Towards a comparative transcriptomics and proteomics approach
PD Dr. Johannes Beckers
Institute of Experimental Genetics l
Most biochemical processes within and between cells are put into effect by the interaction between proteins, or between proteins and their substrates (Ge et al., 2001; Li et al., 2004; Walhout and Vidal, 2001) . The proteome of a cell is the result of controlled biosynthesis, and hence largely (but not exclusively) regulated by gene expression (Kanapin et al., 2003) . Vice versa, the transcriptome can be regarded as a sensitive read-out of the proteome or the biochemical state of the cell. Thus, transcriptome and proteome feed back to each other in a highly complex and controlled way. The understanding of this functional regulation is generally limited to distinct signalling or metabolic pathways. To begin to understand the mutual regulatory interactions between transcriptome and proteome, a comparative approach including the simultaneous monitoring of expression at the RNA and protein levels will be required.
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