metaP
The Metabolomic Platform (metaP) is a scientific interdisciplinary cooperation of Institutes of the Helmholtz Zentrum München.
The activities include both profiling (analyses of all measurable analytes to identify differences) and targeted analyses (quantification of a chosen set of analytes). These activities are possible by the unique contributions of participating Helmholtz Zentrum München institutes in the GAC like: high resolution profiling (FTICR-MS; PD Dr. Philippe Schmitt-Kopplin, IOEC,email), robotics and analyte quantification (GC-MS, LC-MS/MS QTrap; Prof. Dr. Jerzy Adamski, IEG, email), biobanking (PD Dr. Thomas Illig, EPI, email) and bioinformatics/project integration (Prof. Dr. Karsten Sure, IBIS, email).
A general description of MetaP is given here.
To see a comprehensive poster of our Metabolic Platform click here.
We successfully performed studies in the population based human KORA (Cooperative Health Research in the Region of Augsburg) cohort and in animal models in elucidating metabolomic effects in complex diseases or drug development, respectively.
The non-targeted approaches are followed in a lower throughput using two-dimensional chromatography coupled to mass spectrometry and flow injection ultrahigh resolution mass spectrometry with various ionization modes. We recently established the MassTRIX web-service (http://masstrix.org) annotating metabolite elemental compositions from ultrahigh resolution mass spectrometry data in their genomic context on KEGG pathway maps. Processing of data from targeted metabolomics experiments can be done at our automated server http://metabolomics.helmholtz-muenchen.de/metap2/).
