Gabi Kastenmüller
PhD
Email me!
Phone: +49 (0) 89 3187 3578
Fax: +49 (0) 89 3187 3585
Building 56
Room 147
Research Interests
- Targeted and non-targeted metabolomics
- Metabolomics data analysis
- Large-scale comparative analysis of metabolic capabilities
- Metabolomics as tool for biomarker discovery in diagnosis and drug testing
- Human chemical individuality and its effects in health, disease, and treatment
(Metabolome-wide and genome-wide association studies in the general population)
Curriculum Vitae
- 1989 - 1995 studies in chemistry at Ludwig-Maximilians-University, Munich
Degree: master's degree in chemistry (in German: Diplom-Chemiker)
Thesis: "Light-induced reorientation of azo dye containing, cholesteric oligosiloxanes" (in German)
- 1993 - 1998 studies in computer science at Ludwig-Maximilians-University, Munich
Degree: master's degree in computer science (in German: Diplom-Informatikerin)
Thesis: "Similarity search in 3D protein databases" (in German) - 1999 - 2001 research assistant (part time) at Munich information center for protein sequences (MIPS), Max Planck Institute of Biochemistry, Munich
- 2001 - 2009 research assistant at Institute of Bioinformatics and Systems Biology (IBIS), Helmholtz Zentrum München
- 2006 - 2009 Ph.D. student at Genome-oriented Bioinformatics, Life and Food Science Center Weihenstephan, Technische Universität München
Degree: Dr. rer. nat.
Thesis: "In silico prediction and comparison of metabolic capabilities in sequenced genomes"
- since Mar 2009 at Metabolomics group, IBIS, Helmholtz Zentrum München
Publications
- Raffler J., Römisch-Margl W., Petersen AK., Pagel P., Blochl F., Hengstenberg C., Illig T., Meisinger C., Stark K., Wichmann HE., Adamski J., Gieger C., Kastenmüller G., Suhre K. Identification and MS assisted interpretation of genetically influenced NMR signals in human plasma. Genome Med. 2013 Feb 15;5(2):13.
- Altmaier E., Emeny RT., Krumsiek J., Lacruz ME., Lukaschek K., Häfner S., Kastenmüller G., Römisch-Margl W., Prehn C., Mohney RP., Evans AM., Milburn MV., Illig T., Adamski J., Theis F., Suhre K., Ladwig KH. Metabolomic profiles in individuals with negative affectivity and social inhibition: A population-based study of Type D personality. Psychoneuroendocrinology. 2012 Dec 10.
- Ferrannini E., Natali A., Camastra S., Nannipieri M., Mari A., Adam KP., Milburn MV., Kastenmüller G., Adamski J., Tuomi T., Lyssenko V., Groop L., Gall WE. Early Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance. Diabetes. 2012 Nov 16.
- Krumsiek J., Suhre K., Evans AM., Mitchell MW., Mohney RP., Milburn MV., Wägele B., Römisch-Margl W., Illig T., Adamski J., Gieger C., Theis FJ., Kastenmüller G. Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information. PLoS Genet. 2012 Oct;8(10):e1003005.
- Lechner M., Höhn V., Brauner B., Dunger I., Fobo G., Frishman G., Montrone C., Kastenmüller G., Wägele B., Ruepp A. CIDeR: multifactorial interaction networks in human diseases. Genome Biol. 2012 Jul 18;13(7):R62.
- Jourdan C., Petersen AK., Gieger C., Döring A., Illig T., Wang-Sattler R., Meisinger C., Peters A., Adamski J., Prehn C., Suhre K., Altmaier E., Kastenmüller G., Römisch-Margl W., Theis FJ., Krumsiek J., Wichmann HE., Linseisen J. Body fat free mass is associated with the serum metabolite profile in a population-based study. PLoS One. 2012;7(6):e40009.
- Krug S., Kastenmüller G., Stückler F., Rist M.J., Skurk T., Sailer M., Raffler J., Römisch-Margl W., Adamski J., Prehn C., Frank T., Engel K.H., Hofmann T., Luy B., Zimmermann R., Moritz F., Schmitt-Kopplin P., Krumsiek J., Kremer W., Huber F., Oeh U., Theis F.J., Szymczak W., Hauner H., Suhre K., Daniel H. The dynamic range of the human metabolome revealed by challenges. FASEB J. 2012 Jun;26(6):2607-19.
- Petersen A.K., Stark K., Musameh M.D., Nelson C.P., Römisch-Margl W., Kremer W., Raffler J., Krug S., Skurk T., Rist M.J., Daniel H., Hauner H., Adamski J., Tomaszewski M., Döring A., Peters A., Wichmann H.E., Kaess B.M., Kalbitzer H.R., Huber F., Pfahlert V., Samani N.J., Kronenberg F., Dieplinger H., Illig T., Hengstenberg C., Suhre K., Gieger C., Kastenmüller G. Genetic associations with lipoprotein subfractions provide information on their biological nature. Hum Mol Genet. 2012 Mar 15;21(6):1433-43.
- Suhre K., Shin SY., Petersen AK., Mohney RP., Meredith D., Wägele B., Altmaier E; CARDIoGRAM., Deloukas P., Erdmann J., Grundberg E., Hammond CJ., de Angelis MH., Kastenmüller G., Köttgen A., Kronenberg F., Mangino M., Meisinger C., Meitinger T., Mewes HW., Milburn MV., Prehn C., Raffler J., Ried JS., Römisch-Margl W., Samani NJ., Small KS., Wichmann HE., Zhai G., Illig T., Spector TD., Adamski J., Soranzo N., Gieger C., Human metabolic individuality in biomedical and pharmaceutical research. Nature, 477(7362):54-60, 2011
- Yu Z., Kastenmüller G., He Y., Belcredi P., Möller G., Prehn C., Mendes J., Wahl S., Roemisch-Margl W., Ceglarek U., Polonikov A., Dahmen N., Prokisch H., Xie L., Li Y., Wichmann H.-E., Peters A., Kronenberg F., Suhre K., Adamski J., Illig T., Wang-Sattler R., Differences between human plasma and serum metabolite profiles. PLoS One. 6(7):e21230, 2011.
- Kastenmüller G., Römisch-Margl W., Wägele B., Altmaier E., Suhre K., metaP-Server: a web-based metabolomics data analysis tool, J. Biomedicine & Biotechnology, pii:839862, 2011.
- Altmaier E., Kastenmüller G., Römisch-Margl W., Thorand B., Weinberger K.M., Illig T., Adamski J., Döring A., Suhre K., Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics, European Journal of Epidemiology. 2011 Feb;26(2):145-56.
- Fuchs H., Gailus-Durner V., Adler T., Aguilar-Pimentel J.A., Becker L., Calzada-Wack J., Da Silva-Buttkus P., Neff F., Götz A., Hans W., Hölter S.M., Horsch M., Kastenmüller G., Kemter E., Lengger C., Maier H., Matloka M., Möller G., Naton B., Prehn C., Puk O., Rácz I., Rathkolb B., Römisch-Margl W., Rozman J., Wang-Sattler R., Schrewe A., Stöger C., Tost M., Adamski J., Aigner B., Beckers J., Behrendt H., Busch D.H., Esposito I., Graw J., Illig T., Ivandic B., Klingenspor M., Klopstock T., Kremmer E., Mempel M., Neschen S., Ollert M., Schulz H., Suhre K., Wolf E., Wurst W., Zimmer A., Hrabe de Angelis M., Mouse phenotyping, Methods, 2011 Feb;53(2):120-35.
- Illig, T, Gieger, C, Zhai, G, Römisch-Margl, W, Wang-Sattler, R, Prehn, C, Altmaier, E, Kastenmüller, G, Kato, BS , Mewes, HW, Meitinger, T, Hrabé de Angelis, M, Kronenberg, F, Soranzo, N , Wichmann, HE, Spector, TD, Adamski, J, Suhre, K, A genome-wide perspective of genetic variation in human metabolism, Nature Genetics, 42:137-141, 2010, doi:10.1038/ng.507.
- Altmaier, E, Kastenmüller, G, Römisch-Margl, W, Thorand, B, Weinberger, KM, Adamski, J, Illig, T, Döring, A, Suhre K, Variation in the human lipidome associated with coffee consumption as revealed by quantitative targeted metabolomics, Mol. Nutr. Food Res., 53:1357-1365, 2009 [PDF].
- Walter MC, Rattei T, Arnold R, Güldener U, Münsterkötter M, Nenova K, Kastenmüller G, Tischler P, Wölling A, Volz A, Pongratz N, Jost R, Mewes HW, Frishman D. PEDANT covers all complete RefSeq genomes. Nucleic Acids Res. 2009 Jan;37(Database issue):D408-11.
- Kastenmüller G, Schenk ME, Gasteiger J, Mewes HW. Uncovering metabolic pathways relevant to phenotypic traits of microbial genomes. Genome Biol. 2009;10(3):R28.
- Kastenmüller G, Gasteiger J, Mewes HW. An environmental perspective on large-scale genome clustering based on metabolic capabilities. Bioinformatics. 2008 Aug 15;24(16):i56-62.
- Güldener U, Münsterkötter M, Kastenmüller G, Strack N, van Helden J, Lemer C, Richelles J, Wodak SJ, Garcia-Martinez J, Perez-Ortin JE, Michael H, Kaps A, Talla E, Dujon B, Andre B (2005): CYGD: the Comprehensive Yeast Genome Database. Nucleic Acids Res, 33(Database issue), pp. D364-68.
- Frishman D, Mokrejs M, Kosykh D, Kastenmüller G, Kolesov G, Zubrzycki I, Gruber C, Geier B, Kaps A, Albermann K, Volz A, Wagner C, Fellenberg M, Heumann K, Mewes H.-W. (2003): The PEDANT genome database. Nucleic Acids Res, 31(1), pp. 207-11.
- Geier B, Kastenmüller G, Fellenberg M, Mewes HW, Morgenstern B (2001): The HIB database of annotated UniGene clusters. Bioinformatics, 17, pp. 571-72.
- Ankerst M, Kastenmüller G, Kriegel HP, Seidl T (1999): Nearest Neighbor Classification in 3D Protein Databases. Proc. of the 7th Int. Conf. on Intelligent Systems for Molecular Biology (ISMB), Heidelberg, Germany. AAAI Press, pp. 34-43.
- Ankerst M, Kastenmüller G, Kriegel HP, Seidl T (1999): 3D Shape Histograms for Similarity Search and Classification in Spatial Databases. Proc. of the 6th Int. Symposium on Spatial Databases (SSD), Hong Kong, China. Lecture Notes in Computer Science (LNCS), Vol. 1651, Springer Verlag, pp. 207-26.
- Kastenmüller G, Kriegel HP, Seidl T (1998): Similarity Search in 3D Protein Databases. Proc. of the 6th German Conf. on Bioinformatics (GCB), Cologne, Germany.
- Dietrich R, Kastenmüller G, Bourhill G, Bräuchle C, Leigeber HP, Weitzel HP, Kreutzer FH (1996): Generation of noncentrosymmetric structures in glassy liquid crystalline structures. Ber Bunsenges Phys Chem., 100, pp. 1128.