Engert, Silvia
Phone: 0049-89-3187-4733
email: Silvia.Engert@helmholtz-muenchen.de
Functional analysis of endoderm development
The early mammalian embryo consists of three primary germ layers: the ectoderm, the mesoderm and the endoderm which will form all embryonic structures. We focus on the endoderm which gives rise to the gastrointestinal tract and its associated organs, such as lung, liver and pancreas. We are interested in factors and pathways which regulate endoderm development and its specification. For this purpose we generated endoderm-specific Cre mouse lines to identify tissues and organs which derive from endoderm progenitor cells and to inactivate genes of interest within the endoderm to understand the mechanisms involved in endoderm formation and organ specification.
Academic and Research Activities
| Oct. 2003 – Mar. 2009 | Studies of Biology at Ludwigs-Maximilians- Universtität Würzburg Developmental and Cell biology, Physiological chemistry and Genetics (Diploma overall mark: 1.0) |
| May. 2008 – Mar. 2009 | HelmholtzZentrum München Institute of stem cell research, Dr. Heiko Lickert Diploma Thesis: “Characterization of the Sox17-2A-iCre mouse line” (mark: 1.0) |
| since Apr. 2009 | HelmholtzZentrum München Institute of stem cell research, Dr. Heiko Lickert Phd Project: The role of Wnt/ß-catenin in head formation and endoderm development |
Publications
[1] Engert, S., et al., Sox17-2A-iCre: a knock-in mouse line expressing Cre recombinase in endoderm and vascular endothelial cells. Genesis, 2009. 47(9): p. 603-10.
