Prenzel, T., Begus-Nahrmann, Y., Kramer, F., Hennion, M., Hsu, C., Gorsler, T., Hintermair, C., Eick, D., Kremmer, E, Simons, M., Beissbarth, T., and Johnsen, S.A. (2011) Proteasome inhibition blocks estrogen-dependent gene transcription by decreasing histone H2B monoubiquitination in human breast cancer cells. Cancer Research, 71, 5739-5753 (PubMed Abstract)

de Almeida, S.F., Grosso, A.R., Koch, F., Fenouil, R., Carvalho, S., Andrade, J., Levezinho, H., Gut, M., Eick, D., Gut, I., Andrau, J.C., Ferrier, P., and Carmo-Fonseca, M. (2011) Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 lysine 36. Nature Structural & Molecular Biology, 18, 977-983
(PupMed Abstract)

Polier, G., Ding, J., Konkimalla, V.B., Eick, D., Ribeiro, N., Köhler, R., Giaisi, M., Efferth, T., Desaubry, L., Krammer, P.H., and Li-Weber, M.  (2011) The natural flavone wogonin is an inhibitor of CDK9 that induces apoptosis in cancer cells by transcriptional suppression of Mcl-1. Cell Death & Disease, 2, e182
(PupMed Abstract)

Koch, F., Fenouil, R., Gut, M., Cauchy, P., Albert, T.K., Zaccharias-Cabeza, J., Spicuglia, S., Lamy de la Chapelle, A., Heidemann, M., Hintermair, C., Eick, D., Gut, I., Ferrier, P., Andrau, J.C. (2011) Transcription initiation platforms and GTF recruitment at tissue specific enhancers and promoters. Nature Structural & Molecular Biology, 18, 956-963
(PupMed Abstract)

Weidle, U.H., Maisel, D., and  Eick, D. (2011) Synthetic lethality based targets for discocery of new cancer therapeutics. Cancer Genomics and Proteomics, 8, 159-172
(PupMed Abstract)

Heidemann, M., Hintermair, C., Schüller, R., Voß, K., and Eick, D. (2011) Die CTD der RNA-Polymerase-II - Eine neue Ebene der Genregulation. BIOspektrum 17, 270-273
(PupMed Abstract)

Markaki, Y., Gunkel, M., Schermelleh, L., Beichmanis, S., Neumann, J., Heidemann, M., Leonhardt, H., Eick, D., Cremer, C., and Cremer, T. (2011) Functional nuclear architecture of transcription and replication: A topographical marriage between chromatin domains and the interchromatin compartment. Cold Spring Harb. Symp. Quant. Biol., 75, 475-492 (PubMed Abstract)

Berchtold, D., Fesser, S., Bachmann, G., Kaiser, A., Eilert, J.C., Frohns, F., Sadoni, N., Muck, J., Kremmer, E., Eick, D., Layer, P.G., and Zink, D. (2011) Species- and cell type-specific architectures of vertebrate nuclei and their alterations in monolayer cultures. Chromosome Research, 19, 165-18 2(PubMed Abstract)

Sims III, R.J., Rojas, L.A., Beck, D., Bonasio, R., Schüller, R., Drury III, W.J., Eick,  D., and Reinberg, D. (2011) The C-terminal domain of RNA polymerase II is modified by site-specific methylation. Science, 332, 99-103. (PubMed Abstract)


Verbruggen, P., Ruf, P., Blakqori, G., Överby, A., Heidemann, M., Eick, D., and Weber, F. (2011) Interferon antagonist NSs of La Crosse virus triggers a DNA-damage response-like degradation of transcribing RNA polymerase II. J Biol. Chem., 286, 3681-3692
(PubMed Abstract)

Tietjen, J.R., Zhang, D.W., Rodriguez-Molina, J.B., White, B.E., Akhtar, M.S., Heidemann, M., Li, X., Chapman, R.D., Shokat, K., Keles, S.,  Eick, D., and Ansari, A.Z. (2010). Chemical-genomic dissection of RNA polymerase II CTD.  Nature Structural & Molecular Biology, 17, 1154-1161. (PubMed Abstract)

Hölzel, M., Burger, K., Mühl, B., Orban, M., Kellner, M., and Eick, D. (2010) The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword.  OncoTarget, 1, 28-33. (PubMed Abstract)

Burger, K., Mühl, B., Harasim, T., Rohrmoser, M., Malamoussi, A., Orban, M., Kellner, M., Gruber-Eber, A., Kremmer, E., Hölzel, M. and Eick, D. (2010) Chemotherapeutic drugs inhibit ribosome biogenesis at various levels. J. Biol. Chem., 285, 12416-12425 (PubMed Abstract)

Hölzel, M., Orban, M., Hochstatter, J., Rohrmoser, M., Harasim, T., Malamoussi, A., Kremmer, E., Längst, G., and Eick, D. (2010) Defects in 18S or 28S rRNA processing activate the p53 pathway. J. Biol. Chem., 285, 6364-6370 (PubMed Abstract)

Boeing, S., Rigault, C., Heidemann. M., Eick, D., and Meisterernst, M. (2010) RNA PII CTD SER-7 phosphorylation is established in a mediator dependent fashion. J. Biol. Chem., 285, 188-196 (PubMed Abstract)

Kohlhof, H., Hampel, F., Hoffmann, R., Burtscher, H., Weidle, U.H., Eick, D., Hölzel, M., Zimber-Strobl, U., and Strobl L.J. (2009) Notch1, Notch2 and EBNA2 signaling differentially affects proliferation and survival of EBV-infected B cells. Blood, 113, 5506-5515 (PubMed Abstract)

Pirngruber, J., Shchebet, A., Schreiber, L., Shema, E., Minsky, N., Chapman, R.D., Eick, D., Aylon, Y., Oren, M., Johnsen, S.A. (2009) Cdk9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3’ end processing. EMBO Reports, 10, 894-900 (PubMed Abstract)

Akhtar, M.S., Heidemann, M., Tietjen, J., Zhang, D., Chapman, R.D., Eick, D., and Ansari, A.Z. (2009)  TFIIH kinase places bivalent marks on the CTD. Mol Cell, 34, 387-393 (PubMed Abstract)

Fröhlich Archangelo, L., Kremmer, K., Hölzel, M., Eick, D., Przemeck, G.K.H., Hrabé de Angelis, M., Deshpande, A., Buske, C., and Stefan K. Bohlander (2008) The CALM interactor CATS, which influences the subcellular localization of the leukemogenic fusion protein CALM/AF10 is a marker for proliferation. Molecular Oncology 2, 256-267 (PubMed Abstract)

Chapman, R.D., Heidemann, M., Hintermair, C., and Eick, D. (2008) Molecular evolution of RNA polymerase II CTD. Trends in Genetics 24, 289-296 (PubMed Abstract)

Fedorova, E., Sadoni, N. Dahlsveen, I.K., Koch, J. Kremmer, E., Eick, D., Paro, R. and Zink, D. (2008) The nuclear organization of Polycomb/Trithorax group response elements in larval tissues of Drosophila melanogaster. Chromosome Research 16, 649-673 (PubMed Abstract)

Haindl, M., Harasim, T., Eick, D. and Müller, S. (2008) The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing. EMBO Reports 9, 273-279 (PubMed Abstract)

Chapman, R.D., Heidemann, M., Albert, T., Mailhammer, R., Flatley, A., Meisterernst, M., Kremmer, E., and Eick, D. (2007) RNA polymerase II CTD is phosphorylated at serine 7 during the transcription cycle. Science 318, 1780-1782 (PubMed Abstract)

Egloff, S., O’Reilly, D., Chapman, R.D., Taylor, A., Tanzhaus, K., Pitts, L., Eick, D., and Murphy, S. (2007) A specific role for serine 7 of the pol II CTD in expression of human snRNA genes. Science 318,1777-1780 (PubMed Abstract)

Schlee, M., Hölzel, M., Bernard, S., Mailhammer, R., Schuhmacher, M., Eick, D., Marinkovic, D., Wirth, T., Rosenwald, A., Staudt, L.M., Eilers, M., Baran-Marszak, F., Fagard, R., Feuillard, J., Laux, G., and Bornkamm, G.W. (2007) c-MYC activation impairs the NF-kB and the interferon response in conditional B cell systems: implications for the pathogenesis of Burkitt´s lymphoma. Int. J. Cancer, 120, 1387-1895 (PubMed Abstract)

Rohrmoser, M., Hölzel, M., Grimm, T., Malamoussi, A., Harasim, T., Orban, M., Gruber-Eber, A., Kremmer, E., and Eick, D. (2007) Interdependency of Pes1, Bop1, and WDR12 controls the assembly of the PeBoW-complex required for maturation of the large ribosomal subunit. Mol Cell Biol., 27, 3682-3694 (PubMed Abstract)

Wyce, A., Xiao, T., Whelan,  K.A., Kosman, C., Walter, W., Eick, D., Hughes, T,R.,  Krogan, N.J., Strahl, B.D., and Berger, S.L. (2007) H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex. Mol Cell, 27, 275-288 (PubMed Abstract)

Hölzel, M., Rohrmoser, M., Grimm, T., Malamoussi, M., Harasim, T., Gruber-Eber, A., Kremmer, E., and Eick, D. (2007) The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing. Nucleic Acids Research, 35, 789-800 (PubMed Abstract)

Hölzel, M., Rohrmoser, M., Orban, M., Hömig, C., Harasim, T., Malamoussi, A., Gruber-Eber, A., Heissmeyer, V., Bornkamm, G.W. and Eick, D. (2007) Rapid knock-down-knock-in system for mammalian cells. Nucleic Acids Research, 35, e17 (PubMed Abstract)

Grimm, T., Hölzel., Rohrmoser, M., Harasim, T., Malamoussi, A., Gruber-Eber, A., Kremmer, E., and Eick, D. (2006) Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW complex. Nucleic Acids Research, 34, 3030-3043 (PubMed Abstract)

Kiessling, A., Hollis, A., Sperl, B., Eick, D., and Berg, T. (2006) Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules. Chemistry & Biology, 13, 745-751 (PubMed Abstract)

Chapman, R. D., Conrad, M., and Eick, D. (2005). Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferation. Mol Cell Biol 25, 7665-7674. (PubMed Abstract)

Dirmeier, U., Hoffmann, R., Kilger, E., Schultheiss, U., Briseno, C., Gires, O., Kieser, A., Eick, D., Sugden, B., and Hammerschmidt, W. (2005). Latent membrane protein 1 of Epstein-Barr virus coordinately regulates proliferation with control of apoptosis. Oncogene 24, 1711-1717. (PubMed Abstract)

Hölzel, M., Rohrmoser, M., Schlee, M., Grimm, T., Harasim, T., Malamoussi, A., Gruber-Eber, A., Kremmer, E., Hiddemann, W., Bornkamm, G. W., and Eick, D. (2005). Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. J Cell Biol 170, 367-378. (PubMed Abstract)

Lux, C., Albiez, H., Chapman, R. D., Heidinger, M., Meininghaus, M., Brack- Werner , R., Lang, A., Ziegler, M., Cremer, T., and Eick, D. (2005). Transition from initiation to promoter proximal pausing requires the CTD of RNA polymerase II. Nucleic Acids Res 33, 5139-5144. (PubMed Abstract)

Schlosser, I., Hölzel, M., Hoffmann, R., Burtscher, H., Kohlhuber, F., Schuhmacher, M., Chapman, R., Weidle, U. H., and Eick, D. (2005). Dissection of transcriptional programmes in response to serum and c-Myc in a human B-cell line. Oncogene 24, 520-524. (PubMed Abstract)

Chapman, R., Palancade, B., Lang, A., Bensaude, W., and Eick, D. (2004) The last CTD repeat of the mammalian RNA polymerase II large subunit is important for its stability. Nucleic Acids Research 32, 35-44 (PubMed Abstract)

Schlosser, I. , Hölzel, M., Mürnseer, M., Burtscher, H., Weidle, U.H., and Eick, D. (2003) A role of c-Myc in the regulation of ribosomal RNA processing. Nucleic Acids Research 31, 6148-6156 (PubMed Abstract)

Horndasch, M., Raschke, E.-E., Bommer, G., Schuhmacher, M., Dumont , E., Kuklik-Roos, C., Eick, D., and Kempkes, B. (2002) EBV antagonizes the anti-proliferative activity of TGF-beta but does not abolish TGF- beta signaling. Int. J. Cancer 101, 442-427 (PubMed Abstract)

Hoelzel, M., Kohlhuber, F., Schlosser, I. , Hoelzel, D., Luescher, B., and Eick, D. (2001). Myc/Max/Mad regulate the frequency but not the duration of productive cell cycles. EMBO Rep 2, 1125-1132 (PubMed Abstract)

Schuhmacher, M., Kohlhuber, F., Hoelzel, M., Kaiser, C., Burtscher, H., Jarsch, M., Bornkamm, G. W., Laux, G., Polack, A., Weidle, U. H., and Eick, D. (2001). The transcriptional program of a human B cell line in response to Myc. Nucleic Acids Res 29, 397-406 (PubMed Abstract)

Albert, T., Wells, J., Funk, J. O., Pullner, A., Raschke, E. E., Stelzer, G., Meisterernst, M., Farnham, P. J., and Eick, D. (2001). The chromatin structure of the dual c-myc promoter P1/P2 is regulated by separate elements. J Biol Chem 276, 20482-20490 (PubMed Abstract)

Hermeking, H., Rago, C., Schuhmacher, M., Li, Q., Barrett, J. F., Obaya, A. J., O'Connell, B. C., Mateyak, M. K., Tam, W., Kohlhuber, F., et al. (2000). Identification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A 97, 2229-2234 (PubMed Abstract)

Pajic, A., Spitkovsky, D., Christoph, B., Kempkes, B., Schuhmacher, M., Staege, M. S., Brielmeier, M., Ellwart, J., Kohlhuber, F., Bornkamm, G. W., et al. (2000). Cell cycle activation by c-myc in a burkitt lymphoma model cell line. Int J Cancer 87, 787-793 (PubMed Abstract)

Meininghaus, M., Chapman, R. D., Horndasch, M., and Eick, D. (2000). Conditional expression of RNA polymerase II in mammalian cells. Deletion of the carboxyl-terminal domain of the large subunit affects early steps in transcription. J Biol Chem 275, 24375-24382 (PubMed Abstract)

Meininghaus, M., and Eick, D. (1999). Requirement of the carboxy-terminal domain of RNA polymerase II for the transcriptional activation of chromosomal c-fos and hsp70A genes. FEBS Lett 446, 173-176 (PubMed Abstract)

Kaiser, C., Laux, G., Eick, D., Jochner, N., Bornkamm, G. W., and Kempkes, B. (1999). The proto-oncogene c-myc is a direct target gene of Epstein-Barr virus nuclear antigen 2. J Virol 73, 4481-4484 (PubMed Abstract)

Schuhmacher, M., Staege, M. S., Pajic, A., Polack, A., Weidle, U. H., Bornkamm, G. W., Eick, D., and Kohlhuber, F. (1999). Control of cell growth by c-Myc in the absence of cell division. Curr Biol 9, 1255-1258 (PubMed Abstract)

Schneider, E. E., Albert, T., Wolf, D. A., and Eick, D. (1999). Regulation of c-myc and immunoglobulin kappa gene transcription by promoter-proximal pausing of RNA polymerase II. Curr Top Microbiol Immunol 246, 225-231 (PubMed Abstract)

Raschke, E. E., Albert, T., and Eick, D. (1999). Transcriptional regulation of the Ig kappa gene by promoter-proximal pausing of RNA polymerase II. J Immunol 163, 4375-4382 (PubMed Abstract)

Reichert, M., and Eick, D. (1999). Analysis of cell cycle arrest in adipocyte differentiation. Oncogene 18, 459-466 (PubMed Abstract)

Albert, T., Mautner, J., Funk, J. O., Hortnagel, K., Pullner, A., and Eick, D. (1997). Nucleosomal structures of c-myc promoters with transcriptionally engaged RNA polymerase II. Mol Cell Biol 17, 4363-4371 (PubMed Abstract)

Eick, D., and Hermeking, H. (1996). Viruses as pacemakers in the evolution of defence mechanisms against cancer. Trends Genet 12, 4-6 (PubMed Abstract)

Jochner, N., Eick, D., Zimber-Strobl, U., Pawlita, M., Bornkamm, G. W., and Kempkes, B. (1996). Epstein-Barr virus nuclear antigen 2 is a transcriptional suppressor of the immunoglobulin mu gene: implications for the expression of the translocated c-myc gene in Burkitt's lymphoma cells. Embo J 15, 375-382 (PubMed Abstract)

Pullner, A., Mautner, J., Albert, T., and Eick, D. (1996). Nucleosomal structure of active and inactive c-myc genes. J Biol Chem 271, 31452-31457 (PubMed Abstract)

Michelotti, G. A., Michelotti, E. F., Pullner, A., Duncan, R. C., Eick, D., and Levens, D. (1996). Multiple single-stranded cis elements are associated with activated chromatin of the human c-myc gene in vivo. Mol Cell Biol 16, 2656-2669 (PubMed Abstract)

Kohlhuber, F., Hermeking, H., Graessmann, A., and Eick, D. (1995). Induction of apoptosis by the c-Myc helix-loop-helix/leucine zipper domain in mouse 3T3-L1 fibroblasts. J Biol Chem 270, 28797-28805 (PubMed Abstract)

Wolf, D. A., Hermeking, H., Albert, T., Herzinger, T., Kind, P., and Eick, D. (1995). A complex between E2F and the pRb-related protein p130 is specifically targeted by the simian virus 40 large T antigen during cell transformation. Oncogene 10, 2067-2078 (PubMed Abstract)

Wolf, D. A., Strobl, L. J., Pullner, A., and Eick, D. (1995). Variable pause positions of RNA polymerase II lie proximal to the c-myc promoter irrespective of transcriptional activity. Nucleic Acids Res 23, 3373-3379 (PubMed Abstract)

Mautner, J., Joos, S., Werner, T., Eick, D., Bornkamm, G. W., and Polack, A. (1995). Identification of two enhancer elements downstream of the human c-myc gene. Nucleic Acids Res 23, 72-80 (PubMed Abstract)

Herzinger, T., Funk, J. O., Hillmer, K., Eick, D., Wolf, D. A., and Kind, P. (1995). Ultraviolet B irradiation-induced G2 cell cycle arrest in human keratinocytes by inhibitory phosphorylation of the cdc2 cell cycle kinase. Oncogene 11, 2151-2156 (PubMed Abstract)

Plet, A., Eick, D., and Blanchard, J. M. (1995). Elongation and premature termination of transcripts initiated from c- fos and c-myc promoters show dissimilar patterns. Oncogene 10, 319-328 (PubMed Abstract)

Herzinger, T., Wolf, D. A., Eick, D., and Kind, P. (1995). The pRb-related protein p130 is a possible effector of transforming growth factor beta 1 induced cell cycle arrest in keratinocytes. Oncogene 10, 2079-2084 (PubMed Abstract)

Hermeking, H., Funk, J. O., Reichert, M., Ellwart, J. W., and Eick, D. (1995). Abrogation of p53-induced cell cycle arrest by c-Myc: evidence for an inhibitor of p21WAF1/CIP1/SDI1. Oncogene 11, 1409-1415 (PubMed Abstract)

Eick, D., Wedel, A., and Heumann, H. (1994). From initiation to elongation: comparison of transcription by prokaryotic and eukaryotic RNA polymerases. Trends Genet 10, 292-296 (PubMed Abstract)

Henglein, B., Chenivesse, X., Wang, J., Eick, D., and Brechot, C. (1994). Structure and cell cycle-regulated transcription of the human cyclin A gene. Proc Natl Acad Sci U S A 91, 5490-5494 (PubMed Abstract)

Hermeking, H., and Eick, D. (1994). Mediation of c-Myc-induced apoptosis by p53. Science 265, 2091-2093 (PubMed Abstract)

Hermeking, H., Wolf, D. A., Kohlhuber, F., Dickmanns, A., Billaud, M., Fanning, E., and Eick, D. (1994). Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts. Proc Natl Acad Sci U S A 91, 10412-10416 (PubMed Abstract)

Albert, T., Urlbauer, B., Kohlhuber, F., Hammersen, B., and Eick, D. (1994). Ongoing mutations in the N-terminal domain of c-Myc affect transactivation in Burkitt's lymphoma cell lines. Oncogene 9, 759-763 (PubMed Abstract)

Kohlhuber, F., Strobl, L. J., and Eick, D. (1993). Early down-regulation of c-myc in dimethylsulfoxide-induced mouse erythroleukemia (MEL) cells is mediated at the P1/P2 promoters. Oncogene 8, 1099-1102 (PubMed Abstract)

Strobl, L. J., Kohlhuber, F., Mautner, J., Polack, A., and Eick, D. (1993). Absence of a paused transcription complex from the c-myc P2 promoter of the translocation chromosome in Burkitt's lymphoma cells: implication for the c-myc P1/P2 promoter shift. Oncogene 8, 1437-1447 (PubMed Abstract)

Strobl, L. J., and Eick, D. (1992). Hold back of RNA polymerase II at the transcription start site mediates down-regulation of c-myc in vivo. Embo J 11, 3307-3314 (PubMed Abstract)

Apel, T. W., Mautner, J., Polack, A., Bornkamm, G. W., and Eick, D. (1992). Two antisense promoters in the immunoglobulin mu-switch region drive expression of c-myc in the Burkitt's lymphoma cell line BL67. Oncogene 7, 1267-1271 (PubMed Abstract)