Bomi Jung, Post Doc
Phone: 0049-89-3187-4734
email: bomi.jung@helmholtz-muenchen.de
Pitchfork function in Sonic hedgehog signaling
In vertebrates Sonic hedgehog (Shh) signaling depends on primary cilia and failure of cilia formation and mis-regulation of Shh signaling lead to embryonic defects and a variety of human disease. We previously identified Pitchfork (Pifo) as a protein essential for cilia disassembly (Kinzel et al., Dev Cell 19, 66-77, 2010). Pifo is expressed in regions of high Shh signaling in the mouse embryo, is activated by Shh agonist and suppressed by Shh antagonist in cell culture, suggesting that Pifo is a Shh target gene and might function in the Shh signaling pathway. In this regard, the aim of this project is the investigation of Pifo functions in the Shh pathway.
Academic and Research Activities
| March. 2000 – Feb. 2002 | Studies of Biology at Kyung Hee University, Republic of Korea Biology, Molecular Biology, Neurobiology, Genetics BS Thesis: "Neurodegenerative disease: Alzheimer’s disease" |
| March. 2002 – Feb. 2004 | Studies of Medical Science at Kyung Hee University, Republic of Korea Molecular Biology, Neuroscience Master Thesis: "Neuroprotection against amyloid-? by using protein transduction" |
| Jan. 2006 – Feb. 2010 | Technical University of Braunschweig, Germany Department of cell and molecular biology, Prof. Dr. Hans-Henning Arnold PhD Thesis: " Identification of novel Lis1 protein interaction partners: Investigation towards cellular Lis1 functions" |
Publications
[1] Hypolipidemic effects of crude extract of adlay seed (Coix lachrymajobi var. mayuen) in obesity rat fed high fat diet : relations of TNF-alpha and leptin mRNA expressions and serum lipid levels. Kim SO, Yun SJ, Jung B, Lee EH, Hahm DH, Shim I, Lee HJ Life Sci. 2004 Jul 30;75 (11):1391-404
[2] Increased viability of PC12 cells exposed to amyloid-beta peptide by transduction with human TAT-methionine sulfoxide reductase. Jung B, Lee EH, Chung WS, Lee SJ, Shin SH, Joo SH, Kim SK, Lee JH Neuroreport. 2003 Dec 19;14 (18): 2349-53
[3] Down-regulation of the expression of rat inhibitor-of-apoptosis protein-1 and -3 during transforming growth factor-beta1-mediated apoptosis in rat brain microglia. Jung B, Kim MO, Yun SJ, Lee EH Neuroreport. 2003 May 6;14(6):857-60
[4] Reduction but not cleavage of poly (ADP-ribose) polymerase during stress-mediated cell death in the rat hippocampus. Yun SJ, Lee DJ, Kim MO, Jung B, Kim SO, Sohn NW, Lee EH Neuroreport. 2003 May 23;14(7):935-9
