Institut für Diabetesforschung

Schriftgröße »A . A+ . A++ .

Univ-Prof. Dr. med. Anette-Gabriele Ziegler

 

Univ.-Prof. Dr. med. Anette-Gabriele Ziegler

Leiterin

Tel: 089 / 3187 2896
Fax: 089 / 3187 3144


 

Publikationen von Univ.-Prof. Dr. med. Anette-Gabriele Ziegler:

  1. Ziegler AG, Janka HU, Meister P, Spelsberg F, Mehnert H.  Multiple endokrine Neoplasie Typ IIb mit Ganglioneuromatose der Gallenblase, Cholelithiasis und Kleinhirndysplasie.  Akt Endokrin Stoff 1986; 7:156 159.

  2. Ziegler AG, Janka HU, Mehnert H. Transitorische ischämische Attacken bei Hyperparathyreoidismus. Dtsch med Wschr 1987; 112:345-347. IF 0.590

  3. Ziegler AG, Standl E, Lander T, Nerl C, Rieber EP, Mehnert H.  Cell mediated auotimmunity at the onset of Type I diabetes mellitus. Klin Wschr 1987; 65:546-550.

  4. Ziegler AG, Standl E.  Loss of Ia-positive Langerhans cells at the onset of Type 1 (insulin-dependent) diabetes mellitus.  Diabetologia 1988; 31:362-365. IF 6.551

  5. Vardi P, Ziegler AG, Mathews JH, Dib SA, Keller RJ, Ricker AT, Wolfsdorf JI, Herskowitz RD, Rabizadeh A, Eisenbarth GS, Soeldner JS. Concentrations of insulin autoantibodies at onset of Type 1 diabetes: inverse log-linear correlation with age. Diabetes Care , 1988; 11:736-739. IF 6.718

  6. Canadian European Randomized Control Trial Group. Cyclosporin-induced remission of IDDM after early intervention.  Association of 1 yr of Cyclosporin treatment with enhanced insulin secretion.  Diabetes 1988; 37:1574-82. IF 8.505

  7. Park JW, Ziegler AG, Janka HU, Doering W, Mehnert H.  Left ventricular relaxation and filling pattern in diabetic heart muscle disease: An echocardiographic study. Klin Wschr, 1988; 66:773-778.

  8. Ziegler AG, Vardi P, Ricker AT, Hattori M, Soeldner JS, Eisenbarth GS. Radioassay determination of insulin autoantibodies in NOD mice. Correlation with increased progression to overt diabetes.  Diabetes 1989; 38:358-63. IF 8.505

  9. Ziegler AG, Vardi P. Gross D, Bonner-Weir S, Villa-Komaroff L, Halban P, Ikegami H, Soeldner JS, Eisenbarth GS.  Production of insulin antibodies by mice rejecting insulin gene transfected cells.  J Autoimmunity 1989; 2:219-227. IF 7.231

  10. Ziegler AG, Ziegler R, Vardi P, Jackson RA, Soeldner JS, Eisenbarth GS. Life table analysis of progression to diabetes of anti-insulin autoantibody positive relatives of Type 1 diabetics.  Diabetes 1989; 38:1320-25. IF 8.505

  11. Standl R, Stiegler H, Rebell B, Ziegler AG, Schauer G, Roth R, Schulz K, Lehmacher W, Standl E: Der Typ-II-Diabetes in der Praxis des niedergelassenen Arztes: -Konzept einer zentrumsunterstützten Betreuung und Ergebnisse einer Stichproben-Erhebung im Großraum München. Akt. Endokr Stoffw 1990; 11:233-235.

  12. Ziegler AG, Baumgartl HJ, Standl E, Mehnert H: Risk of progression to diabetes of "low titer ICA" positive first degree relatives of Type 1 diabetics in Southern Germany. J Autoimmunity 1990; 3:619-624. IF 7.231

  13. Ziegler AG, Baumgartl HJ, Ede G, Held M, Vogt H, Kolb HJ, Standl E: Low pigment skin type and predisposition for development of type 1 diabetes? Diabetes Care 1990;13:529-31. IF 6.718

  14. Ziegler AG, Standl E, Albert E, Mehnert H. HLA-associated insulin autoantibody (IAA) formation in newly diagnosed type 1 (insulin  dependent) diabetic patients. Diabetes 1991; 40:1146-49. IF 8.505

  15. Ziegler AG, Rabl W, ALbert E, Standl E. Insulin-Autoantikörper und Inselzell-Antikörper in Abhängigkeit vom Manifestationsalter und HLA  Phänotyp bei Patienten mit neumanifestem Typ-I-Diabetes mellitus. Dtsch med Wschr 1991; 116: 1737-1741. IF 0.590

  16. Martin S, Pawlowski B, Greulich B, Ziegler AG, Mandrup-Poulsen T, Mahon J. The natural course of remission in type 1 (insulin-dependent) diabetes during the first year after diagnosis. Diabetes Care 1992; 15: 66-74. IF 6.718

  17. Baumgartl HJ, Standl E, Schmidt-Gayk H, Kolb HJ, Janka HU, Ziegler AG. Changes of Vitamin D3 serum concentrations at the onset of immune  mediated type 1 (insulin-dependent) diabetes mellitus. Diabetes Research 1992; 16:145-148. 

  18. Ziegler AG, Baumgartl HJ, Mühlbauer K, Mehnert S, Standl E. Familienuntersuchung bei Typ-I-Diabetes. Hinweise für eine gemeinsame genetische Komponente von Typ-I- und Typ-II-Diabetes. Diabetes und Stoffwechsel 1992; 1:14-17.

  19. Ziegler AG, Erhard J, Lampeter EF, Nagelkerken LM, Standl E. Involvement of dendritic cells in early insulitis of BB rats. J Autoimmunity 1992; 5:571-579. IF 7.231

  20. Ziegler AG, Mathies R, Ziegelmayer G, Baumgartl HJ, Rodewald A, Chopra V, Standl E. Dermatoglyphics in type 1 diabetes mellitus. Diabetic Medicine 1993; 10:720-24. IF 2.871

  21. Castano L, Ziegler AG, Ziegler R, Shoelson S, Eisenbarth GS. Characterization of insulin autoantibodies in relatives of patients with type 1 diabetes. Diabetes  1993; 42:1202-209. IF  8.505 

  22. Ziegler AG, Hillebrand B, Rabl W, Mayrhofer M, Mollenhauer U, Vordemann J, Lenz A, Standl E: On the appearance of islet associated autoimmunity in offspring of diabetic mothers: a prospective study from birth. Diabetologia 1993; 36:402-408. IF 6.551

  23. Ziegler AG, Hillebarnd B, Standl E. Inselzellantikörper und Insulin  Autoantikörper bei Schwangeren mit Gestationsdiabetes. Diabetes und Stoffwechsel 1993; 2:51-55.

  24. Roll U, Christie MR, Standl E, Ziegler AG. Association of anti-GAD- antibodies with islet cell antibodies and insulin autoantibodies in first degree relatives of type 1 diabetic patients. Diabetes 1994; 43:154-60. IF  8.505

  25. Baumgartl HJ, Trucco M, Albert E, Mehnert S, Knapp M, Standl E, Ziegler AG. Assoziation von HLA-DQ-Markern und Typ-I-Diabetes in süddeutschen Multiplexfamilien. Diabetes und Stoffwechsel 1994; 3:278-282.

  26. Roll U, Scheeser J, Standl E, Ziegler AG. Alterations of lymphocyte subsets in children of diabetic mothers. Diabetologia 1994; 37:1132-1141. IF 6.551

  27. Durinovic-Bello I, Steinle A, Ziegler AG, Schendel D. HLA-DQ-restricted, islet-specific T cell clones of a type 1 diabetic patient: T cell receptor sequence similarities to insulitis-inducing T cells of nonobese diabetic mice. Diabetes 1994; 43:1318-1325. IF 8.505

  28. Roll U, Nuber A, Schröder A, Gerlach E, Janka HU, Ziegler AG. No association of antibodies to glutamic acid decarboxylase (GAD) and diabetic complications in patients with type 1 (insulin-dependent) diabetes mellitus. Diabetes Care 1995; 18:210-215. IF 6.718
  29. Durinovic-Bello I, Hummel M, Ziegler AG. Cellular immune response to divers islet cell antigens. Diabetes 1996; 45:795-801. IF 8.505

  30. Roll U, Christie MR, Füchtenbusch M, Payton MA, Hawkes CJ, Ziegler AG: Perinatal autoimmunity in offspring of diabetic parents: the German multicenter 'BABY-DIAB' study. Detection of humoral immune responses to islet antigens in early childhood. Diabetes 1996; 45:967-973. IF 8.505

  31. Schnell O, Muhr D, Dresel S, Tatsch K, Ziegler AG, Haslbeck M, Standl E. Autoantibodies against symphathetic ganglia and evidence of cardiac sympathetic dysinnervation in newly diagnosed and long-term IDDM patients. Diabetologia 1996; 39:970-975. IF 6.551

  32. Mayrhofer M, Rabin DU, Messenger L, Standl E, Ziegler AG. Value of ICA512 antibodies for prediction and diagnosis of type 1 diabetes. Exp Clin Endocrinol Diabetes 1996; 104:228-234. IF 8.505

  33. Hummel M, Durinovic-Bello I, Ziegler AG. Relation between cellular and humoral immunity to islet cell antigens in type 1 diabetes. J Autoimmunity 1996; 9:427-430. IF 7.231

  34. Hummel M, Ziegler AG and BABY-DIAB participants: Vaccines and the appearance of islet cell antibodies in offspring of diabetic parents: results from the BABY-DIAB study. Diabetes Care 1996; 19:1456-1457. IF 6.718

  35. Naserke HE, Durinovic-Bello I, Seidel D, Ziegler AG. The T-cell receptor beta chain CDR3-region of BV8S1/BJ1S5-transcripts in type 1 diabetes. Immunogenetics 1996; 45:87-96. IF 2.988

  36. Bingley PJ for the ICARUS group. Interactions of age, islet cell antibodies, insulin autoantibodies, and first phase insulin response in predicting risk of progression to IDDM in ICA+ relatives. Diabetes 1996; 45:1720-1728. IF 8.505

  37. Füchtenbusch M, Karges W, Standl E, Dosch HM, Ziegler AG. Antibodies to bovine serum albumine (BSA) in type 1 diabetes and other autoimmune disorders. Exp Clin Endocrinol Diabetes 1997; 105:86-91. IF 1.685

  38. Weichenhain B, Stemplinger J, Ziegler AG, Rabl W, Standl E, Stiegler H. Alström-Syndrom - eine seltene Erkrankung aus dem diabetischen Formenkreis. Med Klin 1997 ;92:175-178. IF 0.473

  39. Endl J, Otto H, Jung G, Meinl E, Hummel M, Ziegler AG, Wank R, Schendel DJ. Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients. J Clin Invest 1997; 99:2405-2415. IF 15.387

  40. Christie MR, Roll U, Payton MA, Hatfield ECI, Ziegler AG. Validity of screening for individuals at risk for type 1 diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care 1997; 20:965-970. IF 6.718

  41. Füchtenbusch M, Ferber K, Standl E, Ziegler AG, and participating centers. Prediction of type 1 diabetes postpartum in patients with gestational diabetes mellitus by combined islet cell autoantibody screening. Diabetes 1997; 46:1459-1467. IF 8.505

  42. Schnell O, Eisfelder B, Standl E, Ziegler AG. High dose intravenous insulin infusion versus intensive insulin treatment in newly diagnosed IDDM. Diabetes 1997; 46:1607-1611. IF 8.505

  43. Muhr D, Mollenhauer U, Ziegler AG, Haslbeck M, Standl E, Schnell O. Autoantibodies to sympathetic ganglia, GAD, or tyrosine phosphatase in long-term IDDM with and without ECG-based cardiac autonomic neuropathy. Diabetes Care 1997; 20:1009-1012. IF 6.718

  44. Dittler J, Seidel D, Schenker M, Ziegler AG. GADIA2-combi determination as first line screening for improved prediction of type 1 diabetes in relatives. Diabetes 1998; 47:592-597. IF 8.505

  45. Füchtenbusch M, Rabl W, Graßl B, Bachmann W, Standl E, Ziegler AG. Delay of type 1 diabetes in high risk first degree relatives by parenteral antigen administration. The Schwabing Insulin Prophylaxis (SIP)-pilot trial. Diabetologia 1998; 41:536-541. IF 6.551

  46. Hummel M, Durinovic-Bello I, Bonifacio E, Lampasona V, Endl J, Fessele S, Trenkwalder C, Standl E, Ziegler AG. Humoral and cellular immune parameters before and during immunsuppressive therapy of a patient with stiff-man syndrome and IDDM. J Neurology, Neurosurgery, Psychiatry 1998; 65:204-208. IF 4.869

  47. Muhr-Becker D, Ziegler AG, Druschky A, Wolfram G, Haslbeck M, Neundörfer B, Standl E, Schnell O. Evidence for specific autoimmunity against sympathetic and parasympathetic nervous tissues in type 1 diabetes mellitus and the relation to cardiac autonomic dysfunction. Diabetic Medicine 1998; 15:467-472. IF 2.871

  48. Naserke H, Dozio N, Ziegler AG, Bonifacio E. Comparison of a novel micro-assay for insulin autoantibodies with the conventional radiobinding assay. Diabetologia1998; 41:681-683. IF 6.551

  49. Seidel DK, Geiss HC, Donner MG, Ritter MM, Schwandt P, Koll RA, Standl E, Ziegler AG. Course of islet autoantibody tiers during Ig-immunoadsorption in a patient with newly diagnosed type 1 diabetes. J Autoimmunity 1998; 11:273-277. IF 7.231

  50. Hummel M, Banholzer P, Rabl W, Ziegler AG. Organspecific lymph node enlargement in autoimmune polyglandular syndrome. Diabetes Care 1998; 21:1573-1574. IF 6.718

  51. Naserke HE, Ziegler AG, Lampasona V, Bonifacio E. Early development and spreading of autoantibodies to epitopes of IA-2 and their association with progression to type 1 diabetes, J Immunology 1998; 161:6963-6969. IF 5.646

  52. Ziegler AG, Hummel M, Schenker M, Bonifacio E. Autoantibody appearance and risk for the development of childhood diabetes in offspring of parents with type 1 diabetes: the two year analysis of the BABYDIAB study. Diabetes 1999; 48, 460-468. IF 8.505

  53. Schenker M, Hummel M, Ferber K, Walter M, Keller E, Albert ED, Janka HU, Kastendiek C, Sorger M, Louwen F, Ziegler AG. Early expression and high prevalence of islet autoantibodies for DR¾ heterozygous and DR4/4 homozygous offspring of parents with type 1 diabetes: The German BABYDIAB study. Diabetologia 1999; 42:671-677. IF 6.551

  54. Naserke HE, Bonifacio E, Ziegler AG. Immunoglobulin G insulin autoantibodies in BABYDIAB offspring appear postnatally: sensitive early detection using a protein A/G-based radiobinding assay. J Clin Endocrinol Metab 1999; 84:1239-1243. IF 6.202

  55. Bonifacio E, Scirpoli M, Kredel K, Füchtenbusch M, Ziegler AG. Early autoantibody responses in prediabetes are IgG1 dominated and suggest antigen-specific regulation. J Immunology 1999; 163:525-532. IF 5.646

  56. Eaves IA, Bennett ST, Forster P, Ferber KM, Ehrmann D, Wilson AJ, Bhattacharyya, Ziegler AG, Brinkmann B, Todd JA. Transmission ratio distortion at the INS-IGF2 VNTR. Nature Genetics 1999; 22:324-325. IF 34.284

  57. Ferber KM, Keller E, Albert ED, Ziegler AG. Predictive value of HLA class II typing for the development of islet autoantibodies and insulin dependent diabetes postpartum in women with gestational diabetes. J Clin Endocrinol Metab 1999; 84 (7):2342-2348. IF 6.202

  58. Naserke HE, Schenker M, Ziegler AG. Frequency of islet autoantibodies in relatives of patients with type 2 diabetes or gestational diabetes. Diabetologia 1999 (letter); 42: 1377. IF 6.551

  59. Bonifacio E, Bernasconi L, Lampasona V, Ziegler AG. Maturation of the humoral autoimmune response to epitopes of GAD in pre-clinical childhood type 1 diabetes. Diabetes 2000; 49:202-208. IF 8.505

  60. Roll U, Turck CW, Gitelman SE, Rosenthal SM, Nolte MS, Ziegler AG, Baekkeskov S. Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in type 1 diabetic patients. Diabetologia 2000; 43:598-608. IF 6.551

  61. Ziegler AG, Bonifacio E. No inverse relationship between total IgE levels and islet autoimmunity in children of parents with type 1 diabetes. Diabetes Care 2000; 23:1205. IF 6.718

  62. Hummel M, Füchtenbusch M, Schenker M, Ziegler AG. No major association of breast-feeding, vaccinations, and childhood viral diseases with early islet autoimmunity in the German BABYDIAB Study. Diabetes Care 2000;23(7):969-74. IF 6.718

  63. Kolm-Litty V, Berlo S, Bonifacio E, Bearzatto M, Engel AM, Christie M, Ziegler AG, Wild T, Endl J. Human monoclonal antibodies isolated from type 1 diabetes patients define multiple epitopes in the protein tyrosine phosphatase-like IA-2 antigen. J Immunology 2000; 165: 4676. IF 5.646

  64. Füchtenbusch M, Kredel K, Bonifacio E, Schnell O, Ziegler AG. Exposure to exogenous insulin promotes IgG1 and the T-helper 2-associated IgG4 responses to insulin but not to other islet autoantigens. Diabetes 2000; 49:918. IF 8.505
  65. Hummel M, Bonifacio E, Stern M, Dittler J, Schimmel A, Ziegler AG. Development of celiac disease-associated antibodies in offspring of parents with type 1 diabetes. Diabetologia 2000; 43:1005. IF 6.551

  66. Hummel M, Heinlein W, Banholzer P, Standl E, Ziegler AG. Erstmanifestation eines Typ 1 Diabetes mit Anämie, Hyperparathyreodismus und abdomineller Lymphadenomatose. Der Internist 2001; 42:279-283.

  67. Schmid S, Schnell O, Bonifacio E, Ziegler AG, Hummel M. Silent celiac disease is not a cause of autonomic neuropathy in patients with type 1 diabetes. Diabetic Medicine 2001; 18:683. IF 2.871

  68. Hummel M, Ziegler AG. Environmental factors and type 1 diabetes - Response to G. Dahlquist. Diabetes Care 2001; 24:181-182. IF 6.718

  69. Hummel M, Schenker M, Ziegler AG. Influence of perinatal factors on the appearance of islet autoantibodies in offspring of parents with type 1 diabetes. Pediatric Diabetes 2001; 2:40. IF 2.628

  70. Hummel M, Ziegler AG, Lewy H, Ashkenazi I, Laron Z. IAA/GAD-positive offspring of diabetic parents have a different seasonality in month of birth than antibody-negative offspring. Diabetes Care 2001; 24:2001. IF 6.718

  71. Hummel M, Williams AJK, Norcross A, Standl E, Bonifacio E, Ziegler AG, Bingley P. Proinsulin-specific autoantibodies are relatively infrequent in young offspring with type 1 diabetes. Diabetes Care 2001; 24:1843. IF 6.718

  72. Bingley PJ, Bonifacio E, Ziegler AG, Schatz DA, Atkinson MA, Eisenbarth GS on behalf of the Immunology of Diabetes Society. Proposed guidelines on screening for risk of type 1 diabetes. Diabetes Care 2001; 24:398. IF 6.718

  73. Naserke H, Bonifacio E, Ziegler AG. Prevalence, characteristics and diabetes risk associated with transient maternally acquired islet antibodies and persistent islet antibodies in offspring of parents with type 1 diabetes (T1D). J Clin Endocrinol Metab 2001;86:4826. IF 6.202

  74. Füchtenbusch M, Irnstetter A, Jäger G, Ziegler AG. No evidence for an association of Coxsackie virus infection during pregnancy and early childhood with development of islet autoantibodies in offspring of mothers or fathers with type 1 diabetes. J Autoimmunity 2001;17: 333-40. IF 7.231

  75. Schnell O, Hammer K, Muhr-Becker D, Ziegler AG, Weiss M, Tatsch K, Standl E. Cardiac sympathetic dysinnervation in Type 2 diabetes mellitus with and without ECG-based cardiac autonomic neuropathy. J Diabetes and Complications 2002; 16:220. IF 2.110

  76. Durinovic-Bello I. Boehm B, Ziegler AG. Predominantly recognized ProInsulin T helper cell epitopes in individuals with and without islet cell autoimmunity. J Autoimmunity 2002; 18: 55-61. IF 7.231

  77. Bearzatto M, Naserke H, Piquer S, Koczwara K, Lampasona V, Williams A, Christie MR, Bingley P, Ziegler AG, Bonifacio E. Two distinctly HLA associated contiguous linear epitopes uniquely expressed within the IA-2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase like protein autoantigens. J Immunology 2002; 168(8):4202-8. IF 5.646

  78. Schmid S, Molteni A, Füchtenbusch M, Naserke H, Ziegler AG, Bonifacio E. Reduced IL-4 associated immune responses in early pre-diabetes. Diabetologia 2002; 45: 677-685. IF 6.551

  79. Hummel M, Bonifacio E, Naserke HE, Ziegler AG. Elimination of dietary gluten does not reduce titers of type 1 diabetes-associated autoantibodies in high risk subjects. Diabetes Care 2002; 25: 1111-1116. IF 6.718

  80. Walter M, Albert E, Conrad M, Keller E, Hummel M, Ferber K, Barratt B J, Todd A, Ziegler AG, Bonifacio E. IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of type 1 diabetes and associated autoimmunity. Diabetologia 2003; 46:712-720. IF 6.551

  81. Koczwara K, Schenker M, Schmid S, Kredel K, Ziegler AG, Bonifacio E. Characterization of antibody responses to endogenous and exogenous antigen in the nonobese diabetic mouse. Clinical Immunology 2003; 106: 155-162. IF 3.863

  82. Herbon N, Werner M, Braig Ch, Gohlke H, Dütsch G, Illig Th, Altmüller J, Hampe J, Lantermann A, Schreiber St, Bonifacio E, Ziegler AG, Schwab S, Wildenauer D, van den Boom D, Braun A, Knapp M, Reitmeir P, Wjst M. High-resolution SNP scan of chromosome 6p21 in pooled samples from patients with complex diseases. Genomics , 2003; 81: 510-518. IF 3.327

  83. Ziegler AG, Schmid S, Huber D, Hummel M, Bonifacio E. Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA , 2003. 290:1721-1728. IF 28.899

  84. Schmid S, Koczwara K, Schwinghammer S, Lampasona V, Ziegler AG, Bonifacio E. Delayed exposure to wheat and barley proteins reduces diabetes incidence in non-obese diabetic mice. Clinical Immunology 2004; 111: 108-118. IF 3.863

  85. Koczwara K, Bonifacio E, Ziegler AG. Transmission of Maternal Islet Antibodies and Risk of Autoimmune Diabetes in Offspring of Mothers With Type 1 Diabetes. Diabetes 2004; 53:3017-3020. IF 8.505

  86. Füchtenbusch M, Bonifacio E, Lampasona V, Knopff A, Ziegler AG. Immune responses to glutamic decarboxylase and insulin in patients with gestational diabetes. Clin Exp Immunol 2004; 135: 318-321. IF 3.009

  87. Koczwara K, Ziegler AG, Bonifacio E. Maternal immunity to insulin does not affect diabetes risk in progeny of non obese diabetic mice. Clin Exp Immunol 2004;136: 56-59. IF 3.009

  88. Achenbach P, Warncke K, Reiter J, Naserke H, Williams AJK, Bingley PJ, Bonifacio E, Ziegler AG. Stratification of Type 1 Diabetes Risk on the Basis of Islet Autoantibody Characteristics. Diabetes 2004; 53:384-392. IF 8.505

  89. Hummel M, Bonifacio E, Schmid S, Walter M, Knopff A, Ziegler AG. Islet Autoantibody Development and Risk for Childhood Type 1 Diabetes in Offspring of Affected parents. Ann of Internal Med 2004; 140: 882-886. IF 16.225

  90. Schmid S, Buuck D, Knopff A, Bonifacio E, Ziegler AG: BABYDIET, a feasibility study to prevent the appearance of islet autoantibodies in relatives of patients with Type 1 diabetes by delaying exposure to gluten. Diabetologia 2004; 47: 1130-1131. IF 6.551

  91. Achenbach P, Koczwara K, Knopff A, Naserke H, Ziegler AG, Bonifacio E: Mature high affinity immune responses to (pro)insulin anticipate the autoimmune cascade leading to type 1 diabetes. J Clin Invest  2004;114: 589-596. IF 15.387

  92. Bonifacio E, Hummel M, Walter M, Schmid S, Ziegler AG: IDDM1 and multiple family history of type 1 diabetes combine to identify neonates at high risk for childhood diabetes. Diabetes Care 2004; 27: 2695-2699. IF 6.718

  93. Lindsay RS, Ziegler AG, Hamilton BA, Calder AA, Johnstone FD, Walker JD. Scottish Multicentre Study of Diabetes in Pregnancy. Type 1 diabetes-related antibodies in the fetal circulation: prevalence and influence on cord insulin and birth weight in offspring of mothers with type 1 diabetes. J Clin Endocrinol Metab 2004; 89: 3436-3439. IF 6.202

  94.  Füchtenbusch M, Ziegler AG, Hummel M. Elimination of dietary gluten and development of type 1 diabetes in high risk subjects. Rev Diab Stud 2004; 1: 43-46.

  95. Hummel M, Ziegler AG, Roth R. Psychological impact of childhood islet autoantibody testing in families participating in the BABYDIAB study. Diabet Med 2004; 21: 324-328. IF 2.871

  96. Viskari H, Ludvigsson J, Uibo R, Salur L, Marciulionyte D, Hermann R, Soltesz G, Fuchtenbusch M, Ziegler AG, Kondrashova A, Romanov A, Knip M, Hyoty H. Relationship between the incidence of type 1 diabetes and enterovirus infections in different European populations: results from the EPIVIR project. J Med Virol 2004; 72: 610-617. IF 2.470

  97. Bonifacio E, Mollenhauer U, Buuck D, Ziegler AG: C-reactive protein concentration is not related to islet autoimmunity status in offspring of parents with type 1 diabetes. Clin Immunol, 2005; 115: 173-177. IF 3.863

  98. Viskari H, Ludvigsson J, Uibo R, Salur L, Marciulionyte D, Hermann R, Soltesz G, Füchtenbusch M, Ziegler AG, Kondrashova A, Romanov A, Kaplan B, Laron Z, Koskela P,  Vesikari T, Huhtala H, Knip M, and Hyöty H. Relationship between the incidence of type 1 diabetes and maternal enterovirus antobodies: time trends and geographical variation. Diabetologia 2005; 48: 1280-1287. IF 6.551

  99. Huppmann H, Baumgarten A, Ziegler AG, Bonifacio E. Neonatal Bacille Calmette-Guerin vaccination and type 1 diabetes mellitus. Diabetes Care , 28,2005; Number 5: 1204-1206. IF 6.718

  100. Keymeulen B, Vandemeulebroucke E, Ziegler AG, Mathieu C, Kaufman L, Hale G, Gorus F, Goldman M, Walter M, Candon S, Schandene L, Crenier L, De Block C, Seigneurin JM, De Pauw P, Pierard D, Weets I, Rebello P, Bird P, Berrie E, Frewin M, Waldmann H, Bach JF, Pipeleers D, Chatenoud L. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med 2005; (25):2642-2644. IF 47.050

  101. Schlosser M, Koczwara K, Kenk H, Strebelow M, Rjasanowski I, Wassmuth R, Achenbach P, Ziegler AG, Bonifacio E. In insulin-autoantibody-positive children from the general population, antibody affinity identifies those at high and low risk. Diabetologia 2005; 48: 1830-1832. IF 6.551

  102. Löbner K, Knopff A, Baumgarten A, Mollenhauer U, Marienfeld S, Garrido-Franco M, Bonifacio E, Ziegler AG. Predictors of postpartum diabetes in women with gestational diabetes mellitus. Diabetes, 2006; 55: 792-797. IF 8.505

  103. Hummel M, Schaaf L, Füchtenbusch M, Standl E, Ziegler AG. Hypertonie, Hypokaliämie und rasch progrediente Ödeme bei einem 62-jährigen Diabetiker. Der Internist 2006; 4: 427-433.

  104. TEDDY Investigators. TEDDY The Environmental Determinants of Diabetes in the Young. An observational clinical trial. Annals of New York Academy of Sciences, 2006; Volume: Immunology of Diabetes IV: progression in understanding, 1079:320-326. IF 2.670

  105. Achenbach P, Warncke K, Reiter J, Williams AJK, Ziegler AG, Bingley PJ, Bonifacio E. Type 1 diabetes risk assessment: improvement by follow-up measurements in young islet autoantibody-positive relatives. Diabetologia 2006; 49:2969-2976. IF 6.551

  106. Achenbach P, Schlosser M, Williams A, Yu L, Mueller P, Bingley P, Bonifacio E. Combined testing of antibody titer and affinity improves insulin autoantibody measurement: Diabetes Antibody Standardization Program. Clinical Immunology 2007; 122(1):85-90. IF 3.863

  107. Hummel S, Hummel M, Banholzer J, Hanak D, Mollenhauer U, Bonifacio E, Ziegler AG. Development of autoimmunity to transglutaminase C in children of patients with type 1 diabetes: relationship to islet autoantibodies and infant feeding. Diabetologia 2007; 50: 390-394. IF 6.551

  108. Hummel S, Winkler C, Schoen S, Knopff A, Marienfeld S, Bonifacio E, Ziegler AG: Breast feeding habits in families with type 1 diabetes. Diabet Med 2007; 24:671-676. IF 2.871

  109. Hummel M, Baumgarten A, Hummel S, König S, Ziegler AG: Smoking behavior during pregnancy of women with type 1 or gestational diabetes. Dtsch Med Wochenschr. 2007; 2132(21):1153-1158. IF 0.590

  110. Hummel M, Marienfeld S, Huppmann M, Knopff A, Voigt M, Bonifacio E, Ziegler AG. Interaction between maternal type 1 diabetes and HLA DR4 increases fetal growth. Diabetologia 2007; 50:850-8. IF 6.551

  111. Mayr A, Schlosser M, Grober N, Kenk H., Ziegler AG, Bonifacio E, Achenbach P: GAD Autoantibody Affinity and Epitope Specificity Identify Distinct Immunization Profiles in Children at Risk for Type 1 Diabetes. Diabetes 2007; 56: 1527-1533. IF 8.505

  112. Koczwara K, Müller D, Achenbach P, Ziegler AG, Bonifacio E. Insulin autoantibodies of IgA isotype that preferentially target non-human insulin. Clin Immunol 2007;124 (1): 77-82. IF 3.863

  113. Monti P, Scirpoli M, Rigamonti A, Mayr A, Jaeger A, Bonfanti R, Chiumello G, Ziegler AG, Bonifacio E : Evidence for in vivo primed and expanded autoreactive T Cells as a specific feature of patients with type 1 diabetes. Journal of Immunology 2007; 179: 5785-5792. IF 5.646

  114. Kiviniemi M, Hermann R, Nurmi J, Ziegler AG, Knip M, Simell O, Veijola R, Lövgren T, Ilonen J; TEDDY Study Group. A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (the Environmental Determinants of Diabetes in the Young) study. Diabetes Technol Ther , 2007;9(5):460-72. IF 2.620

  115. Bonifacio E, Achenbach P, Pan L, Ziegler AG. Mucosal insulin vaccination for type 1 diabetes prevention. Exp Clin Endocrinol Diabetes 2008 Sep; 116 Suppl 1:S 26-9. IF 1.685

  116. Achenbach P, Bonifacio E, Williams AJK, Ziegler AG, Gale EAM, Bingley PJ, and the ENDIT Group. 2008 Autoantibodies to IA-2β improve diabetes risk assessment in high risk relatives. Diabetologia 2008; 51(3):488-92. IF 6.551

  117. Bonifacio E, Pflüger M, Marienfeld S, Winkler C, Hummel M, Ziegler AG. Maternal type 1 diabetes reduces the risk of islet autoantibodies: relationship with birtweight and maternal HbA1c. Diabetologia 2008; 51(7):1245-52. IF 6.551

  118. Görlitz N, Keller M, Ziegler AG. Prävalenzen von Folge- und Begleiterkrankungen des Typ 2 Diabetes. Querschnittuntersuchungen an DMP-Teilnehmern in Bayern. DMW 2008; 133:1667-1672. IF 0.590

  119. Gohlke H, Ferrari U, Koczwara K, Bonifacio E, Illig T, Ziegler AG. SLC30A8 (ZnT8) Polymorphism is Associated with Young Age at Type 1 Diabetes onset. Rev Diabet Stud , 2008; 5(1):25-27.

  120. Hummel M, Geigenberger G, Brand J, Ziegler AG, Füchtenbusch M.:New therapeutic approaches to diabetic gastroparesis, Med Klin (Munich) 2008;103(7):514-8. IF 0.473

  121. Hummel S, Hummel M, Knopff A, Bonifacio E, Ziegler AG: Stillverhalten bei Frauen mit Gestationsdiabetes. DMW 2008; 133(5):180-184. IF 0.590

  122. Kreichauf S, Pflüger M, Hummel S, Ziegler AG: Einfluss des Stillens auf das Risiko für Übergewicht bei Kindern von Müttern mit Typ 1 Diabetes. DMW 2008; 133:1173-1177. IF 0.590

  123. Schoen S, Sichert-Hellert W, Hummel S, Ziegler AG, Kersting M. Breastfeeding duration in families with type 1 diabetes compared to non-affected families: results from BABYDIAB and DONALD studies in Germany. Breastfeed Med 2008; 3(3):171-175.

  124. Winkler C, Hummel S, Pflüger M, Ziegler AG, Geppert J, Demmelmair H, Koletzko B. The effect of maternal T1DM on the fatty acid composition of erythrocyte phosphatidylcholine and phosphatidyethanolamine in infants during early life. Eur J Nutr. 2008 ; 47(3):145-52. IF 2.866

  125. Winkler C, Mollenhauer U, Hummel S, Bonifacio E, Ziegler AG. Exposure to Environmental Factors in Drinking Water: Risk of Islet Autoimmunity and Type 1 Diabetes – The BABYDIAB Study. Horm Metab Res 2008; 40:566-571. IF 2.686

  126. Achenbach P, Lampasona V, Landherr U, Koczwara K, Krause S, Grallert H, Winkler C, Pflüger M, Illig T, Bonifacio E, Ziegler AG. Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk. Diabetologia 2009 ; 52 (9):1881-88. IF 6.551

  127. Bonifacio E, Mayr A, Knopff A, Ziegler AG. Endocrine autoimmunity in families with type 1 diabetes: frequent appearance of thyroid autoimmunity during late childhood and adolescence. Diabetologia 2009; 52(2):185-92. IF 6.551

  128. Badenhoop K, Kahles H, Seidl C, Kordonouri O, Lopez ER, Walter M, Rosinger S, Ziegler A, Böhm BO and the Type 1 Diabetes Genetics Consortium. MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth. Diabetes, Obesity and Metabolism 2009 ;11 (Suppl.1):88-91. IF 4.126

  129. Hummel S, Pflüger M, Kreichauf S, Hummel M, Ziegler AG. Predictors of Overweight during Childhood in Offspring of Parents with Type 1 Diabetes. Diabetes Care 32 2009 ;(5):921-25. IF 6.718

  130. Hummel S, Pflüger M, Kreichauf S, Hummel M, Ziegler AG. Predictors of Overweight during Childhood in Offspring of Parents with Type 1 Diabetes: Response to Rodekamp et al. Diabetes Care 2009; 32 (11):e139. IF 6.718

  131. Mueller DB, Koczwara K, Mueller AS, Pallauf J, Ziegler AG, Bonifacio E. Influence of early nutritional components on the development of murine autoimmune diabetes. Ann Nutr Metab 2009; 54:208-17. IF 1.970

  132. Walter M, Philotheou A, Bonnici F, Ziegler AG, Jimenez R. No effect of the altered peptide ligand NBI-6024 on ß-cell residual function and insulin needs in new-onset type 1 diabetes. Diabetes Care 2009 ;32 (11):2036-40. IF 6.718

  133. Winkler C, Illig T, Koczwara K, Bonifacio E, Ziegler AG. HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes. J Clin Endocrinol Metab. 2009; 94 (10):4113-5. IF 6.202

  134. Winkler C, Marienfeld S, Zwilling M, Bonifacio E, Ziegler AG. Is islet autoimmunity related to insulin sensitivity or body weight in children of parents with type 1 diabetes? Diabetologia 2009; 52(10):2072-8. IF 6.551

  135. Boerschmann H, Walter M, Achenbach P, Ziegler AG. Survey of recent clinical trials of the prevention and immunointervention of type 1 diabetes mellitus. Dtsch Med Wochenschr 2010 Feb; 135(8):350-4. IF 0.590

  136. Keymeulen B, Candon S, Fafi-Kremer S, Ziegler A, Leruez-Ville M, Mathieu C, Vandemeulebroucke E, Walter M, Crenier L, Thervet E, Legendre C, Pierard D, Hale G, Waldmann H, Bach JF, Seigneurin JM, Pipeleers D, Chatenoud L.Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients. Blood 2010; 115(6)1145-55. IF 10.555

  137. Pflüger M, Winkler C, Hummel S. Ziegler AG. Early infant diet in children at high risk for type 1 diabetes. Horm Metab Res 2010; 42:143-8. IF 2.686

  138. Keymeulen B, Walter M, Mathieu C, Kaufman L, Gorus F, Hilbrands R, Vandemeulebroucke E, Van de Velde U, Crenier L, De Block C, Candon S, Waldmann H, Ziegler AG, Chatenoud L, Pipeleers D. Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass. Diabetologia 2010 April; 53(4): 614-23. IF 6.551

  139. Hale G, Rebello P, Al Bakir I, Bolam E, Wiczling P, Jusko WJ,  Vandemeulebroucke E, Keymeulen B, Mathieu C, Ziegler AG, Chatenoud L,  Pipeleers D, Waldmann H. Pharmacokinetics and antibody responses to the CD3 antibody otelixizumab used in the treatment of Type I diabetes. Journal of Clinical Pharmacology. 2010 Nov; 50 (11):1238-48. IF 3.442

  140. Walter M, Kaupper T, Adler K, Foersch J, Bonifacio E, Ziegler AG. No Effect of the 1α,25-dihydroxyvitamin D3 on Beta Cell Residual Function and Insulin Requirement in New-Onset Type 1 Diabetes. Diabetes Care 2010 Jul; 33(7):1443-8. IF 6.718

  141. Bonifacio E, Yu l, Williams A, Eisenbarth G, Bingley P, Marcovina S, Koczwara K, Ziegler AG, Mueller P, Schatz D, Krischer J, Steffes M, Akolkar B. Harmonization of GAD – and IA-2 autoantibody assays for NIDDK consortia. J Clin Endocrinol Metab. 2010 Jul; 95(7):3360-7. IF 6.202

  142. Boerschmann H, Pflüger M, Henneberger L, Ziegler AG, Hummel S. Prevalence and predictors of overweight and insulin resistance in offspring of mothers with gestational diabetes mellitus. Diabetes Care 2010 Aug;33(8):1845-9. IF 6.718

  143. Ziegler AG, Nepom J. Prediction and pathogenesis in type 1 diabetes. Immunity. 2010 Apr 23;32(4):468-78. IF 20.589

  144. Achenbach P, Krause S, Ziegler AG. Pathogenese des Diabetes mellitus Typ 1 – Update 2010. Diabetologie und Stoffwechsel. 2010 Juni 5: R31-R46. IF 0.380

  145. Winkler C, Bonifacio E, Grallert H, Henneberger L, Illig T, Ziegler AG. BMI at age of 8 years is influenced by the type 2 diabetes susceptibility genes HHEX-IDE and CDKAL1. Diabetes. 2010 Aug;59(8):2063-7. IF 8.505

  146. Bonifacio E, Ziegler AG. Advances in the prediction and natural history of type 1 diabetes. Endocrinol Metab Clin North Am. 2010 Sep;39(3):513-25. IF 3.562

  147. Ziegler AG, Walter M. Loss and preservation of beta-cell function: two treatment regimes targeting T or B lymphocytes. Curr Diab Rep. 2010 Oct;10(5):323-5.

  148. Wenzlau JM, Walter M, Gardner TJ, Frisch LM, Yu L, Eisenbarth GS, Ziegler AG, Davidson HW, Hutton JC. Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects. J Clin Endocrinol Metab. 2010 Oct;95(10):4712-9. IF 6.202

  149. Achenbach P, Guo LH, Gick C, Adler K, Krause S, Bonifacio E, Colman PG, Ziegler AG. A simplified method to assess affinity of insulin autoantibodies. Clin Immunol. 2010 Dec;137(3):415-21. IF 3.863

  150. Thümer L, Adler K, Bonifacio E, Hofmann F, Keller M, Milz C, Munte A, Ziegler AG. German new onset diabetes in the young incident cohort study: DiMelli study design and first-year results. Rev Diabet Stud. 2010; 7(3):202-8.

  151. Winkler C, Lauber C, Adler K, Grallert H, Illig T, Ziegler AG, Bonifacio E. An Interferon-Induced Helicase (IFIH1) Gene Polymorphism Associates With Different Rates of Progression From Autoimmunity to Type 1 Diabetes. Diabetes. 2011 Feb;60(2):685-90. IF 8.505

  152. Ziegler AG, Mollenhauer U, Achenbach P, Bonifacio E. Anti-CCL3 autoantibodies are not markers of type 1 diabetes when measured by a commercial ELISA method. Diabetologia. 2011Mar;54(3):699-700. IF 6.551

  153. Ziegler AG, Pflueger M, Winkler C, Achenbach P, Akolkar B, Krischer JP, Bonifacio E. Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children. J Autoimmun. 2011 Mar; [Epub ahead of print]. IF 7.231

  154. Adler K, Mueller DB, Achenbach P, Krause S, Heninger AK, Ziegler AG, Bonifacio E. Insulin autoantibodies with high affinity to the bovine milk protein alpha casein. Clin Exp Immunol. 2011 Apr;164(1):42-9. IF 3.009

  155. Hummel S, Pflüger M, Hummel M, Bonifacio E, Ziegler AG. Primary Dietary Intervention Study to Reduce the Risk of Islet Autoimmunity in Children at Increased Risk for Type 1 Diabetes: The BABYDIET study. Diabetes Care 2011 Apr; [Epub ahead of print]. IF 6.718