Next-generation sequencing analysis group
We deal with sequence data of all major next generation platforms. Our bioinformatic data analyses range from de-novo assembly, transcriptomics, epigenomics to whole exome analysis. In addition to mapping-, assembly-, SNP variants, and statistical analyses, we provide extended biological functional insights by combining sequence-based methods with bioinformatic methods and databases for example with network- and interaction analyses or functional- and structural predictions/modeling. Furthermore, we are especially interested on non-coding RNAs and their regulative roles. Feel free to contact us for any questions regarding Next Generation Sequencing (NGS), data analysis or any related topic
News:
View our Nature Genetics paper in which we describe a novel causative mutation for complex I deficiency. Here, our Bioinformatic pipeline for analysing Next Generation Sequencing (NGS) data allowed us to perform a fast and successful data analysis.
- Haack TB, Danhauser K, Haberberger B, Hoser J, Strecker V, Boehm D, Uziel G, Lamantea E, Invernizzi F, Poulton J, Rolinski B, Iuso A, Biskup S, Schmidt T, Mewes HW, Wittig I, Meitinger T, Zeviani M, Prokisch H
Exome sequencing identifies ACAD9 mutations as a cause of complex I deficiency.
Nature Genetics Nov (2010)
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Publications and Research Interests