GIANT consortium (2007-2011)
Study objectives:
Identifying new genes for anthropometric measures via meta-analysis of genomewide association studies in an international consortium.
Specific aims:
- Study-specific genomewide association (GWA) studies via a uniform protocol using imputed genotype data
- Pooling of GWA results across studies
- Replication of top hits
- Follow-up studies on detected traits
Study design:
Meta-analysis of aggregated statistics across cross-sectional and case-control studies.
Study population:
KORA together with international partners.
Study team location:
Helmholtz Center Munich, Harvard School of Public Health, USA, Cambridge, UK; Oxford, UK; Univesity of Helsinki, Finland; Exeter, UK.
Study methods:
Weighted Z-score meta-analysis of linear regression p-values from genomewide scan.
Study period:
June 2007 - May 2011
Current status:
First Meta-analyses finished and first manuscripts prepared; full GIANT-wide meta-analysis starting
Investigators:
H.-E. Wichmann (PI), Iris M. Heid (Co-PI), Claudia Lamina, Guido Fischer, Christian Gieger (Helmholtz Zentrum München)
Other international PIs:
Joel Hirschhorn (Broad Institute at MIT and Harvard, Harvard Medical School, Boston, USA), Ruth Loos (Addenbrooke’s Hospital, Cambridge, UK), Tim Frayling (Peninsula Medical School, Exeter, UK), David Hunter (Broad Institute at MIT and Harvard, Harvard School of Public Health, Boston, USA), Frank Hu (Harvard School of Public Health, Boston, USA), Leif Groop (Lund University, Malmö, Schweden, University of Helsinki, Helsinki, Finnland), etc.
Funding:
NIH subcontract
Contact:
heid@helmholtz-muenchen.de
wichmann@helmholtz-muenchen.de
Publications:
Lettre G., Jackson A.U.*, Gieger C.*, Schumacher F.R.*, Berndt S.I.*, Serena Sanna S.*, Eyheramendy S., Voight B.F., Butler J.L., Guiducci C., Illig T., Hackett R., Heid I.M., Jacobs K.B., Lysseno V., Uda M., The Diabetes Genetics Initiative, FUSION, KORA, The Prostate, Lung Colorectal and Ovarian Cancer Screening Trial, The Nurses’ Health Study, SardiNIA, Boehnke M., Chanock S.J., Groop L.C., Hu F.B., Isomaa B. , Kraft P., Peltonen L., Salomaa V., Schlessinger D., Hunter D.J., Hayes R.B., Abecasis G.R., Wichmann H.E., Mohlke K.L., Hirschhorn J.N.
Genome-wide association studies identify ten novel loci for height and highlight new biological pathways in human growth.
Nat Genet in press. (* equal contributions)
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