Metabolomics: Publications
Publications 2011
Yu Z, Kastenmüller G, He Y, Belcredi P, Möller G, Prehn C, Mendes J, Wahl S, Roemisch-Margl W, Ceglarek U, Polonikov A, Dahmen N, Prokisch H, Xie L, Li Y, Wichmann HE, Peters A, Kronenberg F, Suhre K, Adamski J, Illig T, Wang-Sattler R. Differences between Human Plasma and Serum Metabolite Profiles. PLoS One. 2011;6(7):e21230.
Krumsiek J, Suhre K, Illig T, Adamski J, Theis FJ. Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data. BMC Syst Biol. 2011 Jan 31;5(1):21.
Floegel A, Drogan D, Wang-Sattler R, Prehn C, Illig T, Adamski J, Joost HG, Boeing H, Pischon T. Reliability of Serum Metabolite Concentrations over a 4-Month Period Using a Targeted Metabolomic Approach. PLoS One. 2011;6(6):e21103
Publications 2010
Altmaier E, Kastenmüller G, Römisch-Margl W, Thorand B, Weinberger KM, Illig T, Adamski J, Döring A, Suhre K. Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics. Eur J Epidemiol. 2010 Nov 30. [Epub ahead of print] PubMed PMID: 21116839.
Suhre K, Meisinger C, Döring A, Altmaier E, Belcredi P, Gieger C, Chang D, Milburn MV, Gall WE, Weinberger KM, Mewes HW, Hrabe de Angelis M, Wichmann HE, Kronenberg F, Adamski J, Illig T.
Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PLoS One. 2010 Nov 11;5(11):e13953. PubMed PMID: 21085649; PubMed Central PMCID: PMC2978704.
Haller F, Prehn C, Adamski J. Quantification of steroids in human and mouse plasma using online solid phase extraction coupled to liquid chromatography tandem mass spectrometry Nature Protocols 2010 10.1038/nprot.2010.22
Illig T, Gieger C, Zhai G, Romisch-Margl W, Wang-Sattler R, Prehn C, Altmaier E, Kastenmuller G, Kato BS, Mewes HW, Meitinger T, de Angelis MH, Kronenberg F, Soranzo N, Wichmann HE, Spector TD, Adamski J, Suhre K A genome-wide perspective of genetic variation in human metabolism. Nature Genetics 2010 42(2): 137-141
Publications 2009
Altmaier E, Kastenmüller G, Römisch-Margl W, Thorand B, Weinberger KM, Adamski J, Illig T, Döring A, Suhre K. Variation in the human lipidome associated with coffee consumption as revealed by quantitative targeted metabolomics. Mol Nutr Food Res. 2009 Nov;53(11):1357-65
Michiels PJ, Ludwig C, Stephan M, Fischer C, Möller G, Adamski J, Messinger J, van Dongen M, Thole H, Günther UL. Ligand-based NMR spectra demonstrate an additional phytoestrogen binding site for 17beta-hydroxysteroid dehydrogenase type 1. J Steroid Biochem Mol Biol. 2009, Nov; 117(4-5):93-8
Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E, Wallace C, Farrall M, Johansson A, Nyholt DR, Aulchenko Y, Beckmann JS, Bergmann S, Bochud M, Brown M, Campbell H; EUROSPAN Consortium, Connell J, Dominiczak A, Homuth G, Lamina C, McCarthy MI; ENGAGE Consortium, Meitinger T, Mooser V, Munroe P, Nauck M, Peden J, Prokisch H, Salo P, Salomaa V, Samani NJ, Schlessinger D, Uda M, Völker U, Waeber G, Waterworth D, Wang-Sattler R, Wright AF, Adamski J, Whitfield JB, Gyllensten U, Wilson JF, Rudan I, Pramstaller P, Watkins H; PROCARDIS Consortium, Doering A, Wichmann HE; KORA Study, Spector TD, Peltonen L, Völzke H, Nagaraja R, Vollenweider P, Caulfield M; WTCCC, Illig T, Gieger C. Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations. PLoS Genet. 2009, Jun; 5(6):e1000504.
Publications 2007, 2008
Altmaier E, Ramsay SL, Graber A, Mewes HW, Weinberger KM, Suhre K. (2008): Bioinformatics analysis of targeted metabolomics--uncovering old and new tales of diabetic mice under medication. Endocrinology. 149, 3478-89
Chen, J., Zhao, X., Fritsche, J., Yin, P., Schmitt-Kopplin, P., Wang, W., Lu X., Haring, H.U., Schleicher, E.D., Lehmann, R., Xu, G. (2008): Practical Approach for the Identification and Isomer Elucidation of Biomarkers Detected in a Metabonomic Study for the Discovery of Individuals at Risk for Diabetes by Integrating the Chromatographic and Mass Spectrometric Information. Anal Chem 80, 1280-1289
Döring, A., Gieger, C., Mehta, D., Gohlke, H., Prokisch, H., Coassin, S., Fischer, G., Henke, K., Klopp, N., Kronenberg, F., Paulweber, B., Pfeufer, A., Rosskopf, D., Völzke, H., Illig, T., Meitinger, T., Wichmann, H.E., Meisinger C. (2008): SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Nat Genet. 40, 430-436
Gaspar, A., Englmann, M., Fekete, A., Harir, M., Schmitt-Kopplin, P. (2008): Trends in CE-MS 2005-2006. Electrophoresis 29, 66-79
Gieger, C.H., Geistlinger, L., Altmaier, E., Hrabé de Angelis, M, Kronenberg, F., Meitinger, T., Mewes, H.W., Wichmann, H.E., Weinberger, K.W., Adamski, J., Illig, T., Suhre, K. (2008): Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLOS Genetics, 2008 Nov; 4(11):e1000282
Hult, M., Ortsäter, H., Schuster G., Graedler F., Beckers, J., Adamski, J., Ploner, A., Jörnvall, H., Bergsten, P., Oppermann, U. (2008): Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms. Mol Cell Endocrinol, in press
Lettre, G., Jackson, A.U., Gieger, C., Schumacher, F.R,. Berndt, S.I., Sanna, S., Eyheramendy, S., Voight, B.F., Butler, J.L., Guiducci, C., Illig, T., Hackett, R., Heid, I.M., Jacobs, K.B., Lyssenko, V., Uda, M.; Diabetes Genetics Initiative; FUSION; KORA; Prostate, Lung Colorectal and Ovarian Cancer Screening Trial; Nurses' Health Study; SardiNIA, Boehnke, M., Chanock, S.J., Groop, L.C., Hu, F.B., Isomaa, B., Kraft, P., Peltonen, L., Salomaa, V., Schlessinger, D., Hunter, D.J., Hayes, R.B., Abecasis, G.R., Wichmann, H.E., Mohlke, K.L., Hirschhorn, J.N. (2008): Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet 40, 584-591
Loos, R.J.F., Lindgren, C.M., Li, S., Wheeler, E., Zhao, J.H., Prokopenko, I., Inouye, M., Freathy, R.M., Attwood, A.P., Beckmann, J.S., Berndt, S.I., The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Bergmann, S., Bennett, A.J., Bingham, S.A., Bochud, M., Brown, M., Cauchi, S., Connell, J.M., Cooper, C., Smith, G.D., Day, I., Dina, C., De, S., Dermitzakis, E.T., Doney, A.S.F., Elliott, K.S., Elliott, P., Evans, D.M., Farooqi, I.S., Froguel, P., Ghori, J., Groves, C.J., Gwilliam, R., Hadley, D., Hall, A.S., Hattersley, A.T., Hebebrand, J., Heid, I.M., KORA, Herrera, B., Hinney, A., Hunt, S.E., Jarvelin, M.-R. Johnson, T., Jolley, J.D.M., Karpe, F., Keniry, A., Khaw, K.-T., Luben, R.N., Mangino, M., Marchini, J., McArdle, W.L., McGinnis, R., Meyre, D., Munroe, P.B., Morris, A.D., Ness, A.R., Neville, M.J., Nica, A.C., Ong, K.K., O'Rahilly, S., Owen, K.R., Palmer, C.N.A., Papadakis, K., Potter, S., Pouta, A., Qi, L., Nurses' Health Study, Randall, J.C., Rayner, N.W., Ring, S.M., Sandhu, M.S., Scherag, A., Sims, M.A., Song, K., Soranzo, N., Speliotes, E.K., Diabetes Genetics Initiative, Syddall, H.E., Teichmann, S.A., Timpson, N.J., Tobias, J.H., Uda, M., The SardiNIA Study, Vogel, C.I.G., Wallace, C., Waterworth, D.M., Weedon, M.N., The Wellcome Trust Case Control Consortium, Willer, C.J., FUSION, Wraight, V.L., Yuan, X., Zeggini, E., Hirschhorn, J.N., Strachan, D.P., Ouwehand, W.H., Caulfield, M.J., Samani, N.J., Frayling, T.M., Vollenweider, P., Waeber, G., Mooser, V., Deloukas, P., McCarthy, M.I., Wareham, N.J., Barroso I. (2008): Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40, 768-775
Martinelli, N., Girelli, D., Malerba, G., Guarini, P., Illig, T., Trabetti, E., Sandri, M., Friso, S., Pizzolo, F., Schaeffer, L., Heinrich, J., Pignatti, P.F., Corrocher, R., Olivieri, O. (2008): FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. Am J Clin Nutr. 88, 941-9.
Suhre, K., Schmitt-Kopplin, P. (2008): MassTRIX: mass translator into pathways. Nucleic Acids Res. 36 (Web Server issue): W481-484.
Wang-Sattler, R., Yu, Y., Mittelstrass, K., Lattka, E., Altmaier, E., Gieger, C.H., Ladwig, K.H., Dahmen, N., Hao, P., Liu, L., Li, Y., Wichmann, H.E., Weinberger, K.H., Adamski, J., Suhre, K., Illig, T. (2009): Metabolic profile analysis reveals distinct variations linked to nicotine consumption in humans. PLOS One, 2008 Nov; 3(12):e3863
Grallert, H., Sedlmeier, E.M., Huth, C., Kolz, M., Heid, I.M., Meisinger, C., Herder, C., Strassburger, K., Gehringer, A., Haak, M., Giani, G., Kronenberg, F., Wichmann, H.E., Adamski, J., Paulweber, B., Illig, T., Rathmann, W. (2007): APOA5 variants and metabolic syndrome in Caucasians. J Lipid Res 48, 2614-2621