Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

About us

  • The Research Unit Analytical Pathology (AAP) carries out scientific development, as a complement to research units with a clinical and fundamental orientation of translational research on diseases that occur in tissue. AAP is involved in the translation of (for example) in-vitro models or animal models to application in humans. AAP thus links basic research with diagnostic application, subsequently translating the findings of experimental and molecular pathology into procedures for the classification of diseases and predictive diagnostics dealing with tissue.

Images

  • Scanning electron microscope image of the developing inner ear of a mouse embryo; Source: Helmholtz Zentrum München

  • Depiction of the absorption of nanoparticles in cells; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • Relationship of active substance distribution in diseased mouse intestines; Source: Helmholtz Zentrum München

  • Active substance distribution (afatinib) in xenograft model; Source: Helmholtz Zentrum München

  • Distribution of different proteins in a mouse brain (MALDI mass spectrometry imaging); Source: Helmholtz Zentrum München

  • Image analysis of islets of Langerhans in various disease stages; Source: Helmholtz Zentrum München

  • In-situ Metabolomics of CONN Adenoma by Imaging Mass Spectrometry: 18-Hydroxycortisol is significantly increased in KCNJ5 patients; Source: Helmholtz Zentrum München

3D Light Sheet Microsopy: Vascularization and Tracer Distribution in a Xenograft Model

Recent publications

  • Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, Porto Freitas F, Seibt T, Mehr L, Aichler M, Walch A, Lamp D, Jastroch M, Miyamoto S, Wurst W, Ursini F, Arnér ESJ, Fradejas-Villar N, Schweizer U, Zischka H, Friedmann Angeli JP, Conrad M.
    Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.
    Cell. 2017 Dec 16 pii: S0092-8674(17)31438-1

    Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Depaolini SR, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner R, Hahne H, Tõnisson N, Kramer K, Götze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif PA, Schneider S, Felder ER, Ruland J, Médard G, Jeremias I, Spiekermann K, Kuster B.
    The target landscape of clinical kinase drugs.
    Science. 2017 Dec 1;358(6367).

    Desbenoit N, Walch A, Spengler B, Brunelle A, Römpp A.
    Correlative mass spectrometry imaging, applying TOF-SIMS and AP-MALDI to a single tissue section.
    Rapid Commun Mass Spectrom. 2017 Nov 3.

    Molatore S, Kügler A, Irmler M, Wiedemann T, Neff F, Feuchtinger A, Beckers J, Robledo M, Roncaroli F, Pellegata NS.
    Characterization of neuroendocrine tumors in heterozygous mutant MENX rats: a novel model of invasive medullary thyroid carcinoma.
    Endocr Relat Cancer. 2017 Nov 15.

    Rodriguez Camargo DC, Korshavn KJ, Jussupow A, Raltchev K, Goricanec D, Fleisch M, Sarkar R, Xue K, Aichler M, Mettenleiter G, Walch AK, Camilloni C, Hagn F, Reif B, Ramamoorthy A.
    Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate.
    Elife. 2017 Nov 17;6

    Aichler M, Kunzke T, Buck A, Sun N, Ackermann M, Jonigk D, Gaumann A, Walch A.
    Molecular similarities and differences from human pulmonary fibrosis and corresponding mouse model: MALDI imaging mass spectrometry in comparative medicine.
    Lab Invest. 2017 Oct 16.

    Urban C, Buck A, Siveke JT, Lordick F, Luber B, Walch A, Aichler M.
    PAXgene fixation enables comprehensive metabolomic and proteomic analyses of tissue specimens by MALDI MSI.
    Biochim Biophys Acta. 2017 Oct 9.