Workgroup Schendel
Dendritic cell – T cell interactions
Research interests
Our research interest is mainly focused on the understanding the molecular and cellular basis of anti-tumor immunity. On the basis of this knowledge, we develop new strategies for the immune therapy of tumors.
Our strategies include:
- the genetic manipulation of well characterized tumor cell lines as vaccines for HLA-partial matched patients,
- the loading of dendritic cells with in vitro transcribed RNA encoding tumor-associated antigens as well as
- the adoptive transfer antigen-specific T-cells with high avidity T-cell receptors in patients after non-myeloablative conditioning and/or bone marrow transplantation.
Moreover, tumor-associated antigens are identified which are expressed in hematological and urological tumors and are able to induce potent T-cell responses against the tumors.
Finally, we seek to understand the molecular reasons for development of hematological malignancies using a transgenic mouse model.
The group cooperates closely with the GMP Working Group and the Clinical Cooperation Groups "Pediatric Immune Regulation" and "Immune Monitoring".
- Fig.: Dendritic cells bear this name due to the dendrite-like cytoplasmatic extensions that they project into the surrounding area. After invading secondary lymphoid organs, dendritic cells interact with many T-cells. The extensions of the dendritic cells enlarge their surface so that better antigen presentation to T-cells is possible.
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Contact details
| Prof. Dolores J. Schendel, PhD | |
|---|---|
| Office: | +49 89 7099 -301 |
| Postdoc office: | +49 89 7099 -314 und -362 |
| Lab: | +49 89 7099 -305, -307, -319, -339 und -349 |
| Fax: | +49 89 7099 -300 |
| Email: | schendel@helmholtz-muenchen.de |
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Staff
Prof. Dolores J. Schendel, PhD (Group leader)
Dr. Bernhard Frankenberger, PhD (Scientist)
Dr. Slavoljub Milosevic, PhD (Scientist)
Dr. Christiane Geiger, (Scientist)
Dr. Silke Raffegerst, MSc (Scientist)
Dr. Stefani Spranger, (Scientist)
Dr. Bettina Brackertz (Scientist)
Christian Ellinger, (Doctorand)
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Publications
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Dissertations
Kress von Kressenstein, Freiin, S.:
Zelluläre Abwehrmechanismen beim humanen Nierenzellkarzinom: Einfluss von Interferon-gamma auf die Tumorzellerkennung durch tumorinfiltrierende Lymphozyten und Lymphokin-aktivierte Killerzellen.
Fakultät für Biologie, LMU München (1997)
Jantzer, P.:
Tumorantigen-spezifische zytotoxische T-Lymphozyten bei Patienten mit Nierenzellkarzinom: Antigen-getriebene Selektion und Langzeitpersistenz in vivo.
Fakultät für Biologie, LMU München (1997)
Huck, C.:
Charakterisierung der molekularen Interaktionen bei der Antigenerkennung Glutaminsäure-Decarboxylase-reaktiver T-Lymphozyten beim insulinabhängigen Diabetes mellitus.
Fakultät für Bio- and Geowissenschaften, Universität Karlsruhe (1998)
Gatz, S.:
Entwicklung eines molekularbiologischen Verfahrens zum spezifischen Nachweis von HLA-A*0201-positiven Patienten für immuntherapeutische Studien.
Medizinische Fakultät, LMU München (2001)
Regn, S.:
Simultane Expansion zytotoxischer T-Lymphozyten, gerichtet gegen Adeno- und Epstein-Barr-Virus-Epitope, zur Therapie von opportunistischen Infektionen nach allogener hämatopoetischer Stammzelltransplantation (HSCT).
Fakultät für Biologie, TU München (2002)
Javorovic, M.:
T-cell stimulation by melanoma RNA-pulsed dendritic cells.
Fakultät für Biologie, LMU München (2004)
Raffegerst, S.:
Hämatopoetische Neoplasien in einem transgenen Mausmodell: Ein Modell für das Hodgkin-Lymphom?
Medizinische Fakultät, LMU München (2007)
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