Alexander Korostylev, PhD
Phone: 0049-89-3187-4735
email: alexander.korostylev@helmholtz-muenchen.de
Drugs influencing pluripotency and differentiation
The forkhead box transcrption factor, Foxa2, is expressed in the endoderm progenitors, in the primitive gut tube, in the pancreas progenitors and in the Insulin-producing beta cells of the pancreas. The underlying rationale of this project is that small molecules inducing Foxa2 expression will have the potential to support endoderm differentiation into the pancreatic lineage. Moreover, in the light of recent findings in the field of stem cell biology that differentiated cell types can be reprogrammed into induced pluripotent stem cells (iPS), another key goal of our screen will be to identify small molecules able to induce pluripotency and replace essential pluripotency transcription factors.
Academic and Research Activities
| Spt. 1997 – Jun. 2001 | Studies in Biotechnology at Moscow State Academy of Fine Chemical Technology, Russia Inorganic and Organic Chemistry, Biochemistry and Biotechnology (Diploma overall mark: 1.6) |
| Spt. 2001 – Jun. 2003 | Studies in Chemistry at Russian University of People’s Friendship Chemistry of High Molecular Compounds (Master of Science overall mark: 1) |
| Apr. 2004 – Nov. 2009 | Graduate Studies in Pharmacology at the Institute of Pharmacology, University of Heidelberg (Magna cum laude) |
Publications
[1] A functional role for Semaphorin 4D-Plexin-B1 interactions in epithelial branching morphogenesis during organogenesis. Korostylev A, Worzfeld T, Deng S, Friedel RH, Swiercz JM, Vodrazka P, Maier V, Hirschberg A, Ohoka Y, Inagaki S, Offermanns S, Kuner R. Development. 2008 Oct;135(20):3333-43. Epub 2008 Sep 17.
[2] Gene deletion mutants reveal a role for semaphorin receptors of the plexin-B family in mechanisms underlying corticogenesis. Hirschberg A, Deng S, Korostylev A, Paldy E, Costa MR, Worzfeld T, Vodrazka P, Wizenmann A, Götz M, Offermanns S, Kuner R. Mol Cell Biol. 2010 Feb;30(3):764-80. Epub 2009 Nov 30.
[3] The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neurons via diverse pathways. Vodrazka P, Korostylev A, Hirschberg A, Swiercz JM, Worzfeld T, Deng S, Fazzari P, Tamagnone L, Offermanns S, Kuner R. Eur J Neurosci. 2009 Oct;30(7):1193-208. Epub 2009 Sep 29.
[4] Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo. Deng S, Hirschberg A, Worzfeld T, Penachioni JY, Korostylev A, Swiercz JM, Vodrazka P, Mauti O, Stoeckli ET, Tamagnone L, Offermanns S, Kuner R. J Neurosci. 2007 Jun 6;27(23):6333-47.
