allergy screen

Head

Prof. Heidrun Behrendt, M.D.

Phone: +49-089/4140-3451
Fax: +49-089/4140-3452
E-Mail: Heidrun.Behrendt@lrz.tu-muenchen.de,
behrendt@helmholtz-muenchen.de

Prof. Markus Ollert, M.D.

Phone: +49-089/4140-3551
Fax: +49-089/4140-3552
E-Mail: Ollert@lrz.tu-muenchen.de

PD Dr. Martin Mempel

Phone: +49-089/4140-3177
Fax: +49-089/4140-3552
E-Mail: martin.mempel@lrz.tu-muenchen.de

Mailing adress

Division of Environmental Dermatology and Allergy TUM/GSF
Department of Dermatology and Allergy
Technical University of Munich
Biedersteiner Strasse 29
80802 Munich

Scientist

Antonio Aguilar-Pimentel

Phone: +49-089/4140-3081
Fax: +49-089/4140-2540
E-Mail: aguilar@helmholtz-muenchen.de

Homepage

http://www.derma-allergie.med.tu-muenchen.de

The Allergy screen of German Mouse Clinic (GMC) aims to search for IgE mutants in order to establish mouse models for allergic diseases with defined genotypes and to develop new therapeutic and diagnostic strategies against allergic diseases.

Primary Screen

Total plasma IgE (Standard allergy parameter) Measurement of total IgE by ELISA technique (Cut-off: 1 ng/ml)

Secondary Screen (10 mutant mice and 10 control mice)

Specific sensitisation with model allergens (Ovalbumin, recombinant grass pollen allergen Phl p5)
Measurement of total IgE and allergen-specific antibody responses by ELISA technique (specific IgE, IgG1, IgG2a)
Evaluation of allergen-specific T-cell-responses

Tertiary Screen

Measurement of bronchial reactivity after inhalative allergen exposure and methacholine challenge
Analysis of bronchopulmonary inflammatory reaction in bronchoalveolar lavage (BAL)
Analysis of cellular subpopulations

On special request:

Organ-specific allergic reaction (phenotype)
Evaluation of dermal allergic reactivity (skin test / active or passive cutaneous anaphylaxis)

top