institute of bioinformatics and systems biology / mips

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Dr. Martin Münsterkötter


Phone: +49 (0) 89 3187 3579
Fax: +40 (0) 89 3187 3585
Building 56
Room 136a

Research Interests

  • Microbial biology
  • Annotation and functional protein classification
  • Comparative genomics and computational biology
  • Analysis of plant pathogenic fungals
  • Analysis of bacteria, causing zoonotic diseases
  • PhD project: Interplay of Chromatinorganisation and Transcriptional Regulation

Projects

  • RhDB - Leibniz Gemeinschaft - Comperative Genomics of scald phytopatogenic Rhynchosporium species
    (Cooperation with Prof. W. Knogge, Leibniz Institut für Pflanzenbiochemie in Halle)

  • CCBDB - Verbund Q-fever - BMBF - Comperative Genomics and proteomics of Coxiella burnetii strains
    (Cooperation with Dr. D. Frangoulidis, Bundeswehr Institut für Mikrobiologie in München)

  • MUMDB, SRDB - Comperative Genomics of Ustilago maydis,Sporisorium eilianum and related species
  • CYGD - Comprehensive Yeast Genome Database
  • MYGD - MIPS Yeast Genome Database
  • EUROFAN II - Functional genome analysis of Saccharomyces cerevisiae

Curriculum Vitae

  • Senior Scientist Fungal Genome Analysis since 2003
  • Postdoc at MIPS 1999 - 2002
  • PhD in Biochemestry at the Ludwig-Maximilians-University of München 2000
  • Study of Chemistry at the Westfälische Wilhelms-University of Münster and the Ludwig-Maximilians-University of München 1986-1992

Publications

  • Schirawski J, Mannhaupt G, Münch K, Brefort T, Schipper K, Doehlemann G, Di Stasio M, Rössel N, Mendoza-Mendoza A, Pester D, Müller O, Winterberg B, Meyer E, Ghareeb H, Wollenberg T, Münsterkötter M, Wong P, Walter M, Stukenbrock E, Güldener U, Kahmann R (2010) Pathogenicity determinants in smut fungi revealed by genome comparison. Science, 330, 1546-8.  PMID: 21148393
  • Wong P, Walter M, Lee W, Mannhaupt G, Münsterkötter M, Mewes HW, Adam G, Güldener U (2010) FGDB: revisiting the genome annotation of the plant pathogen Fusarium graminearum. PMID: 21051345
  • Grisel N, Zoller S, Kunzli-Gontarczyk M, Lampart T, Münsterkötter M, Brunner I, Bovet L, Metraux JP, Sperisen C. (2010) Transcriptome responses to aluminum stress in roots of aspen (Populus tremula). BMC Plant Biol 10(1):185. PMID: 20727216
  • Walter MC, Rattei T, Arnold R, Güldener U, Münsterkötter M, Nenova K, Kastenmüller G, Tischler P, Wölling A, Volz A, Pongratz N, Jost R, Mewes HW, Frishman D. (2009) PEDANT covers all complete RefSeq genomes. Nucleic Acids Res. 2009 Jan;37(Database issue):D408-11. Epub 2008 Oct 21.PMID: 18940859
  • Feldbrügge M, Zarnack K, Vollmeister E, Baumann S, Koepke J, König J, Münsterkkötter M, Mannhaupt G. (2008). The posttranscriptional machinery of Ustilago maydis. Fungal Genetics and Biology Aug; 45 Suppl 1:S40-6.     PMID: 18468465
  • Cuomo CA, Güldener U, Xu JR, Trail F, Turgeon BG, Di Pietro A, Walton J D, Ma LJ, Baker SE, Rep M et al. (2007) The Fusarium graminearum Genome Reveals a Link Between Localized Polymorphism and Pathogen Specialization. Science, 317, 1400-1402. PMID: 17823352
  • Mewes HW, Dietmann S, Frishman D, Gregory R, Mannhaupt G, Mayer KF, Münsterkkötter M, Ruepp A, Spannagl M, Stümpflen V, Rattei T. (2007). MIPS: analysis and annotation of genome information in 2007. Nucleic Acids Res. Dec 23; 8:473 PMID: 18158298
  • Münsterkötter M and Steinberg G (2007). The fungus Ustilago maydis and humans share disease-related proteins that are not found in Saccharomyces cerevisiae. BMC Genomics. Dec. 20; 8:473 PMID: 18096044
  • Kämper J, Kahmann R, Bölker M, Ma LJ, .. Güldener U, et al. (2006). Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis. Nature. Nov 2;444(7115):97-101. PMID: 17080091
  • Güldener U, Mannhaupt G, Münsterkötter M, Haase D, Oesterheld M, Stümpflen V, Mewes HW, Adam G (2006). FGDB: a comprehensive fungal genome resource on the plant pathogen Fusarium graminearum. Nucl. Acids Res. 2006 34: D456-D458.  PMID: 16381910
  • Güldener U, Münsterkötter M, Oesterheld M, Pagel P, Ruepp A, Mewes HW, Stümpflen V (2006). MPact: the MIPS protein interaction resource on yeast. Nucl. Acids Res. 2006 34: D436-D441.  PMID: 16381906
  • Güldener U, Münsterkötter M, Kastenmüller G, Strack N, van Helden J, Lemer C, Richelles J, Wodak SJ, Garcia-Martinez J, Perez-Ortin JE, Michael H, Kaps A, Talla E, Dujon B, Andre B, Souciet JL, De Montigny J, Bon E, Gaillardin C, Mewes HW (2005). CYGD: the Comprehensive Yeast Genome Database. Nucleic Acids Res. 2005 Jan 1;33 Database Issue:D364-8. PMID: 15608217
  • Ruepp A, Zollner A, Maier D, Albermann K, Hani J, Mokrejs M, Tetko I, Güldener U, Mannhaupt G, Münsterkötter M, Mewes HW (2004). The FunCat, a functional annotation scheme for systematic classification of proteins from whole genomes. Nucleic Acids Res 32, 5539-5545. PMID: 15486203
  • Mewes HW, Amid C, Arnold R, Frishman D, Güldener U, Mannhaupt G, Münsterkötter M, Pagel P, Strack N, Stumpflen V, Warfsmann J, Ruepp A (2004). MIPS: analysis and annotation of proteins from whole genomes. Nucleic Acids Res. Jan 1;32 Database issue:D41-4. PMID: 14681354
  • Andreoli C, Prokisch H, Hortnagel K, Mueller JC, Münsterkötter M, Scharfe C, Meitinger T. (2004). MitoP2, an integrated database on mitochondrial proteins in yeast and man. Nucleic Acids Res. 2004 Jan 1;32 Database issue:459-462. PMID: 14681457
  • Bon E, Casaregola S, Blandin G, Llorente B, Neuveglise C, Münsterkötter M, Güldener U, Mewes HW, Van Helden J, Dujon B, Gaillardin C. (2003). Molecular evolution of eukaryotic genomes: hemiascomycetous yeast spliceosomal introns. Nucleic Acids Res. Feb 15;31(4):1121-35.  PMID: 12582231
  • Briza P, Bogengruber E, Thur A, Rutzler M, Münsterkötter M, Dawes IW, Breitenbach M. (2002) Systematic analysis of sporulation phenotypes in 624 non-lethal homozygous deletion strains of Saccharomyces cerevisiae. Yeast. 19, 403-22 PMID: 11921089
  • Mewes HW, Frishman D, Güldener U, Mannhaupt G, Mayer K, Mokrejs M, Morgenstern B, Münsterkötter M, Rudd S, Weil B. (2002). MIPS: a database for genomes and protein sequences. Nucleic Acids Res. Jan 1;30(1):31-4. PMID: 11752246
  • Münsterkötter M, Barbaric S, Hörz W. (2000) Transcriptional regulation of the yeast PHO8 promoter in comparison to the coregulated PHO5 promoter. J Biol Chem. 275, 22678-22685. PMID: 10801809 
  • Gregory PD, Schmid A, Zavari M, Münsterkötter M, Hörz W. (1999) Chromatin remodelling at the PHO8 promoter requires SWI-SNF and SAGA at a step subsequent to activator binding. EMBO J. 18, 6407-6414 PMID: 10562552 
  • Barbaric S, Münsterkötter M, Goding C, Hörz W. (1998) Cooperative Pho2-Pho4 interactions at the PHO5 promoter are critical for binding of Pho4 to UASp1 and for efficient transactivation by Pho4 at UASp2. Mol Cell Biol. 18, 2629-2639 PMID: 9566882 
  • Barbaric S, Münsterkötter M, Svaren J, Hörz W. The homeodomain protein Pho2 and the basic-helix-loop-helix protein Pho4 bind DNA cooperatively at the yeast PHO5 promoter. (1996) Nucleic Acids Res. 24, 4479-4486. PMID: 8948638

Conferences

  • Münsterkötter M, W Splettstoesser, Frangoulidis D (2009). Invited talk: PEDANT3 - Comperative genomics of Coxiella burnetii isolates, medical biodefence conference 2009, Octobre 20-22, Munich, Germany
  • Münsterkötter M, W Splettstoesser, Frangoulidis D (2009). Invited talk: Comperative genomics and proteomics of Coxiella burnetii, 61. Jahrestagung der Deutschen Gesellschaft für Hygiene undMikrobiologie, September 20-23, Göttingen, Germany
  • Güldener U, Mannhaupt G, Münsterkötter M, Mewes HW (2006). Invited Talk: Recent Advances in the Genomics of Fusarium, 9th European Fusarium Seminar, September 19-22, Wageningen, Netherlands
  • Güldener U, Mannhaupt G, Münsterkötter M, Mewes HW (2006). The MIPS comprehensive fungal genome resources 8TH EUROPEAN CONFERENCE ON FUNGAL GENETICS, Vienna University of Technology, April 8-11, 2006, Vienna, Austria
  • Güldener U, Mannhaupt G, Münsterkötter M, Mewes HW (2006). Update on the MIPS Fusarium graminearium database 4th International Fusarium Genomics Workshop, April 7, 2006, University of Natural Resources and Applied Life Sciences (BOKU), Muthgasse 18, A-1190 Vienna, Austria
  • Güldener U, Münsterkötter M, Mannhaupt G, Mewes HW (2005). Comparative Fungal Genomics using the MIPS Comprehensive Resources. Twenty Third Fungal Genetics Conference March 15-20 Asilomar Conference Grounds Pacific Grove California, USA
  • Güldener U, Mannhaupt G, Münsterkötter M, Stümpflen V, Strack V, Mewes HW (2004). MUMDB - The MIPS Ustilago maydis Genome Database 2nd International Ustilago maydis Conference Rauischholzhausen Germany
  • Güldener U, Mannhaupt G. Münsterkötter M, Stümpflen V, Strack N. Haase D, Mewes HW, Adam G (2004). The GEN-AU / MIPS Fusarium graminearum Genome Database 7th European Conference on Fungal Genetics Copenhagen, Denmark
  • Güldener U, Münsterkötter M, Stümpflen V, Kastenmüller G, Mewes HW (2003). On track to provide convenient Genome data: The MIPS Comprehensive Yeast Genome Database. XXI International Conference on Yeast Genetics and Molecular Biology Goeteborg, Sweden
  • Güldener U, Münsterkötter M, Stümpflen V, Kastenmüller G, Mewes HW (2003). On track to provide convenient Genome data: Interaction Data / Related and filamentous Fungi. XXI International Conference on Yeast Genetics and Molecular Biology Goeteborg, Sweden
  • Münsterkötter M, Güldener U, Kastenmüller G, Mewes HW (2002). The MIPS Comprehensive Yeast Genome Database. A resource for Saccharomyces cerevisiae and related yeasts. Annual Conference on 'Yeast Genetics and Molecular Biology' Madison, USA
  • Güldener U, Münsterkötter M, Arnold R, Mewes HW (2001). The Comprehensive Yeast Genome Database (CYGD). XXth International Conference on Yeast Genetics and Molecular Biology Prague, Czech Republic
  • Münsterkötter M, Mewes H-W (2000), The EUROFAN II projects home page at MIPS. EUROFANII Meeting Salamanca, Spain
  •  Münsterkötter M, Stocker S, Mewes H-W (2000). The MIPS Yeast Genome Database (MYGD). (535) Annual Conference on 'Yeast Genetics and Molecular Biology' Seattle, USA

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