Mission
To determine the extend to which individual genetic differences influence the risk of developing thyroid cancer after exposure to radiation.
GENRISK-T brings together a consortium of experts in radiation biology, molecular genetics, mouse models of human cancers, pathologists, oncologists, and bio-mathematicians. Our experimental strategy is to develop and use a series of murine models of thyroid cancer to identify the contribution of genetic variability to the risk of developing thyroid cancer. Through complimentary studies comparing the genetic events accompanying the development of thyroid cancers in the mouse and human tumours we will be able to determine how genetic variation effects risk and use this knowledge to develop long-term strategies to determine if doses below 100mSv can indeed influence risk of developing thyroid malignancy.