institute of virology (viro)

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Selected Publications

 

  • Ebert G, Poek H, Lucifora J, Barschuk N, Esser K, Esposito I, Hartmann G, Protzer U. siRNAs designed to activate retinoic acid–inducible protein I control hepatitis B virus in primary human hepatocytes and in mice. Gastroenterology 2011, accepted for publication.
  • Lucifora J, Arzberger  S, Durantel D, Belloni L, Strubin M, Levrero M, Zoulim F, Hantz O and Protzer U. Hepatitis B Virus X protein is essential to initiate and maintain virus replication after infection. J Hepatology 2011, Mar 1. [Epub ahead of print].
  • John von Freyend M, Untergasser A, Arzberger S, Oberwinkler S, Drebber U, Schirmacher P and Protzer U. Sequential control of hepatitis B virus in a mouse model of acute, self-resolving hepatitis B. Journal of Viral Hepatitis 2011, 18(3):216-26.
  • Arzberger S, Hösel M, Protzer U. Apoptosis of hepatitis B virus infected hepatocytes prevents release of infectious virus. Journal of Virology 2010, 84(22):11994-2001.
  • Marquardt JU, Quasdorff M, Varnholt H, Curth HM, Mesghenna S, Protzer U, Goeser T, Nierhoff D. Neighbor of Punc E11, a novel onco-fetal marker for hepatocellular carcinoma. Int J of Cancer 2010, July 23 [Epub ahead of print].

  • Dembek CJ, Kutscher S, Heltai S, Allgayer S, Biswas P, Ghezzi S, Vicenzi E, Hoffmann D, Reitmeir P, Tambussi G, Bogner JR, Lusso P, Stellbrink HJ, Santagostino E, Vollbrecht T, Goebel FD, Protzer U, Draenert R, Tinelli M, Poli G, Erfle V, Malnati M, Cosma A.
    Nef-specific CD45RA+ CD8+ T cells secreting MIP-1beta but not IFN-gamma are associated with nonprogressive HIV-1 infection.
    AIDS Res Ther. 2010, 7(1):20.

  • Arzberger S, Hösel M, Protzer U. Apoptosis of hepatitis B virus infected hepatocytes prevents release of infectious virus. Journal of Virology 2010, 84(22):11994-2001.
  • Lucifora J, Vincent JE, Berthillon P, Dupinay T, Michelet M, Protzer U, Zoulim F, Durantel D, Trepo C and Chemin I.HBV replication in primary macaque hepatocytes: crossing the species barrier towards a new small primate model. Hepatoloy 2010, 2010 Jun;51(6):1954-60.
  • Kutscher S, Allgayer S, Dembek CJ, Bogner JR, Protzer U, Goebel FD, Erfle V, Cosma A. MVA-nef induces HIV-1-specific polyfunctional and proliferative T-cell responses revealed by the combination of short- and long-term immune assays. Gene Therapy 2010, in press.
  • Stabenow D, Frings M, Trück C, Gärtner K, Förster I, Kurts C, Tüting T, Odenthal M, Dienes HP, Cederbrand K, Protzer U and Knolle PA. Bioluminescence imaging allows measuring CD8 T cell function 1 in the liver. Hepatology 2010, 51: 1430-37.
  • Hoffmann D, Seebach J, Foley BT, Frösner G, Nadas K, Protzer U, Schätzl HM. Isolated norovirus GII.7 strain within an extended GII.4 outbreak. J Med Virol. 2010, 82:1058-64.
  • Sarrazin C, Berg T, Ross RS, Schirmacher P, Wedemeyer H, Neumann U, Schmidt HH, Spengler U, Wirth S, Kessler HH, Peck-Radosavljevic M, Ferenci P, Vogel W, Moradpour D, Heim M, Cornberg M, Protzer U, Manns MP, Fleig WE, Dollinger MM, Zeuzem S. Prophylaxis, diagnosis and therapy of hepatitis C virus (HCV) infection: the German guidelines on the management of HCV infection. Z Gastroenterol. 2010 Feb;48(2):289-351.
  • Hoffmann D, Wolfarth B, Hörterer HG, Halle M, Reichhuber C, Nadas K, Tora C, Erfle V, Protzer U and Schätzl HM. Elevated Epstein–Barr Virus Loads and Lower Antibody Titers in Competitive Athletes. J Med Virology 2010, 82:446–451.
  • Bailly-Maitre B, Belgardt BF, Jordan SD, Coornaert B, John von Freyend M, Kleinridders A, Mauer J, Cuddy M, Kress CL, Willmes D, Essig M, Hampel B, Protzer U, Reed JC, Bruning JC. Hepatic Bax-inhibitor (BI)-1 inhibits IRE1a and protects from obesity-associated insulin resistance and glucose intolerance. J Biol Chem. 2010, 285(9):6198-207.
  • Hösel M, Quasdorff M, Webb D, Zedler  U, Esser K, Arzberger S, Wiegmann K, Kirschning CJ, Langenkamp A, Rose-John S and Protzer U. Not interferon, but IL-6 controls early gene expression in Hepatitis B virus (HBV) infection. Hepatology 2009, 50:1773-1782.
  • Stahl S, Sacher T, Bechtold A, Protzer U, Ganss R, Hämmerling GJ, Arnold B, Garbi N. Tumor agonist peptides break tolerance and elicit effective CTL responses in an inducible mouse model of hepatocellular carcinoma Immunol Letters 2009,123(1):31-7
  • Op den Brouw ML, Binda RS, van Roosmalen MH, Protzer U, Janssen HL, van der Molen RG, Woltman AM. Hepatitis B virus surface antigen impairs myeloid dendritic cell function: a possible immune escape mechanism of hepatitis B virus. Immunology. 2009 Feb;126(2):280-9.
  • Cornberg M, Protzer U, Dollinger MM, Petersen J, Wedemeyer H, Berg T, Jilg W, Erhardt A, Wirth S, Schirmacher P, Fleig WE, Manns MP The German guideline for the management of hepatitis B virus infection: short version. J Viral Hepatitis 2008 Aug;15 Suppl 1:1-21. 
  • Jenke AC, Wilhelm AD, Orth V, Lipps HJ, Protzer U, Wirth S. Long term suppression of HBV replication by shRNA expression using the S/MAR based replicating vector system pEPI-1. Antimicrob Agents Chemotherapy 2008, 52(7):2355-9.
  • Bohne F, Chmielewski M, Ebert G, Wiegmann K, Kürschner T, Schulze A, Urban S, Krönke M, Abken H, Protzer U. T cells Redirected Against Hepatitis B Virus Surface Proteins Eliminate Infected Hepatocytes. Gastroenterology 2008, 134: 239-47.    
  • Quasdorff M, Hösel M, Odenthal M, Zedler U, Bohne F, Gripon P, Dienes HP, Stippel D, Goeser T, Protzer U. A concerted action of HNF1 α and HNF4α links hepatitis B virus replication to hepatocyte differentiation. Cellular Micobiology 2008, 10:1478-1490.
  • Cornberg M, Protzer U, Dollinger M, Petersen J, Wedemeyer H, Berg T, Jilg W, Erhardt A, Wirth S, Schirmacher P, Fleig WE, Manns M. Prophylaxis, diagnosis and therapy of hepatitis B virus (HBV) infection: the german guidelines for the management of HBV infection. Z Gastroenterol. 2007, 45:1281-328
  • Protzer U, Seyfried S, Quasdorff M, Sass G, Svorcova M, Webb D, Bohne F, Hösel M, Schirmacher P, Tiegs G. Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection. Gastroenterology 2007, 133: 1156-65.   
  • Bohne F, Protzer U. Adoptive T-cell therapy as a therapeutic option in chronic viral hepatitis. J. Viral Hepatitis 2007, 14, Suppl 1: 45-50.
  • Wedemeyer H, Cornberg M, Protzer U, Berg T, Dollinger MM. German guidelines on diagnosis and therapy of hepatitis B. Dtsch Med Wochenschr. 2007 Aug;132(34-35):1775-82.
  • Cornberg M, Protzer U, Dollinger M, Petersen J, Wedemeyer H, Berg T, Jilg W, Erhardt A, Wirth S, Schirmacher P, Fleig WE, Manns M. Prophylaxis, Diagnosis and Therapy of Hepatitis-B-Virus-(HBV-)Infection: Upgrade of the German Guideline. Z. Gastroenterologie 2007, 45:525-574.
  • Jost S, Turelli P, Mangeat B, Protzer U, Trono D. Induction of antiviral cytidine deaminases does not explain the inhibition of hepatitis B virus replication by interferons. J Virology 2007, 81: 10588-10596.
  • Untergasser A, Zedler U, Langenkamp A, Hösel M, Quasdorff M, Esser K, Tapperzhofen B, Kolanus W and Protzer U. Dendritic cells take up viral antigens but do not support the early steps of hepatitis B virus infection. Hepatology 2006, 43: 539-547.
  • Siebler J, Protzer U, Wirtz S, Schuchmann M, Hohler T, Galle PR, Neurath MF. Overexpression of STAT-1 by adenoviral gene transfer does not inhibit hepatitis B virus replication. Eur J Gastroenterol Hepatol. 2006 ,18:167-74.
  • Shin E-C, Protzer U, Untergasser A, Feinstone SM, Rice CM, Hasselschwert D, Rehermann B. Liver-Directed Interferon-g Gene Delivery in Chronic Hepatitis C. Journal of Virology 2005, 79:13412-13420.
  • Isogawa M, Kakimi K, Kamamoto H, Moriyasu F, Protzer U and Chisari FV. Differential Dynamics of the Peripheral and Intrahepatic Cytotoxic T Lymphocyte Response to a Secreted Viral Antigen Produced in the Liver. Virology 2005, 333: 293-300.
  • Dumortier J, Schönig K, Giese T, Bujard H, Protzer U. The Tet-system allows tight control and liver-specific gene expression in vivo following adenoviral gene transfer into mice. Gene Therapy 2005, 12:668-677.
  • Zhang Z, Protzer U, Hu Z, Jacob J, Liang TJ. Inhibition of cellular proteasome activities enhances hepadnaviral replication in a HBx dependent manner. Journal of Virology 2004, 78: 4566-4572.
  • Untergasser A & Protzer U. Hepatitis B virus vectors allow elimination of viral gene expression and insertion of foreign promoters. Human Gene Therapy 2004, 15: 203-210.
  • Sprinzl M, Dumortier J, Protzer U. Construction of recombinant adenoviruses that produce infectious hepattis B virus. Methods in Molecular Medicine 2004, 96:203-218.
  • Schulze-Bergkamen H, Untergasser A, Dax A, Vogel H, Büchler P, Klar E, Lehnert T, Friess H, Büchler M, Kirschfink M, Stremmel W, Krammer P, Müller M, Protzer U. Primary human hepatocytes - a valuable tool for investigation of apoptosis and hepatitis B virus infection Journal of Hepatology 2003, 38: 736-744.
  • Klöcker U, Kürschner T, Oberwinkler H, Protzer U. Presence of replicating virus in recombinant hepadnavirus stocks results from homologous recombination and can be eliminated be the use of a packaging cell line. Journal of Virology 2003, 77 (5): 2873-2881.
  • Li Y, Hacker HJ, Protzer U, Kopp-Schneider A, Bannasch P. Woodchuck Hepatitis B Virus Replication and Antigen Expression Gradually Decreases in Preneoplastic Hepatocellular Lineages Journal of Hepatology 2002, 37 (4): 478.
  • Sprinzl M, Oberwinkler H, Schaller H, Protzer U. Hepatitis B virus genome transfer with adenoviral vectors into cultured cells and mice: crossing the species barrier Journal of Virology 2001, 75: 5108-5118.
  • Radecke K, Protzer U, Trippler M, Gerken G. Variation of the Hepatitis B Virus Core Gene during High-dose Interferon Alpha Therapy. Journal of Medical Virology 2000, 62: 479-486.
  • Klöcker U, Schultz U, Schaller H, Protzer U. Liver macrophages release mediators after endotoxin stimulation that inhibit an early step in hepadnavirus replication.  Journal of Virology 2000, 74 (12): 5525-5533.
  • Hegenbarth S, Gerolami R, Protzer U, Tran PL, Brechot C, Gerken G, Knolle PA. Liver sinusoidal endothelial cells are not permissive for adenovirus type 5  Human Gene Therapy 2000, 11 (3): 481-486.
  • Protzer U, Nassal M, Chiang PW, Kirschfink M, Schaller H. Interferon gene transfer by a novel hepatitis B virus vector efficiently suppresses wildtype-virus infection. PNAS 1999, 96: 10818-10823.
  • Herr W,  Protzer U, Lohse A, Meyer zum Büschenfelde KH, Wölfel T. Characterization of cytotoxic T-cell response in HIV infected patients and seronegative high-risk contact persons. Journal of Infectious Diseases 1998,178: 260-165.
  • Protzer U, Naumann U, Bartenschlager R, Berg T, Hopf U, Meyer zum Büschenfelde KH, Neuhaus P, Gerken G. Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation. Hepatology 1998, 27(1): 254-263.
  • Naumann U, Protzer U, Berg T, Leder K, Lobeck H, Fukumoto T, Bechstein WO, Gerken G, Hopf U, Neuhaus P. A pretransplant infection with precore mutants of Hepatitis B Virus does not influence the outcome of orthotopic liver transplantation in patients on high-dose anti-HBs immuno-prophylaxis. Hepatology 1997, 26 (2): 478-484.
  • Protzer U, Ochsendorf FR, Leopolder-Ochsendorf A, Holtermüller KH. Exacerbation of Lichen Planus during Interferon-Alpha-2a Therapy of Chronic Active Hepatitis C. Gastroenterology 1993; 104 (3): 903-905.

Reviews / Buchbeiträge

 

  • Protzer U & Abken H. Can engineered "designer" T cells out-smart chronic hepatitis B? Hepatitis Research and Treatment, 2010, online July 2010.
  •  Ridell S & Protzer U. Carving the CAR (News & Views comment). Gene Therapy 2010, in press.
  • Quasdorff M & Protzer U. Control of Hepatitis B virus at the level of transcription.  J Viral Hepatitis, 2010, 2010 Aug;17(8):527-36.
  •  Laer D, Baum C, Protzer U. Antiviral gene therapy. Handb Exp Pharmacol. 2009;(189):265-97
  • Protzer U & Urban S. Hepatitis B Virus: Targeting the The Viral Life Cycle. In: Protzer U, Weber O (eds). Comparative Hepatitis. Birkenhäuser 2008.
  • Cornberg M, Manns M, Protzer U. Infektionserkrankungender Leber. Virushepatitis. In: Mertes, Marre. Klinische Infektiologie. Urban & Schwarzenegger 2007.
  • Oberwinkler H, Sprinzl M, Untergasser A, Protzer U. Transfer of HBV genomes into mice. In: Roggendorf M, v. Weizsäcker F (eds) „Current Models of Viral Hepatitis“. In: Doerr DW (ser. ed) Monographs in Virology. Karger AG, Basel, Switzerland, 2005.
  •  Construction of recombinant adenoviruses that produce infectious HBV.Sprinzl M, Dumortier J, Protzer U. In: R. Hamatke, J. Lau (eds.). „Hepatitis B and D Protocols“, 96 (Vol. II), Chapter 18, pg 209-218. J.M. Walker (ser. ed.) Methods in Molecular Medicine. The Humana Press Inc., Totowa NJ, 2004.
  • Immune Escape of Hepatitis B Viruses. Protzer U, Schaller H. Virus Genes 2000, 21: 27-37.