institute of structural biology

News

Structure determination of biomolecules in their natural environment.
 Press Release (German)   Press Release (English)
Simon B, Madl T, Mackereth CD, Nilges M  and Sattler M. An efficient protocol for NMR-based structure determination of protein complexes in solution (2010) Angew. Chem. Int. Ed. Engl. in press (http://dx.doi.org/10.1002/anie.200906147)

Trembling hands and a molecular handshake - a novel protein structure involved in hereditary neurodegeneration  Press Release (German),
A. Graebsch, S. Roche, D. Niessing: X-ray structure of Pur-alpha reveals a Whirly-like fold and an unusual nucleic-acid binding surface. PNAS Early Edition Oct. 21. 2009

About us

The Institute of Structural Biology is associated with the Bayerisches NMR-Zentrum and the Chair for Biomolecular NMR-Spectroscopy at the Technische Universität München.

We study the three-dimensional structure of biomolecules that play important roles in the regulation of gene expression and cellular signaling. Our studies provide a structural basis of these processes and a molecular framework for understanding and curing human disease.

The three-dimensional structures of biomacromolecules provide insight into molecular details of essential biological processes. In the institute we investigate the structure, molecular recognition and dynamics of biomolecules using solution state NMR and/or X-ray crystallography. We employ additional biophysical methods as complementary tools to understand the assembly of macromolecular complexes. The Institute of Structural Biology is associated with the Chair for Biomolecular NMR Spectroscopy and the Bavarian NMR Centre (BNMRZ) at the Technische Universtität München. Our research focuses on proteins and protein complexes that play important roles in the regulation of gene expression and cellular signaling and are linked to human disease. [read more]