genome analysis center (gac)

2011

Zarzycki PK, Zarzycka MB, Clifton VL, Adamski J, Glod BK.
Low-parachorsolvents extraction and thermostated micro-thin-layer chromatography separationfor fast screening and classification of spirulina from pharmaceuticalformulations and food samples.
J Chromatogr A. 2011 Aug 19;1218(33):5694-704.

Altmaier E, Kastenmüller G, Römisch-Margl W, Thorand B, Weinberger KM, Illig T, Adamski J, Döring A, Suhre K: Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed ny quantitative tageted metabolomics.
Eur J Epidemiol 26, 145-156 (2011)

Brackertz B, Conrad H, Daniel J, Kast B, Krönig B, Busch DH, Adamski J, Peschel C and Bernhard H.
FLT3-regulated antigens as targets for leukemia-reactive cytotoxic T lymphocytes.
Blood Cancer Journal 1, e11; doi:10.1038/bcj.2011.12 (2011) in press
 
Fuchs H, Gailus-Durner V, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Da Silva-Buttkus P, Neff F, Götz A, Hans W, Hölter SM, Horsch M, Kastenmüller G, Kemter E, Lengger C, Maier H, Matloka M, Möller G, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Römisch-Margl W, Rozman J, Wang-Sattler R, Schrewe A, Stöger C, Tost M, Adamski J, Aigner B, Beckers J, Behrendt H, Busch DH, Esposito I, Graw J, Illig T, Ivandic B, Klingenspor M, Klopstock T, Kremmer E, Mempel M, Neschen S, Ollert M, Schulz H, Suhre K, Wolf E, Wurst W, Zimmer A, Hrabé de Angelis M: Mouse phenotyping.
Methods. 53, 120-135 (2011)

Halama A, Möller G, Adamski J:
Metabolic Signatures in Apoptotic Cancer Cell Lines.
OMICS 15(5), 325-35 (2011)

Horsch M, Seeburg PH, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Garrett L, Götz A, Hans W, Higuchi M, Hölter SM, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Schrewe A, Adamski J, Busch DH, Esposito I, Graw J, Ivandic B, Klingenspor M, Klopstock T, Mempel M, Ollert M, Schulz H, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, de Angelis MH, Beckers J.
Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice.
J. Biol. Chem.  286(21), 18614-22 (2011)

Krumsiek J, Suhre K, Illig T, Adamski J, Theis FJ:
Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data.
BMC Syst. Biol. 5, 21 (2011)

Laaser I, Theis FJ, Hrabé de Angelis M, Kolb HJ, Adamski J:
Huge splicing frequency in human Y chromosomal UTY gene.
OMICS 15(3), 141-154 (2011)

Marchais-Oberwinkler S, Henn C, Möller G, Klein T, Negri M, Oster A, Spadaro A, Werth R, Wetzel M, Xu K, Frotscher M, Hartmann RW, Adamski J:
17ß-Hyroxysteroid-dehydrogenases (17ß-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development.
J. Steroid. Biochem. Mol. Biol. 125(1-2), 66-82 (2011)

Penning TM, Adamski J.
Integration of steroid research: Perspectives on environment factors, homeostasis in health, and disease treatment.
J. Steroid. Biochem. Mol. Biol. (2011)

Römisch-Margl W, Prehn C, Bogumil R, Röhring C, Suhre K, Adamski J.
Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics. Metabolomics, DOI 10.1007/s11306-011-0293-4 (2011) in press

Suhre K, Römisch-Margl W, Hrabé de Angelis M, Adamski J, Luippold G, Augustin R.
Identification of a Potential Biomarker for FABP4 Inhibition: The Power of Lipidomics in Preclinical Drug Testing.
J Biomol. Screen. (2011) [Epub ahead of print]

Schuster D, Kowalik D, Krichmair J, Laggner C, Markt P, Aebische-Gumy C, Ströhle F, Möller G, Wolber G, Wilckens T, Langer T, Odermatt A, Adamski J:
Identification of chemically divers, novel inhibitors of 17beta-hydroxysteroid dehydrogenase type 3 and type 5 by pharmacophore-based virtual screening.
J. Steroid. Biochem. Mol. Biol. 125(1-2), 148-61 (2011)

Vouk K, Smuc T, Guggenberger C, Pucelj MR, Sinkovec J, Husen B, Thole H, Houba P, Thaete C, Adamski J, Rižner TL.
Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis.
J Steroid Biochem. Mol. Biol.  125(3-5), 231-42 (2011)
 

2010

Brandl M, Seidler B, Haller F, Adamski J, Schmid RM, Saur D, Schneider G:
IKKα controls canonical TGFbeta-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells.
J. Cell Sci. 123, 4231-4239 (2010)

Haller F, Moman E, Hartmann RW, Adamski J, Mindnich R:
Molecular framework of steroid/retinoid discrimination in 17beta-hydroxysteroid dehydrogenase type 1 and photoreceptor-associated retinol dehydrogenase.
J. Mol. Biol. 399, 255-267 (2010)

Illig T, Gieger C, Zhai GJ, Römisch-Margl W, Wang-Sattler R, Prehn C, Altmaier E, Kastenmüller G, Kato BS, Mewes H-W, Meitinger T, Hrabé de Angelis M, Kronenberg F, Soranzo N, Wichmann H-E, Spector TD, Adamski J, Suhre K:
A genome-wide perspective of genetic variation in human metabolism.
Nat. Genet. 42, 137-141 (2010)

Lattka E, Eggers S, Möller G, Heim K, Weber M, Mehta D, Prokisch H, Illig T, Adamski J:
A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1.
J. Lipid. Res. 51, 182-191 (2010)

Möller G, Husen B, Kowalik D, Hirvelä L, Plewczynski D, Rychlewski L, Messinger J, Thole H, Adamski J:
Species used for drug testing reveal different inhibition susceptibility for 17beta-hydroxysteroid dehydrogenase type 1.
PLoS One 5:e10969 (2010)

Suhre K, Meisinger C, Döring A, Altmaier E, Belcredi P, Gieger C, Chang D, Milburn MV, Gall WE, Weinberger KM, Mewes H-W, Hrabé de Angelis M, Wichmann H-E, Kronenberg F, Adamski J, Illig T:
Metabolic footprint of diabetes: A multiplatform metabolomics study in an epidemiological setting.
PLoS One 5, e13953 (2010)

2009

Adamski J:
Mission to steroids.
J. Steroid Biochem. Mol. Biol. 113, 1-2 (2009)

Altmaier E, Kastenmüller G, Römisch-Margl W, Thorand B, Weinberger KM, Adamski J, Illig T, Döring A, Suhre K:
Variation in the human lipidome associated with coffee consumption as revealed by quantitative targeted metabolomics.
Mol. Nutr. Food Res. 53, 1357-1365 (2009)

Brozic P, Kocbek P, Sova M, Kristl J, Martens S, Adamski J, Gobec S, Lanisnik Rizner T:
Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.
Mol. Cell. Endocrinol. 301, 229-234 (2009)

Fuchs H, Gailus-Durner V, Adler T, Aguilar Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C, Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Maier H, Mossbrugger I, Mörth C, Naton B, Nöth U, Pasche B, Prehn C, Przemeck GKH, Puk O, Rácz I, Rathkolb B, Rozman J, Schäble K, Schreiner R, Schrewe A, Sina C, Steinkamp R, Thiele F, Willershäuser M, Zeh R, Adamski J, Busch DH, Beckers J, Behrendt H, Daniel H, Esposito I, Favor J, Graw J, Heldmaier G, Höfler H, Ivandic B, Katus H, Klingenspor M, Klopstock T, Lengeling A, Mempel M, Müller W, Neschen S, Ollert M, Quintanilla-Martinez L, Rosenstiel P, Schmidt J, Schreiber S, Schughart K, Schulz H, Wolf E, Wurst W, Zimmer A, Hrabé de Angelis M:
The German Mouse Clinic: A platform for systemic phenotype analysis of mouse models.
Curr. Pharm. Biotechnol. 10, 236-243 (2009)

Haussuehl K, Huesgen PF, Meier M, Dessi P, Glaser E, Adamski J, Adamska I:
Eukaryotic GCP1 is a conserved mitochondrial protein required for progression of embryo development beyond the globular stage in Arabidopsis thaliana.
Biochem. J. 423, 333-341 (2009)

Hult M, Ortsäter H, Schuster G, Graedler F, Beckers J, Adamski J, Ploner A, Jörnvall H, Bergsten P, Oppermann U:
Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms.
Mol. Cell. Endocrinol. 301, 109-116 (2009)

Keller B, Meier M, Adamski J:
Comparison of predicted and experimental subcellular localization of two putative rat steroid dehydrogenases from the short-chain dehydrogenase/reductase protein superfamily.
Mol. Cell. Endocrinol. 301, 43-46 (2009)

Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E, Wallace C, Farrall M, Johansson A, Nyholt DR, Aulchenko Y, Beckmann JS, Bergmann S, Bochud M, Brown M, Campbell H, Connell J, Dominiczak A, Homuth G, Lamina C, McCarthy MI, Meitinger T, Mooser V, Munroe P, Nauck M, Peden J, Prokisch H, Salo P, Salomaa V, Samani NJ, Schlessinger D, Uda M, Völker U, Waeber G, Waterworth D, Wang-Sattler R, Wright AF, Adamski J, Whitfield JB, Gyllensten U, Wilson JF, Rudan I, Pramstaller P, Watkins H, Döring A, Wichmann H-E, Spector TD, Peltonen L, Völzke H, Nagaraja R, Vollenweider P, Caulfield M, Illig T, Gieger C:
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.
PLoS Genet. 5(6), e1000504 (2009)

Kowalik D, Haller F, Adamski J, Möller G:
In search for function of two human orphan SDR enzymes: Hydroxysteroid dehydrogenase like 2 (HSDL2) and short-chain degydrogenase/reductase-orphan (SDR-O).
J. Steroid Biochem. Mol. Biol. 117, 117-124 (2009)

Meier M, Möller G, Adamski J:
Perspectives in understanding the role of human 17beta-hydroxysteroid dehydrogenases in health and disease.
Ann. N.Y. Acad. Sci. 1155, 15-24 (2009)

Meier M, Tokarz J, Haller F, Mindnich R, Adamski J:
Human and zebrafish hydroxysteroid dehydrogenase like 1 (HSDL1) proteins are inactive enzymes but conserved among species.
Chem. Biol. Interact. 178, 197-205 (2009)

Michiels PJ, Ludwig C, Stephans M, Fischer C, Möller G, Adamski J, Messinger J, van Dongen M, Thole H, Günther UL:
Ligand-based NMR spectra demonstrate an additional phytoestrogen binding site for 17beta-hydroxysteroid dehydrogenase type 1.
J. Steroid Biochem. 117, 93-98 (2009)

Mindnich R, Adamski J:
Zebrafish 1beta-hydroxysteroid dehydrogenases: An evolutionary perspective.
Mol. Cell. Endocrinol. 301, 20-26 (2009)

Möller G, Adamski J:
Integrated view on 17beta-hydroxysteroid dehydrogenases.
Mol. Cell. Endocrinol. 301, 7-19 (2009)

Möller G, Deluca D, Gege C, Rosinus A, Kowalik D, Peters O, Droescher P, Elger W, Adamski J, Hillisch A:
Structure-based design, synthesis and in vitro characterization of potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and d-homo-estrone.
Bioorg. Med. Chem. Lett. 19, 6740-6744 (2009)

Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U:
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.
Chem. Biol. Interact. 178, 94-98 (2009)

Prehn C, Möller G, Adamski J:
Recent advances in 17beta-hydroxysteroid dehydrogenases.
J. Steroid Biochem. Mol. Biol. 114, 72-77 (2009)

Rasiah KK, Gardiner-Garden M, Padilla EJD, Möller G, Kench JG, Alles MC, Eggleton SA, Stricker PD, Adamski J, Sutherland RL, Henshall SM, Hayes VM:
HSD17B4 overexpression, an independent biomarker of poor patient outcome in prostate cancer.
Mol. Cell. Endocrinol. 301, 89-96 (2009)

Schedel M, Frei R, Bieli C, Cameron L, Adamski J, Lauener R, Kabesch M:
An IgE-associated polymorphism in STAT6 alters NF-κB binding, STAT6 promoter activity, and mRNA expression.
J. Allergy Clin. Immunol. 124, 583-589 (2009)

Suttner K, Depner M, Klopp N, Illig T, Vogelberg C, Adamski J, von Mutius E, Kabesch M:
Genetic variants in the GATA3 gene are not associated with asthma and atopic diseases in German children.
J. Allergy Clin. Immunol. 123, 1179-1181 (2009)

Suttner K, Ruoss I, Rosenstiel P, Depner M, Pinto LA, Schedel M, Adamski J, Illig T, Schreiber S, von Mutius E, Kabesch M:
HLX1 gene variants influence the development of childhood asthma.
J. Allergy Clin. Immunol. 123, 82-88.e6 (2009)

Suttner K, Rosenstiel P, Depner M, Schedel M, Pinto LA, Ruether A, Adamski J, Klopp N, Illig T, Vogelberg C, Schreiber S, von Mutius E, Kabesch M:
TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants.
J. Allergy Clin. Immunol. 123, 1062-1068 (2009)

Tarrant AM, Reitzel AM, Blomquist CH, Haller F, Tokarz J, Adamski J:
Steroid metabolism in cnidarians: Insights from Nematostella vectensis.
Mol. Cell. Endocrinol. 301, 27-36 (2009)

2008

Gieger C, Geistlinger L, Altmaier E, Hrabé de Angelis M, Kronenberg F, Meitinger T, Mewes H-W, Wichmann H-E, Weinberger KM, Adamski J, Illig T, Suhre K:
Genetics meets metabolomics: A Genome-wide association study of metabolite profiles in human serum.
PLoS Genet. 4, e1000282 (2008)

Kormann MS, Depner M, Hartl D, Klopp N, Illig T, Adamski J, Vogelberg C, Weiland SK, von Mutius E, Kabesch M:
Toll-like receptor heterodimer variants protect from childhood asthma.
J. Allergy Clin. Immun. 122, 86-92 (2008)

Wang-Sattler R, Yu, Y, Mittelstrass K, Lattka E, Altmaier E, Gieger C, Ladwig K-H, Dahmen N, Weinberger KM, Hao P, Liu L, Li, Y, Wichmann H-E, Adamski J, Suhre K, Illig T:
Metabolic profiling reveals distinct variations linked to nicotine consumption in humans - first results from the KORA study.
PLoS ONE 3, e3863 (2008)

2007

Grallert H, Sedlmeier EM, Huth C, Kolz M, Heid IM, Meisinger C, Herder C, Strassburger K, Gehringer A, Haak M, Giani G, Kronenberg F, Wichmann H-E, Adamski J, Paulweber B, Illig T, Rathmann W:
APOA5 variants and metabolic syndrome in Caucasians.
J. Lipid Res. 48, 2614-2621 (2007)

Guggenberger C, Ilgen D, Adamski J:
Functional analysis of cholesterol biosynthesis by RNA interference.
J. Steroid Biochem. Mol. Biol. 104, 105-109 (2007)

Keller B, Adamski J:
RDH12, a retinol dehydrogenase causing Leber's congenital amaurosis, is also involved in steroid metabolism.
J. Steroid Biochem. Mol. Biol. 104, 190-194 (2007)

Kristan K, Adamski J, Lanisnik Rizner T, Stojan J:
His164 regulates accessibility to the active site in fungal 17beta-hydroxysteroid dehydrogenase.
Biochimie 89, 63-71 (2007)

Kristan K, Stojan J, Adamski J, Lanisnik Rizner T:
Rational design of novel mutants of fungal 17beta-hydroxysteroid dehydrogenase.
J. Biotechnol. 129, 123-130 (2007)

Lukacik P, Keller B, Bunkoczi G, Kavanagh K, Lee WH, Adamski J:
Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.
Biochem. J. 402, 419-427 (2007)

Mindnich R, Adamski J:
Functional aspects of 17beta-bydroxysteroid dehydrogenase 1 determined by comparison to a closely related retinol dehydrogenase.
J. Steroid Biochem. Mol. Biol. 104, 334-339 (2007)

Mindnich R, Hrabé de Angelis M, Adamski J:
Functional genome analysis indicates loss of 17beta-hydroxysteroid dehydrogenase type 2 enzyme in the zebrafish.
J. Steroid Biochem. Mol. Biol. 103, 35-43 (2007)

2006

Adamski J:
Search for function and modulation of enzyme activity: The international workshop on 11 beta and 17beta-hydroxysteroid dehydrogenases, 08-11.May 2005, Elmau Castle, Germany.
Mol. Cell. Endocrinol. 248, 1-2 (2006)

Deluca D, Möller G, Rosinus A, Elger W, Hillisch A, Adamski J:
Inhibitory effects of fluorine-substituted estrogens on the activity of 17beta-hydroxysteroid dehydrogenases.
Mol. Cell. Endocrinol. 248, 218-224 (2006)

Ebert R, Schütze N, Adamski J, Jakob F:
Vitamin D signaling is modulated on multiple levels in health and disease.
Mol. Cell. Endocrinol. 248, 149-159 (2006)

Grallert H, Huth C, Kolz M, Meisinger C, Herder C, Strassburger K, Giani G, Wichmann H-E, Adamski J, Illig T, Rathmann W:
IL-6 promoter polymorphisms and qantitative traits related to the metabolic syndrome in KORA S4.
Exp. Gerontol. 41, 737-745 (2006)

Guo K, Lukacik P, Papagrigoriou E, Meier M, Lee WH, Adamski J, Oppermann U:
Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme.
J. Biol. Chem. 281, 10291-10297 (2006)

Keller B, Grote K, Adamski J:
In silico Northern blot, an automated method to determine expression patterns from EST databases, reveals tissue specificity of murine 17beta-hydroxysteroid dehydrogenase type 11.
Mol. Cell. Endocrinol. 248, 242-245 (2006)

Keller B, Ohnesorg T, Mindnich R, Gloeckner CJ, Breitling R, Scharfe M, Möller G, Blöcker H, Adamski J:
Interspecies comparison of gene structure and computational analysis of gene regulation of 17beta-hydroxysteroid dehydrogenase type 1.
Mol. Cell. Endocrinol. 248, 168-171 (2006)

Keller B, Volkmann A, Wilckens T, Möller G, Adamski J:
Bioinformatic identification and characterization of new members of short-chain dehydrogenase/reductase superfamily.
Mol. Cell. Endocrinol. 248, 56-60 (2006)

Möller G, Adamski J:
Multifunctionality of human 17-hydroxysteroid dehydrogenases.
Mol. Cell. Endocrinol. 248, 47-55 (2006)

Ohnesorg T, Adamski J:
Analysis of the 5' flanking regions of human and murine HSD17B7: Identification of a cholesterol dependent enhancer region.
Mol. Cell. Endocrinol. 248, 164-167 (2006)

Ohnesorg T, Keller B, Hrabé de Angelis M, Adamski J:
Transcriptional regulation of human and murine 17beta-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis.
J. Mol. Endocrinol. 37, 185-197 (2006)

Smuc T, Rupreht R, Sinkovec J, Adamski J, Lanisnik Rizner T:
Expression analysis of estrogen-metabolizing enzymes in human endometrial cancer.
Mol. Cell. Endocrinol. 248, 114-117 (2006)