Institute of Lung Biology and Disease (iLBD)

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Research Groups

  • Aerosol Science and Nanoparticle Dosimetry
    Head: Dr. Wolfgang Kreyling ()

    Research is concerned with determining the dosimetry of inhaled engineered nanoparticles and the development of techniques for controlled nanoparticle exposure of cells and rodents. Studies are performed on the deposition and retention in the lungs, clearance pathways from the lungs and particularly translocation from the lungs into the blood circulation and subsequent accumulation in secondary target organs such as liver, spleen, kidneys, brain, heart etc. Ethically approved studies are not only conducted not only on rodents, but also on healthy subjects and patients. Read more ...

  • Molecular Biology and Genetics
    Head: Dr. Tobias Stöger ()

    Research focuses on effects of nanoparticles on redox processes in cell free and cellular systems. Particular attention is devoted to particle-related effects on gene expression, mechanisms of detoxification, stress signaling pathways, inflammation and lipid mediators as highly potent immunologic regulators. Read more ...

  • Cardiopulmonary Physiology
    Head: Professor Holger Schulz ()

    Research focuses on pulmonary and cardiovascular responses to particulate matter on a systemic level as well as on underlying pathomechanisms and identification of genetic constitutions for increased susceptibility. Specific attention is directed towards the investigation of genetic determinants of lung structure, pulmonary function, and regulation of breathing. Accordingly, technical expertise is established to monitor cardiovascular responses in unrestrained animals by radio telemetry and pulmonary function in rodents comparable to that available in pulmonary divisions.  Read more ...

  • Clinical Co-operation Group "Inflammatory Diseases of the Lung"
    Head: Dr. Marion Frankenberger ()

    Research focuses on inflammatory diseases of the lung, in particular COPD (chronic obstructive pulmonary disease). The group aims to identify the inflammatory processes and the underlying pathophysiological mechanisms of the various forms of COPD, and to develop new diagnostic and therapeutic strategies. Read more ...