased NEFA and increased glucose; Fed mice: Trends in females: Phosphate, TP, cholesterol, ASAT increased; Hematology: MPV increased in females; IpGTT: Females loose less weight than expected (trend); basal glucose level in fasted mice increased in females and decreased in males (different from fasted blood).	Immunology Screen Phenotype: Subtle phenotype Phenotype description: Slightly higher levels of IgM in mutants, especially males	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: Phenotype description: pending	Lung Function Screen Phenotype: No phenotype Phenotype description: no phenotype	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: increased body mass especially in male mutants, reduced mean oxygen consumption	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in brain, olfactory bulb, organum subcommissurale, fornix	Report
Hells		Hells helicase, lymphoid specific	Behavioral Screen Phenotype: New phenotype Phenotype description: OF: Increased distance travelled by the male mutants and tendency to decreased centre time by the female mutants; Decreased PPI in the male mutants at the 81dB intensity	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: DXA: decreased body length and body weight in males.	Neurological Screen Phenotype: New phenotype Phenotype description: abnormal gait, improved rotarod performance by female mutants	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Fasted mice: Low cholesterol, non-HDL-Cholesterol and triglyceride levels; IpGTT: Fasting induced weight loss high, AUC no differences	Immunology Screen Phenotype: New phenotype Phenotype description: FACS: High frequency of Nk cells and of NK/CD11b+ cells	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: Increased absolute (ANOVA) and normalized heart weight	Lung Function Screen Phenotype: No phenotype Phenotype description: no phenotype	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: not analysed	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: Decreased body mass; reduced body fat and increased lean mass in females	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in stomach, testes, coagulating gland, ovary, uterus	Report
Uhrf1	Uhrf1^{tm1a(EUCOMM)Wtsi} MGI:4434100	Uhrf1 ubiquitin-like with PHD and ring finger domains 1	Behavioral Screen Phenotype: New phenotype Phenotype description: OF: Increased distance travelled by the male mutants during the 3rd 5 minutes of the test; Decreased PPI in the male mutants	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: decreased BMC in males; decreased body length, body weight (males) and fat mass (males).	Neurological Screen Phenotype: New phenotype Phenotype description: Abnormal gait	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Fasted mice: Low non-HDL-cholesterol and triglycerides (mild); Fed mice: Slightly increased ALP activity?? IpGTT: fasting-induced BW loss high, fasted basal glucose level high, AUC increased	Immunology Screen Phenotype: New phenotype Phenotype description: FACS: Higher frequency of NK cells	Allergy Screen Phenotype: No phenotype Phenotype description: no phenotype	Steroid Screen Phenotype: No phenotype Phenotype description: no phenotype	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: No phenotype Phenotype description: no phenotype	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: no organs collected	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: Decreased body mass, but increased metabolic rate in females, increased RER, but only in females trend of reduced fat mass	Pathology Screen Phenotype: New phenotype Phenotype description: Differences in the expression of ß galactosidase activity between mutant and control mice were observed in ependym, aorta, spleen, ovar, skin	Report
Popdc2	Popdc2^tm1Tbd MGI:3773727	Popdc2 popeye domain containing 2	Behavioral Screen Phenotype: New phenotype Phenotype description: hypoactivtiy (exhaustion, fatigue?)	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Changes in bone homeostasis and body composition (males)	Neurological Screen Phenotype: Additional phenotype Phenotype description: muscle phenotype	Eye Screen Phenotype: No phenotype Phenotype description: no phenotype	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Micro- and polycytic blood cell count. Indications of changes in bone metabolism, muscle energy metabolism, and balance of electrolytes.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: New phenotype Phenotype description: lower IgE levels in female mutants	Steroid Screen Phenotype: Not tested Phenotype description: not tested	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: Not tested Phenotype description: not tested	Lung Function Screen Phenotype: No phenotype Phenotype description: minor changes	Molecular Phenotyping Screen Phenotype: Not tested Phenotype description: No organs selected for expression profiling	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: reduced body weight,	Pathology Screen Phenotype: No phenotype Phenotype description: (BW reduced (males))	Report