Publications of the IEG
2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | bookchapters
Publications 2009
Abe, K., Klaften, M., Narita, A., Kimura, T., Imai, K., Kimura, M., Rubio-Aliaga, I., Wagner, S., Jakob, T., Hrabé de Angelis, M. (2009): Genome-wide search for genes that modulate inflammatory arthritis caused by Ali18 mutation in mice. Mamm Genome 20, 152-161
Adamski, J. (2009): Mission in steroids. J Steroid Biochem Mol Biol 113, 1-2
Adamski, J. (2009): Pre-receptor steroid metabolism as target for pharmacological treatment. Mol Cell Endocrinol 301, 1
Ahting, U., Floss, T., Uez, N., Schneider-Lohmar, I., Becker, L., Kling, E., Iuso, A., Bender, A., Hrabé de Angelis, M., Gailus-Durner, V., Fuchs, H., Meitinger, T., Wurst, W., Prokisch, H., Klopstock, T. (2009): Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitichondrial import. Biochim Biophys Acta (Epub ahead of print)
Aigner, B., Rathkolb, B., Klaften, M., Sedlmeier, R., Klempt, Wagner, S., Michel, D., Mayer, U., Klopstock, T., Hrabé de Angelis, M., Wolf, E. (2009): Generation of ENU-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease models. Exp Physiol 94, 412-421
Aigner, B., Rathkolb, B., Klempt, M., Wagner, Sibylle, Michel, D., Hrabé de Angelis, M., Wolf, E. (2009): N-ethyl-nitrosurea mutagenesis produced a small number of mice with altered plasma elctrolyte levels. J Biomed Sci 16:53
Bazhin, A.V., Dalke, C., Willner, N., Abschütz, O., Wildberger, H.G.H., Philippov, P.P., Dummer, R., Graw, J., Hrabé de Angelis, M., Schadendorf, D., Umansky, V., Eichmüüler S.B. (2009): Cancer-retina antigens as potential paraneoplastic antigens in melanoma-associated retinopathy. Int J Cancer 124, 140-149
Beckers J, Wurst W, Hrabé de Angelis M (2009): Towards better mouse models: enhanced genotypes, systemic phenotyping and envirotype modelling. Nat Rev Genet 10, 371-380
Bosman, E.A., Quint, E., Fuchs, H., Hrabé de Angelis, M., Steel, K.P. (2009): Catweasel mice: A novel role for Six1 in sensory patch development and a model for branchio-oto-renal syndrome. Dev Biol 328, 285-296
Brozic, P., Kocbek, P., Sova, M., Kristl, J., Martens, S., Adamski, J., Gobec, S., Lanisnik Rizner, T. (2009): Flavanoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. Mol Cell Endocrinol 301, 229-234
Enard, W., Gehre, S., Hammerschmidt, K., Höler, S.M., Blass, T., Somel, M., Brückner, M.K., Schreiweis, C., Winter, C., Sohr, R., Becker, L., Wiebe, V., Nickel, B., Giger, T., Müller, U., Groszer, M., Adler, T., Aguilar, A., Bolle, I., Calzada-Wack, J., Dalke, C., Erhardt, N., Favor, J., Fuchs, H., Gailus-Durner, V., Hans, W., Hölzlwimmer, G., Javaheri, A., Kalaydjiev, S., Kallnik, M., Kling, E., Kunder, S., Moßbrugger, I., Naton, B., Racz, I., Rathkolb, B., Rozman, J., Schrewe, A., Busch, D.H., Graw, J., Ivandic, B., Klingenspor, M., Klopstock, T., Oller, M., Quintanilla-Martinez, L., Schulz, H., Wolf, E., Wurst, W., Zimmer, A., Fisher, S.E., Morgenstern, R., Arendt, T., Hrabé de Angelis, M., Fischer, J., Schwarz, J., Pääbo, S. (2009): A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell 137, 961-971
Everett, K.L., Bunney, T.D., Yoon, Y., Rodriguez-Lima, F., Harris, R., Driscoll, P.C., Abe, K., Fuchs, H., Hrabé de Angelis, M., Yu, P., Cho, W., Katan, M. (2009): Characterization of phospholipase C gamma enzymes with gain-of-function mutations. J Biol Chem (Epub ahead of print)
Fuchs, H., Gailus-Durner, V., Adler, T., Pimentel, J.A., Becker, L., Bolle, I., Brielmeier, M., Calzada-Wack, J., Dalke, C., Ehrhardt, N., Fasnacht, N., Ferwagner, B., Frischmann, U., Hans, W., Hölter, S.M., Hölzlwimmer, G., Horsch, M., Javaheri, A., Kallnik, M., Kling, E., Lengger, C., Maier, H., Mossbrugger, I., Mörth C., Naton, B., Nöth, U., Pasche, B., Prehn, C., Przemeck, G., Puk, O., Racz, I., Rathkolb, B., Rozman, J., Schäble, K., Schreiner, R., Schrewe, A., Sina, C., Steinkamp, R., Thiele, F., Willershäuser, M., Zeh, R., Adamski, J., Busch, D.H., Beckers, J., Behrendt, H., Daniel, H., Esposito, I., Favor, J., Graw, J., Heldmaier, G., Höfler, H., Ivandic, B., Katus, H., Klingenspor, M., Klopstock, T., Lengeling, A., Mempel, M., Müller, W., Neschen, S., Ollert, M., Quintanilla-Martinez, L., Rosenstiel, P., Schmidt, J., Schreiber, S., Schughart, K., Schulz, H., Wolf, E., Wurst, W., Zimmer, A., Hrabé de Angelis, M. (2009): The German Mouse Clinic: A Platform for Systemic Phenotype Analysis of Mouse Models. Curr Pharm Biotechnol 10, 236-243
Gailus-Durner, V., Fuchs, H., Adler, T., Aguilar Pimentel, A, Becker, L., Bolle, I., Calzada-Wack, J., Dalke, C., Erhardt, N., Ferwagner, B., Hans, W., Hölter, S.M., Hölzlwimmer, G., Horsch, M., Javaheri, A., Kallnik, M., Kling, E., Langger, C., Mörth, C., Mossbrugger, I., Naton, B., Prehn, C., Puk, O., Rathkolb, B., Rozman, J., Schrewe, A., Thiele, F., Adamski, J., Aigner, B., Behrendt, H., Busch, D.H., Favor, J., Graw, J., Heldmaier, G., Ivandic, B., Katus, H., Klingenspor, M., Kremmer, E., Ollert, M., Quintanilla-Martinez, L., Schulz, H., Wolf, E., Wurst, W., Hrabé de Angelis, M. (2009): Systemic First-Line Phenotyping. In: Gene Knockout Protocols: 2nd Ed., Kühn, R., Wurst, W. (eds.) Methods Mol Biol 530, 463-510
Horsch, M., Recktenwald, C.V., Schädler, S., Hrabé de Angelis, M., Seliger, B., Beckers, J. (2009): Overexpressed vs mutated Kras in murine friboblasts: a molecular phenotyping study. Br J Cancer 100, 656-662
Hult, M., Ortsäter ,H., Schuster, G., Graedler, F., Beckers, J., Adamski, J., Ploner, A., Jörnvall, H., Bergsten, P., Oppermann, U. (2009): Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms. Mol Cell Endocrinol 301, 109-116
Isensee, J., Meoli, L., Zazzu, V., Nabzdyk, C., Witt, H., Soewarto, D., Effertz, K., Fuchs, H., Gailus-Durner, V., Busch, D., Adler, T., Hrabé de Angelis, M., Irgnag M., Otto C., Noppinger P.R. (2009): Expression Pattern of Gpr30 in LacZ Repoerter Mice. Endocrinology 150, 1722-1730
Keller, B., Adamski, J. (2009): Comparison of predicted and experimental subcellular localization of two putative rat steroid dehydrogenases from the short-chain dehydrogenase/reductase protein superfamily. Mol Cell Endocrinol 301, 43-46
Khasawneh, J., Schulz, M.D., Walch, A., Rozman, J., Hrabé de Angelis, M., Klingenspor, M., Buck, A., Schwaiger, M., Saur, D., Schmid, R.M., Klöppel, G., Sipos, B., Greten, F.R., Arkan, M.C. (2009): Inflammation and mitochondrial fatty acid beta-oxidation linke obesity to early tumor promotion. Proc Natl Acad Sci USA 106, 3354-3359
Klonisch, T., Glogowska, A., Gratao, A.A., Grzech, M., Nistor, A., Torchia, M., Weber, E., Hrabé de Angelis, M., Rathkolb, B., Hoang-Vu, C., Wolf, .E, Schneider, M.R. (2009): The C-terminal cytoplasmic domain of human proEGF is a negative modulator of body and organ weights in transgenic mice. FEBS Lett 583, 1349-135
Kolz, M., Johnson, T., Sanna, S., Teumer, A., Vitart, V., Perola, M., Mangino, M., Albrecht, E., Wallace, C., Farall, M., Johanwwon, A., Nyholt, D.R., Aulchenko, Y., Beckmann, J.S., Bergmann, S., Bochud, M., Brown, M., Campbell, H., Connell, J., Dominiczak, A., Homuth, G., Lamina, C., McCarthy, M.I., Meitinger, T., Mooser, V., Munroe, P., Nauck, M., Pedan, J., Prokisch, H., Salo, P., Salomaa, V., Samani, N.J,, Schlessinger D., Uda, M., Völker, U., Waeber, G., Waterworth, D., Wang-Sattler, R., Wright, A.F., Adamski, J., Whitfiled, J.B., Gyllenstein, U., Wilson, J.F., Rudan, I., Pranstaller, P., Watkins, H., Doering, A., Wichmann, H.E., Spector, T.D., Peltonen, L., Völzke, H., Nagaraja, R., Vollenweider, P., Caulfield, M., Illig, T., Gieger, C. (2009): Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genetics 5, e1000504
Lattka, E., Eggers, S., Möller, G., Heim, K., Weber, M., Mehta, D., Prokisch, H., Illig, T., Adamski, J. (2009): A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1. J Lipid Res (Epub ahead of print)
Lewis, M.A., Quint, E., Glazier, A.M., Fuchs, H., Hrabé de Angelis, M., Langford, C., van Dongen, S., Abreu-Goodger, C., Piipari, M., Redshaw, N., Dalmay, T., Moreno-Pelayo, M.A., Enright, A.J., Steel, K.P. (2009): An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice. Nature Gen, doi:10.1038/ng.369 (Epub ahead of print)
Marschall, S., Boersma, A., Hrabé de Angelis, M. (2009): Sperm cryopreservation and in vitro fertilization. In: Gene Knockout Protocols: 2nd Ed., Kühn, R, Wurst, W. (eds.). Methods Mol Biol 530, 407-421
Meier, M., Tokarz J., Haller, F., Mindnich, R., Adamski, J. (2009): Human and zebrafish hydroxysteroid dehydrogenase loke 1 (HSDL1) proteins are inactive enzymes but conserved among species. Chem Biol Interact 178, 197-205
Meier, M., Möller, G., Adamski, J. (2009): Perspectives in understanding the role of human 17beta-hydoxyteroid dehydrogenase in helth and disease. Mol Cell Endocrinol 301, 20-26
Mindnich, R., Adamski, J. (2009): Zebrafish 17beta-hydroxysteroid dehydrogenases: an evolultionary perspective. Mol Cell Endocrinol 301, 20-26
Moeller, G., Adamski, J. (2009): Integrated view of 17beta-hydroxysteroid dehydrogenases. Mol Cell Endocrinol 301, 7-19
Noyes, H.A., Alimohammadian, M.H., Agaba, M., Brass, A., Fuchs, H., Gailus-Durner, V., Hulme, H., Iraqi, F., Kemp, S., Rathkolb, B., Wolf, E., Hrabé de Angelis, M., Roshandel, D., Naessens, J. (2009): Mechanisms controlling anaemia in Trypanosoma congolense infected mice. PLoS One 4(4): e5170
Persson, B., Bray, J.E., Bruford, E., Dellaporta, S.L., Favia, A.D., Duarte, R.G., Jörnvall, H., Kallberg, Y., Kavanagh, K.L., Kedishvili, N., Kisiela, M., Maser, E., Mindnich, R., Orchard, S., Penning, T.M., Thornton, J.M., Adamski, J, Oppermann, U. (2009): THE SDR (short-chain dehydrogenase/reducatse and related enzymes) nomenclature initiative. Chem Biol Interact 178, 94-98
Prehn, C., Möller, G., Adamski, J. (2009): Recent advances in 17 beta-hydroxysteroid dehydrogenases. J Steroid Biochem Mol Biol 114, 72-77
Puk, O., Esposito, I., Söker, T., Löster, J., Budde, B., Nürnberg, P., Michel-Soewarto, D., Fuchs, H., Wolf, E., Hrabé de Angelis, M., Graw, J. (2009): A new Fgf10 mutation in the mouse leads to atrophy of the Harderian gland and slit-eye phenotype in heterozygotes: A novel model for dry-eye disease? Invest Ophthalmol Vis Sci (Epub ahead of print)
Puk, O., Dalke, C., Calzada-Wack, J., Ahmad, N., Klaften, M., Wagner, S., Hrabé de Angelis, M., Graw, J. (2009): Reduced corneal thickness and enlarged anterior chamber in a novel ColVIIIa2G257D mutant mouse. Invest Ophthalmol Vis Sci (Epub ahead of print)
Rasiah, K.K., Gardiner-Garden, M., Padilla, E.J., Möller, G., Kench, J.G., Alles, M.C., Eggleton, S.A., Stricker, P.D., Adamski, J., Sutherland, R.L., Henshall, S.M., Hayes, V.M. (2009): HSD17B4 overexpression, an independent biomarker of poor patient ourcome in prostate cancer. Mol Cell Endocrinol 301, 89-96
Rubio-Aliaga, I., Przemeck, G.K.H., Fuchs, H., Gailus-Durner, V., Adler, T., Hans, W., Horsch, M., Rathkolb, B., Rozman, J., Schrewe, A., Wagner, S., Hölter, S.M., Becker, L., Klopstock, T., Wurst, W., Wolf, E., Klingenspor, M., Ivandic, B.T., Busch, D.H., Becker, J., Hrabé de Angelis, M. (2009): Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes. PLos One 4, e6054
Schneider, M., Förster, H., Boersma, A., Seiler, A., Wehnes, H., Sinowatz, F., Neumüller, C., Deutsch, M.J., Walch, A., Hrabé de Angelis, M., Wurst, W., Ursini, F., Roveri, A., Maleszewski, M., Maiorino, M., Conrad, M. (2009): Mitochondrial glutathione peroxidase 4 disruption cause male infertility. FASEB J (Epub ahead of print)
Soewarto, D., Klaften, M., Rubio-Aliaga, I. (2009): Features and Strategies in ENU mutagenesis. Curr Pharm Biotechnol 10, 198-213
Spyroglou, A., Manolopoulou, J., Wagner, S., Bidlingmaier, M., Reincke, M., Beuschlein, F. (2009): Short term regulation of aldosterone secretion after stimulation and suppression experiments in mice. J Mol Endocrinol (in press)
Suttner, K., Depner, M., Klopp,. N, Illig, T., Vogelberg, C., Adamski, J., von Mutius, E., Kabesch, M. (2009): Genetic variants in the GATA3 gene are not associated with asthma and atopic diseases in German children. J Allergy Clin Immunol 123, 1179-1181
Suttner, K., Ruoss, I., Rosenstiel, P., Depner, M., Pinto, L.A., Schedel, M., Adamski, J., Illig, T., Schreiber, S., von Mutius, E., Kanesch, M. (2009): HLX1 gene variants influence the development of childhood asthma. J Allergy Clin Immunol 123, 82-88e6
Suttner, K., Rosenstiel, P., Depner, M., Schedel, M., Pinto, L.A., Ruether, A., Adamski, J., Klopp, N., Illig, T., Vogelberg, C., Schreiber, S., von Mutius, E., Kabesch, M (2009): TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants. J Allergy Clin Immunol 123, 1062-1068
Tarrant, A.M., Reitzel, A.M., Blomquist, C.H., Haller, F., Tokarz, J., Adamski, J. (2009): Steroid metabolism in cnidarians: Insights from Nematostella vectensis. Mol Cell Endocrinol 301, 27-36
Publications 2008
Abe, K., Wechs, S., Kalaydjiev, S., Franz, T.J., Busch, D.H., Fuchs, H., Soewarto, D., Behrendt, H., Wagner, S., Jakob, T., Hrabé de Angelis, M. (2008): Novel lymphocyte-independent mechanisms to initiate inflammatory arthritis via bone marrow-derived cells of Ali18 mutant mice. Rheumatology 47, 292-300
Aigner, B., Rathkolb, B., Herach, N., Hrabé de Angelis, M., Wanke, R., Wolf, E. (2008): Diabetes models by screening for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects. Am J Physiol Endocrinol Metab 294, E232-E240
Attia, S.M., Badary, O.A., Hamada, F.M., Hrabé de Angelis, M., Adler I.D. (2008): The chemotherapeutic agents nocodazole and amsarcrine cause meiotic delay and noin-disjunction in spermatocytes of mice. Mutat Res 651, 105-113
Bender, A., Beckers, J., Schneider, I., Hölter, S.M., Haack, T., Mader, M., Quintanilla-Martinez, L., Fuchs, H., Gailus-Durner, V., Hrabé de Angelis, M., Wurst, W., Schmidt, J., Klopstock, T. (2008): Creatine improves health and survival of mice. Neurobiol Aging 29, 1404-1411
Bode, M., Irmler, M., Friedenberger, M., May, C., Jung, K., Stephan, C., Meyer, H.E., Lach, C., Hillert, R., Krusche, A., Beckers, J., Marcus, K., Schubert, W. (2008): Interlocking transcriptomics, proteomics and toponomics technologies for brain tissue analysis in murine hippocampus. Proteomics 8, 1170-1178
Fuchs, H., Lisse, T., Hans, W., Abe, K., Thiele, F., Gailus-Durner, V., Hrabé de Angelis, M. (2008): Phenotypic characterization of mouse models for bone-related diseases in the German Mouse Clinic. J Musculoskelet Neuronal Interact. 8, 13-14
Fröhlich Archangelo, L., Greiff, P.A., Hölzel, M., Harasim, T., Kremmer, E., Przemeck, G.K.H., Eick, D., Deshpande, A., J., Buske, C., Hrabéde Angelis, M., Ollala Saad, S.T., Bohlander, S.K. (2008): The CALM and CALM/AF10 interactor CATS is a marker for proliferation. Mol Oncol 2, 356-367
Ganguly, K., Favor, J., Neuhäuser-Klaus, A., Sandulache, R., Puk, O., Beckers, J., Horsch, M., Schädler, S., Vogt-Weisenhorn, D., Wurst, W., Graw, J. (2008): Novel allele of Crybb2 in the mouse and its expression in the brain. Invest Ophth Vis Sci 49, 1533-1541
Gieger, C.H., Geistlinger, L., Altmaier, E., Hrabé de Angelis, M, Kronenberg, F., Meitinger, T., Mewes, H.W., Wichmann, H.E., Weinberger, K.W., Adamski, J., Illig, T., Suhre, K. (2008): Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLOS Genetics, 2008 Nov; 4(11):e1000282
Hartl, D., Irmler, M., Römer, I., Mader, M.T., Mao, L., Zabel, C., Hrabé de Angelis, M., Beckers, J., Klose, J. (2008): Transcriptome and proteome analysis of early embronic mouse brain development. Proteomics 8, 1257-1265
Hertzano, R., Shalit, E., Rzadzinska, A.K., Dror, A.A., Song, L., Ron, U., Tan, J.Z., Shitrit, A.S., Fuchs., H., Hasson, T., Ben-Tal, N., Sweeney, H.L., Hrabé de Angelis, M., Steel. K.P., Avraham, K.B. (2008): A Myo6 Mutation Destroys Coordination between the Myosin Heads, Revealing New Functions of Myosin VI in the Stereocilia of Mammalian Inner Ear Hair Cells. PLoS Genet 4(10): e1000207
Hölter, S.M., Dalke, C., Kallnik, M., Becker, L., Horsch, M., Schrewe, A., Favor, J., Klopstock, T., Beckers, J., Ivandic, B., Gailus-Durner, V., Fuchs, H., Hrabé de Angelis M., Graw, J., Wurst, W. (2008): Sighted C3H mice – a tool for analysing the influence of vision on mouse behaviour? Frontiers in Bioscience 13, 5810-5823
Horsch, M., Schädler, S., Gailus-Durner, V., Fuchs, H., Meyer, H., Hrabé de Angelis, M., Beckers, J. (2008): Systematic gene expression profiling of mouse model series reveals co-expressed genes. Proteomics 8, 1248-1256
Irmler, M., Hartl, D., Schmidt, T., Schuchhardt, J., Lach, C., Meyer, H.E., Hrabé de Angelis, M., Klose, J., Beckers, J. (2008): An approach to handling and interpretation of amibigous data in transcriptome and proteome comparisons. Proteomics 8, 1165-1169
Jakob, T., Köllisch, G.V., Howaldt, M., Bewersdorff, M., Rathkolb, B., Müller, M.L., Sandholzer, N., Nitschke, L., Schiemann, M., Mempel, M., Ollert, M., Neubauer, A., Soewarto, D.A., Kremmer, E., Ring, J., Behrendt, H., Flaswinkel, H. (2008): Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis. J Allergy Clin Immunol 121, 179-184
Kormann, M.S., Depner, M., Hartl, D., Klopp, N., Illig, T., Adamski, J., Vogelberg, C., Weiland, S.K., von Mutius, E., Kabesch, M. (2008): Toll-like receptor heterodimer variants protect from childhood asthma. J Allergy Clin Immunol. 122, 86-92
Lisse, T.S., Thiele, F., Fuchs, H., Hans, W., Przemeck, G.K.H., Abe, K., Rathkolb, B., Quintanilla-Martinez, L., Hoelzlwimmer, G., Helfrich, M., Wolf, E., Ralston, S.H., Hrabé de Angelis, M. (2008): ER-stress mediated apoptosis in a new mouse model of osteogenesis imperfecta. PLoS Genet 4(2): e7
Maier, H., Lengger, C., Simic, B., Fuchs, H., Gailus-Durner, V., Hrabé de Angelis, M. (2008): MausDB: an open source application for phenotype data and mouse colony management in large-scale mouse phenotyping projects. BMC Bioinformatics 9, 169.
Maier, K.L., Alessandrini, F., Beck-Speier, I., Hofer, T.P.J., Diabaté, S., Bitterle, E., Stöger, T., Jakob, T., Behrendt, J., Horsch, M., Beckers, J., Ziesenis, A., Hültner, L., Frankenberger, M., Krauss-Etschmann, S., Schulz, H. (2008): Health effects of ambient particulate matter – biological mechanisms and inflammatory reponse to in vitro and in vivo particle exposures. Inhal Toxicol 20, 319-337
McGowan, K.E., Li, J.Z., Park, C.Y., Beaudry, V., Tabor, H.K., Sabnis, A.J., Zhang, W., Fuchs, H., Hrabé de Angelis, M., Myers, R.M., Attardi, L.D., Barsh, G.S. (2008): Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat Genet 40, 963-970
Pawlak, C.R., Sanchis-Segura, C., Soewarto, D., Wagner, S., Hrabé de Angelis, M., Spanagel, R. (2008): A phenotype-driven ENU mutagenesis screen for the identification of dominant mutations involved in alcohol consumption. Mamm Genome 19, 77-84
Pinto, L., Mader, M.T., Irmler, M., Gentilini, M., Santoni, F., Drechsel, D., Blum, R., Stahl, R., Bulfone, A., Malatesta, P., Beckers, J., Goetz, M. (2008): Prospective isolation of functionally distinct radial glial subtypes - lineage and transcriptome analysis. Mol Cell Neurosci 38, 15-42
Puk, O., Dalke, C., Hrabé de Angelis, M., Graw, J. (2008): Variation of the response to the optokinetic drum among various strains of mice. Front Biosci. 13, 6269-6275
Puk, O., Löster, J., Dalke, C., Soewarto, D., Fuchs, H., Budde, B., Nürnberg, P., Wolf, E., Hrabé de Angelis, M., Jochen Graw, J. (2008): Mutation in a Novel Connexin-like Gene (Gjf1) in the Mouse Affects Early Lens Development and Causes a Variable Small-Eye Phenotype. Investigative Ophthalmology and Visual Science 49, 1525-1532.
Schmidt, S., Gawlik, V., Hölter, S.M., Augustin, R., Scheepers, A., Behrens, M, Wurst, W., Gailus-Durner, V., Fuchs, H., Hrabé de Angelis M, Kluge, R., Joost, H.G., Schürmann A (2008): Deletion of Glucose Transporter GLUT8 in Mice Increases Locomotor Activity. Behav Genet 38, 396-406
Schuchhardt, J., Glintschert, A., Hartl, D., Irmler, M., Beckers, J., Marcus, K., Klose, J., Meyer, H.E., Malik, A. (2008): BrainProfileDB – an integrated platform for managing functional genomics data. Proteomics 8, 1162-1164
Söker, T., Dalke, C., Puk, O., Floss T., Becker L., Bolle I., Favor J., Hans W., Hölter S.M., Horsch M., Kallnik M., Kling E., Mörth C., Schrewe A., Stigloher, C., Topp, S., Gailus-Durner, V., Naton, B., Beckers, J., Fichs, H., Ivandic B., Klopstock T., Schulz, H., Wolf, E., Wurst, W., Bally-Cuif, L, Hrabé de Angelis, M., Graw, J. (2008): Pleiotropic effects in Eya3 knockout mice. BMC Dev Biol 8, 118
Spiden, S.L., Bortolozzi, M., Di Leva, F., Hrabé de Angelis, M., Fuchs, H., Lim, D., Ortolano, S., Ingham, N.J., Brini, M., Carafoli, E., Mammano, F., Steel, K.P. (2008): The Novel Mouse Mutation Oblivion Inactivates the PMCA2 Pump and Causes Progressive Hearing Loss. PLoS Genet 4(10): e1000238
Uez, N., Lickert, H., Kohlhase, J., Hrabé de Angelis, M., Kühn, R., Wurst, W., Floss, T. (2008): Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo. Genesis 46, 463-477
Wang-Sattler, R., Yu, Y., Mittelstrass, K., Lattka, E., Altmaier, E., Gieger, C.H., Ladwig, K.H., Dahmen, N., Hao, P., Liu, L., Li, Y., Wichmann, H.E., Weinberger, K.H., Adamski, J., Suhre, K., Illig, T. (2009): Metabolic profile analysis reveals distinct variations linked to nicotine consumption in humans. PLOS One, 2008 Nov; 3(12):e3863
Zolotukhin, A.S., Schneider, R., Uranishi, H., Bear, J., Tertyakova, I., Michalowski, D., Smulevitch., S., O’Keefe, S., Pavlakis, G.N., Felber, B.K. (2008): The RNA transport element RTE is essential for IAP LTR-retrotransposon mobility. Virology 377, 88-99
Publications 2007
Aigner, B., Rathkolb, B., Herbach, N., Kemter, E., Schessl, C., Klaften, M., Klempt, M., Hrabé de Angelis, M., Wanke, R., Wolf, E. (2007): Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models. Am J Physiol Renal Physiol 292, F1560-F1567
Aigner, B., Rathkolb, B., Mohr, M., Klempt, M., Hrabé de Angelis, M., Wolf, E. (2007): Generation of ENU-Induced Mouse Mutants with Hypocholesterolemia: Novel Tools for Dissecting Plasma Lipoprotein Homeostasis. Lipids 42, 731-737
Beckers, J., Hrabé de Angelis, M. (2007): Mausmodelle: Von der funktionellen Genomforschung zur systematischen Krankheitsanalyse. Biospektrum 05.07, 504-506
Frey, I.M., Rubio-Aliaga, I., Siewert A., Sailer, D., Drobyshev, A., Beckers, J., Hrabé de Angelis, M., Eichinger, H.M., Daniel, H. (2007): Profiling at mRNA, protein and metabolite level reveals alterations in renal amino acid handling and glutathione metabolism in kidney tissue of Pept2-/- mice. Physiol Genomics 28, 302-310
Grallert, H., Sedlmeier, E.M., Huth, C., Kolz, M., Heid, I.M., Meisinger, C., Herder, C., Strassburger, K., Gehringer, A., Haak, M., Giani, G., Kronenberg, F., Wichmann, H.E., Adamski, J., Paulweber, B., Illig, T., Rathmann, W. (2007): APOA5 variants and metabolic syndrome in Caucasians. J Lipid Res 48, 2614-2621
Guggenberger, C,, Ilgen, D., Adamski, J. (2007): Functional analysis of cholesterol biosynthesis by RNA interference. J Steroid Biochem Mol Biol 104, 105-109
Hagn, M., Marschall S., Hrabé de Angelis, M. (2007): EMMA - The European mouse mutant archive. Brief Funct Genomic Proteomic 6, 186-192
Hamacher, M., Stephan, C., Eisenacher, M., Lewczuk, P., Wiltfang, J., Martens, L., Vizcaíno, J.A., Kwon, K.-H., Yoo, J.S., Park, Y,M., Beckers, J., Horsch, M., Hrabé de Angelis, M., Cho, Z.-H., Apweiler, R., Meyer, H.E. (2007): High Performance Proteomics: 7th HUPO Brain Proteome Project Workshop in Hinxton, UK. Proteomics 7, 2490-2496
Hammel, M., Michel, G., Hoefer, C., Klaften, M., Müller-Höcker, J., Hrabé de Angelis, M., Holzinger, A. (2007): Targeted inactivation of the murine Abca3 gene leads to respiratory failure in newborns with defctive lamellar bodies. Biochem Biophys Res Com 359, 947-951
Hancock, J.M., Adams, N.C., Aidinis, V., Blake, A., Blake, J.A., Bogue, M., Brown, S.D.M., Chesler, E., Davidson, D., Duran, C., Eppig, J.T., Gailus-Durner, V., Gates, H., Gkoutos, G.V., Greenaway, S., Hrabé de Angelis, M., Kollias, G., Leblanc, S., Lee, K., Lengger, C., Maier, H., Mallon, A-M., Masuya, H., Melvin, D.G., Müller, W., Parkinson, H., Proctor, G., Reuveni, E., Schofield, P., Shukla, A., Smith, C., Toyoda, T., Vasseur, L., Wakana, S., Walling, A., White, J., Wood, J., Zouberakis, M., (2007): Integration of mouse phenome data resources: The Mouse Phenotype Database Integration Consortium. Mammalian Genome 18, 157-163
Herbach, N., Rathkolb, B., Kemter, E., Pichl, L., Klaften, M., Hrabé de Angelis, M., Halban, PA., Wolf, E., Aigner, B., Wanke, R. (2007): Dominant negative effects of a novel mutated Ins2 allele causes early onset diabetes mellitus and severe beta cell loss in Munich Ins2C95S mutant mice. Diabetes 56, 1268-1276
Kallnik, M., Elvert, R., Ehrhardt, N., Kissling, D., Mahabir, E., Welzl, G., Faus-Kessler, T., Hrabé de Angelis, M., Wurst, W., Schmidt, J., Hölter, S.M., (2007): Impact of IVC housing on emotionality and fear learning in male C3HeB/FeJ and C57BL/6J mice. Mamm Genome 18, 173-186
Keller, B., Adamski, J. (2007): RDH12, a retinol dehydrogenase causing Leber's congenital amaurosis, is also involved in steroid metabolism. J Steroid Biochem Mol Biol 104, 190-194
Kristan, K., Adamski, J., Rizner, T.L., Stojan, J. (2007): His164 regulates accessibility to the active site in fungal 17beta-hydroxysteroid dehydrogenase. Biochimie 89, 63-71
Kristan, K., Sova, M., Lunder, M., Bratkovic, T., Gobec, S., Strukelj, B., Stojan, J., Adamski, J., Lanisnik Rizner T. (2007): Searching for inhibitors of fungal 17beta-hydroxysteroid dehydrogenase. In: Enzymology and Molecular Biology of carbonyl metabolism. (eds.: Weiner, H, Maser, E, Lindahl, R, Plapp, B ), Vol. 13, 263-272. West Lafayette, Indiana, USA: Purdue University Press
Kristan, K., Stojan, J., Adamski, J., Lanisnik Rizner T (2007): Rational design of novel mutants of fungal 17beta-hydroxysteroid dehydrogenase. J Biotechnol 129, 123-130
Lukacik, P., Keller, B., Bunkoczi, G., Kavanagh, K., Li, W.-H., Adamski, J. and Oppermann, U. (2007): Structural and biochemical characterization establishes human DHRS10 as a novel 17beta-hydroxysteroid dehydrogenase. Biochemical Journal 402, 419-427
Magnol, L., Chevallier, M-C., Nalesso, V., Retif, S., Fuchs, H., Klempt, M., Pereira, P., Riottot, M., Andrzejewski, S., Doan, B-T., Panthier, J-J., Puech, A., Beloeil, J-C., Hrabé de Angelis, M., Hérault, Y. (2007): KIT is required for hepatic function during mouse post-natal development. BMC Develop Biol 7, doi:10.1186/1471-213X-7-81
Mayer A., Bulian, D., Scherb, H., Hrabé de Angelis, M., Schmidt, J., Mahabir, E. (2007): Emergency prevention of extinction of a transgenic allele in a less-fertile transgenic mouse line by crossing with an inbred or outbred mouse strain coupled with assisted reproductive technolgies. Reprod Fert Develop 19, 984-994
McGowan, K. A., Fuchs, H., Hrabé de Angelis, M., Brash, G.S. (2007): Identification of a Keratin 4 Mutation in a Chemically Induced Mouse Mutant. J Invest Dermatol 127, 60-64
Meyer, C.W., Elvert, R., Scherag, A., Ehrhardt, N., Gailus-Durner, V., Fuchs, H., Schäfer, H., Hrabé de Angelis, M., Heldmaier, G., Klingenspor, M. (2007) Power matters in closing the phenotyping gap. Naturwissenschaften 94, 401-406
Mindnich, R., Adamski. J. (2007): Functional aspects of 17beta-hydroxysteroid dehydrogenase 1 determined by comparison to a closely related retinol dehydrogenase. J Steroid Biochem Mol Biol 104, 334-339
Mindnich, R., Hrabé de Angelis, M., Adamski, J. (2007): Functional genome analysis indicates loss of 17beta-hydroxysteroid dehydrogenase type 2 enzyme in the zebrafish. J Ster Biochem Mol Biol 103, 35-43
Prehn, C., Ströhle, F., Haller, F., Keller, B., Hrabé de Angelis, M., Adamski, J., Mindnich, R. (2007): A Comparison Of Methods For Assays Of Steroidogenic Enzymes: New GC/MS Versus HPLC And TLC. Purdue University Press, West Lafayette, Indiana, USA
Rubio-Aliaga, I., Soewarto, D., Wagner, S., Klaften, M., Fuchs, H., Kalaydjiev, S., Busch, D.H., Klempt, M., Rathkolb, B., Wolf, E., Abe, K., Zeiser, S., Przemeck, G.K.H., Beckers, J., Hrabé de Angelis, M. (2007): A Genetic Screen for Modifiers of the Delta1-Dependent Notch Signaling Function in the Mouse. Genetics 175, 1-13
Seedorf, H., Klaften, M., Eke, F., Fuchs, H., Seedorf, U., Hrabé de Angelis, M. (2007): A Mutation in the Enamelin Gene in a Mouse Model. J Dent Res 86, 764-768
Teppner, I., Becker, S., Martin Hrabé de Angelis, M., Gossler, A., Beckers, J. (2007): Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints. BMC Develop Biol 7, 68
Tiedemann, H., Schneltzer, E., Zeiser, S., Rubio-Aliaga, I., Wurst, W., Beckers, J., Przemeck, G.K.H., Hrabé de Angelis, M. (2007): Cell-based simulation of dynamic expression patterns in the presomitic mesoderm. J Theoret Biol 248, 120-129
Vauti, F., Goller, T., Beine, R., Becker, L., Klopstock, T., Hölter, S.M., Wurst, W., Fuchs, H., Gailus-Durner, V., Hrabé de Angelis, Arnold, H-H. (2007) The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour. Gene 389, 174-185
Publications 2006
Abe, K., Fuchs, H., Lisse, T., Hans, W., Hrabé de Angelis, M. (2006): New ENU-induced semidominant mutation, ALI18, causes inflammatory arthritis, dermatitis, and osteoporosis in the mouse. Mamm Genome 17, 915-926
del Barco Barrantes, I., Montero-Pedrazuela, A., Gudano-Ferraz, A., Obregon, M.-J., Martinez de Mena, R., Gailus-Durner, V., Fuchs, H., Franz, T.J., Kalaydjiev, S., Klempt, M., Hölter, S., Rathkolb, B., Reinhard, C., Morreale de Escobar, G., Bernal, J., Busch, D.H., Wurst, W., Wolf, E., Schulz, H., Shtrom, S., Greiner, E., Hrabé de Angelis, M., Westphal, H., Niehrs, C. (2006): Generation and Characterization of Dickkopf3 Mutant Mice. Mol Cell Biol 26, 2317-2326
Becker, S., Hrabé de Angelis, M., Beckers, J. (2006): Use of chemical mutagenesis in mouse embryonic stem cells. Methods Mol Biol 329, 397-407
Brielmeier, M., Mahabir, E., Needham, J.R., Lengger, C., Wilhelm, P., and Schmidt, J. (2006): Microbiological monitoring of laboratory mice and biocontainment in individually ventilated cages: a field study. Laboratory Animals 40, 247–260
Deluca, D., Moller, G., Rosinus, A., Elger, W., Hillisch, A., Adamski, J. (2006): Inhibitory effects of fluorine-substituted estrogens on the activity of 17betahydroxysteroid dehydrogenases. Mol Cell Endocrinol 248, 218-224
Ebert, R., Schutze, N., Adamski, J., Jakob, F. (2006): Vitamin D signaling is modulated on multiple levels in health and disease. Mol Cell Endocrinol 248, 149-159
Grallert, H., Huth, C., Kolz, M., Meisinger, C., Herder, C., Strassburger, K., Giani, G., Wichmann, H.E., Adamski, J., Illig T, Rathmann, W. (2006): IL-6 promoter polymorphisms and quantitative traits related to the metabolic syndrome in KORA S4. Exp Gerontol 41, 737-745
Guo, K., Lukacik, P., Papagrigoriou, E., Meier, M., Lee, W.H., Adamski, J., Oppermann, U. (2006): Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase. J Biol Chem 281, 10291-10297
Keller, B., Grote, K., Adamski J. (2006): In silico Northern blot, an automated method to determine expression patterns from EST databases, reveals tissue specificity of murine 17beta-hydroxysteroid dehydrogenase type 11. Mol Cell Endocrinol 248, 242-245
Keller, B., Ohnesorg, T., Mindnich, R., Gloeckner, C.J., Breitling, R., Scharfe, M., Moeller, G., Blocker, H., Adamski, J. (2006): Interspecies comparison of gene structure and computational analysis of gene regulation of 17beta-hydroxysteroid dehydrogenase type I. Mol Cell Endocrinol 248, 168-171
Keller, B., Volkmann, A., Wilckens, T., Moeller, G., Adamski, J. (2006) Bioinformatic identification and characterization of new members of short-chain dehydrogenase/reductase superfamily. Mol Cell Endocrinol 24, 56-60
Kleine-Ostmann, T., Jördens, C., Baaske, K., Weimann, T., Hrabé de Angelis, M., Koch, M. (2006): Conductivity of single-stranded and double-stranded deoxyribose nucleic acid under ambient conditions: The dominance of water. Appl Phys Lett 88, 102102
Klempt, M., Rathkolb, B., Fuchs, E., Hrabé de Angelis, M., Wolf, E., Aigner, B. (2006): Genotype-specific environmental impact on the variance of blood values in inbred and F1 hybrid mice. Mamm Genome 17, 93-102
McGowan, K.A., Aradadhya, S., Fuchs, H., Hrabé de Angelis, M., Barsh, G.S. (2006): A Mouse Keratin1 Mutation Causes Dark Skin and Epidermolytic Hyperkeratosis. J Invest Dermatol 126, 1013-1016
top
Noguchi, Y., Kurima, K., Makishima, T., Hrabé de Angelis, M., Fuchs, H., Frolenkov, G., Kitamura, K., Griffith, A.J. (2006): Multiple quantitative trait loci modify cochlear hair cell degeneration in the Beethoven (Tmc1Bth) mouse model of progressive hearing loss DFNA36. Genetics 173, 2111-2119
Ohnesorg, T., Adamski, J. (2006): Analysis of the 5' flanking regions of human and murine HSD17B7: Identification of a cholesterol dependent enhancer region. Mol Cell Endocrinol 248, 164-167
Ohnesorg, T., Keller, B., Hrabé de Angelis M., Adamski, J. (2006): Transcriptional regulation of human and murine 17-beta-hydroxysteroid dehydrogenase type-7 confers its participtaion in cholesterol biosynthesis. J Mol Endocrinol 37, 185-197
Peters, D.D., Marschall, S., Mahabir, E., Boersma, A., Heinzmann, U., Schmidt, J., Hrabé de Angelis M. (2006): Risk assessment of mouse hepatitis virus infection via in vitro fertilization and embryo transfer by the use of zona-intact and laser-microdissected oocytes. Biol Reprod 74, 246-252
Puk, O., Dalke, C., Favor, J., Hrabé de Angelis, M, Graw, J. (2006): Variations of eye size parameters among different strains of mice. Mamm Genome 17, 851-857
Runkel, F., Klaften, M., Koch, K., Bohnert, V., Bussow, H., Fuchs, H., Franz, T., Hrabé de Angelis, M. (2006): Morphologic and molecular characterization of two novel Krt71 (Krt2-6g) mutations: Krt71rco12 and Krt71rco13. Mamm Genome 17, 1172-1182
Schneider, I., Tirsch, W.S., Faus-Keßler, T., Becker, L., Kling, E., Austin Bussi, R.-L., Bender, A., Feddersen, B., Tritschler, J., Fuchs, H., Gailus-Durner, V., Englmeier, K.-H., Hrabé de Angelis, M., Klopstock, T. (2006): Systematic, standardized and comprehensive neurological phenotyping of inbred mice strains in the German Mouse Clinic. J Neurosci Meth 157, 82-90
Smuc, T., Rupreht, R., Sinkovec, J., Adamski, J., Rizner, T.L. (2006): Expression analysis of estrogen-metabolizing enzymes in human endometrial cancer. Mol Cell Endocinol 248, 114-117
Zeiser, S., Liebscher, H.V., Tiedemann, H., Rubio-Aliaga, I., Przemeck G.K.H., Hrabé de Angelis, M., Winkler, G. (2006): Number of Active Transcription Factor Binding Sites Is Essential for Hes7 Oscillator. Theor Biol Med Model 3, 11-16
Publications 2005
Attia, S.M., Badary, O.A., Hamada, F.M., Hrabé de Angelis M., Adler, I.-D. (2005): Orthovanadate increased the frequency of aneuploid mouse sperm without micronucelus induction in mouse bone marrwo erythrocytes at the same dose level. Mutat Res 583, 158-167
Beckers, J., Herrmann, F., Rieger, S., Drobyshev A.L., Horsch, M., Hrabé de Angelis, M., Seliger, B. (2005): Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis. Int J Cancer 114, 590-597
Brown, S.D.M., Chambon, P., Hrabé de Angelis M., (Eumorphia Consortium) (2005): EMPReSS: standarized phenotype screens for functional annotation of the mouse genome. Nature Genetics 37, 1155
Deluca, D., Fritz, A., Mindnich, R., Möller, G. and Adamski, J. (2005): Biochemical Genetics of 17beta-Hydroxysteroid Dehydrogenases. Curr Top Ster Res 4, 227-242
Deluca, D., Krazeisen, A., Breitling, R., Prehn, C., Möller, G., Adamski. J. (2005): Inhibition of 17beta-hydroxysteroid dehydrogenases by phytoestrogens: comparison with other steroid metabolizing enzymes. J Ster Biochem Mol Bio 93, 285-292
Döhr, S., Klingenhoff, A., Maier, H., Hrabé de Angelis, M., Werner, T., Schneider, R. (2005): Linking disease-associated genes to regulatory networks via promoter organization. Nucleic Acids Res 33, 864-872
Gailus-Durner V., Fuchs, H., Becker, L., Bolle, I., Bielmeier, M., Calzada-Wack, J., Elvert, R., Erhardt, N., Dalke, C., Franz, T.J., Grundner-Culemann, E., Hammelbacher, S., Hölter, S., Hölzlwimmer, G., Horsch, M., Javaheri, A., Kalaydjiev, S., Klempt, M., Kling, E., Kunder, S., Lengger, C., Lisse, T., Mijalski, T., Naton, B., Pedersen, V., Prehn, C., Przemeck, G., Racz, I., Reinhard, C., Reitmeir, P., Schneider, I., Schrewe, A., Steinkamp, R., Zybill, C., Adamski, J., Beckers, J., Behrendt, H., Favor, J., Graw, J., Heldmaier, G., Höfler, H., Ivandic, B., Katus, H., Kirchhof. P., Klingenspor, M., Klopstock, T., Lengeling, A., Müller, W., Ohl, F., Ollert, M., Quintanilla-Martinez, L., Schmidt, J., Schulz, H., Wolf, E., Wurst, W., Zimmer, A., Busch, D.H., and Hrabé de Angelis, M. (2005): Introducing the German Mouse Clinic: Open access platform for standardized phenotyping. Nat Methods 2, 403-404
Gailus-Durner, Adamski, L., Beckers, J., Behrendt, H., Busch, D., Engelmann, B., Floss, T., Fuchs, H., Graw, J., Hansen, G., Heldmaier, G., Himmelbauer, H., Höfler, H., Hölter, S., Ivandic, B., Jakob, H., Katus, H., Klingenspor, M., Laufs, J., Lengeling, A., Lengger, C., Müller, W., Nehls, M., Ollert, M., Quintanilla-Fend, L., Ruiz, P., Schulz, H., von Melchner, H., Wolf, E., Wurst, W., Zeretzke, S., Zimmer, A., Hé de Angelis, M. (2005): Mäuse als Modelle für erbliche Erkrankungen des Menschen. GENOMXPRESS 2, 7-10
Graw, J., Löster, J., Puk, O., Múnster, D., Haubst, N., Soewarto, D., Fuchs, H., Meyer, B., Núrnberg, P., Pretsch, W.,Selby, P., Favor, J., Wolf, E., Hrabé de Angelis, M. (2005): Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters. Ophthalmol Vis Sci 46, 4671-4683
Greenwood, A.D., Horsch, M., Stengel, A., Vorberg, I., Maas, E., Schaedler, S., Erfle, V., Beckers, J., Schätzl, H., Leib-Mösch, C. (2005): Cell line dependent RNA expression profiles of prion infected mouse neuronal cells. J Mol Biol 349, 487-500
top
Hawker, K., Fuchs, H., Hrabé de Angelis, M., Steel, K.P. (2005): Two new mouse mutants with vestibular defects that map to the highly mutable locus on chromosome 4. Int J Audiol 44, 171-177
Jakupoglu, C., Przemeck, G.K.H., Schneider, M., Moreno, S.G., Mayr, N., Hatzopoulus, A.K., Hrabé de Angelis, M., Wurst, W., Bornkamm, G.W., Brielmeier, M., Conrad, M. (2005): Cytoplasmic Thioredoxin Reductase is Essential for Embryogenesis but dispensable for Cardiac Development. Mol Cell Biol 25, 1980-1988
Klaften, M., Hrabé de Angelis, M. (2005): ARTS: A web-based tool for the setup of high-throughput genome wide mapping panels for the SNP genotyping of mouse mutants. Nucleic Acids Res 33, W496-W500
Kristan, K., Deluca, D., Adamski, J., Stojan, J., Rizner, T.L. (2005): Dimerization and enzymatic activity of fungal 17beta-hydroxysteroid dehydrogenase from the short-chain dehydrogenase/reductase superfamily. BMC Biochem. 6, 28
Kristan, K., Stojan, J., Moller, G., Adamski, J., Rizner, T.L. (2005): Coenzyme specificity in fungal 17beta-hydroxysteroid dehydrogenase. Mol Cell Endocrinol 241, 80-7
Maier, H., Döhr, S., Grote, K., O'Keefe, S., Werner, T., Hrabé de Angelis, M., Schneider, R. (2005): LitMiner and WikiGene: identifying problem-related key players of gene regulation using publication abstracts. Nucleic Acids Res 33, W779-W782
Machka, C., Kersten, B., Zobawa, M., Harder, A., Horsch, M., Halder, T., Lottspeich, F., Hrabé de Angelis, M., Beckers, J. (2005): Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling. Gene Expr Patterns 6, 94-101
Mijalski, T., Harder, A., Halder, T., Kersten, M., Horsch, M, Strom, T.M., Liebscher, H.V., Lottspeich, F., Hrabé de Angelis, M., Beckers, J. (2005): Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues. Proc Natl Acad Sci USA 102, 8621-8626
Mindnich, R., Haller, F., Halbach, F., Moeller, G., Hrabé de Angelis, M., Adamski, J. (2005): Androgen metabolism via 17{beta}-hydroxysteroid dehydrogenase type 3 in mammalian and non-mammalian vertebrates: comparison of the human and the zebrafish enzyme. J Mol Endocrinol 35, 305-16
Ohnesorg, T., Adamski, J. (2005): Promoter analyses of human and mouse 17beta-hydroxysteroid dehydrogenase type 7. J Ster Biochem Mol Biol 94, 259-261
Pasche, B., Kalaydjiev, S., Franz, T., Kremmer, E., Gailus-Durner, V., Fuchs, H., Hrabé de Angelis, M., Lengeling, A., Busch, D.H. (2005): Sex-Dependent Susceptibilty to Listeria monocytogenes Infection Is Mediated by Differential Interleukin-10 Production. Infect Immun 73, 5952-5960
Pau, H., Fuchs, H., Hrabé de Angelis, M., Steel K.P. (2005): Hush puppy: a new mouse mutant wih pinna, ossicle, and inner ear defects. Laryngoscope 115, 116-124
Rathkolb, B., Tuyen, V.T., Klempt, M., Hrabé de Angelis, M, Wanke, R., Wolf, E., Aigner, B. (2005): Large scale albuminuria screen for Nephropathy models in chemically induced mouse mutants. Experimental Nephrology 100, 143-149
Reinhard, C., Meyer, B., Fuchs, H., Stoeger, T., Eder, G., Rüschendorf, F., Heyder, J., Nürnberg, P., Hrabé de Angelis, M., Schulz, H. (2005): Genomewide linkage analysis identifies novel genetic loci for lung function in mice. Am J Resp Crit Care 171, 880-888
Seltmann, M., Horsch, M., Drobyshev, A., Chen, Y., Hrabé de Angelis, M., Beckers, J. (2005): Assessment of a systematic expression profiling approach. In: ENU-induced mouse mutant lines. Mamm Genome 16, 1-10
Smulevitch, S., Michalowski, D., Zolotukhin, A.S., Schneider, R., Bear, J., Roth, P., Pavlakis, G.N., Felber, B.K. (2005): Structural and Functional Analysis of the RNA Transport Element, a Member of an Extensive Family Present in the Mouse Genome. J Virol 79, 2356-2365
Yu, P., Constien, R., Dear, N., Katan, M., Hanke, P., Bunney, T.D., Kunder, S., Quintanilla-Martinez, L., Huffstadt, U., Schröder, A., Peters, T., Fuchs, H., Hrabé de Angelis, M., Nehls, M., Grosse, J., Wabnitz, P., Meyer, T.P.H., Yasuda, K., Schneider-Fresenius, C., Jagla, W., Russ, A., Popp, A., Laufs, J., Schmittwolf, C., Wagner, H., Pfeffer, K., Mudde, G.C. (2005): Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C2 that specifically increase external Ca2+ entry. Immunity 22, 451-465
Publications 2004
Adler, I.-D., Gonda, H., Hrabé de Angelis, M., Jentsch, I., Otten, I. S., Speicher, M. R. (2004): Heritable translocations induced by dermal exposure of male mice to acrylamide. Cytogenet Genome Res 104, 271-276
Ahituv, N., Erven, A., Fuchs, H., Guy, K., Ashery-Padan, R., Williams, T., Hrabé de Angelis, M., Avraham, K.B., Steel, K.P. (2004): An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice. Mamm Genome 15, 424-432
Auwerx, J., Avner, P., Baldock, R., Ballabio, A., Balling, R., Barbacid, M., Berns, A., Bradley, A., Brown, S., Carmeliet, P., Chambon, P., Cox, R., Davidson, D., Davies, K., Duboule, D., Forejt, J., Granucci, F., Hastie, N., Hrabé de Angelis, M., Jackson, J., Kioussis, D., Kollias, G., Lathrop, M., Lendahl, U., Malumbres, M., von Melchner, H., Müller, W., Partanen, J., Ricciardi-Castagnoli, P., Rigby, P., Rosen, B., Rosenthal, N., Skarnes, B., Stewart, A.F., Thornton, J., Tocchini-Valentini, G., Wagner, E., Wahli. W., Wurst, W. (2004): The European dimension for the mouse genome mutagenesis programm. Nature Genetics 36, 925-927
Crass, T., Antes, I., Basekow, R., Bork, P., Buning, C., Christensen, M., Claußen, H., Ebeling, C., Ernst, P., Gailus-Durner, V. et al. (2004): The Helmholtz Network for Bioinformatics: an intergrative web portal for bioinformatics resources. Bioinformatics 20, 268-270
Dalke, C., Löster, J., Fuchs, H., Gailus-Durner, V., Soewarto, D., Favor, J., Neuhäuser-Klaus, A., Pretsch, W., Gekeler, F., Shinoda, K., Zrenner, E., Meitinger, T., Hrabé de Angelis, M., Graw, J. (2004): Electroretinography as a Screening Methods for Mutations Causing Retinal Dysfunction in Mice. Invest Ophtalmol Vis Sci 45, 601-609
Ebert, R., Jovanovic, M., Ulmer, M., Schneider, D., Meissner-Weigl, J., Adamski J., Jakob, F. (2004): Down-regulation by nucelar factor kappaB of human 25-hydroxyvitamin D3 1alpha-hydroxylase promoter. Mol Endocrinol 18, 2440-2450
top
Hansdottir, A.G., Palsdottir, K., Favor, J., Neuhäuser-Klaus, A., Fuchs, H., Hrabé de Angelis, M., Steingrimsson, E. (2004): The novel microphthalmia mutations Mitf(mi-enu5) andMitf(mi-bcc2) produce dominant negative Mitf proteins. Genomics 83, 932-935
Ivandic B., Kirchhof P., Fuchs H., Gailus-Durner V., Katus H., Hrabé de Angelis M. (2004): The German Mouse clinic - Establishment of a new cardiovascular primary screen. Perfusion 9, 373
Mahabir, E., Mayer, A., Marschall, S., Hrabé de Angelis, M., Schmidt, J. (2004): Importance of embryo transfers in transgenic mouse facilities. Reprod Fert Develop 16, 211-212
Meyer, C.W.E., Korthaus, D., Jagla, W., Cornali, E., Grosse, J., Fuchs, H., Klingenspor, M., Roemheld, S., Tschöp, M., Heldmaier, G., Hrabé de Angelis, M., Nehls, M. (2004): A Novel Missense Mutation in the Mouse Growth Hormone Gene Causes Semidominant Dwarfism, Hyperghrelinemia and Obesity. Endocrinology 14, 2531-2541
Mindnich, R., Deluca, D., Adamski, J. (2004): Identification and characterization of 17beta-hydroxysteroid dehydrogenases in the zebrafish, Danio rerio. Mol Cell Endocrinol 215, 19-30
Mindnich, R., Möller, G., Adamski, J. (2004): The role of 17beta-hydroxysteroid dehydrogenases. Mol Cell Endocrinol 218, 7-20
Mohr, M., Klempt, M., Rathkolb, B., Hrabé de Angelis, M., Wolf, E., Aigner, B. (2004): Hypercholesterolemia in ENU-induced mouse mutants. J Lipid Res 45, 2132-2137
Naschberger, E., Werner, T., Vicente, A.B., Guenzi, E., Töpolt, K., Leubert, R., Lubeseder-Martellato, C., Nelson, P.J., Stürzl, M. (2004): Nuclear factor-kappaB motif and interferon-alpha-stimulated response element co-operate in the activation of guanylate-binding protein-1 expression by inflammatory cytokines in endothelial cells. Biochem J 379, 409-420
Pau, H., Hawker, K., Fuchs, H., Hrabé de Angelis, M., Steel, K.P. (2004): Characterization of a New Mouse Mutant, Flouncer, with a Blance Defect and Inner Ear Malformation. Otol Neurotol 25 , 707-713
Rhodes, C.R., Hertzano, R., Fuchs, H., Bell, R.E., Hrabé de Angelis, M., Steel, K.B., Avraham, K.B. (2004): A Myo7a mutation cosegregtaes with stereocilia defects and low-frequency hearing impairment. Mamm Genome 15, 686-697
Runkel, F., Marquardt, A., Stoeger, C., Kochmann, E., Simon, D., Kohnke, B., Korthaus, D., Wattler, F., Fuchs, H., Hrabé de Angelis, M., Stumm, G., Nehls, M., Wattler, S., Franz, T., Augustin, M. (2004): The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3. Genomics 84, 824-835
Seedorf, H, Springer, I.N., Grundner-Culemann E., Albers, H.-K., Reis, A., Fuchs, H., Hrabé de Angelis, M., Acil, Y. (2004): Amelogenesis imperfecta in a new animal model – a mutation in chromosome 5 (human 4q21). J Dent Res 83, 608-612
Santhiya, S.T., Mansisastry, S.M., Rawlley, D., Malathi, R., Anishetty, S., Gopinath, P.M., Vijayalakshmi, P., Namperumalsamy, P., Adamski, J., Graw, J. (2004): Mutation analysis of congenital cataratcs in Indian families: identification of SNPs and a new causative allele in CRYBB2 gene. Invest Ophth Vis Sci 45, 3599-3607
Van Raamsdonk, C.D., Fitch, K. R., Fuchs, H., Hrabé de Angelis, M., Barsh, G.S. (2004): Effects of G-protein mutations on skin color. Nature Genetics 36, 961-968
Willer, T., Belén, P., Falcón-Pérez, J.M., Renner-Müller, I., Przemeck, G.K.H., Lommel, M., Coloma, A., Valero, M.C., Hrabé de Angelis, M., Tanner, W., Wolf, E., Strahl, S., Cruces, J. (2004): Targeted disruption of the Walker-Warburg syndrome gene Pomt1 in mouse results in embryonic lethality. Proc Natl Acad Sci USA 101, 14126-14131
Publications 2003
Adler, I.-D., Attia, S.M. (2003): Nicotine is not clastogenic at doses of 1 or 2 mg/kg body weight given orally to male mice. Mutat Res 542, 139-142
Attia, S.M., Kliesch, U., Schriever-Schwemmer, G., Badary, O.A., Hamada, F.M., Adler, I.-D. (2003): Etoposide and Merbarone are Clastogenic and Aneugenic in the Mouse Bone Marrow Micronucleus Test Complemented by Fluorescence in Situ Hybridization with the Mouse minor Satellite DNA Probe. Environ Mol Mutagen 41, 99-103
Breitling, R., Laubner, D., Clizbe, D., Adamski, J., Krisans, S.K. (2003): Isopentenyl-Diphosphate Isomerases in Human and Mouse: Evolutionary Analysis of a Mammalian Gene Duplication. J Mol Evol 57, 282-291
Drobyshev, A.L., Machka, C:, Horsch, M., Seltmann, M., Liebscher, V., Hrabé de Angelis, M., Beckers, J. (2003): Specificity assessment from fractionation experiments (SAFE): a novel method to evaluate microarray probe specificity based on hybridisation stringencies. Nucleic Acids Res 31, 2-10
Drobyshev, A.L., Hrabé de Angelis, M., Beckers, J. (2003): Artefacts and Reliability of DNA Microarray Expression Profiling Data. Curr Genomics 4, 615-621
Fitch, K.R., McGowan, K.A., Van Raamsdonk, C.D., Fuchs, H., Lee, D., Puech, A., Herault, Y., Threadgill, D.W., Hrabé de Angelis, M., Barsh, G.S. (2003): Genetics of dark skin in mice. Genes Dev 17, 214-228
Grandbarbe, L., Bouissac, J., Rand, M., Hrabé de Angelis, M., Artavanis-Tsakonas, S., Mohier, E. (2003): Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process. Development 130, 1391-1402
Jakob, T., Soewarto, D., Köllisch, G., Howaldt, M., Sandholzer, N., Kremmer, E., Hrabé de Angelis, M., Balling, R., Behrendt, H., Pfeffer, K., Wolf, E., Flaswinkel, H. (2003) Phenotype analysis and chromosomal mapping of a hyper IgE mouse mutant identified in the ENU Mouse Mutagenesis Project. Allergo J 12, 42
Hafezparast, M., Klocke, R., Ruhrberg, C., Marquardt, A., Ahmad-Annuar, A., Bowen, S., Lalli, G., Witherden A.S., Hummerich, H., Nicholson, S., Morgan, P.J., Oozageer, R., Priestly, J.V., Averill, S., King, V.R., Ball, S., Peters, J., Toda, T., Yamamoto, A., Hiraoka, Y., Augustin, M., Korthaus, D., Wattler, S., Wabnitz, P., Dickneite, C., Lampel, S., Boehme, F., Peraus, G., Popp, A., Rudelius, M., Schlegel, J., Fuchs, H., Hrabé de Angelis, M., Shciavo, G., Shima, D.T., Russ, A.P., Stumm, G., Martin, J.E., Fisher, E.M.C. (2003): Mutations in Dynein link motor neuron degeneration to defects in retrograde transport. Science 300, 808-812
Husen, B., Adamski, J., Brüns, A., Deluca, D., Fuhrmann, K., Möller, G., Schwabe, I., Einspanier, A. (2003): Characterization of 17beta-hydroxysteroid dehydrogenase type 7 in reproductive tissues of the marmoset monkey. Biol Reprod 68, 2092-2099
Kappler, R., Calzada-Wack, J., Schnitzbauer, U., Koleva, M., Herwig, A., Piontek, G., Graedler, F., Adamski, J., Heinzmann, U., Schlegel, J., Hemmerlein, B., Quintanilla-Martinez, L., Hahn, H. (2003): Molecular characterization of patched-associated rhabdomyosarcoma. J Pathol 200, 348-356
Kristan, K., Rizner, T.L., Stojan, J., Gerber, J.K., Kremmer, E., Adamski, J. (2003): Significance of individual amino acid residues for coenzyme and substrate specificity of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus. Chem-Biol Interact 143-144, 493-501
Laubner, D., Breitling, R., Adamski, J. (2003): Embryonic expression of cholesterogenic genes restricted to distinct domains and colocalises with apoptotic regions in mice. Mol Brain Res 115, 87-92
Marschall, S., Hrabé de Angelis M. (2003): In vitro fertilization/cryopreservation. Methods Mol Biol 209, 35-50
Marijanovic, Z., Laubner, D., Möller, G., Gege, C., Husen, B., Adamski, J., Breitling, R. (2003): Closing the Gap: Identification of Human 3-Ketosteroid Reductase, the Last Unknown Enzyme of Mammalian Cholesterol Biosynthesis. Mol Endocrinol 17, 1715-1725
Peters, T., Sedlmeier, R., Büssow, H., Runkel, F., Lüers, G.H., Korthaus, D., Fuchs, H., Hrabé de Angelis, M., Stumm, G., Russ, A.P., Porter, R.M., Augustin, M., Franz, T. (2003): Alopecia in a Novel Mouse Model RCO3 Is Caused by mK6irs1 Deficiency. J Invest Dermatol 121, 674-680
Pfister, S., Przemeck G.K.H., Gerber, J.-K., Beckers, J., Adamski, J., Hrabé de Angelis M. (2003): Interaction of the MAGUK Family Member Acvrinp1 and the Cytoplasmic Domain of the Notch Ligand Delta1. J Mol Biol 333, 229-235
Przemeck, G.K.H., Heinzmann, U., Beckers, J., Hrabé de Angelis, M. (2003): Node and midline defects are associated with left-right development in Delta1 mutant embryos. Development 130 (1), 3-13
Schulz, H., Reinhard, C., Eder, G., Fuchs, H., Meyer, B., Rüschendorf, F., Hrabé de Angelis M., Nürnberg, P., Heyder, J. (2003) Studies on the inheritance of lung function in a mouse model. Am J Respir Crit Care Med 167, A833
Schulz, H., Reinhard, C., Eder, G., Fuchs, H., Meyer, B., Rüschendorf, F., Hrabé de Angelis, M., Nürnberg, P., Heyder, J. (2003): Studien am Mausmodell zum Vererbungsmodus der Lungenfunktion. Pneumologie S1, 91
Schulz, H., Reinhard, C., Eder, G., Ziesenis, A., Fuchs, H., Meyer, B., Rüschendorf, F., Hrabé de Angelis M., Nürnberg, P., Heyder, J. (2003) Genetic influences respiratory lung function. Eur J Physiol 445, S91
Schulz, H., Reinhard, C., Eder, Ziesenis, A., Fuchs, H., Hrabé de Angelis M., Nürnberg, P., Heyder, J. (2003) Variabilität der Lungenfunktion bei Maus-Inzuchtstämmen. Atemw.-Lungenkrkh 29, 331-333
Soewarto, D., Blanquet, V., Hrabé de Angelis, M. (2003): Random ENU mutagenesis. Methods Mol Biol 209, 249-66
Werner, T., Fessele, S., Maier, H., Nelson, P.J. (2003): Computer modeling of promoter organization as a tool to study transcriptional coregulation. Faseb J 17, 1228-1237
Werner, T. (2003): Promoters can contribute to the elucidation of protein function. Trends Biotechnol 21, 9-13
Werner, T. (2003): The state of the art of mammalian promoter recognition. Brief Bioinform 4, 22-30
Werner, T. (2003): Yeast expression-array analysis goes molecular. Trends Genet 19, 467-469
Wolff, H., Brack-Werner, R., Neumann, M., Werner, T., Schneider, R. (2003): Integrated functional and bioinformatics approach for the identification and experimental verification of RNA signals: application to HIV-1 INS. Nucleic Acids Res 31, 2839-2851
Zeretzke, S. (2003): Das Europäische Maus Mutanten Archiv. Biospektrum 5, 628-630
Ziegler-Heitbrock, L., Lotzerich, M., Schaefer, A., Werner, T., Frankenberger, M., Benkhart, E. (2003): IFN-alpha induces the human IL-10 gene by recruiting both IFN regulatory factor 1 and Stat3. J Immunol 171, 285-290
Publications 2002
Adler, I.-D., Kliesch, U., Jentsch, I., Speicher, M.R. (2002): Induction of chromosomal aberrations by dacarbazine in somatic and germinal cells of mice. Mutagenesis 17, 383-389
Adler, I-D., Schmid, T.E., Baumgartner, A. (2002): Induction of aneuploidy in male mouse germ cells detected by the sperm-FISH assay: A review of the present data base. Mutat Res 504, 173-182
Attia, S.M., Schmid, T.E., Badary, O.A., Hamada, F.M., Adler, I.-D. (2002): Molecular cytogenetic analysis in mouse sperm of chemically induced aneuploidy: Studies with topoisomerase II inhibitors. Mutat Res 520, 1-13
Beckers, J., Hrabé de Angelis, M. (2002): Large-scale mutational analysis for the annotation of the mouse genome. Curr Opin Chem Biol 6 (1), 17-23
Beckers, J., Hoheisel, J., Mewes, W., Vingron, M., Hrabé de Angelis, M. (2002): Molecular Phenotyping of Mouse Mutant Resources by RNA Expression Profiling. Current Genomics 3, 121-129
Dinkel, K., Rickert, M., Möller, G, Adamski, J., Meinck, H.-M., Richter W. (2002): Stiffman syndrome: Identification of 17beta-hydroxysteroid dehydrogenase type 4 as a novel 80-kDa antineuronal antigen. J Neuroimmunol 130, 184-193
Draper, N., Echwald, S.M., Lavery, G.G., Walker, E.A., Fraser, R., Davies, E., Sörensen, T.I.A., Astrup, A., Adamski, J., Hewison, M., Connell, J.M., Pedersen, O., Stewart, P.M. (2002): Association Studies between Microsatellite Markers within the Gene Encoding Human 11beta-Hydroxysteroid Dehydrogenase Type 1 and Body Mass Index, Waist to Hip Ratio and Glucocorticoid Metabolism. J Clin Endocr Metab 87, 4984-4990
Erben, R.G., Soegiarto, D.W., Weber, K., Zeitz, U., Lieberherr, M., Gniadecki, R., Möller, G., Adamski, J., Balling, R. (2002): Deletion of Deoxyribonucleid Acid Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D. Mol Endocrinol 16, 1542-1537
Fessele, S., Maier, H., Zischek, C., Nelson, P.J., Werner, T. (2002): Regulatory context is a crucial part of gene function. Trends Genet 18, 60-63
Frisch, M., Frech, K., Klingenhoff, A., Cartharius, K., Liebich, I., Werner, T. (2002): In silico prediction of scaffold/matrix attachment regions in large genomic sequences. Genome Res 12, 349-354
Gerber, J.-K., Richter, T., Kremmer, E., Adamski, J., Höfler, H., Balling, R., Peters, H. (2002): Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus. J Pathol 197, 293-297
Graw, J., Löster, J., Soewarto, D., Fuchs, H., Reis, A., Wolf, E., Balling, R., Hrabé de Angelis, M. (2002): V76D mutation in a conserved gD-crystallin region leads to dominant cataracts in mice. Mamm Genome 13 (8), 452-455
Klingenhoff, A., Frech, K., Werner, T. (2002): Regulatory modules shared within gene classes as well as across gene classes can be detected by the same in silico approach. In Silico Biol 2, 17-26
Krazeiesen, A., Breitling, R., Möller, G., Adamski J. (2002): Human 17beta-hydroxysteroid dehydrogenase type 5 is inhibited by dietary flavonoid. Adv Exp Med Biol 505, 151-161
Reinhard. C., Eder, G., Fuchs, H., Ziesenis, A., Heyder, J., Schulz, H. (2002): Inbred strain variation in lung function. Mamm Genome 13 (8), 429-437
Van Montfoort, J.E., Schmid, T.E. Adler, I.-D., Meier, P.J., Hagenbuch, B. (2002): Functional characterization of the mouse organic-anion-transporting polypeptide 2. BBA-Biomembranes 1564, 183-188
Vreugde, S., Erven A., Kros, C.J., Marcotti, W., Fuchs, H., Kurima, K., Wilcox, E.R., Friedmann, T.B., Griffith, A.J., Balling R., Hrabé de Angelis, M., Avraham, K.B., Steel, K.P. (2002): Beethoven, a mouse model for dominant progressive hearing loss DFNA36. Nat Genet 30, 257-258
Yun, K., Fischman, S., Johnson, J., Hrabé de Angelis, M., Weinmaster, G., Rubenstein J.L. (2002): Modulation of the Notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon. Development 129 (21), 5029-5040
Werner, T. (2002): Finding and Decrypting of Promoters Contributes to the Elucidation of Gene Function. In Silico Biol 2, 1-7
Publications 2001
Adamski, J., Jakob, F.J. (2001): A guide to 17beta-hydroxysteroid dehydrogenases. Mol Cell Endocrinol 171, 1-4
Alessandrini F., Jakob T., Wolf, A., Wolf, E., Balling, R., Hrabé de Angelis, M., Ring, J., Behrendt, H. (2001): Enu mouse mutagenesis: generation of mouse mutants with aberrant plasma IgE levels. Int Arch Allergy Immunol 124, 25-28
Baumgartner A., Schmid, T.E., Maerz, H.K., Adler, I.-D., Tarnok A., Nuesse, M. (2001): Automated evaluation of frequencies of aneuploid sperm by laser-scanning cytometry (LSC) Cytometry 44, 156-160
Baumgartner, A., Schmid, T.E., Schuetz, C.G., Adler, I.-D. (2001): Detection of aneuploidy in rodent and human sperm by muticolor FISH after chronic exposure to diazepam. Mutat Res 490, 11-19
Beckers, J., Hrabé de Angelis, M. (2001): Large-scale mutational analysis for the annotation of the mouse genome. Curr Opin Chem Biol 6, 17-23
Berti, L., Mittler, G., Przemeck, G.K.H., Stelzer, G., Gunzler, B., Amati, F., Conti, E., Dallapiccola, B., Hrabé de Angelis, M., Novelli, G., Meisterernst, M. (2001): Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit. Genomics 74, 320-332
Breitling, R., Krazeisen, A., Möller, G., Adamski, J. (2001): 17beta-hydroxysteroid dehydrogenase type 7 - an ancient 3-ketosteroid reductase of cholesterogenesis. Mol Cell Endocrinol 171, 199-204
Breitling, R., Laubner, D., Adamski, J. (2001): Structure-based phylogenetic analysis of short-chain alcohol dehydrogenases and reclassification of the 17beta-hydroxysteroid dehydrogenase family. Mol Biol Evol 18, 2154-2161
Breitling, R., Marijanovic, Z., Perovic, D., Adamski, J. (2001): Evolution of 17beta-HSD type 4, a multifunctional protein of beta-oxidation. Mol Cell Endocrinol 171, 205-210
Gailus-Durner, V., Scherf, M., Werner, T. (2001): Experimental data of a single promoter can be used for in silico detection of genes with related regulation in the absence of sequence similarity. Mamm Genome 12, 67-72
Gardiner, K., Weissman, S., Werner, T. (2001): Report on the Eleventh International Workshop on the Identification of Transcribed Sequences 2001. November 9-11, 2001. Washington, DC, USA. Cytogenet Cell Genet 95, 1-8
Graw, J., Löster, J., Soewarto, D., Fuchs, H., Meyer, B., Reis, A., Wolf, E., Balling, R., Hrabé de Angelis, M. (2001): Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene. Invest Ophthalmol Vis Sci 42, 2909-2915
Graw, J., Löster, J., Soewarto, D., Fuchs, H., Meyer, B., Reis, A., Wolf, E., Balling, R., Hrabé de Angelis, M. (2001): Characterization of a mutation in the lens-specific MP70 encoding gene of the mouse leading to a dominant cataract. Exp Eye Res 73 (6), 867-876
Graw, J., Löster, J., Soewarto, D., Fuchs, H., Reis, A., Wolf, E., Balling, R., Hrabé de Angelis, M. (2001): Aey2, a new mutation in the betaB2-crystallin-encoding gene. Invest Ophtalmol Vis Sci 42, 1574-1580
Graw, J., Klopp, N., Löster, J., Soewarto, D., Fuchs, H., Becker-Follmann, J., Reis, A., Wolf, E., Balling, R., Hrabé de Angelis, M. (2001): Ethylnitrosourea-induced mutation in mice leads to the expression o a novel protein in the eye and to dominant cataracts. Genetics 157, 1313-1320
Fessele, S., Boehlk, S., Mojaat, A., Miyamoto, N.G., Werner, T., Nelson, E.L., Schlondorff, D., Nelson, P.J. (2001): Molecular and in silico characterization of a promoter module and C/EBP element that mediate LPS-induced RANTES/CCL5 expression in monocytic cells. Faseb J 15, 577-579
Hrabé de Angelis, M., Strivens, M. (2001): Large-scale production of mouse phenotypes. The search for animal models for inherited diseases in humans. Brief Bioinform 2, 170-180
Kiernan, A.E., Ahituv, N., Fuchs, H., Balling, R., Avraham, K.B., Steel, K.P., Hrabé de Angelis, M. (2001): The Notch ligand Jagged1 is required for inner ear sensory development. Proc Natl Acad Sci USA 98, 3873-3878
Korn, B., Weissman, S., Werner, T., Gardiner, K. (2001): Report on the tenth international workshop on the identification of transcribed sequences 2000. Heidelberg, Germany, October 28-31, 2000. Cytogenet Cell Genet 92, 49-58
Krazeisen, A., Breitling, R., Möller, G., Adamski, J. (2001): 17beta-hydroxysteroid dehydrogenase type 5. Mol Cell Endocrinol 171, 151-162
Möller, G., van Grunsven, E.G., Wanders, R.J., Adamski, J. (2001): Molecular Basis of D-bifunctional protein deficiency. Mol Cell Endocrinol 171, 61-70
Nadeau, J.H., Balling, R., Barsh, G., Beier, D., Brown, S.D., Bucan, M., Camper, S., Carlson, G., Copeland, N., Eppig, J., Fletcher, C., Frankel, W.N., Ganten, D., Goldowitz, D., Goodnow, C., Guenet, J.L., Hicks, G., Hrabé de Angelis, M., Jackson, I., Jacob, H.J., Jenkins, N., Johnson, D., Justice, M., Kay, S., Kingsley, D., Lehrach, H., Magnuson, T., Meisler, M., Poustka, A., Rinchik, E.M., Rossant, J., Russel, L.B., Schimenti, J., Shiroishi, T., Skarnes, W.C., Soriano, P., Stanford, W., Takahashi, J.S., Wurst, W., Zimmer, A. (2001): Sequence interpretation. Functional annotation of mouse genome sequences. Science 291, 1251-1255
Nappi, F., Schneider, R., Zolotukhin, A., Smulevitch, S., Michailowski, D., Bear, J., Felber, B.K., Pavlakis, G.N. (2001): Identification of a noval posttranscriptional control element by using Rev- and RRE-mutated Human Immunodeficiency Virus Type 1 DNA proviral clone as a molecular trap. J Virol 75, 4558-4569
Santagati, F., Gerber, J.K., Blusch, J.H., Kokubo, C., Peters, H., Adamski, J., Werner, T., Balling, R., Imai, K. (2001): Comparative analysis of the genomic organization of Pax9 and its conserved physical association with Nkx2-9 in the human, mouse and pufferfish genomes. Mamm Genome 12, 232-237
Scherf, M., Klingenhoff, A., Frech, K., Quandt, K., Schneider, R., Grote, K., Frisch, M., Gailus-Durner, V., Seidel, A., Brack-Werner, R. Werner, T. (2001): First pass annotation of promoters on human chromosome 22. Genome Res 11, 333-340
Schmid, T.E., Attia, S., Baumgartner, A., Nuese, M., Adler, I.-D. (2001): Effect of chemicals on the duration of male meiosis in mice detected with laser scanning cytometry. Mutagenesis 16, 339-343
Werner, T. (2001): Cluster analysis and promoter modelling as bioinformatics tools for the identification of target genes from expression array data. Pharmacogenomics 2, 25-36
Werner, T. (2001): Target gene identification from expression array data by promoter analysis. Biomol Eng 17, 87-94
Werner, T. (2001): The promoter connection. Nat Genet 29, 105-106
Publications 2000
Adler, I.-D., Andrae, U., Kreis, P., Neumann, H.G., Thier, R., Wild, D. (2000): Recommendations fort the categorization of germ cell mutagens. Int Arch Occup Environ Health 73, 428-432
Adler, I.-D., Baumgartner, A., Gonda, H., Friedman, M.A., Skerhut, M. (2000): 1-Aminobenzotriazole inhibits acrylamide-induced dominant lethal effects in spermatids of male mice. Mutagenesis 15, 133-136
Adler, I.-D. (2000): Spermatogenesis and mutagenicity of environmental hazards: extrapolation of genetic risk from mouse to man. Andrologia 32, 233-237
Balling, R., Brown, S.D.M, Hrabé de Angelis, M., Justice, M., Nadeau, J. (2000): Great times for mouse genetics: getting ready for large-scale ENU-mutagenesis. Mamm Genome 11, 471
Balling, R., Hrabé de Angelis, M. (2000): From developmental biology to developmental toxicology. Ann N Y Acad Sci 919, 239-245
Beckers, J., Caron, A., Hrabé de Angelis, M., Hans, S., Campos-Ortega, J.A., Gossler, A. (2000): Distinct regulatory elements direct delta1 expression in the nervous system and paraxial mesoderm of transgenic mice. Mech Develop 95, 23-34
Beckers, J., Schlautmann, N., Gossler, A. (2000): The mouse rib-vertebrae mutation disrupts anterior-posterior somite patterning and genetically interacts with a Delta1 null allele. Mech Develop 95, 35-46
Benkhart, E.M., Siedlar, M., Wedel, A., Werner, T., Ziegler-Heitbrock, H.W. (2000): Role of Stat3 in lipopolysaccharide-induced IL-10 gene expression. J Immunol 165, 1612-1617
Böhlk, S., Fessele, S., Mojaat, A., Miyamoto, N.G., Werner, T., Nelson, E.L., Schlondorff, D. and Nelson, P.J. (2000): ATF and Jun transcription factors, acting through an Ets / CRE promoter module, mediate lipopolysaccharide inducibility of the chemokine RANTES in monocytic Mono Mac 6 cells. Eur J Immunol 30, 1102-1112
Erven, A., Kiernan, A. E., Hrabé de Angelis, M., Fuchs, H., Balling, R., Guenet, J.L., Avraham, K.B., Ben-David, O., Vreugde, S., Nolan, P., Peters, J., Cattanach, B., Skynner, M., Allen, N., Brown, S.D.M., Steel, K.P. (2000): Phenotypic analysis of new deaf and vestibular mouse mutants. Brit J Audiol 34, 85-85
Flaswinkel, H., Alessandrini, F., Rathkolb, B., Decker, T., Kremmer, E., Servatius, A., Jakob, T., Soewarto, D., Marschall, S., Fella, C., Behrendt, H., Ring, J., Wolf, E., Balling, R., Hrabé de Angelis, M., Pfeffer, K. (2000): Identification of immunological relevant phenotypes in ENU mutagenized mice. Mamm Genome 11, 526-527
Fuchs, H., Schlee, P., Blusch, J., Werner, T., Stein, H., Rottmann, O. (2000): Phylogenetic studies in cyprinid species from central Europe by cytochrome b sequences of mitochondrial DNA. J Appl Ichthyol 16, 79-82
Fuchs, H., Schughart, K., Wolf, E., Balling, R., Hrabé de Angelis, M. (2000): Screening for dysmorphological abnormalities -- a powerful tool to isolate new mouse mutants. Mamm Genome 11, 528-530
Gardiner, K., Mural, R., Werner, T. (2000): Report of the ninth international workshop on the identification of transcribed sequences. Cytogenet Cell Genet 88, 1-10
Gloeckner, C.J., Mayerhofer, P.U., Landgraf, P., Muntau, A.C., Holzinger, A., Gerber, J.K., Kammerer, S., Adamski, J., Roscher, A.A. (2000): Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p. Biochem Biophys Res Commun 271, 144-150
Hrabé de Angelis, M., Flaswinkel, H., Fuchs, H., Rathkolb, B., Soewarto, D., Marschall, S., Heffner, S., Pargent, W., Wuensch, K., Jung, M., Reis, A., Richter, T., Alessandrini, F., Jakob, T., Fuchs, E., Kolb, H., Kremmer, E., Schaeble, K., Rollinski, B., Roscher, A., Peters, C., Meitinger, T., Strom, T., Steckler, T., Holsboer, F., Klopstock, T., Gekeler, F., Schindewolf, C., Jung, T., Avraham, K., Behrendt, H., Ring, J., Zimmer, A., Schughart, K., Pfeffer, K., Wolf, E., Balling, R. (2000): Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet 25, 444-447
top
Kiernan, A.E., Erven, A., Fuchs, H., Hrabé de Angelis, M., Balling, R., Guenet, J., Ahituv, N., Avraham, K.B., Tang, A., Cheah, K., Tease, C., Nolan, P., Peters, J., Brown, S.D.M., Steel, K.P. (2000): Several new mouse mutations affect semicircular canal morphogenesis of the inner ear. Brit J Audiol 34, 85-86
Jouve, C., Palmeirim, I., Henrique, D., Beckers, J., Gossler, A., Ish-Horowicz, D., Pourquie, O. (2000): Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm. Development 127, 1421-1429
Justice, M.J., Carpenter, D.A., Favor, J., Neuhauser-Klaus, A., Hrabé de Angelis, M., Soewarto, D., Moser, A., Cordes, S., Miller, D., Chapman, V., Weber, J.S., Rinchik, E.M., Hunsicker, P.R., Russell, W.L., Bode, V.C. (2000): Effects of ENU dosage on mouse strains. Mamm Genome 11, 484-488
Leimeister, C., Dale, K., Fischer, A., Klamt, B., Hrabé de Angelis, M., Radtke, F., McGrew, M.J., Pourquie, O., Gessler, M. (2000): Oscillating expression of c-hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors. Dev Biol 227(1), 91-103
Nacke, S., Schäfer, R., Hrabé de Angelis, M., Mundlos, S. (2000): Mouse mutant "rib-vertebrae" (rv): A defect in somite polarity. Dev Dyn 219, 192-200
Pargent, W., Heffner, S., Schäble, K.F, Soewarto, D., Fuchs, H., Hrabé de Angelis, M. (2000): MouseNet database: digital management of a large-scale mutagenesis project. Mamm Genome 11, 590-593
Rathkolb, B., Decker, T., Fuchs, E., Soewarto, D., Fella, C., Heffner, S., Pargent, W., Wanke, R., Balling, R., Hrabé de Angelis, M., Kolb, H.J., Wolf, E. (2000): The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: screening for clinically relevant phenotypes. Mamm Genome 11, 543-546
Rathkolb, B., Fuchs, E., Kolb, H. J., Renner-Müller, I., Krebs, O., Balling, R., Hrabé de Angelis, M., Wolf, E. (2000): Large Scale N-ethyl-N-nitrosourea mutagenesis of mice – from phneotypes to genes. Exp Physiol 85, 1-10
top
Rolinski, B., Arnecke, R., Dame, T., Kreischer, J., Olgemöller, B., Wolf, E., Balling, R., Hrabé de Angelis, M., Roscher, A.A. (2000): The biochemical metabolite screen in the Munich ENU Mouse Mutagenesis Project: determination of amino acids and acylcarnitines by tandem mass spectrometry. Mamm Genome 11, 547-551
Roulet, E., Bucher, P., Schneider, R., Wingender, E., Dusserre, Y., Werner, T. and Mermod, N. (2000): Experimental analysis and computer prediction of CTF/NF-1 transcription factor DNA binding sites. J Mol Biol 297, 833-848
Scherf, M., Klingenhoff, A., Werner, T. (2000): Highly specific localization of promoter regions in large genomic sequences by PromoterInspector: a novel context analysis approach. J Mol Biol 297, 599-606
Schindewolf, C., Lobenwein, K., Trinczek, K., Gomolka, M., Soewarto, D., Fella, C., Pargent, W., Singh, N., Jung, T., Hrabé de Angelis, M. (2000): Comet assay as a tool to screen for mouse models with inherited radiation sensitivity. Mamm Genome 11, 552-554
Shi, Q., Adler, I.-D., Zhang, J., Zhang, X., Martin, R. (2000): Incidence of mosaic cell lines in vivo of trisomy 21 patients: detection by fluorescence in situ hybridization on binucleated lymphocytes. Hum Genet 106, 29-35
Soewarto, D., Fella, C., Teubner, A., Rathkolb, B., Pargent, W., Heffner, S., Marschall, S., Wolf, E., Balling, R., Hrabé de Angelis, M. (2000): The large-scale Munich ENU-mouse-mutagenesis screen. Mamm Genome 11, 507-510
Sun, F.Y., Schmid, T.E., Schmid, E., Baumgartner, A., Adler, I.-D. (2000): Trichlorfon induces spindle disturbances in V79 cells and aneuploidy in male mouse germ cells. Mutagenesis 15, 17-24
Werner, T., Wingender, E. (2000): In Memory of Dan S. Prestidge. In Silicio Biology 2, 1-2
Werner, T. (2000): Identification and functional modelling of DNA sequence elements of transcription. Brief Bioinform 1, 372-380
Bookchapters
Hrabé de Angelis, M., Michel, D., Wagner, S., Becker, S., Beckers, J. (2007): Chemical Mutagenesis in Mice. In: The Mouse in Biomedical Research, 2nd ed. (eds.: Hrabé de Angelis, M., Fox, J., Barthold, S., Davisson, M.T., Newcomer, C., Quimby, F., Smith, A.), Elsevier Press
Becker, S., Hrabé de Angelis, M. and Beckers, J. (2006): Use of Chemical Mutagenesis in Mouse Embryonic Stem Cells. In: Methods in Molecular Biology, Nonhuman Embryonic Stem Cell Protocols. (ed.: Turksen, K.) Humana Press Inc., Totowa, NJ, Vol. 1, Chapter 27, 397-408
Beckers, J. (2006) Gene Expression Profiling: In: Phenotyping the Laboratory Mouse: Molecular Phenotyping (eds.: Hrabé de Angelis, M., Chambon, P., Brown, S.) WILEY-VCH Verlag
Beckers, J., Michel, D., Hrabé de Angelis, M., (2006): Large scale ENU mutagenesis in mice. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. (eds.: Ganten, D., Ruckpaul, K.) ISBN-13: 978-3-540-44244-8
Fuchs, H., Lisse, T., Abe, K., Hrabé de Angelis, M., (2006): Screening for bone and cartilage pheno-types in mice. In: Phenotyping of the Laboratory Mouse. (eds.: Hrabé de Angelis M., Chambon P. and Browns S.) Wiley-VCH, Weinheim, 35-86
Hrabé de Angelis, M., Chambon, P., Brown, S. (eds.) (2006): Standards of Mouse Model Phenotyping. John Wiley & Sons Ltd.
Hrabé de Angelis, M., Michel, D., Wagner, S., Becker, S., Beckers, J. (2006) Chemical Mutagenesis in Mice. In: The Mouse in Biomedical Research, 2nd ed. (eds.: Fox, J., Barthold, S., Davisson, M.T., Newcomer, C., Quimby, F., Smith, A.), Elsevier Press
Prehn, C., Ströhle, F., Haller, F., Keller, B., Hrabé de Angelis, M., Adamski, J., Mindnich, R., (2006): A Comparison of Methods for Assays of Steroidogenic Enzymes: New GC/MS Versus HPLC and TLC. In: Enzymology and Molecular Biology of Carbonyl Metabolism (eds.: Weiner, H., Plapp, B., Lindhal, R., Maser, E. ), Purdue University Press, West Lafayette, Indiana, USA
Adamski, J. (2005): Lokale Aktivierung und Inaktivierung der Steroidhormone, insbesondere der Sexualhormone. In: Molekulare medizinische Grundlagen von Endokrinopathien 2. Para- und autokrine Regulation. (ed.: Ruckpaul, K.), Springer-Verlag, Berlin
Kristan, K., Kovacic, B., Adamski, J., Rizner, T.L. (2005): Further insight into the structural basis of coenzyme and substrate specificity of fungal 17beta-hydroxysteroid dehydrogenase. In: Enzymology and Molecular Biology of Carbonyl Metabolism 12, (eds.: Weiner, H., et al.), West Lafayette, Indiana: Purdue University Press, 352-359
Hrabé de Angelis, M., Adler, A., Beckers, J., Soewarto, D., Wagner, S., Gailus-Durner, V., Imai, K. (2004): ENU mutagenesis. In: The Laboratory Mouse. (eds.: Hedrich, H.H., Bullock, G.) Academic Press, Chapter 4, 47-85
Reinhard, C., Eder. G., Fuchs, H., Ziesenis, A., Meyer, B., Rueschendorf, F., Hrabé de Angelis, M., Heyder, J., Schulz, H. (2004): Differences in lung function among mouse inbred strains are genetically determined. In: INIS Monographs, Effects of air contaminants on the respiratory tract - Interpretations from molecular to meta analysis. 9. International Inhalation Symposium, Heinrich, U., Stuttgart; Fraunhofer IRB Verlag, 435-444
Marschall S., Hrabé de Angelis M. (2003): In vitro fertilization/cryopreservation. In: Methods Mol Biol: Transgenic Methods and Protocols 209, 35-50
Soewarto D., Blanquet V., Hrabé de Angelis M. (2003): Random ENU Mutagenesis. In: Methods Mol Biol: Transgenic Methods and Protocols 209, 249-266
Werner, T., Krawetz, S.A., Womble, D.D. (2003): The role of transcription factor binding sites in promoters and their in silico detection. In: Introduction to Bioinformatics: A Theoretical and Practical Approach. (ed.: Totowa, N.J.), Humana Press, 523-538
Werner, T., Mewes, H.-W., Seidel, H., Weiss, B. (2002): Promoter Analysis. In: Bioinformatics and Genome Analysis: Ernst Schering Res Found Workshop 38, 66-82
Werner, T. (2002): Promoter Analysis. In: Bioinformatics and Genome Analysis. (eds.: Mewes, H.-W., Seidel, H. and Weiss, B.), Springer Verlag, 65-82
Werner, T. (2001): Analyzing regulatory regions in genomes. Wiley-VCH, New York
Werner, T. (2001): Cis-acting Locus. In: Encyclopedia of Genetics. (eds.: Brenner, S. and Miller, J. H.) p 377-380 Academic Press, Boston, London, Orlando, New York, San Diego, Sydney
Werner, T. (2000). Computer-assisted analysis of transcription control regions. Matinspector and other programs. In: Bioinformatics Methods and Protocols. (eds.: Misener, S. and Krawetz, S.A.) Vol. 132, 337-49. Humana Press, Inc., Totowa, NJ.