Anika Böttcher, Post Doc
Phone: 0049-89-3187-4733
e-mail: anika.lange@helmholtz-muenchen.de
Cilia function in development
Cilia are microtubule-based structures present on almost all vertebrate cells that can be grouped into non-motile and motile cilia regulating signalling and fluid transport, respectively. Defects in cilia or their absence can cause dramatic developmental defects and a variety of disorders commonly referred to as ciliopathies including for instance polycystic kidney disease, retinitis pigmentosa and Joubert syndrome.
I am currently working on a newly identified protein which is highly expressed in mono- and multi-ciliated tissues and seems to play a role in ciliogenesis
Academic and Research Activities
| since Oct. 2010 | Helmholtz Zentrum Muenchen, Institute for Stem cell Research, Neuherberg, Germany Post doc in Endoderm development group |
| Sept. 2005 – Sept. 2010 | Max Planck Institute of Biochemistry, Martinsried, Germany; Department of Molecular Medicine PhD thesis “Dissecting the integrin-linked kinase (ILK) kinase activity in vivo” Supervisor: Prof. Dr. Reinhard Fässler |
| June 2004 – Aug. 2005 | Friedrich-Schiller University of Jena, Germany Department of Medical Biochemistry Diploma thesis “Adjustable expression of oligomeric Ras-Raf binding domains to block Ras-mediated cellular signalling in a reversible manner” Supervisor: Prof. Dr. Karlheinz Friedrich |
| Aug. 2002 – June 2003 | University of Lund, Sweden Graduate Studies in biology (genetics and immunology) |
| Sept. 1999 – Sept. 2004 | Friedrich-Schiller University of Jena, Germany Graduate studies in biology |
Publications
[1] Kim, M., Ogawa, M., Fujita, Y., Yoshikawa, Y., Nagai, T., Koyama, T., Nagai, S., Lange, A., Fässler, R., and Sasakawa, C. (2009a). Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment. Nature 459, 578-582.
[2] Lange, A., Wickstrom, S.A., Jakobson, M., Zent, R., Sainio, K., and Fässler, R. (2009). Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature 461, 1002-1006.
[3] Smeeton, J., Zhang, X., Bulus, N., Mernaugh, G., Lange, A., Karner, C.M., Carroll, T.J., Fässler, R., Pozzi, A., Rosenblum, N.D., et al. (2010). Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development. Development 137, 3233-3243.
[4] Wickstrom, S.A., Lange, A., Hess, M.W., Polleux, J., Spatz, J.P., Kruger, M., Pfaller, K., Lambacher, A., Bloch, W., Mann, M., et al. (2010a). Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell 19, 574-588.
[5] Wickstrom, S.A., Lange, A., Montanez, E., and Fässler, R. (2010b). The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! Embo J 29, 281-291.
