Independent Young Investigator Group Molecular Endocrinology

Aim: To understand the molecular mechanisms underlying the regulation of metabolic homeostasis by nuclear receptors and their associated transcription factors.

Main Projects

  • Elucidating the cis-regulatory code of GR-mediated repression by analyzing transcriptional complexes assembled on inflammatory enhancers in macrophages (cutting edge genomics and proteomics);
  • Screening for protein-protein interactions between the nuclear receptor and transcription factor families to determine their potential impact on the regulation of energy metabolism;
  • Exploring the role of potential nuclear receptor coregulators in vivo using knockout mice;
  • Investigating the influence of selected nuclear receptor family members in glucose homeostasis employing a combination of mouse genetics with next generation sequencing studies.