Group Leader Fungal & Microbial Genomics

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Phone: +49 (0) 89 3187 3582
Fax: +40 (0) 89 3187 3585
Building 56
Room 131

• Fungal biology, taxonomy
• Fungal structural genome comparative annotation
• Functional annotation
• Genome analysis to identify unique features of species

• DFG Fusarium 'Identification of the moniliformin and fusarin C biosynthetic genes, their regulation and biosynthetic pathways in Fusarium fujikuroi'
• FUSARIUM - FWF-SFB (Coordinator Prof. G. Adam, BOKU, Vienna) - Fusarium metabolites and detoxification reactions: determinants of pathogen virulence and plant resistance
• MUMDB, MSRDB - Ustilago maydis and related species genome annotation and analysis
• FGDB - GEN-AU project - Set up of a Fusarium graminearum database and analysis
• CYGD - Comprehensive Yeast Genome Database
• EUROFAN I + II - Functional genome analysis of Saccharomyces cerevisiae

• Group manger Fungal Genome Analysis since 2006
• Senior Scientific Curator 2003 - 2005
• Postdoc at MIPS 2000 - 2003
• PhD in Giessen 2000
• Study of biology in Darmstadt and Giessen 1989-1996

• Hegemann JH, Güldener U, Köhler GJ (2006). Gene disruption in the budding yeast Saccharomyces cerevisiae. Methods Mol Biol. 2006;313:129-44. PMID: 16118431
• Güldener U, Köhler GJ, Haussmann C, Bacher A, Kricke J, Becher D, Hegemann JH (2004). Characterization of the Saccharomyces cerevisiae Fol1 Protein: Starvation for C1 Carrier Induces Pseudohyphal Growth. Mol Biol Cell. Aug;15(8):3811-28. Epub 2004 May 28. PMID: 15169867
• Mewes HW, Amid C, Arnold R, Frishman D, Güldener U, Mannhaupt G, Münsterkötter M, Pagel P, Strack N, Stumpflen V, Warfsmann J, Ruepp A (2004). MIPS: analysis and annotation of proteins from whole genomes. Nucleic Acids Res. Jan 1;32 Database issue:D41-4. PMID: 14681354
• Bon E, Casaregola S, Blandin G, Llorente B, Neuveglise C, Münsterkötter M, Güldener U, Mewes HW, Van Helden J, Dujon B, Gaillardin C. (2003). Molecular evolution of eukaryotic genomes: hemiascomycetous yeast spliceosomal introns. Nucleic Acids Res. Feb 15;31(4):1121-35.  PMID: 12582231
• Giaever G, Chu AM, Ni L, Connelly C, Riles L, Veronneau S, Dow S, Lucau-Danila A, Anderson K, Andre B, Arkin AP, Astromoff A, El-Bakkoury M, Bangham R, Benito R, Brachat S, Campanaro S, Curtiss M, Davis K, Deutschbauer A, Entian KD, Flaherty P, Foury F, Garfinkel DJ, Gerstein M, Gotte D, Güldener U et al. (2002). Functional profiling of the Saccharomyces cerevisiae genome. Nature Jul 25;418(6896):387-91.  PMID: 12140549
• Güldener U, Heinisch J, Köhler GJ, Voss D, and Hegemann JH (2002). A second set of loxP marker cassettes for Cre-mediated multiple gene knock-outs in budding yeast. Nucleic Acids Res.Mar 15;30(6):e23.  PMID: 11884642
• Mewes HW, Frishman D, Güldener U, Mannhaupt G, Mayer K, Mokrejs M, Morgenstern B, Münsterkötter M, Rudd S, Weil B. (2002). MIPS: a database for genomes and protein sequences. Nucleic Acids Res. Jan 1;30(1):31-4. PMID: 11752246
• Ramos CW, Güldener U, Klein S, Hegemann JH, Gonzalez S, Rodriguez-Medina JR (2000). Molecular analysis of the Saccharomyces cerevisiae YHR076w gene. IUBMB Life.Dec;50(6):371-7. PMID: 11327310
• Niedenthal R, Riles L, Güldener U, Klein S, Johnston M. and Hegemann JH (1999). Systematic analysis of S. cerevisiae chromosome VIII genes. Yeast 15, 1775-96 PMID: 10590466
• Hegemann J. H, Klein S, Heck S, Güldener U, Niedenthal R. K. and Fleig U. (1999). A fast method to diagnose chromosome and plasmid loss in Saccharomyces cerevisiae strains. Yeast 15, 1009-1019. PMID: 10407280
• Entian KD, Schuster T, Hegemann J. H, Becher D, Feldmann H, Güldener U, Goetz R, Hansen M, Hollenberg C. P, Jansen G, Kramer W, Klein S, Kötter P, Kricke J, Launhardt H, Mannhaupt G, Maierl A, Meyer P, Mewes W, Munder T, Niedenthal R. K, Ramazani Rad M, Roehmer A, Rose M, Schäfer B, Siegler ML, Vetter J, Wilhelm N, Wolf K, Zimmermann FK, Zollner A and Hinnen A (1999). Functional analysis of 150 deletion mutants in Sacharomyces cerecisiae by a systematic approach. Mol Gen Genet, 262, 683-702. PMID: 10628851
• Karpova T. S, Moltz S. L, Riles L, Güldener U, Hegemann J. H, Veronneau S, Bussey H and Cooper JA (1998). Depolarization of the actin cytoskeleton is a specific phenotype in Saccharomyces cerevisiae. J Cell Sci 111, 2689-96. PMID: 9701567
• Philippsen P, Kleine K, Pohlmann R, Dusterhoft A, Hamberg K, Hegemann J. H, Obermaier B, Urrestarazu L. A, Aert R, Albermann K, Altmann R, Andre B, Baladron V, Ballesta JP, Becam AM, Beinhauer J, Boskovic J. Buitrago MJ, Bussereau F, Coster F, Crouzet M, D'Angelo M, Dal Pero F, De Antoni A, Güldener U, Hani J and et al. (1997). The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. Nature 387 93-8. PMID: 9169873
• Sen-Gupta M, Güldener U, Beinhauer JD, Fiedler T and Hegemann JH (1997). Sequence analysis of the 33 kb long region between ORC5 and SUI1 from the left arm of chromosome XIV from Saccharomyces cerevisiae. Yeast 13 849-60. PMID: 9234673
• Güldener U, Heck S, Fiedler T, Beinhauer JD and Hegemann JH (1996). A new efficient gene disruption cassette for repeated use in budding yeast. Nucleic Acids Res 24 2519-24. PMID: 8692690
  
  
  

• Güldener U, Mannhaupt G, Münsterkötter M, Mewes HW (2006). Invited Talk: Recent Advances in the Genomics of Fusarium, 9th European Fusarium Seminar, September 19-22, Wageningen, Netherlands
• Güldener U, Mannhaupt G, Münsterkötter M, Mewes HW (2006). The MIPS comprehensive fungal genome resources 8TH EUROPEAN CONFERENCE ON FUNGAL GENETICS, Vienna University of Technology, April 8-11, 2006, Vienna, Austria
• Mitterbauer R, Cziferszky A, Wiesenberger G, Güldener U, Brunner K, Hellmer H, Mach R, Adam G (2006) Development of new tools for Fusarium graminearum: Cre/lox mediated marker excision and bar-coded insertion mutants 8TH EUROPEAN CONFERENCE ON FUNGAL GENETICS, Vienna University of Technology, April 8-11, 2006, Vienna, Austria
• Güldener U, Mannhaupt G, Münsterkötter M, Mewes HW (2006). Update on the MIPS Fusarium graminearium database 4th International Fusarium Genomics Workshop, April 7, 2006, University of Natural Resources and Applied Life Sciences (BOKU), Muthgasse 18, A-1190 Vienna, Austria
• Güldener U (2005). MIPS (CYGD MNCDB FGDB MUMDB) mips.gsf.de/projects/fungi Comparative genomics using the MIPS comprehensive fungal resources ESF-EMBO Symposium on Comparative Genomics of Eukaryotic Microorganisms 12-17 November Sant Feliu de Guixols Spain
• Güldener U, Münsterkötter M, Mannhaupt G, Mewes HW (2005). Comparative Fungal Genomics using the MIPS Comprehensive Resources. Twenty Third Fungal Genetics Conference March 15-20 Asilomar Conference Grounds Pacific Grove California USA
• Güldener U, Trail F, Xu JR, Adam G and Kistler HC (2005). Development of an Affymetrix GeneChip Microarray using the GEN-AU / MIPS Fusarium graminearum Genome Database. Plant and Animal Genome XIII Conference San Diego USA
• Güldener U, Trail F, Xu JR, Adam G and Kistler HC (2004). Development of an Affymetrix GeneChip Microarray using the GEN-AU / MIPS Fusarium graminearum Genome Database. 2nd International Symposium on Fusarium Head Blight Orlando USA
• Güldener U, Mannhaupt G, Münsterkötter M, Stümpflen V, Strack V, Mewes HW (2004). MUMDB - The MIPS Ustilago maydis Genome Database 2nd International Ustilago maydis Conference Rauischholzhausen Germany
• Güldener U, Mannhaupt G. Münsterkötter M, Stümpflen V, Strack N. Haase D, Mewes HW, Adam G (2004). The GEN-AU / MIPS Fusarium graminearum Genome Database 7th European Conference on Fungal Genetics Copenhagen Denmark
• Güldener U (2004). The GEN-AU / MIPS Fusarium graminearum Genome Database (talk) Second International Fusarium Genomics Workshop Copenhagen Denmark
• Güldener U, Münsterkötter M, Stümpflen V, Kastenmüller G, Mewes HW (2003). On track to provide convenient Genome data: The MIPS Comprehensive Yeast Genome Database. XXI International Conference on Yeast Genetics and Molecular Biology Goeteborg Sweden
• Güldener U, Münsterkötter M, Stümpflen V, Kastenmüller G, Mewes HW (2003). On track to provide convenient Genome data: Interaction Data / Related and filamentous Fungi. XXI International Conference on Yeast Genetics and Molecular Biology Goeteborg/Sweden
• Münsterkötter M, Güldener U, Kastenmüller G, Mewes HW (2002). The MIPS Comprehensive Yeast Genome Database. A resource for Saccharomyces cerevisiae and related yeasts. Annual Conference on 'Yeast Genetics and Molecular Biology' Madison/USA
• Güldener U, Münsterkötter M, Arnold R, Mewes HW (2001). The Comprehensive Yeast Genome Database (CYGD). XXth International Conference on Yeast Genetics and Molecular Biology Prag
• Hegemann JH, Bogengruber E, Breitenbach M, Eder S. Güldener U, Kohlwein S, Kötter P, Launhardt H, Munder T, Van der Schueren J, Volckaert G, Winsor B (2000). talk + poster: Functional Analysis of novel essential genes by regulated gene expression in Saccharomyces cerevisiae ISY2000 10th International Symposium on Yeasts: "The Rising Power of Yeasts in Science and Industry"
• Güldener U, Köhler G, Voss D, Heinisch JH and Hegemann JH (2000). A new set of heterologous markers for gene deletion in Saccharomyces cerevisiae. ISY2000
• Güldener U, Freidel K, Klein S and Hegemann JH (1999). Functional analysis of 35 unknown essential genes identifies determinants of genomic stability. EUROFAN II Rimini
• Güldener U, Haussmann C, Bacher A, Kricke J, Becher D and Hegemann JH (1999). Identification and characterisation of the trifunctional folic acid synthesis Fol1p protein from Saccharomyces cerevisiae. EUROFAN II Rimini
• Güldener U and Hegemann JH (1998). A second generation of GFP-vectors for subcellular localization studies in budding yeast. EUROFAN Leidenhorst EUROFAN'98: The Third Meeting