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Work-related stress is a risk factor for type 2 diabetes
Job strain can significantly increase the risk of developing diabetes. This conclusion was based on prospective data from a population-based study conducted by scientists at the Helmholtz Zentrum München. The findings have been published in the scientific journal Psychosomatic Medicine.
Workplace stress can have a range of adverse effects on health with an increased risk of cardio-vascular diseases in the first line. However, to date, convincing evidence for a strong association between work stress and incident Type 2 diabetes mellitus is missing.
Risk of diabetes about 45 percent higher
As the team of scientists headed by Dr. Cornelia Huth and Prof. Karl-Heinz Ladwig has now discovered that individuals who are under a high level of pressure at work and at the same time perceive little control over the activities they perform face an about 45 percent higher risk of developing type 2 diabetes than those who are subjected to less stress at their workplace.
The scientists from the Institute of Epidemiology II (EPI II) at the Helmholtz Zentrum München (HMGU) in collaboration with Prof. Johannes Kruse from the University Hospital of Giessen and Marburg examined data prospectively collected from more than 5,300 employed individuals aged between 29 and 66 who took part in the population-based MONICA/KORA* cohort study. At the beginning of the study, none of the participants had diabetes, while in the post-observation period, which covered an average of 13 years, almost 300 of them were diagnosed with type 2 diabetes. The increase in risk in work-related stress was identified independently of classic risk factors such as obesity, age or gender.
Holistic prevention is important – also at the workplace“
According to our data, roughly one in five people in employment is affected by high levels of mental stress at work. By that, scientists do not mean ‘normal job stress’ but rather the situation in which the individuals concerned rate the demands made upon them as very high, and at the same time they have little scope for maneuver or for decision making. We covered both these aspects in great detail in our surveys,” explains Prof. Ladwig, who led the study. “In view of the huge health implications of stress-related disorders, preventive measures to prevent common diseases such as diabetes should therefore also begin at this point,” he added.
Environmental and lifestyle factors play a key role in the development of widespread diseases in Germany such as diabetes mellitus. The aim of the Helmholtz Zentrum München, a partner of the German Center for Diabetes Research (DZD), is to develop new approaches to the diagnosis, treatment and prevention of the most common diseases.
*For more than 20 years, the research platform Cooperative Health Research in the Augsburg Region (KORA) has been collecting and analyzing data on the health of thousands of people living in the Augsburg region. The objective is to elucidate the effects of environmental factors, behavior and genes. KORA focuses on the development and course of chronic diseases, in particular myocardial infarction and diabetes mellitus. Risk factors are analyzed with regard to individual health behavior (e.g. smoking, diet, exercise), environmental factors (e.g. air pollution, noise) and genetics. From the perspective of health care research, questions regarding the utilization of health care resources and the cost of health care are also studied.
Huth, C. et al. (2014), Job Strain as a Risk Factor for the Onset of Type 2 Diabetes Mellitus: Findings From the MONICA/KORA Augsburg Cohort Study, Psychosomatic Medicine, doi: 10.1097/PSY.0000000000000084
Link to publication
The project was funded by the German Center for Diabetes Research (DZD) and the Competence network Diabetes mellitus.
Helmholtz Zentrum München, as German Research Center for Environmental Health, pursues the goal of developing personalized medical approaches for the diagnosis, treatment and prevention of major widespread diseases such as diabetes mellitus and lung diseases. To achieve this, it investigates the interaction of genetics, environmental factors and lifestyle. The head office of the Center is located in Neuherberg in the north of Munich. Helmholtz Zentrum München has a staff of about 2,200 people and is a member of the Helmholtz Association, a community of 18 scientific-technical and medical-biological research centers with a total of about 34,000 staff members. www.helmholtz-muenchen.de
The German Center for Diabetes Research e.V. brings together experts in the field of diabetes research and combines basic research, epidemiology and clinical applications. The members of the association are the German Diabetes Center (DDZ) in Düsseldorf, the German Institute of Human Nutrition (DifE) in Potsdam-Rehbrücke, the Helmholtz Zentrum München – the German Research Center for Environmental Health, the Paul Langerhans Institutes of the Carl Gustav Carus University Hospital in Dresden and the Eberhard Karl University of Tübingen as well as the Gottfried Wilhelm Leibniz Research Association and the Helmholtz Association of German Research Centers. The aim of the DZD is to find answers to unsolved questions in diabetes research by adopting a novel, integrative approach and to make a significant contribution towards improving the prevention, diagnosis and treatment of diabetes mellitus.
The Institute of Epidemiology II (EPI II) focuses on the assessment of environmental and lifestyle risk factors which jointly affect major chronic diseases such as diabetes, heart disease and mental health. Research builds on the unique resources of the KORA cohort, the KORA myocardial infarction registry, and the KORA aerosol measurement station. Aging-related phenotypes have been added to the KORA research portfolio within the frame of the Research Consortium KORA-Age. The institute’s contributions are specifically relevant for the population as modifiable personal risk factors are being researched that could be influenced by the individual or by improving legislation for the protection of public health.
Prof. Karl-Heinz Ladwig, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Institute of Epidemiology II, Ingolstädter Landstr. 1, 85764 Neuherberg - Phone: 089-3187-3623 - Email