Institut für Epidemiologie (EPI)

Head (interim): H.-Erich Wichmann, Christian Gieger

Selected Publications / Ausgewählte Publikationen

Rodríguez E, Baurecht H, Herberich E, Wagenpfeil S, Brown SJ, Cordell HJ, Irvine AD, Weidinger S.
Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease.
J Allergy Clin Immunol. 2009 Jun;123(6):1361-70.e7.

Esparza-Gordillo J, Weidinger S, Fölster-Holst R, Bauerfeind A, Ruschendorf F, Patone G, Rohde K, Marenholz I, Schulz F, Kerscher T, Hubner N, Wahn U, Schreiber S, Franke A, Vogler R, Heath S, Baurecht H, Novak N, Rodriguez E, Illig T, Lee-Kirsch MA, Ciechanowicz A, Kurek M, Piskackova T, Macek M, Lee YA, Ruether A.
A common variant on chromosome 11q13 is associated with atopic dermatitis.
Nat Genet. 2009 May;41(5):596-601. Epub 2009 Apr 6.

Soranzo N*, Spector TD*, Mangino M*, Kühnel B, Rendon A, Teumer A, Willenborg C, Wright B, Chen L, Li M, Salo P, Voight BF, Burns P, Laskowski RA, Xue Y, Menzel S, Altshuler D, Bradley JR, Bumpstead S, Burnett M-S, Devaney J, Döring A, Elosua R, Epstein S, Erber W, Falchi M, Garner SF, Ghori MJR, Goodall AH, Gwilliam R, Hakonarson HH, Hall AS, Hammond N, Hengstenberg C, Illig T, König IR, Knouff CW, McPherson R, Melander O, Mooser V, Nauck M, Nieminen MS, O'Donnell CJ, Peltonen L, Potter SC, Prokisch H, Rader DJ, Rice CM, Roberts R, Salomaa V, Sambrook J, Schreiber S, Schunkert H, Schwartz SM, Serbanovic-Canic J, Sinisalo J, Siscovick DS, Stark K, Surakka I, Stephens J, Thompson JR, Völker U, Völzke H, Watkins NA, Wells GA, Wichmann H-E, Van Heel DA, Tyler-Smith C, Thein SL, Kathiresan S, Perola M, Reilly MP, Stewart AFR, Erdmann J, Samani NJ, Meisinger C, Greinacher A, Deloukas P*, Ouwehand WH*, Gieger C*.
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
Nat Genet 2009 Nov;41(11):1182-90. (* equal contributions)

Dupuis J*, Langenberg C*, Prokopenko I*, Saxena R*, Soranzo N*, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, Elliott P, Rybin D, Thorleifsson G, Steinthorsdottir V, Henneman P, Grallert H, Dehghan A, Hottenga JJ, Franklin CS, Navarro P, Song K, Goel A, Perry JRB, Egan JM, Lajunen T, Grarup N, Sparsø T, Doney A, Voight BF, Stringham HM, Li M, Kanoni S, Shrader P, Cavalcanti-Proença C, Kumari M, Qi L, Timpson NJ, Gieger C, …, Boehnke M†, McCarthy M†, Florez JC† and Barroso I† for the MAGIC investigators.
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Nature Genetics 2010 Feb;42(2):105-16.  * These authors contributed equally to this work ; †  Co-corresponding

Linsel-Nitschke P, Heeren J, Aherrahrou Z, Bruse P, Gieger C, Illig T, Prokisch H, Heim K, Doering A, Peters A, Meitinger T, Wichmann HE, Hinney A, Reinehr T, Roth C, Ortlepp JR, Soufi M, Sattler AM, Schaefer J, Stark K, Hengstenberg C, Schaefer A, Schreiber S, Kronenberg F, Samani NJ, Schunkert H, Erdmann J.
Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.
Atherosclerosis. 2010 Jan;208(1):183-9.

Gudbjartsson DF, Holm H, Gretarsdottir S, Thorleifsson G, Walters GB, Thorgeirsson G, Gulcher J, Mathiesen EB, Njølstad I, Nyrnes A, Wilsgaard T, Hald EM, Hveem K, Stoltenberg C, Kucera G, Stubblefield T, Carter S, Roden D, Ng MC, Baum L, So WY, Wong KS, Chan JC, Gieger C, Wichmann HE, Gschwendtner A, Dichgans M, Kuhlenbäumer G, Berger K, Ringelstein EB, Bevan S, Markus HS, Kostulas K, Hillert J, Sveinbjörnsdóttir S, Valdimarsson EM, Løchen ML, Ma RC, Darbar D, Kong A, Arnar DO, Thorsteinsdottir U, Stefansson K.
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.
Nat Genet. 2009 Aug;41(8):876-8 .

Breitling LP, Dahmen N, Mittelstrass K, Rujescu D, Gallinat J, Fehr C, Giegling I, Lamina C, Illig T, Müller H, Raum E, Rothenbacher D, Wichmann HE, Brenner H, Winterer G.
Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans.
Pharmacogenomics J. 2009 Aug;9(4):219-24. Epub 2009 Mar 17.

Hersberger M, Müller M, Marti-Jaun J, Heid IM, Coassin S, Young TF, Waechter V, Hengstenberg C, Meisinger C, Peters A, König W, Holmer S, Schunkert H, Klopp N, Kronenberg F, Illig T.
No association of two functional polymorphisms in human ALOX15 with myocardial infarction.
Atherosclerosis. 2009 Jul;205(1):192-6. Epub 2008 Nov 27.

Mobascher A, Rujescu D, Mittelstraß K, Giegling I, Lamina C, Nitz B, Brenner H, Fehr C, Breitling LP, Gallinat J, Rothenbacher D, Raum E, Müller H, Ruppert A, Hartmann AM, Möller HJ, Gal A, Gieger C, Wichmann HE, Illig T, Dahmen N, Winterer G.
Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction.
Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):684-90.

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, Jackson AU, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko YS, Chambers JC, Drong A, Luan J, Lyon HN, Rivadeneira F, Sanna S, Timpson NJ, Zillikens MC, Zhao JH, Almgren P, Bandinelli S, Bennett AJ, Bergman RN, Bonnycastle LL, Bumpstead SJ, Chanock SJ, Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney AS, Ebrahim S, Elliott P, Erdos MR, Estrada K, Ferrucci L, Fischer G, Forouhi NG, Gieger C, Grallert H, Groves CJ, Grundy S, Guiducci C, Hadley D, Hamsten A, Havulinna AS, Hofman A, Holle R, Holloway JW, Illig T, Isomaa B, Jacobs LC, Jameson K, Jousilahti P, Karpe F, Kuusisto J, Laitinen J, Lathrop GM, Lawlor DA, Mangino M, McArdle WL, Meitinger T, Morken MA, Morris AP, Munroe P, Narisu N, Nordström A, Nordström P, Oostra BA, Palmer CN, Payne F, Peden JF, Prokopenko I, Renström F, Ruokonen A, Salomaa V, Sandhu MS, Scott LJ, Scuteri A, Silander K, Song K, Yuan X, Stringham HM, Swift AJ, Tuomi T, Uda M, Vollenweider P, Waeber G, Wallace C, Walters GB, Weedon MN; Wellcome Trust Case Control Consortium, Witteman JC, Zhang C, Zhang W, Caulfield MJ, Collins FS, Davey Smith G, Day IN, Franks PW, Hattersley AT, Hu FB, Jarvelin MR, Kong A, Kooner JS, Laakso M, Lakatta E, Mooser V, Morris AD, Peltonen L, Samani NJ, Spector TD, Strachan DP, Tanaka T, Tuomilehto J, Uitterlinden AG, van Duijn CM, Wareham NJ, Hugh Watkins; Procardis Consortia, Waterworth DM, Boehnke M, Deloukas P, Groop L, Hunter DJ, Thorsteinsdottir U, Schlessinger D, Wichmann HE, Frayling TM, Abecasis GR, Hirschhorn JN, Loos RJ, Stefansson K, Mohlke KL, Barroso I, McCarthy MI; Giant Consortium.
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
PLoS Genet. 2009 Jun;5(6):e1000508. Epub 2009 Jun 26.

Böhme M, Grallert H, Klapper M, Gieger C, Fischer A, Heid I, Wichmann HE, Döring F, Illig T.
Association between functional FABP2 promoter haplotypes and body mass index: analyses of 8072 participants of the KORA cohort study.
Mol Nutr Food Res. 2009 Jun;53(6):681-5.

Rodríguez E, Baurecht H, Herberich E, Wagenpfeil S, Brown SJ, Cordell HJ, Irvine AD,
Weidinger S.
Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease.
J Allergy Clin Immunol. 2009 Jun;123(6):1361-70.e7.

Esparza-Gordillo J, Weidinger S, Fölster-Holst R, Bauerfeind A, Ruschendorf F, Patone G, Rohde K, Marenholz I, Schulz F, Kerscher T, Hubner N, Wahn U, Schreiber S, Franke A, Vogler R, Heath S, Baurecht H, Novak N, Rodriguez E, Illig T, Lee-Kirsch MA, Ciechanowicz A, Kurek M, Piskackova T, Macek M, Lee YA, Ruether A.
A common variant on chromosome 11q13 is associated with atopic dermatitis.
Nat Genet. 2009 May;41(5):596-601. Epub 2009 Apr 6.

Kääb S, Darbar D, van Noord C, Dupuis J, Pfeufer A, Newton-Cheh C, Schnabel R, Makino S, Sinner MF, Kannankeril PJ, Beckmann BM, Choudry S, Donahue BS, Heeringa J, Perz S, Lunetta KL, Larson MG, Levy D, MacRae CA, Ruskin JN, Wacker A, Schömig A, Wichmann HE, Steinbeck G, Meitinger T, Uitterlinden AG, Witteman JC, Roden DM, Benjamin EJ, Ellinor PT.
Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation.
Eur Heart J. 2009 Apr;30(7):813-9. Epub 2009 Jan 13.

Fischer A, Grallert H, Böhme M, Gieger C, Boomgaarden I, Heid I, Wichmann HE, Döring F, Illig T.
Association analysis between the prostaglandin E synthase 2 R298H polymorphism and body mass index in 8079 participants of the KORA study cohort.
Genet Test Mol Biomarkers. 2009 Apr;13(2):223-6.

Vogel CI, Greene B, Scherag A, Müller TD, Friedel S, Grallert H, Heid IM, Illig T, Wichmann HE, Schäfer H, Hebebrand J, Hinney A.
Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry.
BMC Med Genet. 2009 Feb 19;10:14.

Marquard V, Beckmann L, Heid IM, Lamina C, Chang-Claude J.
Impact of genotyping errors on the type I error rate and the power of haplotype-based association methods.
BMC Genet. 2009 Jan 29;10:3.

Petrásek J, Hubácek JA, Stickel F, Sperl J, Berg T, Ruf E, Wichmann HE, Pfeufer A, Meitinger T, Trunecka P, Spicák J, Jirsa M.
Do common genetic variants in endotoxin signaling pathway contribute to predisposition to alcoholic liver cirrhosis?
Clin Chem Lab Med. 2009;47(4):398-404.

Nelis M, Esko T, Mägi R, Zimprich F, Zimprich A, Toncheva D, Karachanak S, Piskácková T, Balascák I, Peltonen L, Jakkula E, Rehnström K, Lathrop M, Heath S, Galan P, Schreiber S, Meitinger T, Pfeufer A, Wichmann HE, Melegh B, Polgár N, Toniolo D, Gasparini P, D'Adamo P, Klovins J, Nikitina-Zake L, Kucinskas V, Kasnauskiene J, Lubinski J, Debniak T, Limborska S, Khrunin A, Estivill X, Rabionet R, Marsal S, Julià A, Antonarakis SE, Deutsch S, Borel C, Attar H, Gagnebin M, Macek M, Krawczak M, Remm M, Metspalu A.
Genetic structure of Europeans: a view from the North-East.
PLoS One. 2009;4(5):e5472. Epub 2009 May 8.

Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E, Wallace Chr, Farrall M, Johansson A, Nyholt DR, Aulchenko Y, Beckmann JS, Bergmann S, Bochud M, Brown M, Campbell H, Connell J, Dominiczak A, Homuth G, Lamina C, McCarthy MI, Meitinger T, Mooser V, Munroe P, Nauck M, Peden J, Prokisch H, Salo P, Salomaa V, Samani N, Schlessinger D, Uda M, Völker U, Waeber G, Waterworth D, Wang-Sattler R, Wright AF, Adamski J, Whitfield JB, Gyllensten U, Wilson JF, Rudan I, Pramstaller P, Watkins H, Doering A, Wichmann HE, Spector TD, Peltonen L, Völzke H, Nagaraja R, Vollenweider P, Caulfield M, Illig T, Gieger Chr.
Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci that Influence Uric Acid Concentrations.
PLoS Genetics 2009 Jun;5(6):e1000504. Epub 2009 Jun 5

Ljungman P, Bellander T, Nyberg F, Lampa E, Jacquemin B, Kolz M, Lanki T, Mitropoulos J, Müller M, Picciotto S, Pistelli R, Rückerl R, Koenig W, Peters A; for the AIRGENE Study Group.
DNA variants, plasma levels and variability of Interleukin-6 in myocardial infarction survivors: Results from the AIRGENE study.
Thromb Res. 2009 May;124(1):57-64.

Pfeufer A, Sanna S, Arking DE, Müller M, Gateva V, Fuchsberger C, Ehret GB, Orrú M, Pattaro C, Köttgen A, Perz S, Usala G, Barbalic M, Li M, Pütz B, Scuteri A, Prineas RJ, Sinner MF, Gieger C, Najjar SS, Kao WH, Mühleisen TW, Dei M, Happle C, Möhlenkamp S, Crisponi L, Erbel R, Jöckel KH, Naitza S, Steinbeck G, Marroni F, Hicks AA, Lakatta E, Müller-Myhsok B, Pramstaller PP, Wichmann HE, Schlessinger D, Boerwinkle E, Meitinger T, Uda M, Coresh J, Kääb S, Abecasis GR, Chakravarti A.:
Common variants at ten loci modulate the QT interval duration in the QTSCD Study.
Nat Genet. 2009 Apr;41(4):407-14.

Laumen, H., Saningong, A.D., Heid, I.M., Hess, J., Herder, C., Claussnitzer, M., Baumert, J., Lamina, C., Rathmann, W., Sedlmeier, E.M., Klopp, N., Thorand, B., Wichmann, H.E., Illig, T., Hauner, H,:
Functional characterization of promoter variants of the adinopectin gene complemented by epidemiological data.
Diabetes, 2009 Apr;58(4):984-91. Epub 2008 Dec 15.

Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, Papadakis K, Voight BF, Scott LJ, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers JC, Khaw KT, Nilsson P, van der Harst P, Polidoro S, Grobbee DE, Onland-Moret NC, Bots ML, Wain LV, Elliott KS, Teumer A, Luan J, Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL; Wellcome Trust Case Control Consortium, Brown M, Dominiczak A, Newhouse SJ, Samani NJ, Webster J, Zeggini E, Beckmann JS, Bergmann S, Lim N, Song K, Vollenweider P, Waeber G, Waterworth DM, Yuan X, Groop L, Orho-Melander M, Allione A, Di Gregorio A, Guarrera S, Panico S, Ricceri F, Romanazzi V, Sacerdote C, Vineis P, Barroso I, Sandhu MS, Luben RN, Crawford GJ, Jousilahti P, Perola M, Boehnke M, Bonnycastle LL, Collins FS, Jackson AU, Mohlke KL, Stringham HM, Valle TT, Willer CJ, Bergman RN, Morken MA, Döring A, Gieger C, Illig T, Meitinger T, Org E, Pfeufer A, Wichmann HE, Kathiresan S, Marrugat J, O'Donnell CJ, Schwartz SM, Siscovick DS, Subirana I, Freimer NB, Hartikainen AL, McCarthy MI, O'Reilly PF, Peltonen L, Pouta A, de Jong PE, Snieder H, van Gilst WH, Clarke R, Goel A, Hamsten A, Peden JF, Seedorf U, Syvänen AC, Tognoni G, Lakatta EG, Sanna S, Scheet P, Schlessinger D, Scuteri A, Dörr M, Ernst F, Felix SB, Homuth G, Lorbeer R, Reffelmann T, Rettig R, Völker U, Galan P, Gut IG, Hercberg S, Lathrop GM, Zelenika D, Deloukas P, Soranzo N, Williams FM, Zhai G, Salomaa V, Laakso M, Elosua R, Forouhi NG, Völzke H, Uiterwaal CS, van der Schouw YT, Numans ME, Matullo G, Navis G, Berglund G, Bingham SA, Kooner JS, Connell JM, Bandinelli S, Ferrucci L, Watkins H, Spector TD, Tuomilehto J, Altshuler D, Strachan DP, Laan M, Meneton P, Wareham NJ, Uda M, Jarvelin MR, Mooser V, Melander O, Loos RJ, Elliott P, Abecasis GR, Caulfield M, Munroe PB.
Genome-wide association study identifies eight loci associated with blood pressure.
Nature Genetics 41, 666-676.

Gudbjartsson DF, Holm H, Gretarsdottir S, Thorleifsson G, Walters GB, Thorgeirsson G, Gulcher J, Mathiesen EB, Njølstad I, Nyrnes A, Wilsgaard T, Hald EM, Hveem K, Stoltenberg C, Kucera G, Stubblefield T, Carter S, Roden D, Ng MC, Baum L, So WY, Wong KS, Chan JC, Gieger C, Wichmann HE, Gschwendtner A, Dichgans M, Kuhlenbäumer G, Berger K, Ringelstein EB, Bevan S, Markus HS, Kostulas K, Hillert J, Sveinbjörnsdóttir S, Valdimarsson EM, Løchen ML, Ma RC, Darbar D, Kong A, Arnar DO, Thorsteinsdottir U, Stefansson K.
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.
Nat Genet. 2009 Aug;41(8):876-8. Epub 2009 Jul 13.

Chio, A., Schymick, J., Restagno, G., Scholz, S.W., Lonbardo, F., Lai, S.L., Mora, G., Fung, H.C., Britton, A., Arepalli, S., Gibbs, R., Nalls, M., Berger, S., Kwee, L., Oddone, E., Ding, J., Crews, C., Rafferty, I., Washecka, N., Hernandez, D., Ferucci, L., Bandinelli, S., Gurlanik, J., Macciardi, F., Torri, F., Lupoli, S., Chanock, S.J., Thomas, G., Hunter, D., Traynor, B., Gieger, C., Wichmann, H.E., Calvo, A., Mutani, R., Battistini, S., Giannini, F., Caponetto, C., Mancardi, G.L., La Bella, V., Valentino, F., Monsurro, M.R., et al.:
A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.
Hum Mol Genet. 2009 Apr 15;18(8):1524-32. Epub 2009 Feb 4.

Org E, Eyheramendy S, Juhanson P, Gieger C, Lichtner P, Klopp N, Veldre G, Döring A, Viigimaa M, Sõber S, Tomberg K, Eckstein G; KORA, Kelgo P, Rebane T, Shaw-Hawkins S, Howard P, Onipinla A, Dobson RJ, Newhouse SJ, Brown M, Dominiczak A, Connell J, Samani N, Farrall M; BRIGHT, Caulfield MJ, Munroe PB, Illig T, Wichmann HE, Meitinger T, Laan M.
Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations.
Hum Mol Genet. 2009 Jun 15;18(12):2288-96. Epub 2009 Mar 20

Peters, A., Greven, S., Heid, I.M., Baldari, F, Breitner, S., Bellander, T., Chrysohoou, C., Illig, T., Jacquemin, B., Koenig, W., Lanki, T., Nyberg, F., Pekkanen, J., Pistelli, R., Rückerl, R., Stefanadis, C., Schneider, A., Sunyer, J., Wichmann, H.E. for the AIRGENE Study Group:
Fibrinogen Genes Modify the Fibrinogen Response to Ambient Particulate Matter.
AJRCCM, 2009 Mar 15;179(6):484-91. Epub 2009 Jan 8.

Trégouet, D.A., König, I.R., Erdmann, J., Munteanu, A., Braund, P.S., Hall, A.S., Großhennig, A., Linsel-Nitschke, P., Perret, C., DeSuremain, M., Meitinger, T., Wright, B.J., Preuss, M., Balmforth, A.J., Ball, S.G., Meisinger, C., Germain, C., Evans, A., Arveiler, D., Luc, G., Ruidavets, J.B., Morrison, C., van der Harst, P., Schreiber, S., Neureuther, K., Schäfer, A., Bugert, P., El Mokhtari, N.E., Schrezenmeir, J., Stark, K., Rubin, D., Wichmann, H.E. et al.:
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.
Nat Genet, 2009 Mar;41(3):283-5. Epub 2009 Feb 8.

Freilinger, T., Bevan, S., Ripke, S., Gschwendtner, A., Lichtner, P., Müller-Myhsok, B., Wichmann, H.E:, Markus, H.S., Meitinger, T., Dichgans, M.:
Genetic Variation in the Lymphotoxin-Alpha Pathway and the Risk of Ischemic Stroke in European Populations.
Stroke, 2009 Mar;40(3):970-2. Epub 2009 Jan 29.

Myocardial Infarction Genetics Consortium, with Kathiresan, S., Wichmann, H.E., et al.:
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
Nat Genet, 2009 Mar;41(3):334-41. Epub 2009 Feb 8.

Müller M, Ruf E, Weinauer F, Martin S, Becker C, Illig T, Döring A, Wichmann HE, Rapp S.:
The BSD Health Study: A Pilot Study to Examine the Comparability of Bavarian Blood Donors with the Bavarian General Population by a Comparison with KORA S4.
Gesundheitswesen. 2009 Aug;71(8-9):481-8. Epub 2009 Mar 13

Soranzo N*, Rendon A*, Gieger C*, Jones CI, Watkins NA, Menzel S, Doring A, Stephens J, Prokisch H, Erber W, Potter SC, Bray SL, Burns P, Jolley J, Falchi M, Kuhnel B, Erdmann J, Schunkert H, Samani N, Illig T, Garner SF, Rankin A, Meisinger C, Bradley JR, Thein SL, Goodall AH, Spector TD, Deloukas P, Ouwehand WH.
A novel variant on chromosome 7Q22.3 associated with mean platelet volume, counts and function.
Blood. 2009 Apr 16;113(16):3831-7. Epub 2009 Feb 12 (* equal contributions)

Meisinger C, Prokisch H, Gieger C, Soranzo N, Mehta D, Rosskopf D, Lichtner P, Klopp N, Stephens J, Watkins NA, Deloukas P, Greinacher A, Koenig W, Nauck M, Rimmbach C, Völzke H, Peters A, Illig T, Ouwehand WH, Meitinger T, Wichmann HE, Döring A.
A genome-wide association study identifies three loci associated with mean platelet volume.
Am J Hum Genet. 2009 Jan;84(1):66-71.

Huth C, Illig T, Herder C, Gieger C, Grallert H, Vollmert C, Rathmann W, Hamid YH, Pedersen O, Hansen T, Thorand B, Meisinger C, Doring A, Klopp N, Gohlke H, Lieb W, Hengstenberg C, Lyssenko V, Groop L, Ireland H, Stephens JW, Wernstedt Asterholm I, Jansson JO, Boeing H, Mohlig M, Stringham HM, Boehnke M, Tuomilehto J, Fernandez-Real JM, Lopez-Bermejo A, Gallart L, Vendrell J, Humphries SE, Kronenberg F, Wichmann HE, Heid IM.
Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.
Ann Med. 2009;41(2):128-38.

Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP, Penninx BW, Janssens AC, Wilson JF, Spector T, Martin NG, Pedersen NL, Kyvik KO, Kaprio J, Hofman A, Freimer NB, Jarvelin MR, Gyllensten U, Campbell H, Rudan I, Johansson A, Marroni F, Hayward C, Vitart V, Jonasson I, Pattaro C, Wright A, Hastie N, Pichler I, Hicks AA, Falchi M, Willemsen G, Hottenga JJ, de Geus EJ, Montgomery GW, Whitfield J, Magnusson P, Saharinen J, Perola M, Silander K, Isaacs A, Sijbrands EJ, Uitterlinden AG, Witteman JC, Oostra BA, Elliott P, Ruokonen A, Sabatti C, Gieger C, Meitinger T, Kronenberg F, Döring A, Wichmann HE, Smit JH, McCarthy MI, van Duijn CM, Peltonen L; ENGAGE Consortium.
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
Nat Genet. 2009 Jan;41(1):47-55.

Kolz, M., Baumert, J., Gohlke, H., Grallert, H., Döring, A., Peters, A., Wichmann, H.E., Koenig, W., Illig, T.: Association study between variants in the fibrinogen gene cluster, fibrinogen levels and hypertension: Results from the MONICA/KORA study. Thromb Haemost 101, 317-324 (2009)

Prokopenko, I., Langenberg, C., Florez, J.C., Saxena, R., Soranzo, N., Thorleifson, G., Loos, R.J., Manning, A.K., Jackson, A.U., Aulchenko, Y., Potter, S.C., Erdos, M.R., Sanna, S., Hottenga, J.J., Wheeler, E., Kaakinen, M., Lyssenko, V., Chen, W.M., Ahmadi, K., Beckmann, J.S., Illig, T., Wichmann, H.E., et al.:
Variants in MTNR1B influence fasting glucose levels.
Nat Genet 41(1), 77-81 (2009)

Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N; Wellcome Trust Case Control Consortium, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN; Genetic Investigation of ANthropometric Traits Consortium.
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
Nat Genet. 2009 Jan;41(1):25-34.

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Gieger C, Geistlinger L, Altmaier E, Hrabé de Angelis M, Kronenberg F, Meitinger T, Mewes HW, Wichmann HE, Weinberger KM, Adamski J, Illig T, Suhre K.
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.
PLoS Genet. 2008 Nov;4(11):e1000282.

Rabstein S, Unfried K, Ranft U, Illig T, Kolz M, Mambetova C, Vlad M, Roman C, Weiss T, Becker D, Bruning T, Pesch B.
Lack of association of delta-aminolevulinate dehydratase polymorphisms with blood lead levels and hemoglobin in Romanian women from a lead-contaminated region.
J Toxicol Environ Health A. 2008;71:716-724.

Heid IM, Lamina C, Kuchenhoff H, Fischer G, Klopp N, Kolz M, Grallert H, Vollmert C, Wagner S, Huth C, Muller J, Muller M, Hunt SC, Peters A, Paulweber B, Wichmann HE, Kronenberg F, Illig T.
Estimating the single nucleotide polymorphism genotype misclassification from routine double measurements in a large epidemiologic sample.
Am J Epidemiol. 2008;168:878-889.

Heid IM, Boes E, Müller M, Kollerits B, Lamina C, Coassin S, Gieger C, Döring A, Klopp N, Frikke-Schmidt R, Tybjærg-Hansen A, Brandstätter A, Luchner A, Meitinger T, Wichmann HE, Kronenberg F.
Genome-Wide Association Analysis of High-Density Lipoprotein Cholesterol in the Population-Based KORA Study Sheds New Light on Intergenic Regions.
Circ Cardiovasc Genet. 2008;1:10-20

Sunyer J, Pistelli R, Plana E, Andreani M, Baldari F, Kolz M, Koenig W, Pekkanen J, Peters A, Forastiere F.
Systemic inflammation, genetic susceptibility and lung function.
Eur Respir J. 2008;32:92-97.

Kolz M, Koenig W, Muller M, Andreani M, Greven S, Illig T, Khuseyinova N, Panagiotakos D, Pershagen G, Salomaa V, Sunyer J, Peters A.
DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study.
Eur Heart J. 2008;29:1250-1258.

Rückert I-M, Böcken J, Mielck A.
Are German patients burdened by the practice charge for physician visits ('Praxisgebuehr')? A cross sectional analysis of socio-economic and health related factors.
BMC Health Services Research 2008, 12;8:232.

Rückert I-M, Altnöder A, Schrödl M.
Computer-based 3D anatomical reconstruction and systematic placement of the mesopsammic gastropod Platyhedyle denudata Salvini-Plawen, 1973 (Opisthobranchia, Sacoglossa).
Organisms, Diversity & Evolution 2008, 8: 358–367.

Rückert I-M, Mielck A.
Soziale Ungleichheit beim Stillen in Deutschland: Stand der empirischen Forschung und Handlungsempfehlungen (Beastfeeding: socio-economic differences in Germany. State of empirical analyses and recommendations).
Prävention und Gesundheitsförderung 2008, 3:56-66.

Holzapfel C, Baumert J, Grallert H, Müller AM, Thorand B, Khuseyinova N, Herder C, Meisinger C, Hauner H, Wichmann HE, Koenig W, Illig T, Klopp N.
Genetic variants in the USF1 gene are associated with low-density lipoprotein cholesterol levels and incident type 2 diabetes mellitus in women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002.
Eur J Endocrinol. 2008 Oct;159(4):407-16.

Herder, C, Illig, T, Baumert, J, Müller, M, Klopp, N, Khuseyinova, N, Meisinger, C, Martin, S, Thorand, B, Koenig, W.
Macrophage migration inhibitory factor (MIF) and risk for coronary heart disease: Results from the MONICA/KORA Augsburg case-cohort study, 1984-2002.
Atherosclerosis 2008 Oct; 200(2):380-8.

Müller, M., Döring, A., Küchenhoff, H., Lamina, C., Malzahn, D., Bickeböller, H., Vollmert, C., Klopp, N., Meisinger, C., Heinrich, J., Kronenberg, F., Wichmann, H.-E., Heid, I.M.
Quantifying the contribution of genetic variants for survival phenotypes.
Genetic Epidemiology. 2008 Sep;32(6):574-85.

Jacquemin B, Antoniades C, Nyberg F, Plana E, Müller M, Greven S, Salomaa V, Sunyer J, Bellander T, Chalamandaris AG, Pistelli R, Koenig W, Peters A.
Common genetic polymorphisms and haplotypes of fibrinogen alpha, beta, and gamma chains affect fibrinogen levels and the response to proinflammatory stimulation in myocardial infarction survivors: the AIRGENE study.
J Am Coll Cardiol. 2008 Sep 9;52(11):941-52.

Weidinger S*, Gieger C*, Rodriguez E, Baurecht H, Mempel M, Klopp N, Gohlke H, Wagenpfeil S, Ollert M, Ring J, Behrendt H, Heinrich J, Novak N, Bieber T, Krämer U, Berdel D, von Berg A, Bauer CP, Herbarth O, Koletzko S, Prokisch H, Mehta D, Meitinger T, Depner M, von Mutius E, Liang L, Moffatt M, Cookson W, Kabesch M, Wichmann HE, Illig T.
Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.
PLoS Genet. 2008 Aug;4(8):e1000166, Epub 2008 Aug 22 (* equal contributions).

Weidinger S, Baurecht H, Wagenpfeil S, Henderson J, Novak N, Sandilands A, Chen H, Rodriguez E, O'Regan GM, Watson R, Liao H, Zhao Y, Barker JN, Allen M, Reynolds N, Meggitt S, Northstone K, Smith GD, Strobl C, Stahl C, Kneib T, Klopp N, Bieber T, Behrendt H, Palmer CN, Wichmann HE, Ring J, Illig T, McLean WH, Irvine AD.
Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk.
J Allergy Clin Immunol. 2008 Sep;122(3):560-8.e4. Erratum in: J Allergy Clin Immunol. 2008 Nov;122(5):976.

Weidinger S, O'Sullivan M, Illig T, Baurecht H, Depner M, Rodriguez E, Ruether A, Klopp N, Vogelberg C, Weiland SK, McLean WH, von Mutius E, Irvine AD, Kabesch M.
Filaggrin mutations, atopic eczema, hay fever, and asthma in children.
J Allergy Clin Immunol. 2008 May;121(5):1203-1209.e1. Epub 2008 Apr 8.

Lao O, Lu TT, Nothnagel M, Junge O, Freitag-Wolf S, Caliebe A, Balascakova M, Bertranpetit J, Bindoff LA, Comas D, Holmlund G, Kouvatsi A, Macek M, Mollet I, Parson W, Palo J, Ploski R, Sajantila A, Tagliabracci A, Gether U, Werge T, Rivadeneira F, Hofman A, Uitterlinden AG, Gieger C, Wichmann HE, Rüther A, Schreiber S, Becker C, Nürnberg P, Nelson MR, Krawczak M, Kayser M.
Correlation between genetic and geographic structure in Europe.
Curr Biol. 2008 Aug 26;18(16):1241-8.

Schormair B, Kemlink D, Roeske D, Eckstein G, Xiong L, Lichtner P, Ripke S, Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Högl B, Frauscher B, Gschliesser V, Poewe W, Peglau I, Vodicka P, Vávrová J, Sonka K, Nevsimalova S, Montplaisir J, Turecki G, Rouleau G, Gieger C, Illig T, Wichmann HE, Holsboer F, Müller-Myhsok B, Meitinger T, Winkelmann J.
PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome.
Nat Genet. 2008 Aug;40(8):946-8.

Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI; Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM; KORA, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L; Nurses' Health Study, Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK; Diabetes Genetics Initiative, Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M; SardiNIA Study, Vogel CI, Wallace C, Waterworth DM, Weedon MN; Wellcome Trust Case Control Consortium, Willer CJ; FUSION, Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I, Jacobs KB, Chanock SJ, Hayes RB, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Kraft P, Hankinson SE, Hunter DJ, Hu FB, Lyon HN, Voight BF, Ridderstrale M, Groop L, Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D, Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL.
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
Nat Genet. 2008 Jun;40(6):768-75.

Kolz, M., Koenig, W., Müller, M., Andreani, M., Greven, S., Illig, T., Khuseyinova, N., Panagiotakos, D., Pershagen, G., Salomaa, V., Sunyer, J., Peters, A., for the AIRGENE Study Group
DNA variants, plasma levels and variability of C-reactive protein in Myocardial infarction survivors: results from the AIRGENE study.
Eur Heart J, 2008 May;29(10):1250-8.

Lettre G., Jackson A.U.*, Gieger C.*, Schumacher F.R.*, Berndt S.I.*, Serena Sanna S.*, Eyheramendy S., Voight B.F., Butler J.L., Guiducci C.,  Illig T., Hackett R., Heid I.M., Jacobs K.B., Lysseno V., Uda M., The Diabetes Genetics Initiative, FUSION, KORA, The Prostate, Lung Colorectal and Ovarian Cancer Screening Trial, The Nurses’ Health Study, SardiNIA, Boehnke M., Chanock S.J., Groop L.C.,  Hu F.B., Isomaa B. , Kraft P., Peltonen L.,  Salomaa V., Schlessinger D., Hunter D.J., Hayes R.B., Abecasis G.R., Wichmann H.E., Mohlke K.L., Hirschhorn J.N.
Genome-wide association studies identify ten novel loci for height and highlight new biological pathways in human growth.
Nat Genet. 2008 May;40(5):584-91 (* equal contributions)

W. Sauter, A. Rosenberger, L. Beckmann, S. Kropp, K. Mittelstrass, M. Timofeeva, G., A. Steinwachs, D. Scheiner, E. Meese, G. Sybrecht, F. Kronenberg, H. Dienemann, J. Chang-Claude, T. Illig, H.-E. Wichmann, H. Bickeböller, A. Risch, and the LUCY-Consortium.
Matrix metalloproteinase 1 (MMP1) is associated with early onset lung cancer.
Cancer Epidemiology Biomarkers and Prevention. 2008 May;17(5):1127-35.

Herder C, Illig T, Baumert J, Müller M, Klopp N, Khuseyinova N, Meisinger C, Poschen U, Martin S, Koenig W, Thorand B.
RANTES/CCL5 gene polymorphisms, serum concentrations, and incident type 2 diabetes: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002.
Eur J Endocrinol. 2008 May;158(5):R1-5.

Sinner MF, Pfeufer A, Akyol M, Beckmann BM, Hinterseer M, Wacker A, Perz S, Sauter W, Illig T, Näbauer M, Schmitt C, Wichmann HE, Schömig A, Steinbeck G, Meitinger T, Kääb S.
The non-synonymous coding IKr-channel variant KCNH2-K897T is associated with atrial fibrillation: results from a systematic candidate gene-based analysis of KCNH2 (HERG).
Eur Heart J. 2008 Apr;29(7):907-14. Epub 2008 Jan 25.

Döring A.*, Gieger C.*, Mehta D., Gohlke H., Prokisch H., Coassin S., Fischer G., Henke K., Klopp N., Kronenberg F., Paulweber B., Pfeufer A., Rosskopf D., Volzke H., Illig T., Meitinger T., Wichmann H.-E., Meisinger C.
A genome wide association study reveals SLC2A9 as a major gene for uric acid levels with pronounced gender-specific effects.
Nat Genet. 2008 Apr;40(4):430-6. (* equal contributions)

J. Lasky-Su,H. N. Lyon, V. Emilsson, G. Thorleifsson, U. Thorsteinsdottir, K. Stefansson, R. Lazarus, B. Klanderman, B. A. Raby,  M. E. Soto-Quiros, L. Avila, E. K. Silverman, J. C. Celedón, S. T. Weiss, I. M. Heid, F. Kronenberg, C. Vollmert, T. Illig ,H.-E. Wichmann, C. S. Fox, D. Levy, C. J. O’Donnell, N. Laird, Xi. Ding, M. McQueen, C. Molony, E. Schadt, J. Butler, K. Ardlie, J. Hirschhorn, C. Papoutsakis, G. Dedoussis, C. Lange
On the replication of genetic associations: timing can be everything.
Am J Hum Genet. 2008 Apr;82(4):849-58.

Döring A.*, Gieger C.*, Mehta D., Gohlke H., Prokisch H., Coassin S., Fischer G., Henke K., Klopp N., Kronenberg F., Paulweber B., Pfeufer A., Rosskopf D., Volzke H., Illig T., Meitinger T., Wichmann H.-E., Meisinger C.
A genome wide association study reveals SLC2A9 as a major gene for uric acid levels with pronounced gender-specific effects.
Nat Genet. 2008 Apr;40(4):430-6.  (* equal contributions)

Boes E, Kollerits B, Heid IM, Hunt SC, Pichler M, Paulweber B, Coassin S, Adams TD, Hopkins PN, Lingenhel A, Wagner SA, Kronenberg F.
INSIG2 Polymorphism Is Neither Associated With BMI Nor With Phenotypes of Lipoprotein Metabolism.
Obesity (Silver Spring). 2008 Apr;16(4):827-33. Epub 2008 Jan 31.

Lamina C, Bongardt F, Küchenhoff H, Heid IM.
Haplotype Reconstruction Error as a Classical Misclassification Problem: Introducing Sensitivity and Specificity as Error Measures.
PLos One, 2008 Mar 26;3(3):e1853.

Gibson J, Tapper W, Cox D, Zhang W, Pfeufer A, Gieger C, Wichmann HE, Kääb S, Collins AR, Meitinger T, Morton N.
A multimetric approach to analysis of genome-wide association by single markers and composite likelihood.
Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2592-7. Epub 2008 Feb 11.

Kolz, M., Baumert, J., Müller, M., Khuseyinova, N., Klopp, N., Thorand, B., Meisinger, C., Herder, C., Koenig, W. and Illig, T.
Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol.
BMC Medical Genetics. 2008 Feb 25;9:9.

Luca D, Ringquist S, Klei L, Lee AB, Gieger C, Wichmann HE, Schreiber S, Krawczak M, Lu Y, Styche A, Devlin B, Roeder K, Trucco M.
On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants.
Am J Hum Genet. 2008 Feb;82(2):453-63. Epub 2008 Jan 24.

Novak N, Baurecht H, Schäfer T, Rodriguez E, Wagenpfeil S, Klopp N, Heinrich J, Behrendt H, Ring J, Wichmann E, Illig T, Weidinger S.
Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel.
J Invest Dermatol. 2008 Jun;128(6):1430-5. Epub 2007 Nov 29.

Heid IM, Vollmert C, Kronenberg F, Huth C, Ankerst DP, Luchner A, Hinney A, Brönner G, Wichmann HE, Illig T, Döring A, Hebebrand J.
Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study. Obesity (Silver Spring). 2008 Feb;16(2):369-76.

A. Rosenberger, T. Illig, K. Korb, N. Klopp, H. Bickeböller, V. Zietemann, G. Wölke, E. Meese, G. Sybrecht, F. Kronenberg, M. Cebulla, M. Degen, P. Drings, A. Gröschel, N. Konietzko, K. Kreymborg, K. Häußinger, G. Höffken, B. Jilge, Y.-D. Ko, H. Morr, C. Schmidt, E.- W. Schmidt, D.Täuscher, H.-E. Wichmann.
Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years.
BMC Cancer. 2008 Feb 25;8(1):60

Herder, C, Klopp, N, Baumert, J, Muller, M, Khuseyinova, N, Meisinger, C, Martin, S, Illig, T, Koenig, W, Thorand, B.
Effect of macrophage migration inhibitory factor (MIF) gene variants and MIF serum concentrations on the risk of type 2 diabetes: results from the MONICA/KORA Augsburg Case-Cohort Study, 1984-2002.
Diabetologia 2008; 51: 276-284.

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Baurecht H, Irvine AD, Novak N, Illig T, Bühler B, Ring J, Wagenpfeil S, Weidinger S.
Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data.
J Allergy Clin Immunol. 2007 Dec;120(6):1406-12. Epub 2007 Nov 5.

Novak N, Yu CF, Bussmann C, Maintz L, Peng WM, Hart J, Hagemann T, Diaz-Lacava A, Baurecht HJ, Klopp N, Wagenpfeil S, Behrendt H, Bieber T, Ring J, Illig T, Weidinger S.
Putative association of a TLR9 promoter polymorphism with atopic eczema.
Allergy. 2007 Jul;62(7):766-72.

Grallert H, Sedlmeier EM, Huth C, Kolz M, Heid IM, Meisinger C, Herder C, Strassburger K, Giani G, Kronenberg F, Wichmann HE, Adamski J, Paulweber B, Illig T, Rathmamn W.
APOA5 variants: A role in the metabolic syndrome?  Results from KORA S4 and SAPHIR, two population based studies.
J Lipid Res 2007, 48: 2614-21

Lyon HN, Emilsson V, Hinney A, Heid IM, Nguyen TT, Scherag A, Pfeufer A, Meitinger T, Bronner G, Rief W, Vollmert C, Celedon JC, Wichmann HE, Hebebrand J, Hirschhorn JN.
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.
PLoS Genet. 2007; 3:e61.

Schoenborn V, Gohlke H, Heid IM, Illig T, Utermann G, Kronenberg F.
Sample selection algorithm to improve quality of genotyping from plasma-derived DNA: to separate the wheat from the chaff.
Hum Mutat. 2007 Nov;28(11):1141-9.

Winkelmann J, Schormair B, Lichtner P, Ripke S, Xiong L, Jalilzadeh S, Fulda S, Pütz B, Eckstein G, Hauk S, Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Peglau I, Eisensehr I, Montplaisir J, Turecki G, Rouleau G, Gieger C, Illig T, Wichmann HE, Holsboer F, Mueller-Myhsok B, Meitinger T.
Genome-wide association study in restless legs syndrome identifies common variants in three genomic regions.
Nat Genet. 2007 Aug;39(8):1000-6

Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, Konig IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H, WTCCC and the Cardiogenics Consortium.
Genomewide association analysis of coronary artery disease.
N Engl J Med. 2007 Aug 2; 357(5):443-53

Wichmann HE, Gieger C
Biobanks.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2007 Feb; 50(2):192-9
    
Vollmert C, Hahn S, Lamina C, Huth C, Kolz M, Schöpfer-Wendels A, Mann K, Bongardt F, Mueller JC, Kronenberg F, Wichmann HE, Herder C, Holle R, Löwel H, Illig T, Janssen OE; the KORA group.
Calpain-10 variants and haplotypes are associated with polycystic ovary syndrome in Caucasians.
Am J Physiol Endocrinol Metab. 2007 Mar;292(3)

Gieger C., Wichmann H.E.
Biobanks in Genetic-epidemiological Research such as KORA-gen.
it - Information Technology. 2007 Dec;49(6):381-387.

Wichmann H.E., Gieger C. (2007)
Biobanks with and without population reference.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2007 50(2):192-9.

Kollerits, B., Fliser, D., Heid, I.M., Ritz, E., Kronenberg, F., for the MMKD Study Group.
Gender-specific association of adinopectin as a predictor of progression of chronic kidney disease: The Mild to Moderate Kidney Disease Study.
Kidney Int 71, 1279-1286 (2007)

Huth, C., Siegert, N., Meisinger, C., König, J., Kääb, S., Wichmann, H.E., Döring, A. and the KORA Group.
Individuals With Very Low Alcohol Consumption: A Heterogeneous Group.
J Stud Alcohol 68, 6-10 (2007)

Marzi, C., Huth, C., Kolz, M., Grallert, H., Meisinger, C., Wichmann, H.E., Rathmann, W., Herder, C., Illig, T.
Variants of the Transcription Factor 7-Like 2 Gene (TCF7L2) are Strongly Associated with Type 2 Diabetes but not with the Metabolic Syndrome in the MONICA/KORA Surveys.
Horm Metab Res 39, 46-52 (2007)

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Steffens M, Lamina C, Illig T, Bettecken T, Vogler R, Entz P, Suk EK, Toliat MR, Klopp N, Caliebe A, König IR, Köhler K, Ludemann J, Diaz Lacava A, Fimmers R, Lichtner P, Ziegler A, Wolf A, Krawczak M, Nūrnberg P, Hampe J, Schreiber S, Meitinger T, Wichmann HE, Roeder K, Wienker TF, Baur MP:
SNP-based analysis of genetic substructure in the German population.
Hum Hered. 2006;62(1):20-9

Heid IM, A Schaffrath Rosario, L Kreienbrock, H Küchenhoff, HE Wichmann:
Impact of measurement error in exposures in german radon studies.
J Tox Env Health, 2006 Apr;69(7):701-21.

Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, Wichmann HE, Meitinger T,
Hunter D, Hu FB, Colditz G, Hinney A, Hebebrand J, Koberwitz K, Zhu X, Cooper R, Ardlie
K, Lyon H, Hirschhorn JN, Laird NM, Lenburg ME, Lange C, Christman MF.
A common genetic variant is associated with adult and childhood obesity.
Science. 2006 Apr 14;312(5771):279-83.

Huth C, Heid IM, Vollmert C, Gieger C, Grallert H, … Boeing H,… Wichmann HE, Herder C, Illig T.
IL6 Promoter Polymorphisms and Type 2 Diabetes Mellitus:Joint Analysis of Individual Participants’ Data from 21 Studies.
Diabetes. 2006; 55:2915-21.

Heid IM, Wagner SA, Gohlke H, Müller J, Illig T, Kronenberg F, Paulweber B.
Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1727 healthy Caucasians.
Diabetes. 2006;55:375-84.

Schoenborn V*, Heid IM*, Vollmert C*, Lingenhel A, Adams TD, Hopkins PN, Illig T, Zimmermann R, Zechner R, Hunt SC, Kronenberg F.
The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes.
Diabetes 2006; 55:1270-1275.  *contributed equally        

Schaeffer L, Gohlke H, Müller M, Heid IM, Palmer LJ, Kompauer I, Demmelmair H, Illig T, Koletzko J, Heinrich J.
Desaturase gene polymorphisms are associated with the fatty acid composition in serum phospholipids.
Hum Mol Genet 2006, 15:1745-1756.

Lamina C, Meisinger C, Heid IM, Löwel H, Rantner B, Koenig W, Kronenberg F; Kora Study Group.
Association of ankle-brachial index and plaques in the carotid and femoral arteries with cardiovascular events and total mortality in a population-based study with 13 years of follow-up.
Eur Heart J. 2006 Nov;27(21):2580-7.

Arking DE, Pfeufer A, Post W, Kao WH, Newton-Cheh C, Ikeda M, West K, Kashuk C, Akyol M, Perz S, Jalilzadeh S, Illig T, Gieger C, Guo CY, Larson MG, Wichmann HE, Marban E, O'donnell CJ, Hirschhorn JN, Kaab S, Spooner PM, Meitinger T, Chakravarti A.
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.
Nat Genet. 2006 Jun;38(6):644-51.

Heid IM, Küchenhoff H, Rosario AS, Kreienbrock L, Wichmann HE.
Impact of measurement error in exposures in german radon studies.
J Toxicol Environ Health A. 2006 Apr;69(7):701-21.

Grallert H, Huth C, Kolz M, Meisinger C, Herder C, Strassburger K, Giani G, Wichmann HE, Adamski J, Illig T, Rathmann W.
IL-6 promoter polymorphisms and quantitative traits related to the metabolic syndrome in KORA S4.
Experimental Gerontology 41: 737–745, 2006

Weidinger S, Novak N, Klopp N, Baurecht H, Wagenpfeil S, Rummler L, Ring J, Behrendt H, Illig T.
Lack of association between Toll-like receptor 2 and Toll-like receptor 4 polymorphisms and atopic eczema.
J Allergy Clin Immunol. 2006 Jul;118(1):277-9. Epub 2006 Jun 6.

Weidinger S, Illig T, Baurecht H, Irvine AD, Rodriguez E, Diaz-Lacava A, Klopp N, Wagenpfeil S, Zhao Y, Liao H, Lee SP, Palmer CN, Jenneck C, Maintz L, Hagemann T, Behrendt H, Ring J, Nothen MM, McLean WH, Novak N.
Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.
J Allergy Clin Immunol. 2006 Jul;118(1):214-9. Epub 2006 Jun 9. Erratum in: J Allergy Clin Immunol. 2006 Oct;118(4):922. J Allergy Clin Immunol. 2006 Sep;118(3):724.

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Illig T, Bongardt F, Schöpfer-Wendels A, Huth C, Heid IM, Rathmann W, Martin S, Vollmert C, Holle R, Thorand B, Wichmann HE, Koenig W, Kolb H, Herder C, for the KORA Study Group.
Genetics of Type 2 Diabetes: Impact of Interleukin-6 Gene Variants. Genetik von Typ 2 Diabetes: Einfluss von Interleukin-6 Genvarianten.
Gesundheitswesen 2005; 67

Heid IM, Vollmert C, Hinney A, Doring A, Geller F, Lowel H, Wichmann HE, Illig T, Hebebrand J, Kronenberg F; KORA Group:
Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys.
J Med Genet. 2005;42(4):e21

Pfeufer A, Jalilzadeh S, Perz S, Mueller JC, Hinterseer M, Illig T, Akyol M, Huth C, Schopfer-Wendels A, Kuch B, Steinbeck G, Holle R, Nabauer M, Wichmann HE, Meitinger T, Kaab S:
Common variants in myocardial ion channel genes modify the QT interval in the general population: results from the KORA study.
Circ Res 96(6): 693-701 (2005)

Wichmann, H.E., Gieger, C., Illig, T. for the KORA Study Group:
KORA-gen. Resource for population genetics, controls and a broad spectrum of disease phenotypes.
Gesundheitwesen 2005; 67 Suppl. 1, 26-30

Holle R., Happich M., Löwel H., Wichmann H.E., for the KORA Study Group.
KORA - A research platform for population based health research.
Gesundheitswesen 2005; 67 Suppl. 1, 19-25

Mueller JC, Lohmussaar E, Magi R, Remm M, Bettecken T, Lichtner P, Biskup S, Illig T, Pfeufer A, Luedemann J, Schreiber S, Pramstaller P, Pichler I, Romeo G, Gaddi A, Testa A, Wichmann HE, Metspalu A, Meitinger T.:
Linkage disequilibrium patterns and tagSNP transferability among European populations.
Am J Hum Genet. 2005 Mar;76(3):387-98

Weidinger S, Klopp N, Rummler L, Wagenpfeil S, Novak N, Baurecht HJ, Groer W, Darsow U, Heinrich J, Gauger A, Schafer T, Jakob T, Behrendt H, Wichmann HE, Ring J, Illig T.
Association of NOD1 polymorphisms with atopic eczema and related phenotypes.
J Allergy Clin Immunol. 2005 Jul;116(1):177-84

Weidinger S, Rümmler L, Klopp N, Wagenpfeil S, Baurecht HJ, Fischer G, Holle R, Gauger A, Schäfer T, Jakob T, Ollert M, Behrendt H, Wichmann HE, Ring J, Illig T.
Association study of mast cell chymase polymorphisms with atopy.
Allergy. 2005 Oct;60(10):1256-61

Weidinger S, Klopp N, Rümmler L, Wagenpfeil S, Baurecht HJ, Gauger A, Darsow U, Jakob T, Novak N, Schäfer T, Heinrich J, Behrendt H, Wichmann HE, Ring J, Illig T; KORA study group.
Association of CARD15 polymorphisms with atopy-related traits in a population-based cohort of Caucasian adults.
Clin Exp Allergy. 2005 Jul;35(7):866-72

Wichmann, H.E., Gieger, C., Illig, T.
KORA-gen: Ressource für Populationsgenetik, Kontrollen und ein weites Spektrum an Krankheitsphänotypen.
GenomXPress 3/05, 19-21 (2005)

Wichmann H.E.:
Genetic epidemiology in Germany - from biobanking to genetic statistics.
Methods Inf Med. 44(4):584-9 (2005)

Heid, I. M., Lamina, C., Bongardt, F., Fischer, G., Klopp, N., Huth, C., Küchenhoff, H., Kronenberg, F., Wichmann, H. E., Illig, T.:
Wie gut können Haplotypen in den populationsbasierten KORA-Studien rekonstruiert werden? How About the Uncertainty in the Haplotypes in the Population-Based KORA Studies?
Das Gesundheitswesen 67(S 01), 132-136 (2005)

Lamina, C., Steffens, M., Müller, J., Lohmussaar, E., Meitinger, T., Wichmann, H.-E.
Genetic diversity in German and European Populations: Looking for Substructures and Genetic Patterns; Genetische Diversität in Deutschen und Europäischen Bevölkerungen: Suche nach Substrukturen und genetischen Mustern.
Das Gesundheitswesen 67(S 01), 127-131 (2005)

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Illig, T., Bongardt, F., Schöpfer, A., Müller-Scholze, S., Rathmann, W., Koenig, W., Thorand, B., Vollmert, C., Holle, R., Kolb, H., Herder, C.
Significant association of the interleukin-6 gene polymorphisms C-174G and A-598G with type 2 diabetes.
J. Clin. Endocr. Metab. 89, 5053-5058 (2004)

Cichon, S., …, Klopp, N., …, Illig, T. et al.:
Lack of support for a genetic association of the XBP1 promoter polymorphismm with bipolar disorder in probands of European origin.
Nature Genetics 2004;36(8), 783-784

Heid IM, H Küchenhoff, J Miles, L Kreienbrock, HE Wichmann.
Two dimensions of measurement error: Classical and Berkson error in residential radon exposure assessment.
J Expo Anal Env Epi 2004, 14, 365-377

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Illig, T., Bongardt, F., Schöpfer, A., Holle, R., Müller, S., Rathmann, W., Koenig, W., Meisinger, C., Wichmann, H.-E., Kolb, H., KORA Study Group:
The Endotoxin Receptor TLR4 Polymorphism is Not Associated with Diabetes or Components of the Metabolic Syndrome.
Diabetes 52, 2861-2864 (2003)

Heid IM, M Gerken, J Wellmann, H. Küchenhoff, L Kreienbrock, HE Wichmann.
On the potential of measurement error to induce differential bias between groups: an example from radon epidemiology.
Stat Med 2002, 21:3261-3278

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