Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

About us

  • The Research Unit Analytical Pathology (AAP) carries out scientific development, as a complement to research units with a clinical and fundamental orientation of translational research on diseases that occur in tissue. AAP is involved in the translation of (for example) in-vitro models or animal models to application in humans. AAP thus links basic research with diagnostic application, subsequently translating the findings of experimental and molecular pathology into procedures for the classification of diseases and predictive diagnostics dealing with tissue.

Images

  • Scanning electron microscope image of the developing inner ear of a mouse embryo; Source: Helmholtz Zentrum München

  • Depiction of the absorption of nanoparticles in cells; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • Relationship of active substance distribution in diseased mouse intestines; Source: Helmholtz Zentrum München

  • Active substance distribution (afatinib) in xenograft model; Source: Helmholtz Zentrum München

  • Distribution of different proteins in a mouse brain (MALDI mass spectrometry imaging); Source: Helmholtz Zentrum München

  • Image analysis of islets of Langerhans in various disease stages; Source: Helmholtz Zentrum München

  • In-situ Metabolomics of CONN Adenoma by Imaging Mass Spectrometry: 18-Hydroxycortisol is significantly increased in KCNJ5 patients; Source: Helmholtz Zentrum München

3D Light Sheet Microsopy: Vascularization and Tracer Distribution in a Xenograft Model

Recent publications

  • Görgülü K, Diakopoulos KN, Ai J, Schoeps B, Kabacaoglu D, Karpathaki AF, Ciecielski KJ, Kaya-Aksoy E, Ruess DA, Berninger A, Kowalska M, Stevanovic M, Wörmann SM, Wartmann T, Zhao Y, Halangk W, Voronina S, Tepikin A, Schlitter AM, Steiger K, Artati A, Adamski J, Aichler M, Walch A, Jastroch M, Hartleben G, Mantzoros CS, Weichert W, Schmid RM, Herzig S, Krüger A, Sainz B Jr, Lesina M, Algül H.
    Levels of the Autophagy Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice.
    Gastroenterology. 2018 Oct 5.

    Clemmensen C, Jall S, Kleinert M, Quarta C, Gruber T, Reber J, Sachs S, Fischer K, Feuchtinger A, Karlas A, Simonds SE, Grandl G, Loher D, Sanchez-Quant E, Keipert S, Jastroch M, Hofmann SM, Nascimento EBM, Schrauwen P, Ntziachristos V, Cowley MA, Finan B, Müller TD, Tschöp MH.
    Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes.
    Nat Commun. 2018 Oct 23;9(1):4304.

    Harrison L, Schriever SC, Feuchtinger A, Kyriakou E, Baumann P, Pfuhlmann K, Messias AC, Walch A, Tschöp MH, Pfluger PT.
    Fluorescent blood-brain barrier tracing shows intact leptin transport in obese mice.
    Int J Obes (Lond). 2018 Oct 3.

    Suwandhi L, Hausmann S, Braun A, Gruber T, Heinzmann SS, Gálvez EJC, Buck A, Legutko B, Israel A, Feuchtinger A, Haythorne E, Staiger H, Heni M, Häring HU, Schmitt-Kopplin P, Walch A, Cáceres CG, Tschöp MH, Rutter GA, Strowig T, Elsner M, Ussar S.
    Chronic d-serine supplementation impairs insulin secretion.
    Mol Metab. 2018 Oct;16:191-202

    Wintergerst L, Selmansberger M, Maihoefer C, Schüttrumpf L, Walch A, Wilke C, Pitea A, Woischke C, Baumeister P, Kirchner T, Belka C, Ganswindt U, Zitzelsberger H, Unger K, Hess J.
    A prognostic mRNA expression signature of four 16q24.3 genes in radio(chemo)therapy-treated head and neck squamous cell carcinoma (HNSCC).
    Mol Oncol. 2018 Sep 26

    Maihoefer C, Schüttrumpf L, Macht C, Pflugradt U, Hess J, Schneider L, Woischke C, Walch A, Baumeister P, Kirchner T, Zitzelsberger H, Belka C, Ganswindt U.
    Postoperative (chemo) radiation in patients with squamous cell cancers of the head and neck - clinical results from the cohort of the clinical cooperation group "Personalized Radiotherapy in Head and Neck Cancer".
    Radiat Oncol. 2018 Jul 3;13(1):123. doi: 10.1186/s13014-018-1067-1.

    Buck A, Heijs B, Beine B, Schepers J, Cassese A, Heeren RMA, McDonnell LA, Henkel C, Walch A, Balluff B.
    Round robin study of formalin-fixed paraffin-embedded tissues in mass spectrometry imaging.
    Anal Bioanal Chem. 2018 Jul 3.

    Bräuer KE, Brockers K, Moneer J, Feuchtinger A, Wollscheid-Lengeling E, Lengeling A, Wolf A.
    Phylogenetic and genomic analyses of the ribosomal oxygenases Riox1 (No66) and Riox2 (Mina53) provide new insights into their evolution.
    BMC Evol Biol. 2018 Jun 19;18(1):96.

    Lohöfer F, Hoffmann L, Buchholz R, Huber K, Glinzer A, Kosanke K, Feuchtinger A, Aichler M, Feuerecker B, Kaissis G, Rummeny EJ, Höltke C, Faber C, Schilling F, Botnar RM, Walch AK, Karst U, Wildgruber M.
    Molecular imaging of myocardial infarction with Gadofluorine P - A combined magnetic resonance and mass spectrometry imaging approach.
    Heliyon. 2018 Apr;4(4).

    Saller MM, Huettl RE, Mayer JM, Feuchtinger A, Krug C, Holzbach T, Volkmer E.
    Neural Regen Res. 2018 May;13(5):854-861.

    Rodriguez Camargo DC, Garg D, Buday K, Franko A, Rodriguez Camargo A, Schmidt F, Cox SJ, Suladze S, Haslbeck M, Mideksa YG, Gemmecker G, Aichler M, Mettenleiter G, Schulz M, Walch AK, Hrabě de Angelis M, Feige MJ, Sierra CA, Conrad M, Tripsianes K, Ramamoorthy A, Reif B.
    hIAPP forms toxic oligomers in plasma.
    Chem Commun (Camb). 2018 May 10.

    Wilke CM, Braselmann H, Hess J, Klymenko SV, Chumak VV, Zakhartseva LM, Bakhanova EV, Walch AK, Selmansberger M, Samaga D, Weber P, Schneider L, Fend F, Bösmüller HC, Zitzelsberger H, Unger K.
    A genomic copy number signature predicts radiation exposure in post-Chernobyl breast cancer.
    Int J Cancer. 2018 Apr 16.

    Sun N, Wu Y, Nanba K, Sbiera S, Kircher S, Kunzke T, Aichler M, Berezowska S, Reibetanz J, Rainey WE, Fassnacht M, Walch A, Kroiss M.
    High resolution tissue mass spectrometry imaging reveals a refined functional anatomy of the human adult adrenal gland.
    Endocrinology. 2018 Jan 29.

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