research unit
protein science (prot)

Azimzadeh O, Scherthan H, Yentrapalli R, Barjaktarovic Z, Ueffing M, Conrad M, Neff F, Calzada-Wack J, Aubele M, Buske C, Atkinson MJ, Hauck SM, Tapio S. Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation. J Proteomics. 2012 Apr 18;75(8):2384-95. Epub 2012 Feb 23. PubMed

Buters JTM, Thibaudon M, Smith M, Kennedy R, Rantio-Lehtimäki A, Albertini R, Reese G, Weber B, Galan C, Brandao R, Antunes CM, Jäger S, Berger U, Celenk S, Grewling Ł, Jackowiak B, Sauliene I, Weichenmeier I, Pusch G, Sarioglu H, Ueffing M, Behrendt H, Prank M, Sofiev M, Cecchi L, The HIALINE working group. Release of Bet v 1 from birch pollen from 5 European countries. Results from the HIALINE study, Atmospheric Environment, Volume 55, August 2012, Pages 496-505, ISSN 1352-2310, 10.1016/j.atmosenv.2012.01.054. ScienceDirect

Degroote RL, Hauck SM, Kremmer E, Amann B, Ueffing M, Deeg CA. Altered expression of talin 1 in peripheral immune cells points to a significant role of the innate immune system in spontaneous autoimmune uveitis. J Proteomics. 2012 Jan 28. [Epub ahead of print] PubMed

Elsner M, Rauser S, Maier S, Schöne C, Balluff B, Meding S, Jung G, Nipp M, Sarioglu H, Maccarrone G, Aichler M, Feuchtinger A, Langer R, Jütting U, Feith M, Küster B, Ueffing M, Zitzelsberger H, Höfler H, Walch A. MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma. J Proteomics. 2012 Feb 17. [Epub ahead of print] PubMed

Griciuc A, Aron L, Ueffing M. Looking into eyes: rhodopsin pathologies in Drosophila. Adv Exp Med Biol. 2012;723:415-23. PubMed

Meding S, Balluff B, Elsner M, Schöne C, Rauser S, Nitsche U, Maak M, Schäfer A, Hauck SM, Ueffing M, Langer R, Höfler H, Friess H, Rosenberg R, Walch A. Tissue Based Proteomics Reveals FXYD3, S100A11 and GSTM3 as Novel Markers for Regional Lymph Node Metastasis in Colon Cancer. J Pathol. 2012 Mar 19. doi: 10.1002/path.4021. [Epub ahead of print] PubMed

Sriharshan A, Boldt K, Sarioglu H, Barjaktarovic Z, Azimzadeh O, Hieber L, Zitzelsberger H, Ueffing M, Atkinson MJ, Tapio S. Proteomic analysis by SILAC and 2D-DIGE reveals radiation-induced endothelial response: Four key pathways. J Proteomics. 2012 Feb 20. [Epub ahead of print] PubMed

Trifunovic D, Sahaboglu A, Kaur J, Mencl S, Zrenner E, Ueffing M, Arango-Gonzalez B, Paquet-Durand F. Neuroprotective Strategies for the Treatment of Inherited Photoreceptor Degeneration. Curr Mol Med. 2012 Apr 18. [Epub ahead of print] PubMed

Zipplies JK, Hauck SM, Eberhardt C, Hirmer S, Amann B, Stangassinger M, Ueffing M, Deeg CA. Miscellaneous vitreous-derived IgM antibodies target numerous retinal proteins in equine recurrent uveitis. Vet Ophthalmol. 2012 Mar 20. doi: 10.1111/j.1463-5224.2012.01010.x. [Epub ahead of print] PubMed

Azimzadeh O., Scherthan H., Sarioglu H., Barjaktarovic Z., Conrad M., Vogt A., Calzada-Wack J., Neff F., Aubele M., Buske C., Atkinson M.J., Tapio S.: Rapid proteomic remodelling of cardiac tissue caused by total body ionizing radiation. Proteomics 11, 3299-3311 (2011) PubMed

Balluff B, Rauser S, Meding S, Elsner M, Schöne C, Feuchtinger A, Schuhmacher C, Novotny A, Jütting U, Maccarrone G, Sarioglu H, Ueffing M, Braselmann H, Zitzelsberger H, Schmid RM, Höfler H, Ebert MP, Walch A. MALDI Imaging Identifies Prognostic Seven-Protein Signature of Novel Tissue Markers in Intestinal-TypeGastric Cancer. Am J Pathol. 2011 Oct 17. [Epub ahead of print] PubMed

Barjaktarovic Z, Schmaltz D, Shyla A, Azimzadeh O, Schulz S, Haagen J, Dörr W, Sarioglu H, Schäfer A, Atkinson MJ, Zischka H, Tapio S. Radiation-induced signaling results in mitochondrial impairment in mouse heart at 4 weeks after exposure to X-rays. PLoS One. 2011;6(12):e27811. Epub 2011 Dec 8. PubMed PMID: 22174747; PubMed Central PMCID: PMC3234240. PubMed

Boldt K, Mans DA, Won J, van Reeuwijk J, Vogt A, Kinkl N, Letteboer SJ, Hicks WL, Hurd RE, Naggert JK, Texier Y, den Hollander AI, Koenekoop RK, Bennett J, Cremers FP, Gloeckner CJ, Nishina PM, Roepman R, Ueffing M. Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice. J Clin Invest. 2011 Jun 1;121(6):2169-80. doi: 10.1172/JCI45627. Epub 2011 May 23. PubMed

Coene KL, Mans DA, Boldt K, Gloeckner CJ, van Reeuwijk J, Bolat E, Roosing S, Letteboer SJ, Peters TA, Cremers FP, Ueffing M, Roepman R. The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase. Hum Mol Genet. 2011 Jun 29. [Epub ahead of print] PubMed

Del Río, P. , Irmler, M., Arango-Gonzalez, B., Favor, J., Bobe, C., Bartsch, U., Vecino, E., Beckers, J., Hauck, SM, Ueffing, M: GDNF-induced osteopontin secretion from Müller glial cells promotes photoreceptor survival in the Pde6brd1 mouse model of retinal degeneration. Glia 2011 May;59(5):821-32 PubMed

Dong G, Callegari EA, Gloeckner CJ, Ueffing M, Wang H. Prothymosin-α Interacts with Mutant Huntingtin and Suppresses Its Cytotoxicity in Cell Culture. J Biol Chem. 2012 Jan 6;287(2):1279-89. Epub 2011 Nov 22. PubMed

Eberhardt C, Amann B, Feuchtinger A, Hauck SM*, Deeg CA. Differential expression of inwardly rectifying K(+) channels and aquaporins 4 and 5 in autoimmune uveitis indicates misbalance in Müller glial cell-dependent ion and water homeostasis. Glia. 2011 May;59(5):697-707. doi: 10.1002/glia.21139. Epub 2011 Feb 8. PubMed

Eberhardt C, Amann B, Stangassinger M, Hauck SM, Deeg CA. Isolation, characterization and establishment of an equine retinal glial cell line: a prerequisite to investigate the physiological function of Müller cells in the retina. J Anim Physiol Anim Nutr (Berl). 2011 Apr 30. doi: 10.1111/j.1439-0396.2011.01147.x. [Epub ahead of print] PubMed

Griciuc A, Aron L, Ueffing M. ER stress in retinal degeneration: a target for rational therapy? Trends Mol Med. 2011 May 25. [Epub ahead of print] PubMed

Hofmaier F, Hauck SM, Amann B, Degroote RL, Deeg CA. Changes in matrix metalloproteinase network in spontaneous autoimmune uveitis model. Invest Ophthalmol Vis Sci. 2011 Jan 12. [Epub ahead of print] PubMed

Holzmeister C, Fröhlich A, Sarioglu H, Bauer N, Durner J, Lindermayr C. Proteomic analysis of defense response of wildtype Arabidopsis thaliana and plants with impaired NO- homeostasis. Proteomics. 2011 Mar 9. doi: 10.1002/pmic.201000652. [Epub ahead of print]  PubMed

Kiel C, Vogt A, Campagna A, Chatr-aryamontri A, Swiatek-de Lange M, Beer M, Bolz S, Mack AF, Kinkl N, Cesareni G, Serrano L, Ueffing M. Structural and functional protein network analyses predict novel signaling functions for rhodopsin. Molecular Systems Biology 7; Article number 551; doi:10.1038/msb.2011.83 PubMed

Lemberger SIK, Deeg CA, Hauck SM, Amann B, Hirmer S, Hartmann K, Dorsch R: Comparison of urine protein profiles in cats without urinary tract disease and cats with idiopathic cystitis, bacterial urinary tract infection, or urolithiasis. AJVR, Vol 72, No. 10, October 2011 PubMed

Limb GA, Martin KR, and the Sixth ARVO/Pfizer Ophthalmics ResearchInstitute Conference Working Group: Current Prospects in Optic Nerve Protection and Regeneration: Sixth ARVO/Pfizer Ophthalmics Research Institute Conference. IOVIS, DOI:10.1167/iovs.10-6894 Investigative Ophthalmology & Visual Science, July 2011, Vol. 52, No. 8 PubMed

Meixner A, Boldt K, Van Troys M, Askenazi M, Gloeckner CJ, Bauer M, Marto JA, Ampe C, Kinkl N, Ueffing M.: A QUICK screen for Lrrk2 interaction partners - leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics. Mol Cell Proteomics. 2011 Jan;10(1):M110.001172. PubMed

Nipp M, Elsner M, Balluff B, Meding S, Sarioglu H, Ueffing M, Rauser S, Unger K, Höfler H, Walch A, Zitzelsberger H. S100-A10, thioredoxin, and S100-A6 as biomarkers of papillary thyroid carcinoma with lymph node metastasis identified by MALDI Imaging. J Mol Med (Berl). 2011 Sep 22. [Epub ahead of print] PubMed

Piccoli G, Condliffe SB, Bauer M, Giesert F, Boldt K, De Astis S, Meixner A, Sarioglu H, Vogt-Weisenhorn DM, Wurst W, Gloeckner CJ, Matteoli M, Sala C, Ueffing M. LRRK2 Controls Synaptic Vesicle Storage and Mobilization within the Recycling Pool. J Neurosci. 2011 Feb 9;31(6):2225-2237. PubMed

Sibbing D., Pfeufer A, Perisic T, Mannes A.M., Fritz-Wolf K., Unwin S., Sinner M.F., Gieger C., Gloeckner CJ, Wichmann HE, Kremmer E., Schäfer Z., Walch A., Hinterseer M., Näbauer M., Kääb S., Kastrati A., Schörnig A., Meitinger T., Bornkamm GW, Conrad M., von Beckerat N.: Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy, European Neart Journal (ahead of print) PubMed

Van Campenhout CA, Eitelhuber A, Gloeckner CJ, Giallonardo P, Gegg M, Oller H, Grant SGN, Krappmann D, Ueffing M, Lickert H: Dlg3 Trafficking and and apical tight junction formation is regulated by Nedd4 and Nedd4-2 E3 ubiquitin legases. Dev. Cell 21, 479-491, Sep 13, 2011 PubMed

Webb KJ, Coolen M, Gloeckner CJ, Stigloher C, Bahn B, Topp S, Ueffing M, Bally-Cuif L. The Enhancer of split transcription factor Her8a is a novel dimerisation partner for Her3 that controls anterior hindbrain neurogenesis in zebrafish. BMC Dev Biol. 2011 May 17;11:27.  PubMed

Gloeckner CJ, Boldt K, von Zweydorf F, Helm S, Wiesent L, Sarioglu H, Ueffing M. Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2. J Proteome Res. 2010 Apr 5;9(4):1738-45. pubmed

Griciuc A, Aron L, Piccoli G, Ueffing M. Clearance of Rhodopsin(P23H) aggregates requires the ERAD effector VCP. Biochim Biophys Acta. 2010 Mar;1803(3):424-434. pubmed

Griciuc A, Aron L, Roux MJ, Klein R, Giangrande A, Ueffing M.: Inactivation of VCP/ter94 suppresses retinal pathology caused by misfolded rhodopsin in Drosophila. PLoS Genet.  2010 Aug 26;6(8). pii: e1001075. pubmed

Haebig K, Gloeckner CJ, Miralles MG, Gillardon F, Schulte C, Riess O, Ueffing M, Biskup S, Bonin M. ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. PLoS One. 2010 Oct 29;5(10):e13762.  pubmed

Hauck SM, Dietter J, Kramer RL, Hofmaier F, Zipplies JK, Amann B, Feuchtinger A, Deeg CA, Ueffing M: Deciphering membrane-associated molecular processes in target tissue of autoimmune uveitis by label-free quantitative mass spectrometry. Mol Cell Proteomics. 2010 Oct;9(10):2292-305. Epub 2010 Jul 4. pubmed

Kinzel D, Boldt K, Davis EE, Burtscher I, Trümbach D, Diplas B, Attié-Bitach T, Wurst W, Katsanis N, Ueffing M, Lickert H.: Pitchfork regulates primary cilia disassembly and left-right asymmetry. Dev Cell. 2010 Jul 20;19(1):66-77. pubmed

Kortvely E, Hauck SM, Duetsch G, Gloeckner CJ, Kremmer E, Alge-Priglinger CS, Deeg C, Ueffing M: ARMS2 is a constituent of the extracellular matrix providing a link between familial and sporadic age-related macular degenerations. Invest Ophthalmol Vis Sci. 2010 Jan;51(1):79-88. Epub 2009 Aug 20. pubmed

Lemberger SI, Dorsch R, Hauck SM, Amann B, Hirmer S, Hartmann K, Deeg CA. Decrease of Trefoil factor 2 in cats with feline idiopathic cystitis. BJU Int. 2010 Jul 16. [Epub ahead of print] pubmed

Vincendeau M, Kramer S, Hadian K, Rothenaigner I, Bell J, Hauck SM, Bickel C, Nagel D, Kremmer E, Werner T, Leib-Mösch C, Brack-Werner R. Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp). AIDS. 2010 Oct 23;24(16):2433-42. pubmed

Zipplies JK, Hauck SM, Schöffmann S, Amann B, van der Meijden CH, Stangassinger M, Ueffing M, Deeg C: Kininogen in autoimmune uveitis: decrease in peripheral blood stream versus increase in target tissue. Invest Ophthalmol Vis Sci. 2010 Jan;51(1):375-82. Epub 2009 Aug 20. pubmed

Zipplies JK, Kirschfink M, Amann B, Hauck SM, Stangassinger M, Deeg CA: Complement factor B expression profile in a spontaneous uveitis model. Immunobiology. 2010 Dec;215(12):949-55. Epub 2010 Mar 1. pubmed

Apweiler R, Aslanidis C, Deufel T, Gerstner A, Hansen J, Hochstrasser D, Kellner R, Kubicek M, Lottspeich F, Maser E, Mewes HW, Meyer HE, Müllner S, Mutter W, Neumaier M, Nollau P, Nothwang HG, Ponten F, Radbruch A, Reinert K, Rothe G, Stockinger H, Tárnok A, Taussig MJ, Thiel A, Thiery J, Ueffing M, Valet G, Vandekerckhove J, Wagener C, Wagner O, Schmitz G. Approaching clinical
proteomics: current state and future fields of application in cellular proteomics. Cytometry A. 2009 Oct;75(10):816-32. Review. pubmed

Apweiler R, Aslanidis C, Deufel T, Gerstner A, Hansen J, Hochstrasser D, Kellner R, Kubicek M, Lottspeich F, Maser E, Mewes HW, Meyer HE, Müllner S, Mutter W, Neumaier M, Nollau P, Nothwang HG, Ponten F, Radbruch A, Reinert K, Rothe G, Stockinger H, Tarnok A, Taussig MJ, Thiel A, Thiery J, Ueffing M, Valet G, Vandekerckhove J, Verhuven W, Wagener C, Wagner O, Schmitz G: Approaching clinical proteomics: current state and future fields of application in fluid proteomics. Clin Chem Lab Med. 2009;47(6):724-44. pubmed

Bauer M, Kinkl N, Meixner A, Kremmer E, Riemenschneider M, Förstl H, Gasser T, Ueffing M: Prevention of interferon-stimulated gene expression using microRNA-designed hairpins. Gene Ther. 2009 Jan; 16(1): 142-7 [pubmed]

Becker KF, Walch A, Ueffing M: Protein analysis of tissues--current views and clinical perspectives. Virchows Arch. 2009 Aug;455(2):191-2. Epub 2009 Jun 26. pubmed

Boldt K, van Reeuwijk J, Gloeckner CJ, Ueffing M, Roepman R. Tandem affinity purification of ciliopathy-associated protein complexes. Methods Cell Biol. 2009; 91:143-60. Epub 2009 Dec 1. [pubmed]

Braun RJ, Kinkl N, Zischka H, Ueffing M: 16-BAC/SDS-PAGE Analysis of Membrane Proteins of Yeast Mitochondria Purified by Free Flow Electrophoresis. Methods Mo Biol. 2009; 528:83-107 [pubmed]

Gloeckner CJ, Schumacher A, Boldt K, Ueffing M: The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro.  J Neurochem. 2009 May;109(4):959-68. Epub pubmed

Gloeckner CJ, Boldt K, Schumacher A, Ueffing M: Tandem Affinity Purification of Protein Complexes from Mammalian Cells by the Strep/FLAG (SF)-TAP Tag. Methods Mol Biol. 2009;564:359-72. pubmed

Gloeckner CJ, Boldt K, Ueffing M.: Strep/FLAG tandem affinity purification (SF-TAP) to study protein interactions. Curr Protoc Protein Sci. 2009 Aug;Chapter 19:Unit19.20. pubmed

Gloriam DE, Orchard S, Bertinetti D, Björling E, Bongcam-Rudloff E, Borrebaeck CA, Bourbeillon J, Bradbury AR, de Daruvar A, Dübel S, Frank R, Gibson TJ, Gold L, Haslam N, Herberg FW, Hiltke T, Hoheisel JD, Kerrien S, Koegl M, Konthur Z, Korn B, Landegren U, Montecchi-Palazzi L, Palcy S, Rodriguez H, Schweinsberg S, Sievert V, Stoevesandt O, Taussig MJ, Ueffing M, Uhlén M, van der Maarel S, Wingren C, Woollard P, Sherman DJ, Hermjakob H. A community standard format for the representation of protein affinity reagents. Mol Cell Proteomics. 2010 Jan;9(1):1-10. Epub 2009 Aug 11. pubmed

Hadian K, Vincendeau M, Mäusbacher N, Nagel D, Hauck SM, Ueffing M, Loyter A,
Werner T, Wolff H, Brack-Werner R. Identification of a heterogeneous nuclear
ribonucleoprotein-recognition region in the HIV Rev protein. J Biol Chem. 2009
Nov 27;284(48):33384-91. Epub 2009 Oct 5.pubmed

Hauck SM, Ueffing M. [Müller-cell-derived neurotrophic factors, a road to
neuroprotective therapy in the retina]. Arch Soc Esp Oftalmol. 2009
Sep;84(9):423-5. Spanish pubmed

Paquet-Durand F, Hauck SM, van Veen T, Ueffing M, Ekström P: PKG activity causes photoreceptor cell death in two retinitis pigmentosa models. J Neurochem. 2009 Feb; 108(3); 796-810 [pubmed]

Zipplies, JK, Hauck, SM, Schoeffmann, S, Amann, B, Stangassinger, M, Ueffing, M, Deeg, CA: Serum PEDF Levels Are Decreased in a Spontaneous Animal Model for Human Autoimmune Uveitis, J Proteome Res. 2009 Feb; 8(2) 992-8 [pubmed]

Functional proteomics. Preface. Thompson JD, Schaeffer-Reiss C, Ueffing M. Methods Mol Biol. 2008;484:v-vii. pubmed

Bauer M, Szulc J, Meyer M, Jensen CH, Terki AT, Meixner A, Kinkl N, Gasser T, Aebischer P, Ueffing M: Delta-like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons. J. Neurochem. 2008 Feb :104(4):1001-15. [infoscience] [pubmed]

Braun RJ, Zischka H: Mechanism of Cdc48/VCP-mediated cell death: from yeast apoptosis to human disease. Biochim Biophys Acta. 2008 Jul; 1783(7): 1418-35 [pubmed]

Braus BK, Hauck SM, Amann B, Heinrich C, Fritsche J, Köstlin R, Deeg CA: Neuron-specific enolase antibodies in patients with sudden acquired retinal degeneration syndrome. Vet Immunol Immunopathol. 2008 Jul 15; 124(1-2):177-83 [pubmed]

Buse C, Altmann F, Amann B, Hauck SM, Poulsen Nautrup C, Ueffing M, Strangassinger M, Deeg CA: Discovering novel targets for antibodies in dilated cardiomyopathy. Electrophoresis. 2008 Mar; 29(6):1325-32 [pubmed]

Deeg CA, Hauck SM, Amann B, Pompetzki D, Altmann F, Raith A, Schmalzl T, Stangassinger M, Ueffing M: Equine Recurrent Uveitis – A Spontaneous Horse Model of Uveitis. Ophthalmic Res. 2008; 40(3-4): 151 - 153 [pubmed]

Delic S, Streif S, Deussig JM, Weber P, Ueffing M, Hölter SM, Wurst W, Kühn R: Genetic Mouse Models for Behavioral Analysis through Transgenic RNAi  Technology. Genes Brain Behav. 2008 Oct; 7(7); 821- 30 [pubmed]

Favor J, Gloeckner CJ, Neuhäuser-Klaus A, Pretsch W, Sandulache R, Saule S, Zaus I: Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus. Genetics 2008 Jul; 179(3); 1345-1355 [pubmed]

Hamacher F, Herberg F, Ueffing M, Meyer HE: Seven successful years of Omics research: the Human Brain Proteome Project within the National German Research Network (NGFN). Proteomics. 2008 Mar; 8(6): 1116-7 [pubmed]

Hauck SM, Gloeckner CJ, Harley ME, Schöffmann S, Boldt K, Eckström P, Ueffing M: Identification of paracrine neuroprotective candidate proteins by a functional assay-driven proteomics approach. Mol Cell Proteomics. 2008 Jul; 7(7):1349-61 [mcb] [pubmed]

Lange MS, Müller B, Ueffing M: Native fractionation: isolation of native membrane-bound protein complexes from porcine rod outer segments using isopycnic density gradient centrifugation. Methods Mol Biol. 2008; 484:161-75 Buchbeitrag [pubmed]

Zischka H, Kinkl N, Braun RJ, Ueffing M: Purification of Saccharomyces cerevisiae mitochondria by zone-electrophoresis in free flow device (ZE-FFE). Methods in Mol. Biol 2008; 432: 51-64 [pubmed]

Sarioglu H, Brandner S, Haberger M, Jacobsen C, Lichtmannegger J, Wormke M, Andrae U: Analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced proteome changes in 5L rat hepatoma cells reveals novel targets of dioxin action including the mitochondrial apoptosis regulator VDAC2. Mol Cell Proteomics. 2008 Feb; 7(2): 394-410 [pubmed]

Braun RJ, Kinkl N, Beer M, and Ueffing M: Two-dimensional electrophoresis of membrane proteins. Anal Bioanal Chem. 2007Oct; 389(4): 1033-45 [pubmed]

Deeg CA, Raith AJ, Altmann F,  Amman B, Crabb JW, Thurau SR, Hauck SM, Ueffing M, Wildner  G, Stangassinger M: CRALBP is a highly prevalent autoantigen for human autoimmune uveitis. Clin Dev Immunol. 2007; 2007: 39245 [pubmed]

Deeg CA, Altmann F, Hauck SM, Kremmer E, Schoeff,man S, Amann B, Stangassinger M, Ueffing M: Downregulation of PEDF in uveitic lesions associates with focal VEGF expression and breakdown of the blood retinal barrier. Proteomics, 2007 May; 7(9); 1540-1548 [pubmed]

Deeg CA, Hauck SM, Altmann F, Schoeff,man S, Amann B, Stangassinger M, Ueffing M: Major retinal autoantigens remain stably expressed during all stages of spontaneous uveitis (2007). Mol Immunol. 2007 Jul; 44(3): 3291-6 [pubmed]

Den Hollander AI, Koenekoop RK, Mohamed MD, Arts HH, Boldt K, Towns KV, Sedmak T, Beer M, Nagel-Wolfrum K, McKibbin M, Dharmaraj S, Lopez I, Irvings L, Williams GA, Springell K, Woods CG, Jafri H, Rashild Y, Strom TM, van der Zwaag B, Gosens I, Kersten FF, van Wijk E, Veltman JA, Zonneveld MN, van Beersum SE, Maumnenee IH, Wolfrum U, Cheetham ME, Ueffing M, Cremers FP, Inglehearn CF, Roepman R: Mutations in LCA5,encoding the ciliary protein lebercilin, cause Leber congenital amaurosis. Nat Genet. 2007 Jul; 39(7); 889-895 [pubmed]

Gloeckner CJ, Boldt K, Schumacher A, Roepman R, Ueffing M: A novel tandem affinity purification strategy for the efficient isolation and  characterization of native protein complexes. Proteomics. 2007 Dec; 7(23): 4228-34 [pubmed]

Hauck SM, Schoeff,man S, Amann B, Stangassinger M, Ueffing M, Deeg CA: Retinal Mueller Glial Cells Trigger the Hallmark Inflammatatory Process in Autoimmune Uveitis. J Proteome Res. 2007 Jun; 6(6): 2121-31 [pubmed]

Kiemer L, Costa S, Ueffing M, Cesareni G: WI-PHI: A weighted yeast interactome enriched for direct physical interactions. Proteomics. 2007 Mar; 7(6): 932-943 [pubmed]

Paquet-Durand F, Silva J, Talukdar T, Johnson LE, Azadi S, van Veen T, Ueffing M, Hauck SM, Ekström PA: Excessive activation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse. J Neurosci. 2007: 27(38): 10311-9 [pubmed]

Swiatek-de Lange M, Stampfl A, Hauck SM, Zischka H, Ueffing M: Membrane-Initiated Effects of Progesterone on Calcium Dependent Signaling and Activation of VEGF Gene Expression in Retinal Glia Cells. Glia. 2007 Aug; 55(10): 1061-73 [pubmed]

Taussig MJ, Stoevesandt O, Borrebaeck CA, Bradbury AR, Cahill D, Cambillau C, de Daruvar A, Dubel S, Eichler J, Frank R, Gibson TJ, Gloriam D, Gold L, Herberg FW, Hermjakob H, Hoheisel JD, Joos TO, Kallioniemi O, Koegll M, Konthur Z, Korn B, Kremmer E, Krobitsch S, Landegren U, van der Maarel S, McCafferty J, Muyldermans S, Nygren PA, Palcy S, Pluckthun A, Polic B, Przybylski M, Saviranta P, Sawyer A, Sherman  DJ, Skerra A, Templin M, Ueffing M, Uhlen M: ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nat Methods. 2007 Jan; 4(1):13-7. [pubmed]

Alge CS, Hauck SM, Priglinger SG, Kamplik A, Ueffing M: Differential protein profiling of primary versus immortalized human RPE cells identifies expression patterns associated with cytoskeletal remodeling and cell survival. J. Proteome Res. 2006 Apr; 5(4): 862-878 [pubmed]

Bauer M, Kristensen BW, Meyer M, Gasser T, Widmer HR, Zimmer J, Ueffing M: Toxic effects of lipid-mediated gene transfer in ventral mesencephalic explat cultures. Basic Clin Pharmacol Toxicol. 2006 Apr; 98(4): 395-400 [pubmed]

Bauer M, Ueffing M: Reverse genetics for proteomics: from proteomic discovery to scientific content. J. Neural Transm. 2006 Aug; 113(8) 1033-40 [pubmed]

Braun RJ, Zischka H, Madeo F, Eisenberg T, Wissing S, Büttner S, Engelhardt SM, Büringer D, Ueffing M: Crucial mitochondrial impairment upon CDC48 mutation in apoptotic yeast. J  Biol Chem. 2006 Sep 1: 281(35): 25757-67 [pubmed]

Deeg CA, Pompetzki D, Raith AJ, Hauck SM, Amann B, Suppmann S, Goebel TW, Olazabal U, Gerhards H, Reese S, Stangassinger M, Kaspers B, Ueffing M: Identification and functional validation of novel autoantigens in equine uveitis. Mol Cell Proteomics 2006; 5(8): 1462-1470 [pubmed]

Deeg CA, Amann B, Hauck SM, Kaspers B: Defining cytochemical markers for different cell types in the equine retina. Anat Histol Ebryol. 2006 Dec; 35(6): 412-415 [pubmed]

Gloeckner CJ, Kinkl N, Schumacher A, Braun RJ, O’Neill E, Meitinger T, Kolch W, Prokisch H, Ueffing M: The Parkinson disease causing LRRK2 mutation I2020T is associated with increase kinase activity. Hum Mol Genet. 2006 Jan 15; 15(2): 223-232 [pubmed]

Hauck SM, Ekström PAR, Ahuja-Jensen P; Suppmann S, Paquet-Durand F, van Veen T, Ueffing M: Differential modification of phosducin protein in degeneration rf1 retina is associated with constitively active Ca2+/calmodulin kinase II in rod outer segments. Mol Cell Proteomics 2006 Feb; 5(2): 324-336 [pubmed]

Hauck SM, Kinkl N, Deeg CA, Swiatek-de Lange M, Schöffmann S, Ueffing M: GDNF family legands trigger indirect neuroprotective signaling in retinal glial cells. Mol Cell Biol. 2006 Apr: 26(7): 2746-57 [pubmed]

Islinger M, Lüers GH, Zischka H, Ueffing M, Völkl A: Insights into the membrane proteome of rat liver peroxisomes: Microsomal glutathione-S-transferase is shared by both subcellular compartments. Proteomics. 2006 Feb;  6(3): 804-816 [pubmed]

Paquet-Durand F, Azadi S, Hauck SM, Ueffing M, van Veen T, Ekström P: Calpain is activated in degenerating photoreceptors in the rd1 mouse. J Neurochem. 2006 Feb; 96(3) 802-814 [pubmed]

Rinnerthaler M, Jarolim S, Heeren G, Palle E, Perju S, Klinger H, Nogengruber E, Madeo F, Braun RJ, Breitenbach-Koller L, Breitenbach M, Laun P: MMII (YKL056c), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria. Biochem Biophys Acta 2006 May-Jun; 1757(5-6): 631-638 [pubmed]

Zischka H, Braun RJ, Marantidis EP, Büringer D, Bornhövd C, Hauck SM, Demmert O, Gloeckner CJ, Reichert AS, Madeo F, Ueffing M: Differential Analysis of Saccaromyces cerevisiae mitochondria by free flow electrophoresis. Mol Cell Proteomics. 2006 Nov: 5(11): 2185-200 [pubmed]

Sarioglu H, Brandner S, Jacobsen C, Meindl T, Schmidt A, Kellermann J, Lottspeich F, Andrae U: Quantitative analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced proteome alterations in 5L rat hepatoma cells using isotope-coded protein labels. Proteomics. 2006 Apr; 6(8): 2407-21 [pubmed]

Hauck SM, Schöffmann S, Deeg CA, Gloeckner CJ, Swiatek-de Lange M, Ueffing M: Proteomic analysis of the porcine interphotoreceptor matrix. Proteomics. 2005 Sep; 5(14): 3623-36. Erratum in: Proteomics. 2005 Nov; 5(17): 4637 [pubmed]

Prokisch H, Andreoli C, Kozany C, Zischka H, Ueffing M, Meitinger T: Integrative analysis of the mitochondrial proteome in yeast. PloS Biol. 2004 Jun; 2(6): 795-804 [pubmed]

Zischka H, Gloeckner CJ, Klein C, Willmann S, Swiatek-de Lange M, Ueffing M: Improved mass spectrometric identification of gel-separated hydrophobic membrane proteins after sodium dodecyl sulfate removal by ion-pair extraction. Proteomics 2004 Dec; 4(12) 3776-82 [pubmed]

Alge CS, Suppmann S, Proglinger SG, Nuebauer AS, May CA, Hauck SM, Welge-Lussen U, Ueffing M, Kampik A: Comparative proteome analysis of native differentiated and cultured dedifferentiated human RPE cells. Invest Ophthalmol Vis Sci. 2003 Aug; 44(8): 3629-41 [pubmed]

Elsässer A, Franzen M, Kohlmann A, Weisser M, Schnittger S, Schoch S, Reddy VA, Burel S, Zhang D, Ueffing M, Tenen DG, Hiddermann W, Behre G: The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner. Oncogen. 2003 Aug 28; 22(36): 5646-57 [pubmed]

Hauck SM, Suppmann S, Ueffing M: Proteomic profiling of primary retinal Müller glia cells reveals a shift expression patterns upon adaptation to in vitro conditions. Glia. 2003 Dec;  44(3): 251-263 [pubmed]

Ueffing M. and Meitinger T. (2003) Stammzellen-Grundlagen und Perspektiven. In: Oduncu /Schroth/Vosssenkuhl(Hg.) Transplantation, p 349-63; Vandenhoeck & Ruprecht 2003

Zischka H, Weber G, Weber PJA, Posch A, Braun RJ, Bühringer D, Schneider U, Nissum M, Meitinger T Ueffing M, Eckerskorn C: Improved proteome analysis of Saccharomyces cerevisiae mitochondria by free-flow electrophoresis. Proteomics. 2003 Jun;  3(6): 906-916 [pubmed]

Gires, O., Ueffing, M. and Hammerschmidt, W. (2001) Chimeric and mutated variants of LMP1: a helpful tool to analyse the structure-function relationship of a pseudoreceptor, in: Wilson/May (Hg.) Methods Mol Biol.174:313-23; Humana Press 2001 [pubmed]