institute of stem cell research

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Institute of Stem Cell Research

AG 2: Hematopoiesis > Homepage of Frank-Peter Wachs

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Curriculum Vitae

  • since 2007: Scientist in the Clinical Analysis Department at Bavarian Nordic Martinsried/Munich, Germany

  • Febuary 2006 - June 2007
    PostDoc
    Independent Research Group for Hematopoiesis, Institute of Stem Cell Research
    Helmholtz Zentrum München German Research Center for Environmental Health

  • 2000-2006: PostDoc at the Institute of Neurology, University of Regensburg; Germany:
    Isolation and in vitro growth of adult neural stem cells – influence of different growth factors on cellular plasticity

  • 1997-2000: Ph.D. thesis at the Institute of Inner Medicine I, University of Regensburg, Germany:
    Biological effects of bile acids on colon-carcinoma cell lines and primary colonic epithelial cells

  • 1990-1997: Study in Biology at the University of Regensburg, Germany with specialisation in Cell Biology and Immunology

    • Diploma thesis at the Institute of Pathology/Tumorimmunology, University of Regensburg, Germany: “Relevance of thrombocyte-adhesion and thrombocyte-aggregation for tumor-metastasis and shock pathogenesis”

Patent Applications

  • Wachs Frank-Peter, Schänzer Anne, Kuhn Georg H, Plate KarlHeinz, Zhao Ming, Delfani Kioumars, Janson Ann Marie. Treatment of central nervous system disorders. US2003203844 (2003)

  • Wachs Frank-Peter, Schänzer Anne, Kuhn Georg H, Plate KarlHeinz, Zhao Ming, Delfani Kioumars, Janson Ann Marie. Treatment of central nervous system disorders by use of PDGF or VEGF. EP1443955; WO03024478 (2004).

  • Wachs Frank-Peter, Bogdahn Ulrich, Aigner Ludwig. Inhibitors of TGF-R signaling for treatment of CNS disorders. WO2005074981 (2005).

Research Publications (in chronological order)

  • Nieswandt B., Echtenacher B., Wachs F.-P., Schroder J., Gessner J.E., Schmidt R.E., Grau G.E., Mannel D.N. (1999). Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice. Blood. Jul 15; 94(2): 684.

  • Schlottmann K., Wachs F.-P., Kullmann F., Falk W., Schölmerich J., Rogler G. (1999). Mechanisms of bile acid-induced apoptosis in intestinal epithelial cells. Gastroenterology 116: 498.

  • Brockhoff G., Fleischmann S., Meier A., Wachs F.-P., Hofstädter F., Knuechel R. (1999). Use of a mechanical dissociation device to improve standardization of flow cytometric cytokeratin DNA measurements of colon carcinomas. Cytometry (Comm. Clin. Cytometry) 38: 184.

  • Schlottmann K*., Wachs F.-P.*, Krieg R.C., Kullmann F., Schölmerich J., Rogler G. (2000). Characterization of bile salt-induced apoptosis in colon cancer cell lines. Cancer Res. 60 (15):4270. *equal contribution.

  • Wachs F.-P., Couillard-Despres S., Engelhardt M., Wilhelm D., Ploetz S., Vroemen M., Kaesbauer J., Uyanik G., Klucken J., Karl C., Tebbing J., Svendsen C.N., Weidner N., Kuhn H.-G., Winkler J., Aigner L. (2003). High Efficacy of Clonal Growth and Expansion of Adult Neural Stem Cells Lab Invest. Jul, 83 (7): 949.

  • Engelhardt M., Wachs F.-P., Couillard-Despres S., Aigner L. (2004). The neurogenic competence of progenitors from the postnatal rat retina in vitro. Exp Eye Res. May, 78 (5): 1025.

  • Schänzer A.*, Wachs F.-P.*, Wilhelm D., Acker T., Cooper-Kuhn C., Beck H., Winkler J., Aigner L., Plate K.H., Kuhn H.G. (2004). Direct Stimulation of Adult Neural Stem Cells In Vitro and Neurogenesis In Vivo by Vascular Endothelial Growth Factor. Brain Path., 14 (3): 237. *equal contribution.

  • Schlottmann K.*, Wachs F.-P.*, Grossmann J., Vogl D., Maendel M., Falk W., Schölmerich J., Andus T., Rogler G. (2004). Interferon gamma downregulates IL-8 production in primary human colonic epithelial cells without induction of apoptosis. Int J Colorectal Dis., Sep, 19 (5): 421. *equal contribution.

  • Schlottmann K., Wachs F.-P., Grossmann J., Vogl D., Maendel M., Falk W., Schölmerich J., Andus T., Rogler G. (2004). Interferon gamma downregulates IL-8 production in primary human colonic epithelial cells without induction of apoptosis. Int J Colorectal Dis. Sep,19 (5):421.

  • Wachs F.-P., Krieg R.C., Rodrigues C.M., Messmann H., Kullmann F., Knüchel-Clarke R., Schölmerich J., Rogler G., Schlottmann K. (2005). Bile salt-induced apoptosis in human colon cancer cell lines involves the mitochondrial transmembrane potential but not the CD95 (Fas/Apo-1) receptor. Int J Colorectal Dis., Mar, 20 (2): 103.

  • Wachs F.-P., Winner B., Couillard-Despres S., Schiller T., Aigner R., Winkler J., Bogdahn U., Aigner L. (2006). Transforming growth factor-ß1 is a negative regulator of adult neurogenesis. J Neuropathol Exp Neurol., Apr, 65 (4): 358.

  • Fraenzer J.-T., Wachs F.-P., Gleich O., Licht A.-K., Strutz J. (2006). Evaluation of vascular endothelial growth factor addition in vitro on mouse inner ear progenitor cell cultures. NeuroReport, Sep, 17 (13): 1369.

Awards

First Price at the Route28 Summits in Neurobiology, Seattle (2001)