Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

Our focus:
Develops translational research on diseases that manifest in tissues

About us

  • The Research Unit Analytical Pathology (AAP) carries out scientific development, as a complement to research units with a clinical and fundamental orientation of translational research on diseases that occur in tissue. AAP is involved in the translation of (for example) in-vitro models or animal models to application in humans. AAP thus links basic research with diagnostic application, subsequently translating the findings of experimental and molecular pathology into procedures for the classification of diseases and predictive diagnostics dealing with tissue.

Images

  • Scanning electron microscope image of the developing inner ear of a mouse embryo; Source: Helmholtz Zentrum München

  • Depiction of the absorption of nanoparticles in cells; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • In-situ hybridization of HER-2 in neoplastic tissue; Source: Helmholtz Zentrum München

  • Relationship of active substance distribution in diseased mouse intestines; Source: Helmholtz Zentrum München

  • Active substance distribution (afatinib) in xenograft model; Source: Helmholtz Zentrum München

  • Distribution of different proteins in a mouse brain (MALDI mass spectrometry imaging); Source: Helmholtz Zentrum München

  • Image analysis of islets of Langerhans in various disease stages; Source: Helmholtz Zentrum München

  • In-situ Metabolomics of CONN Adenoma by Imaging Mass Spectrometry: 18-Hydroxycortisol is significantly increased in KCNJ5 patients; Source: Helmholtz Zentrum München

3D Light Sheet Microsopy: Vascularization and Tracer Distribution in a Xenograft Model

Recent publications

  • Maihoefer C, Schüttrumpf L, Macht C, Pflugradt U, Hess J, Schneider L, Woischke C, Walch A, Baumeister P, Kirchner T, Zitzelsberger H, Belka C, Ganswindt U.
    Postoperative (chemo) radiation in patients with squamous cell cancers of the head and neck - clinical results from the cohort of the clinical cooperation group "Personalized Radiotherapy in Head and Neck Cancer".
    Radiat Oncol. 2018 Jul 3;13(1):123. doi: 10.1186/s13014-018-1067-1.

    Buck A, Heijs B, Beine B, Schepers J, Cassese A, Heeren RMA, McDonnell LA, Henkel C, Walch A, Balluff B.
    Round robin study of formalin-fixed paraffin-embedded tissues in mass spectrometry imaging.
    Anal Bioanal Chem. 2018 Jul 3.

    Bräuer KE, Brockers K, Moneer J, Feuchtinger A, Wollscheid-Lengeling E, Lengeling A, Wolf A.
    Phylogenetic and genomic analyses of the ribosomal oxygenases Riox1 (No66) and Riox2 (Mina53) provide new insights into their evolution.
    BMC Evol Biol. 2018 Jun 19;18(1):96.

    Lohöfer F, Hoffmann L, Buchholz R, Huber K, Glinzer A, Kosanke K, Feuchtinger A, Aichler M, Feuerecker B, Kaissis G, Rummeny EJ, Höltke C, Faber C, Schilling F, Botnar RM, Walch AK, Karst U, Wildgruber M.
    Molecular imaging of myocardial infarction with Gadofluorine P - A combined magnetic resonance and mass spectrometry imaging approach.
    Heliyon. 2018 Apr;4(4).

    Saller MM, Huettl RE, Mayer JM, Feuchtinger A, Krug C, Holzbach T, Volkmer E.
    Neural Regen Res. 2018 May;13(5):854-861.

    Rodriguez Camargo DC, Garg D, Buday K, Franko A, Rodriguez Camargo A, Schmidt F, Cox SJ, Suladze S, Haslbeck M, Mideksa YG, Gemmecker G, Aichler M, Mettenleiter G, Schulz M, Walch AK, Hrabě de Angelis M, Feige MJ, Sierra CA, Conrad M, Tripsianes K, Ramamoorthy A, Reif B.
    hIAPP forms toxic oligomers in plasma.
    Chem Commun (Camb). 2018 May 10.

    Wilke CM, Braselmann H, Hess J, Klymenko SV, Chumak VV, Zakhartseva LM, Bakhanova EV, Walch AK, Selmansberger M, Samaga D, Weber P, Schneider L, Fend F, Bösmüller HC, Zitzelsberger H, Unger K.
    A genomic copy number signature predicts radiation exposure in post-Chernobyl breast cancer.
    Int J Cancer. 2018 Apr 16.

    Sun N, Wu Y, Nanba K, Sbiera S, Kircher S, Kunzke T, Aichler M, Berezowska S, Reibetanz J, Rainey WE, Fassnacht M, Walch A, Kroiss M.
    High resolution tissue mass spectrometry imaging reveals a refined functional anatomy of the human adult adrenal gland.
    Endocrinology. 2018 Jan 29.

    Franko A, Rodriguez Camargo DC, Böddrich A, Garg D, Rodriguez Camargo A, Rathkolb B, Janik D, Aichler M, Feuchtinger A, Neff F, Fuchs H, Wanker EE, Reif B, Häring HU, Peter A, Hrabě de Angelis M.
    Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice.
    Sci Rep. 2018 Jan 18;8(1):1116.

    Absmaier M, Napieralski R, Schuster T, Aubele M, Walch A, Magdolen V, Dorn J, Gross E, Harbeck N, Noske A, Kiechle M, Schmitt M.
    PITX2 DNA-methylation predicts response to anthracycline-based adjuvant chemotherapy in triple-negative breast cancer patients.
    Int J Oncol. 2018 Jan 8.

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