Institute of Toxicology
Director: Martin Göttlicher
Research at the institute of toxicology aims at understanding fundamental responses of the organism to chemicals. Our goal is to better understand their mechanisms of action in the context of development or progression of chronic diseases.
Chronic diseases such as cancer, diabetes, neurodegenerative diseases, or cardiovascular disorders result from a complex interplay of environmental factors, genetic disposition, and individual life style-associated factors. Research on the mechanisms of action of environmental factors shall lead to novel insights into cellular signaling networks and genetically encoded response programs that contribute to chronic diseases. Our results will support identification, quantification and reduction of risk factors for health. They shall support better decisions for preventive measures, early diagnosis and the development of innovative therapeutic strategies for environment-related chronic diseases.
- Epigenetic control: Role of histone deacetylases (HDACs) in tumor development and therapy (group Göttlicher)
- The NF-κB signaling pathway and signaling network in the immune system (group Krappmann)
- Oxidative cell death (group Summer; group Zischka)
- Crosstalk of the Ah receptor with other cellular signaling systems (group Göttlicher/Andrae)
- Influence of nanomaterial on cardiac function (group Stampfl)
- Functional Ionchannel Analysis (group Klostermann)
- Toxicokinetics and estimation of the potential health risks of environmental and work place chemicals to humans
(group Filser) - Flow Cytometry Laboratory (group Beisker)