Lung

Effective Therapies against lung diseases: Giving new breath

Approaches to and successes in lung research

By tightly connecting basic and clinical research, Helmholtz Zentrum München makes a difference in lung research contributing to new approaches in diagnosis, therapy and prevention of chronic lung diseases. 

Basis

Projects

     

  • Mechanisms of tissue remodeling in COPD and lung fibrosis
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  • Pathogenic mechanisms of lung cancer 
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  • Immune biology of the lung
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  • Role of the proteasome in lung diseases
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  • Function and different phenotypes of alveolar epithelial cells and their role in lung regeneration
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  • Inflammatory reactions in the lung
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  • Influence of chemokines on lung diseases
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Successes

     

  • Personalized prediction of asthma risk
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  • Receptor blockade improves lung function in cystic fibrosis
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  • Signaling through growth factors is misdirected in COPD
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  • Downregulation of specific microRNAs plays a role in the prevention of lung fibrosis
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New Approaches to Therapy and Diagnosis

Projects

     

  • New approaches for a cell-based therapy in COPD and fibrosis
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  • Personalized approaches for lung cancer therapy
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  • Alveolar epithelial cell-based lung regeneration
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  • Immunopathology of COPD
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Successes

     

  • New therapy approach for fibrosing lung diseases: WISP1 and serotonin
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  • Immune cells as markers for asthma
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  • Nanoparticles aggravate asthma
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  • Live diagnosis of lung tumors with early arriving photon laser
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New Prevention Strategies

Projects

     

  • Environmental factors for development of asthma and mechanisms of the loss of immune tolerance in relation to environmental factors
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  • Epidemiology of lung cancer and asthma
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Successes

     

  • Asthma and allergies are based on different pathogenic mechanisms
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  • Radon in buildings increases lung cancer risk
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Healthcare Research

Projects

     

  • Disease phases and quality of life in COPD
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  • long-term economics of COPD prevention
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Successes

     

  • Developed measurement of quality of life in acute phases
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  • Mathematical COPD model
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  • Smoking prevention saves costs
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