institute of virology (viro)

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Retroviral persistence in humans

Human endogenous retroviruses
(Prof. Dr. Christine Leib-Mösch)

Selected Publications

  • Vincendeau M, Kramer S, Hadian K, Rothenaigner I, Bell J, Hauck SM, Bickel C, Nagel D, Kremmer E, Werner T, et al: Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp). AIDS 24 (16) : 2433-42 (2010)
  • Diem O, Schäffner M, Frohnmeyer M, Hemby S.E, Frank O, Seifarth W, Leib-Mösch, C: Influence of antipsychotic medication on endogenous retrovirus (ERV) expression in brain cells. Proceedings of the Centennial Retrovirus Meeting (R. Daniel, J. Hejnar, A.M. Skalka, J. Svoboda, Eds.), pp 39 - 43, Medimond International Proceedings, Bologna, 2010.
  • Schön U, Diem O, Leitner L, Gunzburg WH, Mager DL, Salmons B, Leib-Mösch C: Human endogenous retroviral long terminal repeat sequences as cell type-specific promoters in retroviral vectors. J Virol 2009, 83:12643-50.
  • Bach C, Gilch S, Rost R, Greenwood AD, Horsch M, Hajj GN, Brodesser S, Facius A, Schadler S, Sandhoff K, et al: Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells. J Biol Chem 2009, 284:31260-9.
  • Frank O, Verbeke C, Schwarz N, Mayer J, Fabarius A, Hehlmann R, Leib-Mösch C, Seifarth W: Variable transcriptional activity of endogenous retroviruses in human breast cancer. J Virol 2008, 82:1808-18.
  • Flockerzi A, Ruggieri A, Frank O, Sauter M, Maldener E, Kopper B, Wullich B, Seifarth W, Muller-Lantzsch N, Leib-Mösch C, et al: Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project. BMC Genomics 2008, 9:354.
  • Zeilfelder U, Frank O, Sparacio S, Schon U, Bosch V, Seifarth W, Leib-Mösch C: The potential of retroviral vectors to cotransfer human endogenous retroviruses (HERVs) from human packaging cell lines. Gene 2007, 390:175-9.
  • Flockerzi A, Maydt J, Frank O, Ruggieri A, Maldener E, Seifarth W, Medstrand P, Lengauer T, Meyerhans A, Leib-Mösch C, et al: Expression pattern analysis of transcribed HERV sequences is complicated by ex vivo recombination. Retrovirology 2007, 4:39.
  • Stengel A, Roos C, Hunsmann G, Seifarth W, Leib-Mösch C, Greenwood AD: Expression profiles of endogenous retroviruses in Old World monkeys. J Virol 2006, 80:4415-21.
  • Stengel A, Bach C, Vorberg I, Frank O, Gilch S, Lutzny G, Seifarth W, Erfle V, Maas E, Schätzl H, et al: Prion infection influences murine endogenous retrovirus expression in neuronal cells. Biochem Biophys Res Commun 2006, 343:825-31.
  • Frank O, Jones-Brando L, Leib-Mösch C, Yolken R, Seifarth W: Altered transcriptional activity of human endogenous retroviruses in neuroepithelial cells after infection with Toxoplasma gondii. J Infect Dis 2006, 194:1447-9.
  • Seifarth W, Frank O, Zeilfelder U, Spiess B, Greenwood AD, Hehlmann R, Leib-Mösch C: Comprehensive analysis of human endogenous retrovirus transcriptional activity in human tissues with a retrovirus-specific microarray. J Virol 2005, 79:341-52.
  • Greenwood AD, Stengel A, Erfle V, Seifarth W, Leib-Mösch C: The distribution of pol containing human endogenous retroviruses in non-human primates. Virology 2005, 334:203-13.
  • Greenwood AD, Leib-Mösch C, Seifarth W: Abyss1: a novel L2-like non-LTR retroelement of the snakelocks anemone (Anemonia sulcata). Cytogenet Genome Res 2005, 110:553-8.
  • Greenwood AD, Horsch M, Stengel A, Vorberg I, Lutzny G, Maas E, Schadler S, Erfle V, Beckers J, Schatzl H, et al: Cell line dependent RNA expression profiles of prion-infected mouse neuronal cells. J Mol Biol 2005, 349:487-500.
  • Frank O, Giehl M, Zheng C, Hehlmann R, Leib-Mösch C, Seifarth W: Human endogenous retrovirus expression profiles in samples from brains of patients with schizophrenia and bipolar disorders. J Virol 2005, 79:10890-901.
  • Spiess B, Buchheidt D, Baust C, Skladny H, Seifarth W, Zeilfelder U, Leib-Mösch C, Morz H, Hehlmann R: Development of a LightCycler PCR assay for detection and quantification of Aspergillus fumigatus DNA in clinical samples from neutropenic patients. J Clin Microbiol 2003, 41:1811-8.
  • Seifarth W, Spiess B, Zeilfelder U, Speth C, Hehlmann R, Leib-Mösch C: Assessment of retroviral activity using a universal retrovirus chip. J Virol Methods 2003, 112:79-91.
  • Schön U, Seifarth W, Baust C, Hohenadl C, Erfle V, Leib-Mösch C: Cell type-specific expression and promoter activity of human endogenous retroviral long terminal repeats. Virology 2001, 279:280-91.
  • Buchheidt D, Baust C, Skladny H, Ritter J, Südhoff T, Baldus M, Seifarth W, Leib-Mösch C, Hehlmann R: Detection of Aspergillus species in blood and bronchoalveolar lavage samples from immunocompromised patients by means of 2-step polymerase chain reaction: clinical results. Clin Infect Dis 2001, 33:428-35.
  • Baust C, Seifarth W, Schön U, Hehlmann R, Leib-Mösch C: Functional activity of HERV-K-T47D-related long terminal repeats. Virology 2001, 283:262-72.
  • Seifarth W, Krause U, Hohenadl C, Baust C, Hehlmann R, Leib-Mösch C: Rapid identification of all known retroviral reverse transcriptase sequences with a novel versatile detection assay. AIDS Res Hum Retroviruses 2000, 16:721-9.
  • Seifarth W, Baust C, Schön U, Reichert A, Hehlmann R, Leib-Mösch C: HERV-IP-T47D, a novel type C-related human endogenous retroviral sequence derived from T47D particles. AIDS Res Hum Retroviruses 2000, 16:471-80.
  • Domansky AN, Kopantzev EP, Snezhkov EV, Lebedev YB, Leib-Mösch C, Sverdlov ED: Solitary HERV-K LTRs possess bi-directional promoter activity and contain a negative regulatory element in the U5 region. FEBS Lett 2000, 472:191-5.
  • Baust C, Seifarth W, Germaier H, Hehlmann R, Leib-Mösch C: HERV-K-T47D-Related long terminal repeats mediate polyadenylation of cellular transcripts. Genomics 2000, 66:98-103.
  • Skladny H, Buchheidt D, Baust C, Krieg-Schneider F, Seifarth W, Leib-Mösch C, Hehlmann R: Specific detection of Aspergillus species in blood and bronchoalveolar lavage samples of immunocompromised patients by two-step PCR. J Clin Microbiol 1999, 37:3865-71.
  • Seifarth W, Krieg-Schneider F, Skladny H, Marachelian A, Germaier H, Hehlmann R, Leib-Mösch C: Impact of human endogenous retroviral elements on cellular genes: strategy for isolation of LTR-driven chimeric transcripts. Leukemia 1999, 13 Suppl 1:S97-8.
  • Hohenadl C, Germaier H, Walchner M, Hagenhofer M, Herrmann M, Stürzl M, Kind P, Hehlmann R, Erfle V, Leib-Mösch C: Transcriptional activation of endogenous retroviral sequences in human epidermal keratinocytes by UVB irradiation. J Invest Dermatol 1999, 113:587-94.
  • Seifarth W, Baust C, Murr A, Skladny H, Krieg-Schneider F, Blusch J, Werner T, Hehlmann R, Leib-Mösch C: Proviral structure, chromosomal location, and expression of HERV-K-T47D, a novel human endogenous retrovirus derived from T47D particles. J Virol 1998, 72:8384-91.
  • Casper C, Leib-Mösch C, Salmons B, Günzburg WH, Baumann G, Hofler H, Erfle V, Atkinson MJ: Mapping of a mouse mammary tumor virus integration site by retroviral LTR--arbitrary polymerase chain reaction. Virus Res 1998, 54:207-15.
  • Willer A, Saussele S, Gimbel W, Seifarth W, Kister P, Leib-Mösch C, Hehlmann R: Two groups of endogenous MMTV related retroviral env transcripts expressed in human tissues. Virus Genes 1997, 15:123-33.
  • Walchner M, Leib-Mösch C, Messer G, Germaier H, Plewig G, Kind P: Endogenous retroviral sequences in the pathogenesis of systemic autoimmune disease. Arch Dermatol 1997, 133:767-71.
  • Hehlmann R, Willer A, Heimpel H, Hasford J, Kolb HJ, Pralle H, Hossfeld DK, Queisser W, Loffler H, Hochhaus A, et al: Randomized studies with interferon in chronic myelogenous leukemia (CML) and comparative molecular aspects. German CML Study Group. Leukemia 1997, 11 Suppl 3:506-11.
  • Blusch JH, Haltmeier M, Frech K, Sander I, Leib-Mösch C, Brack-Werner R, Werner T: Identification of endogenous retroviral sequences based on modular organization: proviral structure at the SSAV1 locus. Genomics 1997, 43:52-61.
  • Walchner M, Leib-Mösch C, Messer G, Kind P: [Endogenous retroviral sequences as a factor in the pathogenesis of systemic lupus erythematosus]. Hautarzt 1996, 47:502-9.
  • Schenk M, Leib-Mösch C, Schenck IU, Jaenicke M, Indraccolo S, Saeger HD, Dallenbach-Hellweg G, Hehlmann R: Lower frequency of allele loss on chromosome 18q in human breast cancer than in colorectal tumors. J Mol Med 1996, 74:155-9.
  • Menin C, Indraccolo S, Montagna M, Corneo B, Bonaldi L, Leib-Mösch C, Chieco-Bianchi L, D'Andrea E: Identification of a human endogenous LTR-like sequence using HIV-1 LTR specific primers. Mol Cell Probes 1996, 10:443-51.
  • Hohenadl C, Leib-Mösch C, Hehlmann R, Erfle V: Biological significance of human endogenous retroviral sequences. J Acquir Immune Defic Syndr Hum Retrovirol 1996, 13 Suppl 1:S268-73.
  • Seifarth W, Skladny H, Krieg-Schneider F, Reichert A, Hehlmann R, Leib-Mösch C: Retrovirus-like particles released from the human breast cancer cell line T47-D display type B- and C-related endogenous retroviral sequences. J Virol 1995, 69:6408-16.
  • Indraccolo S, Simon M, Hehlmann R, Erfle V, Chieco-Bianchi L, Leib-Mösch C: Genetic instability of a dinucleotide repeat-rich region in three hematologic malignancies. Leukemia 1995, 9:1517-22.
  • Indraccolo S, Günzburg WH, Leib-Mösch C, Erfle V, Salmons B: Identification of three human sequences with viral superantigen-specific primers. Mamm Genome 1995, 6:339-44.
  • Haltmeier M, Seifarth W, Blusch J, Erfle V, Hehlmann R, Leib-Mösch C: Identification of S71-related human endogenous retroviral sequences with full-length pol genes. Virology 1995, 209:550-60.
  • Simon M, Haltmeier M, Papakonstantinou G, Werner T, Hehlmann R, Leib-Mösch C: Transcription of HERV-K-related LTRs in human placenta and leukemic cells. Leukemia 1994, 8 Suppl 1:S12-7.
  • von Dalnok GK, Kleinschmidt A, Neumann M, Leib-Mösch C, Erfle V, Brack-Werner R: Productive expression state confers resistance of human immunodeficiency virus (HIV)-2-infected lymphoma cells against superinfection by HIV-1. Arch Virol 1993, 131:419-29.
  • Leib-Mösch C, Haltmeier M, Werner T, Geigl EM, Brack-Werner R, Francke U, Erfle V, Hehlmann R: Genomic distribution and transcription of solitary HERV-K LTRs. Genomics 1993, 18:261-9.
  • Leib-Mösch C, Bachmann M, Brack-Werner R, Werner T, Erfle V, Hehlmann R: Expression and biological significance of human endogenous retroviral sequences. Leukemia 1992, 6 Suppl 3:72S-75S.
  • Werner T, Brack-Werner R, Leib-Mösch C, Backhaus H, Erfle V, Hehlmann R: S71 is a phylogenetically distinct human endogenous retroviral element with structural and sequence homology to simian sarcoma virus (SSV). Virology 1990, 174:225-38.

Selected Reviews

  • Seifarth W, Frank O, Schreml J, Leib-Mösch C: RetroArray – a comprehensive diagnostic DNA chip for rapid detection and identification of retroviruses, retroviral contaminants and mistaken identity of cell lines. In: “DNA: Fingerprinting, Sequencing and Chips.” (K. Ovesen and U. Matthiesen, eds.), pp 87-118, Nova Science Publishers, Inc., New York, USA, 2009.
  • Leib-Mösch C, Seifarth W, Schön U: Influence of human endogenous retroviruses on cellular gene expression. In: "Retroviruses and Primate Genome Evolution", (E. Sverdlov, ed.), pp 123-143, Landes Bioscience, Georgetown, Texas, 2005.
  • Leib-Mösch C, Seifarth W: Evolution and biological significance of human retroelements. Virus Genes 1995, 11:133-45.
  • Leib-Mösch C, Brack-Werner R, Werner T, Bachmann M, Faff O, Erfle V, Hehlmann R: Endogenous retroviral elements in human DNA. Cancer Res 1990, 50:5636S-5642S.

Selected Patents

  • Seifarth, Leib-Mösch, Baust. (1999) Method for specifically detecting and identifying retroviral nucleic acids/retroviruses in an item to be examined. German (PCT /DE 00/01071) and international (EU, Australia, USA) patents: EP1177320 B1-part AT, EP1177320 B1- part CH/LI, EP1177320 B1- part BE, EP1177320 B1- part DE, EP1177320 B1- part FR, EP1177320 B1- part GB, AU 49104/00 und US10/009,705.