Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

About us

  • The Research Unit Analytical Pathology (AAP) carries out scientific development, as a complement to research units with a clinical and fundamental orientation of translational research on diseases that occur in tissue. AAP is involved in the translation of (for example) in-vitro models or animal models to application in humans. AAP thus links basic research with diagnostic application, subsequently translating the findings of experimental and molecular pathology into procedures for the classification of diseases and predictive diagnostics dealing with tissue.

Images

  • Scanning electron microscope image of the developing inner ear of a mouse embryo; Source: Helmholtz Zentrum München

  • Depiction of the absorption of nanoparticles in cells; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • Relationship of active substance distribution in diseased mouse intestines; Source: Helmholtz Zentrum München

  • Active substance distribution (afatinib) in xenograft model; Source: Helmholtz Zentrum München

  • Distribution of different proteins in a mouse brain (MALDI mass spectrometry imaging); Source: Helmholtz Zentrum München

  • Image analysis of islets of Langerhans in various disease stages; Source: Helmholtz Zentrum München

  • In-situ Metabolomics of CONN Adenoma by Imaging Mass Spectrometry: 18-Hydroxycortisol is significantly increased in KCNJ5 patients; Source: Helmholtz Zentrum München

3D Light Sheet Microsopy: Vascularization and Tracer Distribution in a Xenograft Model

Recent Publications

  • Schneider A, Kurz S, Manske K, Janas MK, Heikenwälder M, Misgeld T, Aichler M, Weissmann SF, Zischka H, Knolle P, Wohlleber D
    Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection.
    Sci. Rep. 9:8492 (2019)

    Huber K, Kunzke T, Buck A, Langer R, Luber B, Feuchtinger A, Walch AK
    Multimodal analysis of formalin-fixed and paraffin-embedded tissue by MALDI imaging and fluorescence in situ hybridization for combined genetic and metabolic analysis.
    Lab. Invest., accepted (2019)

    von Gamm M, Schaub A, Jones A, Wolf C, Behrens G, Lichti J, Essig K, Macht A, Pircher J, Ehrlich A, Davari K, Chauhan D, Busch B, Wurst W, Feederle R, Feuchtinger A, Tschöp MH, Friedel CC, Hauck SM, Sattler M, Geerlof A, Hornung V, Heissmeyer V, Schulz C, Heikenwalder M, Glasmacher E.
    Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
    J. Exp. Med., accepted (2019)

    Backman M, Flenkenthaler F, Blutke A, Dahlhoff M, Ländström E, Renner S, Philippou-Massier J, Krebs S, Rathkolb B, Prehn C, Grzybek M, Coskun Ü, Rothe M, Adamski J, Hrabě de Angelis M, Wanke R, Fröhlich T, Arnold GJ, Blum H, Wolf E
    Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus.
    Mol. Metab., accepted (2019)

    Dombrowsky A, Schauer J, Sammer M, Blutke A, Walsh DWM, Schwarz B, Bartzsch S, Feuchtinger A, Reindl J, Combs SE, Dollinger G, Schmid TE
    Acute skin damage and late radiation-induced fibrosis and inflammation in murine ears after high-dose irradiation.
    Cancers 11:727 (2019)

    Bechmann N, Poser I, Seifert V, Greunke C, Ullrich M, Qin N, Walch AK, Peitzsch M, Robledo M, Pacak K, Pietzsch J, Richter S, Eisenhofer G
    Impact of extrinsic and intrinsic hypoxia on catecholamine biosynthesis in absence or presence of Hif2α in pheochromocytoma cells.
    Cancers 11:594 (2019)

    Sperling S, Fiedler P, Lechner M, Pollithy A, Ehrenberg S, Schiefer AI, Kenner L, Feuchtinger A, Kühn R, Swinerd G, Schmidt-Supprian M, Strobl LJ, Zimber-Strobl U
    Chronic CD30-signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells.
    Blood, accepted (2019)

    Ratner, C. ; He, Z. ; Grunddal, K.V. ; Skov, L.J. ; Hartmann, B. ; Zhang, F. ; Feuchtinger, A. ; Bjerregaard, A. ; Christoffersen, C. ; Tschöp, M.H. ; Finan, B. ; DiMarchi, R.D. ; Leinninger, G.M. ; Williams, K.W. ; Clemmensen, C. ; Holst, B.
    Long Acting Neurotensin Synergizes with Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway.
    Diabetes, accepted (2019)

    Norheim F, Hasin-Brumshtein Y, Vergnes L, Chella Krishnan K, Pan C, Seldin MM, Hui ST, Mehrabian M, Zhou Z, Gupta S, Parks BW, Walch A, Reue K, Hofmann SM, Arnold AP, Lusis AJ.
    Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits.
    Cell Metab. 2019 Jan 8

    Gujrati V, Prakash J, Malekzadeh-Najafabadi J, Stiel A, Klemm U, Mettenleiter G, Aichler M, Walch A, Ntziachristos V.
    Bioengineered bacterial vesicles as biological nano-heaters for optoacoustic imaging.
    Nat Commun. 2019 Mar 7;10(1):1114. doi: 10.1038/s41467-019-09034-y.

    Papathomas TG, Sun N, Chortis V, Taylor AE, Arlt W, Richter S, Eisenhofer G, Ruiz-Babot G, Guasti L, Walch AK.
    Novel methods in adrenal research: a metabolomics approach.
    Histochem Cell Biol. 2019 Mar;151(3):201-216. doi: 10.1007/s00418-019-01772-w. Epub 2019 Feb 6. Review.

    Ogrinc Wagner A, Friedrich V, Barthels C, Marconi P, Blutke A, Brombacher F, Brocker T.
    Strain specific maturation of Dendritic cells and production of IL-1β controls CD40-driven colitis.
    PLoS One. 2019 Jan 17;14(1):e0210998.

    Yang L, Feuchtinger A, Moeller W, Ding Y, Kutschke D, Möller G, Schittny JC, Burgstaller G, Hofmann W, Stoeger T, Razansky D, Walch A, Schmid O. Three-Dimensional Quantitative Co-Mapping of Pulmonary Morphology and Nanoparticle Distribution with Cellular Resolution in Non-Dissected Murine Lungs.
    ACS Nano. 2018 Dec 19.

    Balluff B, Buck A, Martin-Lorenzo M, Dewez F, Langer R, McDonnell LA, Walch A, Heeren RMA.
    Integrative Clustering in Mass Spectrometry Imaging for Enhanced Patient Stratification.
    Proteomics Clin Appl. 2018 Dec 2.

    Clemmensen C, Jall S, Kleinert M, Quarta C, Gruber T, Reber J, Sachs S, Fischer K, Feuchtinger A, Karlas A, Simonds SE, Grandl G, Loher D, Sanchez-Quant E, Keipert S, Jastroch M, Hofmann SM, Nascimento EBM, Schrauwen P, Ntziachristos V, Cowley MA, Finan B, Müller TD, Tschöp MH.<br/>Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes.
    Nat Commun. 2018 Oct 23;9(1):4304.

    Görgülü K, Diakopoulos KN, Ai J, Schoeps B, Kabacaoglu D, Karpathaki AF, Ciecielski KJ, Kaya-Aksoy E, Ruess DA, Berninger A, Kowalska M, Stevanovic M, Wörmann SM, Wartmann T, Zhao Y, Halangk W, Voronina S, Tepikin A, Schlitter AM, Steiger K, Artati A, Adamski J, Aichler M, Walch A, Jastroch M, Hartleben G, Mantzoros CS, Weichert W, Schmid RM, Herzig S, Krüger A, Sainz B Jr, Lesina M, Algül H.
    Levels of the Autophagy Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice.
    Gastroenterology. 2018 Oct 5.

    Harrison L, Schriever SC, Feuchtinger A, Kyriakou E, Baumann P, Pfuhlmann K, Messias AC, Walch A, Tschöp MH, Pfluger PT.
    Fluorescent blood-brain barrier tracing shows intact leptin transport in obese mice.
    Int J Obes (Lond). 2018 Oct 3.

    Suwandhi L, Hausmann S, Braun A, Gruber T, Heinzmann SS, Gálvez EJC, Buck A, Legutko B, Israel A, Feuchtinger A, Haythorne E, Staiger H, Heni M, Häring HU, Schmitt-Kopplin P, Walch A, Cáceres CG, Tschöp MH, Rutter GA, Strowig T, Elsner M, Ussar S.
    Chronic d-serine supplementation impairs insulin secretion.
    Mol Metab. 2018 Oct;16:191-202

    Wintergerst L, Selmansberger M, Maihoefer C, Schüttrumpf L, Walch A, Wilke C, Pitea A, Woischke C, Baumeister P, Kirchner T, Belka C, Ganswindt U, Zitzelsberger H, Unger K, Hess J.
    A prognostic mRNA expression signature of four 16q24.3 genes in radio(chemo)therapy-treated head and neck squamous cell carcinoma (HNSCC).
    Mol Oncol. 2018 Sep 26

    Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, Porto Freitas F, Seibt T, Mehr L, Aichler M, Walch A, Lamp D, Jastroch M, Miyamoto S, Wurst W, Ursini F, Arnér ESJ, Fradejas-Villar N, Schweizer U, Zischka H, Friedmann Angeli JP, Conrad M.
    Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.
    Cell. 2017 Dec 16 pii: S0092-8674(17)31438-1

    Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Depaolini SR, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner R, Hahne H, Tõnisson N, Kramer K, Götze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif PA, Schneider S, Felder ER, Ruland J, Médard G, Jeremias I, Spiekermann K, Kuster B.
    The target landscape of clinical kinase drugs.
    Science. 2017 Dec 1;358(6367).

    Desbenoit N, Walch A, Spengler B, Brunelle A, Römpp A.
    Correlative mass spectrometry imaging, applying TOF-SIMS and AP-MALDI to a single tissue section.
    Rapid Commun Mass Spectrom. 2017 Nov 3.

    Molatore S, Kügler A, Irmler M, Wiedemann T, Neff F, Feuchtinger A, Beckers J, Robledo M, Roncaroli F, Pellegata NS.
    Characterization of neuroendocrine tumors in heterozygous mutant MENX rats: a novel model of invasive medullary thyroid carcinoma.
    Endocr Relat Cancer. 2017 Nov 15.

    Rodriguez Camargo DC, Korshavn KJ, Jussupow A, Raltchev K, Goricanec D, Fleisch M, Sarkar R, Xue K, Aichler M, Mettenleiter G, Walch AK, Camilloni C, Hagn F, Reif B, Ramamoorthy A.
    Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate.
    Elife. 2017 Nov 17;6

    Aichler M, Kunzke T, Buck A, Sun N, Ackermann M, Jonigk D, Gaumann A, Walch A.
    Molecular similarities and differences from human pulmonary fibrosis and corresponding mouse model: MALDI imaging mass spectrometry in comparative medicine.
    Lab Invest. 2017 Oct 16.


    Urban C, Buck A, Siveke JT, Lordick F, Luber B, Walch A, Aichler M.
    PAXgene fixation enables comprehensive metabolomic and proteomic analyses of tissue specimens by MALDI MSI.
    Biochim Biophys Acta. 2017 Oct 9.


    Jacobs L, Habringer S, Slawska J, Huber K, Hauf E, Li Z, Refaeli Y, Schwaiger M, Rudelius M, Walch A, Keller U.
    Functional imaging in combination with mutation status aids prediction of response to inhibiting B-cell receptor signaling in lymphoma.
    Oncotarget. 2017 Aug 24;8(45):78917-78929.


    Hachmöller O, Aichler M, Schwamborn K, Lutz L, Werner M, Sperling M, Walch A, Karst U.
    Investigating the influence of standard staining procedures on the copper distribution and concentration in Wilson's disease liver samples by laser ablation-inductively coupled plasma-mass spectrometry.
    J Trace Elem Med Biol. 2017 Dec;44:71-75.


    Wilke CM, Hess J, Klymenko SV, Chumak VV, Zakhartseva LM, Bakhanova EV, Feuchtinger A, Walch AK, Selmansberger M, Braselmann H, Schneider L, Pitea A, Steinhilber J, Fend F, Bösmüller HC, Zitzelsberger H, Unger K.
    Expression of miRNA-26b-5p and its target TRPS1 is associated with radiation exposure in post-Chernobyl breast cancer.
    Int J Cancer. 2017 Sep 25.

    Fichter CD, Przypadlo CM, Buck A, Herbener N, Riedel B, Schäfer L, Nakagawa H, Walch A, Reinheckel T, Werner M, Lassmann S.
    A new model system identifies EGFR/HER2 and HER2/HER3 heterodimers as potent inducers of oesophageal epithelial cell invasion.
    J Pathol. 2017 Sep 20.

    Schlecht A, Leimbeck SV, Jägle H, Feuchtinger A, Tamm ER, Braunger BM.
    Deletion of Endothelial TGF-β Signaling Leads to Choroidal Neovascularization.
    Am J Pathol. 2017 Aug 17. pii: S0002-9440(17)30415-7.


    Yang F, Aubele M, Walch A,
    Gross E, Napieralski R, Zhao S, Ahmed N, Kiechle M, Reuning U, Dorn J, Sweep F, Magdolen V, Schmitt M.
    Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer.
    Biol Chem. 2017 Jul 28.


    Kunzke T, Balluff B, Feuchtinger A, Buck A, Langer R, Luber B, Lordick F, Zitzelsberger H, Aichler M, Walch A.
    Native glycan fragments detected by MALDI-FT-ICR mass spectrometry imaging impact gastric cancer biology and patient outcome.
    Oncotarget. 2017 Jul 10.

    Aichler M, Borgmann D, Krumsiek J, Buck A, MacDonald PE, Fox JEM, Lyon J, Light PE, Keipert S, Jastroch M, Feuchtinger A, Mueller NS, Sun N, Palmer A, Alexandrov T, Hrabe de Angelis M, Neschen S, Tschöp MH, Walch A.
    N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes.
    Cell Metab. 2017 Jun 6;25(6):1334-1347


    Düwel S, Hundshammer C, Gersch M, Feuerecker B, Steiger K, Buck A, Walch A, Haase A, Glaser SJ, Schwaiger M, Schilling F.
    Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid.
    Nat Commun. 2017 May 11;8:15126.

    Arlt W, Lang K, Sitch AJ, Dietz AS, Rhayem Y, Bancos I, Feuchtinger A, Chortis V, Gilligan LC, Ludwig P, Riester A, Asbach E, Hughes BA, O'Neil DM, Bidlingmaier M, Tomlinson JW, Hassan-Smith ZK, Rees DA, Adolf C, Hahner S, Quinkler M, Dekkers T, Deinum J, Biehl M, Keevil BG, Shackleton CHL, Deeks JJ, Walch AK, Beuschlein F, Reincke M.
    Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism.
    JCI Insight. 2017 Apr 20;2(8). pii: 93136

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