Stefan Hasenöder, PhD
Phone: 0049-89-3187-3759
email: stefan.hasenoeder@helmholtz-muenchen.de
The role of Oct4 in endoderm development_
The transcription factor Oct4 has, together with Nanog and Sox2, an essential role in controlling pluripotency in embryonic stem (ES) cells and embryos. To elucidate the role of Oct4 in endoderm differentiation we have generated Oct4 conditional knock-outs (CKO) in Foxa2 expressing mesendodermal progenitor cells in mice.
The CKO embryos are embryonic lethal and show a defect in hindgut development at E8.5. The aim of this project is to understand the molecular mechanisms underlying the function of Oct4 in endoderm development.
Academic and Research Activities
| Oct. 2001 – Mar. 2007 | Studies of Biology Ludwig-Maximilians University Munich, Human Genetics, Cell Biology, Immunology, Pharmacology and Toxicology |
| May 2006 – Mar. 2007 | Ludwig-Maximilians University Munich Department of Human Genetics, Prof. Heinrich Leonhardt Diploma Thesis: “The role of the zinc-finger domain in the murine DNA methyltransferase 1” |
| Feb 2008 – Apr. 2010 | Lab Manager in the lab of Dr. Nadeem Moghal working on adult human tracheal stem cells Ontario Institute of Cancer Research, Toronto, Canada |
Publications
[1] Different binding properties and function of CXXC zinc finger domains in Dnmt1 and Tet1
Frauer C, Rottach A, Meilinger D, Bultmann S, Fellinger K, Hasenöder S, Wang M, Qin W, Söding J, Spada F, Leonhardt H. PLoS One. 2011 Feb 2;6(2):e16627.
