Ingo Burtscher, PhD
Phone: 0049-89-3187-3759
email: ingo.burtscher@helmholtz-muenchen.de
Project
During embryonic mouse development lineage segregation leading to the formation of the germ layers of ectoderm, mesoderm and endoderm, occurs during the process of gastrulation. Due to intrauterine development, the cellular and molecular processes involved in this process are poorly understood. This project utilizes ex vivo embryo culture and time-lapse fluorescent imaging technology to study the process of gastrulation in more detail. The focus is on resolving cell migration as well as morphogenetic cell changes in a time-dependent manner. Theses tools allow us to study wild type and mutant embryos with endoderm phenotypes in greater detail, deciphering the primary cause of endoderm defects. We have also elaborated this technology to monitor pancreas development in organ explant cultures.
Academic and Research Activities
| Since Feb. 2005 | Postdoctorial Research Fellow in the Group of Dr. Heiko Lickert, Endoderm Research, Stem Cell Institute, Helmholtz Zentrum Munich |
| Oct 2000 – Oct 2004 | PhD at Queen Mary & Westfield College, University of London, Group of Prof. Dean Nizetic Title:” Characterisation of USP25, a chromosome 21 gene potentially contributing to specific features of Down syndrome, and the effects of its overexpression on cellular structures, function & behaviour |
| Jan. 1998 – Jun 1999 | Institue of Molecular Pathology, Vienna Group of Dr. Gerhard Christofori Diploma Thesis: “IGF-Mediated Survival Signaling in SV-40 T Antigen-mediated Tumorigenesis” Diploma mark: Mit Auszeichnung bestanden |
| Feb. 1993 – Jul. 1999 | Studies of Biology at University of Vienna Genetics, Biochemistry and Microbiology Diploma overall mark: Bestanden |
Publications
[1] Pitchfork regulates primary cilia disassembly and left-right asymmetry. Kinzel D, Boldt K, Davis EE, Burtscher I, Trümbach D, Diplas B, Attié-Bitach T, Wurst W, Katsanis N, Ueffing M, Lickert H. Dev Cell. 2010 Jul 20;19(1):66-77.
[2] Sox17-2A-iCre: a knock-in mouse line expressing Cre recombinase in endoderm and vascular endothelial cells.
Engert S, Liao WP, Burtscher I, Lickert H. Genesis. 2009 Sep;47(9):603-10.
[3] Generation of a mouse line expressing Sox17-driven Cre recombinase with specific activity in arteries. Liao WP, Uetzmann L, Burtscher I, Lickert H. Genesis. 2009 Jul;47(7):476-83.
[4] Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo. Burtscher I, Lickert H. Development. 2009 Mar;136(6):1029-38.
[5] Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation. Egea J, Erlacher C, Montanez E, Burtscher I, Yamagishi S, Hess M, Hampel F, Sanchez R, Rodriguez-Manzaneque MT, Bösl MR, Fässler R, Lickert H, Klein R. Genes Dev. 2008 Dec 1;22(23):3349-62.
[6] A mouse line expressing Foxa2-driven Cre recombinase in node, notochord, floorplate, and endoderm. Uetzmann L, Burtscher I, Lickert H. Genesis. 2008 Oct;46(10):515-22.
[7] Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder. Groet J, McElwaine S, Spinelli M, Rinaldi A, Burtscher I, Mulligan C, Mensah A, Cavani S, Dagna-Bricarelli F, Basso G, Cotter FE, Nizetic D. Lancet. 2003 May 10;361(9369):1617-20.
[8] The IGF/IGF-1 receptor signaling pathway as a potential target for cancer therapy. Burtscher I, Christofori G.
Drug Resist Updat. 1999 Feb;2(1):3-8.
[9] An insulin-like growth factor-mediated, phosphatidylinositol 3' kinase-independent survival signaling pathway in beta tumor cells. Burtscher I, Compagni A, Lamm GM, Christofori G.
Cancer Res. 1999 Aug 15;59(16):3923-6.
