Publikationen

2017

Schlecht A, Leimbeck SV, Jägle H, Feuchtinger A, Tamm ER, Braunger BM.
Deletion of Endothelial TGF-β Signaling Leads to Choroidal Neovascularization.
Am J Pathol. 2017 Aug 17. pii: S0002-9440(17)30415-7

Ma X, Phi Van V, Kimm MA, Prakash J, Kessler H, Kosanke K, Feuchtinger A, Aichler M, Gupta A, Rummeny EJ, Eisenblätter M, Siveke J, Walch AK, Braren R, Ntziachristos V, Wildgruber M.
Integrin-Targeted Hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography for Imaging Tumor Progression and Early Response in Non-Small Cell Lung Cancer.

Neoplasia. 2017 Jan;19(1):8-16

Kunzke T, Balluff B, Feuchtinger A, Buck A, Langer R, Luber B, Lordick F, Zitzelsberger H, Aichler M, Walch A.
Native glycan fragments detected by MALDI-FT-ICR mass spectrometry imaging impact gastric cancer biology and patient outcome.
Oncotarget. 2017 Jul 10.

Yang F, Aubele M, Walch A, Gross E, Napieralski R, Zhao S, Ahmed N, Kiechle M, Reuning U, Dorn J, Sweep F, Magdolen V, Schmitt M.
Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer.

Biol Chem. 2017 Jul 28.

Aichler M, Borgmann D, Krumsiek J, Buck A, MacDonald PE, Fox JEM, Lyon J, Light PE, Keipert S, Jastroch M, Feuchtinger A, Mueller NS, Sun N, Palmer A, Alexandrov T, Hrabe de Angelis M, Neschen S, Tschöp MH, Walch A.
N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes.
Cell Metab. 2017 Jun 6;25(6):1334-1347.e4.

Arlt W, Lang K, Sitch AJ, Dietz AS, Rhayem Y, Bancos I, Feuchtinger A, Chortis V, Gilligan LC, Ludwig P, Riester A, Asbach E, Hughes BA, O'Neil DM, Bidlingmaier M, Tomlinson JW, Hassan-Smith ZK, Rees DA, Adolf C, Hahner S, Quinkler M, Dekkers T, Deinum J, Biehl M, Keevil BG, Shackleton CHL, Deeks JJ, Walch AK, Beuschlein F, Reincke M.
Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism.
JCI Insight. 2017 Apr 20;2(8). pii: 93136

Dislich B, Stein A, Seiler CA, Kröll D, Berezowska S, Zlobec I, Galvan J, Slotta-Huspenina J, Walch A, Langer R.
Expression patterns of programmed death-ligand 1 in esophageal adenocarcinomas: comparison between primary tumors and metastases.
Cancer Immunol Immunother. 2017 Mar 13. doi: 10.1007/s00262-017-1982-2.

Rodriguez Camargo DC, Tripsianes K, Buday K, Franko A, Göbl C, Hartlmüller C, Sarkar R, Aichler M, Mettenleiter G, Schulz M, Böddrich A, Erck C, Martens H, Walch AK, Madl T, Wanker EE, Conrad M, de Angelis MH, Reif B.
The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.
Sci Rep. 2017 Mar 13;7:44041

Franko A, Neschen S, Rozman J, Rathkolb B, Aichler M, Feuchtinger A, Brachthäuser L, Neff F, Kovarova M, Wolf E, Fuchs H, Häring HU, Peter A, Hrabě de Angelis M.
Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice.
Mol Metab. 2017 Jan 6;6(3):256-266.

Knüppel L, Ishikawa Y, Aichler M, Heinzelmann K, Hatz R, Behr J, Walch A, Bächinger HP, Eickelberg O, Staab-Weijnitz CA.
A Novel Antifibrotic Mechanism of Nintedanib and Pirfenidone: Inhibition of Collagen Fibril Assembly.
Am J Respir Cell Mol Biol. 2017 Mar 3

Echtler K, Konrad I, Lorenz M, Schneider S, Hofmaier S, Plenagl F, Stark K, Czermak T, Tirniceriu A, Eichhorn M, Walch A, Enders G, Massberg S, Schulz C.
Platelet GPIIb supports initial pulmonary retention but inhibits subsequent proliferation of melanoma cells during hematogenic metastasis.
PLoS One. 2017 Mar 2;12(3).

Buck A, Aichler M, Huber K, Walch A.
In Situ Metabolomics in Cancer by Mass Spectrometry Imaging.

Adv Cancer Res. 2017;134:117-132. doi: 10.1016/bs.acr.2016.11.004

2016

Schenck TL, Lin S, Stewart JK, Koban KC, Aichler M, Rezaeian F, Giunta RE.
Sensory reanimation of the hand by transfer of the superficial branch of the radial nerve to the median and ulnar nerve.

Brain Behav. 2016 Oct 9;6(12)

Ma X, Phi Van V, Kimm MA, Prakash J, Kessler H, Kosanke K, Feuchtinger A, Aichler M, Gupta A, Rummeny EJ, Eisenblätter M, Siveke J, Walch AK, Braren R, Ntziachristos V, Wildgruber M.
Integrin-Targeted hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography for Imaging Tumor Progression and Early Response in Non-Small Cell Lung Cancer.
Neoplasia. 2016 Dec 7;19(1):8-16.

Zhao S, Dorn J, Napieralski R, Walch A, Diersch S, Kotzsch M, Ahmed N, Hooper JD, Kiechle M, Schmitt M, Magdolen V.
Plasmin(Ogen) Serves As A Favorable Biomarker For Prediction Of Survival In Advanced High-Grade Serous Ovarian Cancer.
Biol Chem. 2016 Nov 24

Koch M, de Jong JS, Glatz J, Symvoulidis P, Lamberts LE, Adams A, Kranendonk ME, Terwisscha van Scheltinga AG, Aichler M, Jansen L, de Vries J, Lub-de Hooge MN, Schröder CP, Jorritsma-Smit A, Linssen MD, de Boer E, van der Vegt B, Nagengast WB, Elias SG, Oliveira S, Witkamp A, Mali WP, van der Wall E, Garcia-Allende BP, Van Diest PJ, de Vries EG, Walch A, van Dam GM, Ntziachristos V.
Threshold analysis and biodistribution of fluorescently labeled bevacizumab in human breast cancer.
Cancer Res. 2016 Nov 22. pii: canres.1773.2016.

Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Trümbach D, Mao G, Qu F, Bayir H, Füllekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Angeli JP, Conrad M.
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.
Nat Chem Biol. 2016 Nov 14

Wittmann A, Grimm MO, Scherthan H, Horsch M, Beckers J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Ford SJ, Burton NC, Razansky D, Trümbach D, Aichler M, Walch AK, Calzada-Wack J, Neff F, Wurst W, Hartmann T, Floss T.
Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice.
PLoS One. 2016 Oct 27;11(10):e0164298. doi: 10.1371/journal.pone.0164298.

Feuchtinger A, Walch A, Dobosz M.
Deep tissue imaging: a review from a preclinical cancer research perspective.
Histochem Cell Biol. 2016 Oct 4. Review.

Huber MC, Mall R, Braselmann H, Feuchtinger A, Molatore S, Lindner K, Walch A, Gross E, Schmitt M, Falkenberg N, Aubele M.
uPAR enhances malignant potential of triple-negative breast cancer by directly interacting with uPA and IGF1R.
BMC Cancer. 2016 Aug 8;16(1):615.

Mendler CT, Feuchtinger A, Heid I, Aichler M, D'Alessandria C, Pirsig S, Blechert B, Wester HJ, Braren R, Walch A, Skerra A, Schwaiger M.
Tumor uptake of anti-CD20 Fabs depends on tumor perfusion.
J Nucl Med. 2016 Jul 14. pii: jnumed.116.176784. [Epub ahead of print]

Ly A, Buck A, Balluff B, Sun N, Gorzolka K, Feuchtinger A, Janssen KP, Kuppen PJ, van de Velde CJ, Weirich G, Erlmeier F, Langer R, Aubele M, Zitzelsberger H, McDonnell L, Aichler M, Walch A.
High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue.
Nat Protoc. 2016 Aug;11(8):1428-43. doi: 10.1038/nprot.2016.081. Epub 2016 Jul 14.

Bader E, Migliorini A, Gegg M, Moruzzi N, Gerdes J, Roscioni SS, Bakhti M, Brandl E, Irmler M, Beckers J, Aichler M, Feuchtinger A, Leitzinger C, Zischka H, Wang-Sattler R, Jastroch M, Tschöp M, Machicao F, Staiger H, Häring HU, Chmelova H, Chouinard JA, Oskolkov N, Korsgren O, Speier S, Lickert H.
Identification of proliferative and mature β-cells in the islets of Langerhans.
Nature. 535(7612):430-434, 2016


Buck A
, Balluff B, Voss A, Langer R, Zitzelsberger H, Aichler M, Walch A.
How suitable is MALDI-TOF for metabolite imaging from clinical formalin-fixed and paraffin-embedded tissue samples in comparison to MALDI-FT-ICR mass spectrometry?
Anal Chem. 88(10):5281-9,2016

Cassese A, Ellis S, Ogrinc Potočnik N, Burgermeister E, Ebert M, Walch A, van den Maagdenberg AM, McDonnell LA, Heeren RM, Balluff B.
Spatial autocorrelation in mass spectrometry imaging.
Anal Chem. 2016 May 14. [Epub ahead of print]

Dorn J, Yassouridis A, Walch A, Diamandis EP, Schmitt M, Kiechle M, Wang P, Drecoll E, Schmalfeldt B, Loessner D, Kotzsch M, Magdolen V.
Assessment of kallikrein-related peptidase 5 (KLK5) protein expression in tumor tissue of advanced ovarian cancer patients by immunohistochemistry and ELISA: correlation with clinical outcome.

Am J Cancer Res.
; 6(1):61-70, 2016

Franko A, Huypens P, Neschen S, Irmler M, Rozman J, Rathkolb B, Neff F, Prehn C, Dubois G, Baumann M, Massinger R, Gradinger D, Przemeck GK, Repp B, Aichler M, Feuchtinger A, Schommers P, Stöhr O, Sanchez-Lasheras C, Adamski J, Peter A, Prokisch H, Beckers J, Walch AK, Fuchs H, Wolf E, Schubert M, Wiesner RJ, Hrabě de Angelis M.

Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice.
Diabetes. 2016 Jun 9 (ahead of print)

Girst S, Greubel C, Reindl J, Siebenwirth C, Zlobinskaya O, Walsh DW, Ilicic K, Aichler M, Walch A, Wilkens JJ, Multhoff G, Dollinger G, Schmid TE
Proton Minibeam Radiation Therapy Reduces Side Effects in an In Vivo Mouse Ear Model.

Int J Radiat Oncol Biol Phys.
95(1):234-41, 2016

Grüner BM, Winkelmann I, Feuchtinger A, Sun N, Balluff B, Teichmann N, Herner A, Kalideris E, Steiger K, Braren R, Aichler M, Esposito I, Schmid RM, Walch A, Siveke JT
Modeling therapy response and spatial tissue distribution of erlotinib in pancreatic cancer.

Mol Cancer Ther.
15(5):1145-52, 2016

Hachmöller O, Buzanich AG, Aichler M, Radtke M, Dietrich D, Schwamborn K, Lutz L, Werner M, Sperling M, Walch A, Karst U.
Elemental bioimaging and speciation analysis for the investigation of Wilson's disease using μXRF and XANES.
Metallomics
. 35: 97-102, 2016

Huber M, Falkenberg N, Hauck S, Priller M, Braselmann H, Feuchtinger A, Walch A, Schmitt M, Aubele M
Cyr61 and YB-1 are novel interacting partners of uPAR and elevate the malignancy of triple-negative breast cancer.

Oncotarget Mai 2016
doi: 10.18632/oncotarget.9853. [Epub ahead of print]

Lahiri S, Sun N, Buck A, Imhof A, Walch A
MALDI imaging mass spectrometry as a novel tool for detecting histone modifications in clinical tissue samples.

Expert Rev Proteomics.
12:1-10, 2016

Lahiri S, Sun N, Solis-Mezarino V, Fedisch A, Ninkovic J, Feuchtinger A, Götz M, Walch A, Imhof A
In situ detection of histone variants and modifications in mouse brain using imaging mass spectrometry.
Proteomics 16(3):437-447, 2016 und
Inside front cover: Proteomics. 2016 Feb; 16(3):NA

Ly A, Buck A
, Balluff B, Sun N, Gorzolka K, Feuchtinger A, Janssen KP, Kuppen PJ, van de Velde CJ, Weirich G, Erlmeier F, Langer R, Aubele M, Zitzelsberger H, McDonnell L, Aichler M, Walch A.
High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue.

Nat Protoc
. 11(8):1428-43, 2016

Mall S, Yusufi N, Wagner R, Klar R, Bianchi H, Steiger K, Straub M, Audehm S, Laitinen I, Aichler M, Peschel C, Ziegler S, Mustafa M, Schwaiger M, D'Alessandria C, Krackhardt AM.
Immuno-PET Imaging of Engineered Human T Cells in Tumors.

Cancer Res
. 2016 Jun 28. [Epub ahead of print]

Mendler CT, Feuchtinger A, Heid I, Aichler M, D'Alessandria C, Pirsig S, Blechert B, Wester HJ, Braren R, Walch A, Skerra A, Schwaiger M.
Tumor uptake of anti-CD20 Fabs depends on tumor perfusion.

J Nucl Med. 2016 Jul 14. pii: jnumed.116.176784. [Epub ahead of print]

Sun N, Fernandez IE, Wei M, Wu Y, Aichler M, Eickelberg O, Walch A
Pharmacokinetic and pharmacometabolomics study of pirfenidone in normal mouse tissues using high mass resolution MALDI-FTICR-mass spectrometry imaging.

Histochem Cell Biol. 145(2):201-211, 2016. Epub 2015

2015

Aichler M, Huber K, Schilling F, Lohöfer F, Kosanke K, Meier R, Rummeny EJ, Walch A, Wildgruber M
Spatially Resolved Quantification of Gadolinium(III)-Based Magnetic Resonance Agents in Tissue by MALDI Imaging Mass Spectrometry after In Vivo MRI.
Angew Chem Int Ed Engl. 54(14):4279-4283, 2015

Aichler M, Walch A
MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice.

Lab Invest. 95(4):422-431, 2015

Almstätter I, Mykhaylyk O, Settles M, Altomonte J, Aichler M, Walch A, Rummeny EJ, Ebert O, Plank C, Braren R
Characterization of magnetic viral complexes for targeted delivery in oncology.
Theranostics. 5(7):667-685, 2015. eCollection 2015

Balluff B, Frese CK, Maier SK, Schöne C, Kuster B, Schmitt M, Aubele M, Höfler H, Deelder AM, Heck AJ, Hogendoorn PC, Morreau J, Altelaar AF, Walch A, McDonnell LA
De novo discovery of phenotypic intratumor heterogeneity using imaging mass spectrometry.

J Pathol. 235(1):3-13, 2015

Bauer L, Takacs A, Slotta-Huspenina J, Langer R, Becker K, Novotny A, Ott K, Walch A, Hapfelmeier A, Keller G
Clinical Significance of NOTCH1 and NOTCH2 Expression in Gastric Carcinomas: An Immunohistochemical Study.
Front Oncol
. 5:94, 2015. eCollection 2015

Baumgart A, Mazur PK, Anton M, Rudelius M, Schwamborn K, Feuchtinger A, Behnke K, Walch A, Braren R, Peschel C, Duyster J, Siveke JT, Dechow T
Opposing role of Notch1 and Notch2 in a KrasG12D-driven murine non-small cell lung cancer model.
Oncogene
. 34(5):578-588, 2015

Berchtold S, Grünwald B, Krüger A, Reithmeier A, Hähl T, Cheng T, Feuchtinger A, Born D, Erkan M, Kleeff J, Esposito I
Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma.
Cancer Lett. 356(2 Pt B):721-732, 2015

Bi Z, Merl-Pham J, Uehlein N, Zimmer I, Mühlhans S, Aichler M, Walch AK, Kaldenhoff R, Palme K, Schnitzler JP, Block K
RNAi-mediated downregulation of poplar plasma membrane intrinsic proteins (PIPs) changes plasma membrane proteome composition and affects leaf physiology.
J Proteomics.  128:321-332, 2015

Buck A, Halbritter S, Späth C, Feuchtinger A, Aichler M, Zitzelsberger H, Janssen KP, Walch A
Distribution and quantification of irinotecan and its active metabolite SN-38 in colon cancer murine model systems using MALDI MSI.

Anal Bioanal Chem
. 407(8):2107-2116, 2015

Buck A, Ly A, Balluff B, Sun N, Gorzolka K, Feuchtinger A, Janssen KP, Kuppen PJ, van de Velde CJ, Weirich G, Erlmeier F, Langer R, Aubele M, Zitzelsberger H, Aichler M, Walch A.
High-resolution MALDI-FT-ICR MS Imaging for the analysis of metabolites from formalin-fixed paraffin-embedded clinical tissue samples.
J Pathol. 237(1):123-132, 2015

Chekkoury A, Gateau J, Driessen W, Symvoulidis P, Bézière N, Feuchtinger A, Walch A, Ntziachristos V
Optical mesoscopy without the scatter: broadband multispectral optoacoustic mesoscopy.

Biomed Opt Express. 6(9):3134-3148, 2015. eCollection 2015

Diakopoulos KN, Lesina M, Wörmann S, Song L, Aichler M, Schild L, Artati A, Römisch-Margl W, Wartmann T, Fischer R, Kabiri Y, Zischka H, Halangk W, Demir IE, Pilsak C, Walch A, Mantzoros CS, Steiner JM, Erkan M, Schmid RM, Witt H, Adamski J, Algül H
Impaired Autophagy Induces Chronic Atrophic Pancreatitis in Mice via Sex- and Nutrition-dependent Processes.
Gastroenterology
. 148(3):626-639.e17, 2015

Erlmeier F, Feuchtinger A, Borgmann D, Rudelius M, Autenrieth M, Walch AK, Weirich G
Supremacy of modern morphometry in typing renal oncocytoma and malignant look-alikes.
Histochem Cell Biol
. 144(2):147-156, 2015

Ermolayev V, Mohajerani P, Ale A, Sarantopoulos A, Aichler M, Kayser G, Walch A, Ntziachristos V
Early recognition of lung cancer by integrin targeted imaging in K-ras mouse model.
Int J Cancer
.
137(5):1107-1118, 2015

Feuchtinger A, Stiehler T, Jütting U, Marjanovic G, Luber B, Langer R, Walch A
Image analysis of immunohistochemistry is superior to visual scoring as shown for patient outcome of esophageal adenocarcinoma.

Histochem Cell Biol. 143(1):1-9, 2015

Genitsch V, Novotny A, Seiler CA, Kröll D, Walch A, Langer R
Epstein-barr virus in gastro-esophageal adenocarcinomas - single center experiences in the context of current literature.
Front Oncol. 5:73, 2015. eCollection 2015

Groß C, Steiger K, Sayyed S, Heid I, Feuchtinger A, Walch A, Heß J, Unger K, Zitzelsberger HF, Settles M, Schlitter AM, Dworniczak J, Altomonte J, Ebert O, Schwaiger M, Rummeny EJ, Steingötter A, Esposito I, Braren R
Model matters: differences in orthotopic rat hepatocellular carcinoma physiology determine therapy response to sorafenib.
Clin Cancer Res. 21(19):4440-4450, 2015

Helmbrecht MS, Soellner H, Truckenbrodt AM, Sundermeier J, Cohrs C, Hans W, de Angelis MH, Feuchtinger A, Aichler M, Fouad K, Huber AB
Loss of Npn1 from motor neurons causes postnatal deficits independent from Sema3A signaling.
Dev Biol.
399(1):2-14, 2015

Ingold I, Aichler M, Yefremova E, Roveri A, Buday K, Doll S, Tasdemir A, Hoffard N, Wurst W, Walch A, Ursini F, Angeli JP, Conrad M
Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility.
J Biol Chem. 290(23):14668-14678, 2015

Kiermayer C, Northrup E, Schrewe A, Walch A, de Angelis MH, Schoensiegel F, Zischka H, Prehn C, Adamski J, Bekeredjian R, Ivandic B, Kupatt C, Brielmeier M
Heart-Specific Knockout of the Mitochondrial Thioredoxin Reductase (Txnrd2) Induces Metabolic and Contractile Dysfunction in the Aging Myocardium.
J Am Heart Assoc. 4(7), 2015

Ly A, Schöne C, Becker M, Rattke J, Meding S, Aichler M, Suckau D, Walch A, Hauck SM, Ueffing M
High-resolution MALDI mass spectrometric imaging of lipids in the mammalian retina.
Histochem Cell Biol. 143(5):453-462, 2015

McDonnell LA, Römpp A, Balluff B, Heeren RM, Albar JP, Andrén PE, Corthals GL, Walch A, Stoeckli M
Discussion point: reporting guidelines for mass spectrometry imaging.
Anal Bioanal Chem
. 407(8):2035-2045, 2015

Oetjen J, Veselkov K, Watrous J, McKenzie JS, Becker M, Hauberg-Lotte L, Kobarg JH, Strittmatter N, Mróz AK, Hoffmann F, Trede D, Palmer A, Schiffler S, Steinhorst K, Aichler M, Goldin R, Guntinas-Lichius O, von Eggeling F, Thiele H, Maedler K, Walch A, Maass P, Dorrestein PC, Takats Z, Alexandrov T
Benchmark datasets for 3D MALDI- and DESI-imaging mass spectrometry.
Gigascience. 4:20, 2015. eCollection 2015

Pfluger PT, Kabra DG, Aichler M, Schriever SC, Pfuhlmann K, García VC, Lehti M, Weber J, Kutschke M, Rozman J, Elrod JW, Hevener AL, Feuchtinger A, Hrabě de Angelis M, Walch A, Rollmann SM, Aronow BJ, Müller TD, Perez-Tilve D, Jastroch M, De Luca M, Molkentin JD, Tschöp MH.
Calcineurin Links Mitochondrial Elongation with Energy Metabolism.
Cell Metab. 22(5):838-850, 2015

Schenck TL, Stewart J, Lin S, Aichler M, Machens HG, Giunta RE
Anatomical and histomorphometric observations on the transfer of the anterior interosseous nerve to the deep branch of the ulnar nerve.
J Hand Surg Eur
40(6):591-596, 2015

Schmitt S, Eberhagen C, Weber S, Aichler M, Zischka H
Isolation of mitochondria from cultured cells and liver tissue biopsies for molecular and biochemical analyses.
Methods Mol Biol. 1295:87-97, 2015

Schulz S, Lichtmannegger J, Schmitt S, Leitzinger C, Eberhagen C, Einer C, Kerth J, Aichler M, Zischka H
A protocol for the parallel isolation of intact mitochondria from rat liver, kidney, heart, and brain.
Methods Mol Biol. 1295:75-86, 2015

Selmansberger M, Feuchtinger A, Zurnadzhy L, Michna A, Kaiser JC, Abend M, Brenner A, Bogdanova T, Walch A, Unger K, Zitzelsberger H, Hess J
CLIP2 as radiation biomarker in papillary thyroid carcinoma.
Oncogene.
34(30):3917-3925, 2015

Teiluf K, Seidl C, Blechert B, Gaertner FC, Gilbertz KP, Fernandez V, Bassermann F, Endell J, Boxhammer R, Leclair S, Vallon M, Aichler M, Feuchtinger A, Bruchertseifer F, Morgenstern A, Essler M
α-Radioimmunotherapy with 213Bi-anti-CD38 immunoconjugates is effective in a mouse model of human multiple myeloma.
Oncotarget. 6(7):4692-4703, 2015

Velikova V, Müller C, Ghirardo A, Rock TM, Aichler M, Walch A, Schmitt-Kopplin P, Schnitzler JP.
Knocking down of isoprene emission modifies the lipid matrix of thylakoid membranes and influences the chloroplast ultrastructure in poplar.
Plant Physiol. 168(3):859-870, 2015

2014

Aichler M, Luber B, Lordick F, Walch A
Proteomic and metabolic prediction of response to therapy in gastric cancer.

World J Gastroenterol. 20(38):13648-13657, 2014

Aichler M, Motschmann M, Jütting U, Luber B, Becker K, Ott K, Lordick F, Langer R, Feith M, Siewert JR, Walch A
Epidermal growth factor receptor (EGFR) is an independent adverse prognostic factor in esophageal adenocarcinoma patients treated with cisplatin-based neoadjuvant chemotherapy.

Oncotarget. 5(16):6620-6632, 2014

Aichler M, Walch A
In Brief: The (Molecular) Pathogenesis of Barrett's Oesophagus.
J Pathol. 232(4):383-385, 2014

Becker L, Kling E, Schiller E, Zeh R, Schrewe A , Hölter S, Moßbrugger I, Calzada-Wack J, Strecker V, Wittig I, Dumitru I, Wenz T, Bender A, Aichler M, Janik D, Neff F, Walch A, Quintanilla-Fend L, Floss T, Bekeredjian R, Gailus-Durner V, Fuchs H, Wurst W, Meitinger T, Prokisch H, Hrabě de Angelis M, Klopstock T
MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy
PLoS One.
9(12):e114918, 2014 eCollection 2014

Beziere N, von Schacky C, Kosanke Y, Kimm M, Nunes A, Licha K, Aichler M, Walch A, Rummeny EJ, Ntizachristos V, Meier R.
Optoacoustic imaging and staging of arthritic inflammation.
Arthritis Rheumatol. 66(8):2071-2078, 2014

Buck A, Walch A.
In situ drug and metabolite analyzes in biological and clinical research by MALDI MS imaging.

Bioanalysis
. 6(9):1241-1253, 2014

Dekker TJ, Balluff BD, Jones EA, Schöne CD, Schmitt M, Aubele M, Kroep JR, Smit VT, Tollenaar RA, Mesker WE, Walch A, McDonnell LA
Multicentre matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) identifies proteomic differences in breast cancer-associated stroma.
J Proteome Res.
13(11):4730-4738, 2014

Friedmann Angeli JP, Schneider M, Proneth B, Tyurina Y, Tyurin V, Hammond V, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Radmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Förster H, Wanke R, Yefremova O, Heinrichmeyer M, Bornkamm G, Geissler E, Thomas S, Stockwell B, O´Donnell V, Kagan V, Schick J, Conrad M
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Nat Cell Biol. 16(12):1180-1191, 2014

Gegg M, Böttcher A, Burtscher I, Hasenöder S, Van Campenhout C, Aichler M, Walch A, Grant SG, Lickert H
Flattop regulates basal body docking and positioning in mono- and multiciliated cells.
Elife.
3:03842, 2014

Gorzolka K, Walch A
MALDI mass spectrometry imaging of formalin-fixed paraffin-embedded tissues in clinical research.

Histol Histopathol.
29(11):1365-1376, 2014

Graf N, Li Z, Herrmann K, Weh D, Aichler M, Slawska J, Walch A, Peschel C, Schwaiger M, Buck AK, Dechow T, Keller U
Positron emission tomographic monitoring of dual phosphatidylinositol-3-kinase and mTOR inhibition in anaplastic large cell lymphoma.
Onco Targets Ther. 7:789-798, 2014

Huber K, Aichler M, Sun N, Buck A, Li Z, Fernandez IE, Hauck SM, Zitzelsberger H, Eickelberg O, Janssen KP, Keller U, Walch A
A rapid ex vivo tissue model for optimising drug detection and ionisation in MALDI imaging studies.

Histochem Cell Biol.
142(4):361-371, 2014

Huber K, Feuchtinger A, Borgmann DM, Li Z, Aichler M, Hauck SM, Zitzelsberger H, Schwaiger M, Keller U, Walch A
A novel approach of MALDI drug imaging, immunohistochemistry, and digital image analysis for drug distribution studies in tissues.

Anal Chem
. 86(21):10568-10575, 2014

Kahle M, Schäfer A, Seelig A, Schultheiß J, Wuj M, Aichler M, Leonhardt J, Rathkolb B, Rozman J, Sarioglu H, Hauck SM, Ueffing M, Wolf E, Kastenmueller G, Adamski J, Walch A, Hrabè de Angelis M, Neschen S
High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice.
Mol Metab. 4(1):39-50, 2014

Kucharska J, Del Río P, Arango-Gonzalez B, Gorza M, Feuchtinger A, Hauck SM, Ueffing M
Cyr61 activates retinal cells and prolongs photoreceptor survival in rd1 mouse model of retinitis pigmentosa.
J Neurochem.
130(2):227-240, 2014

Li Z, Herrmann K, Pirsig S, Philipp-Abbrederis K, Henninger M, Aichler M, Feuchtinger A, Walch A, Beer AJ, Ringshausen I, Pomykala KL, Scheidhauer K, Schwaiger M, Keller U, Buck AK
Molecular imaging for early prediction of response to Sorafenib treatment in sarcoma.
Am J Nucl Med Mol Imaging. 4(1):70-79, 2014

Maier SK, Bashkueva K, Rösli C, Skerra A, Kuster B
PAS-cal: A repetitive peptide sequence calibration standard for MALDI mass spectrometry.
Proteomics. 14(21-22):2427-2431, 2014

McDonnell LA, Walch A, Stoeckli M, Corthals GL
MSiMass list: a public database of identifications for protein MALDI MS imaging.
J Proteome Res. 13(2):1138-1142, 2014

Schmitt S, Schulz S, Schropp EM, Eberhagen C, Simmons A, Beisker W, Aichler M, Zischka H
Why to compare absolute numbers of mitochondria.
Mitochondrion
. 19 Pt A:113-123, 2014

Slotta-Huspenina J, Becker KF, Feith M, Walch A, Langer R
Heat Shock Protein 90 (HSP90) and Her2 in Adenocarcinomas of the Esophagus.
Cancers
(Basel).
6(3):1382-1393, 2014

Stribl C, Samara A, Trümbach D, Augustin R, Neumann M; Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Rathkolb B, Wolf E, Beckers J, Horsch M, Neff F, Kremmer E, Reichert A, Koob S, Hans W, Rozman J, Klingenspor M, Aichler M, Walch AK, Hölter SM, Glasl L, Wurst W, Floss T
Mitochondrial dysfunction and decrease of body weight in a knock-in mouse model for TDP-43
J Biol Chem. 289(15):10769-10784, 2014

Sun N, Ly A, Meding S, Witting M, Hauck SM, Ueffing M, Schmitt-Kopplin P, Aichler M, Walch A
High-Resolution Metabolite Imaging of Light and Dark Treated Retina Using MALDI-FTICR Mass Spectrometry.

Proteomics.
14(7-8):913-923, 2014

Wildgruber M, Bielicki I, Aichler M, Kosanke K, Feuchtinger A, Settles M, Onthank DC, Cesati RR, Robinson SP, Huber AM, Rummeny EJ, Walch AK, Botnar RM
Assessment of Myocardial Infarction and Post-infarction Scar Remodeling with an Elastin-specific Magnetic Resonance Agent.
Circ Cardiovasc Imaging. 7(2):321-329, 2014

2013

Aichler M, Elsner M, Ludyga N, Feuchtinger A, Zangen V, Maier SK, Balluff B, Schöne C, Hierber L, Braselmann H, Meding S, Rauser S, Zischka H, Aubele M, Schmitt M, Feith M, Hauck SM, Ueffing M, Langer R, Kuester B, Zitzelsberger H, Höfler H, Walch AK
Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria.
J Pathol. 230(4):410-419, 2013

Ale A, Siebenhaar F, Kosanke K, Aichler M, Radrich K, Heydrich S, Schiemann M, Bielicki I, Noel PB, Braren R, Maurer M, Walch AK, Rummeny EJ, Ntziachristos V, Wildgruber M
Cardioprotective C-kit(+) Bone Marrow Cells Attenuate Apoptosis after Acute Myocardial Infarction in Mice - In-vivo Assessment with Fluorescence Molecular Imaging.
Theranostics
. 3(11):903-913, 2013

Altomonte J, Marozin S, Detoni EN, Rizzani A, Esposito I, Steiger K, Feuchtinger A, Hellerbrand C, Schmid RM, Ebert O.
Antifibrotic properties of transarterial oncolytic VSV therapy for hepatocellular carcinoma in rats with thioacetamide-induced liver fibrosis.
Mol Ther
. 21(11):2032-2042, 2013

Azimzadeh O, Sievert W, Sarioglu H, Yentrapalli R, Barjaktarovic Z, Sriharshan A, Ueffing M, Janik D, Aichler M, Atkinson M, Multhoff G, Tapio S
PPAR alpha: a novel radiation target in locally exposed Mus musculus heart revealed by quantitative proteomics.
J Proteome Res. 12(6):2700-2714, 2013

Berezowska S, Novotny A, Bauer K, Feuchtinger A, Slotta-Huspenina J, Becker K, Langer R, Walch A
Association between HSP90 and Her2 in Gastric and Gastroesophageal Carcinomas.

PLoS One. 8(7):e69098, 2013

Bettstetter M, Berezowska S, Keller G, Walch A, Feuchtinger A, Slotta-Huspenina J, Feith M, Drecoll E, Höfler H, Langer R
Epidermal growth factor receptor, phosphatidylinositol-3-kinase catalytic subunit/PTEN, and KRAS/NRAS/BRAF in primary resected esophageal adenocarcinomas: loss of PTEN is associated with worse clinical outcome.
Hum Pathol.
44(5):829-836, 2013

Falkenberg N, Anastasov N, Rappl K, Braselmann H, Auer G, Walch A, Huber M, Höfig I, Schmitt M, Höfler H, Atkinson M, Aubele M
MiR-221/-222 differentiate prognostic groups in advanced breast cancers and influence cell invasion
.
Br J Cancer.
109(10):2714-2723, 2013

Franko A, Baris OR, Bergschneider E, von Toerne C, Hauck SM, Aichler M, Walch AK, Wurst W, Wiesner RJ, Johnston IC, de Angelis MH
Efficient Isolation of Pure and Functional Mitochondria from Mouse Tissues Using Automated Tissue Disruption and Enrichment with Anti-TOM22 Magnetic Beads.
PLoS One
.;8(12):e82392, 2013

Graf N, Herrmann K, Numberger B, Zwisler D, Aichler M, Feuchtinger A, Schuster T, Wester HJ, Senekowitsch-Schmidtke R, Peschel C, Schwaiger M, Keller U, Dechow T, Buck AK
[(18)F]FLT is superior to [(18)F]FDG for predicting early response to antiproliferative treatment in high-grade lymphoma in a dose-dependent manner.
Eur J Nucl Med Mol Imaging. 40(1):34-43, 2013

Hahne H, Pachl F, Ruprecht B, Maier SK, Klaeger S, Helm D, Médard G, Wilm M, Lemeer S, Kuster B
DMSO enhances electrospray response, boosting sensitivity of proteomic experiments.
Nat Methods.
10(10):989-991, 2013

Krebs K, Böttinger N, Huang LR, Chmielewski M, Arzberger S, Gasteiger G, Jäger C, Schmitt E, Bohne F, Aichler M, Uckert W, Abken H, Heikenwalder M, Knolle P, Protzer U
T Cells Expressing a Chimeric Antigen Receptor That Binds Hepatitis B Virus Envelop Proteins Control Virus Replication in Mice.
Gastroenterology. 145(2): 456-465, 2013

Ludyga N, Englert S, Pflieger K, Rauser S, Braselmann H, Walch A, Auer G, Höfler H, Aubele M
The impact of Cysteine-Rich Intestinal Protein 1 (CRIP1) in human breast cancer.
Mol Cancer. 12(1):28, 2013

Maier SK, Hahne H, Moghaddas Gholami A, Balluff B, Meding S, Schoene C, Walch AK, Kuster B
Comprehensive identification of proteins from MALDI imaging.
Mol Cell Proteomics 12(10):2901-2910, 2013

Marinoni I, Lee M, Mountford S, Perren A, Bravi I, Jennen L, Feuchtinger A, Drouin J, Roncaroli F, Pellegata NS
Characterization of MENX-associated pituitary tumours.
Neuropathol Appl Neurobiol. 39(3):256-269, 2013

Meding S, Walch A
MALDI imaging mass spectrometry for direct tissue analysis.

Methods Mol Biol.
931:537-546, 2013

Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Küchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH
p62 Links β-adrenergic input to mitochondrial function and thermogenesis.
J Clin Invest. 123(1):469–478, 2013

Neubert P, Walch A
Current frontiers in clinical research application of MALDI Imaging mass spectrometry
.
Expert Rev Proteomics.
10(3):259-273, 2013

Oetjen J, Aichler M, Trede D, Strehlow J, Berger J, Heldmann S, Becker M, Gottschalk M, Kobarg JH, Wirtz S, Schiffler S, Thiele H, Walch A, Maass P, Alexandrov T
MRI-compatible pipeline for three-dimensional MALDI imaging mass spectrometry using PAXgene fixation.
J Proteomics. 90:52-60, 2013

Pallua JD, Schaefer G, Seifarth C, Becker M, Meding S, Rauser S, Walch A, Handler M, Netzer M, Popovscaia M, Osl M, Baumgartner C, Lindner H, Kremser L, Sarg B, Bartsch G, Huck CW, Bonn GK, Klocker H
MALDI-MS tissue imaging identification of biliverdin reductase B overexpression in prostate cancer.
J Proteomics, 91C:500-514, 2013

Schmitt S, Saathoff F, Meissner L, Schropp EM, Lichtmannegger J, Schulz S, Eberhagen C, Borchard S, Aichler M, DiSpirito AA, Adamski J, Plesnila N, Rothenfusser S, Kroemer G, Zischka H
A semi-automated method for isolating functionally intact mitochondria from cultured cells and tissue biopsies.
Anal Biochem
. 443(1):66-74, 2013

Schöne C, Höfler H, Walch A
MALDI Imaging Mass Spectrometry in Cancer Research: Combining Proteomic Profiling and Histological Evaluation.

Clin Biochem. 46(6):539-545, 2013

Schulz S, Schmitt S, Wimmer R, Aichler M, Eisenhofer S, Lichtmannegger J, Eberhagen C, Artmann R, Tookos F, Walch A, Krappmann D, Brenner-Jan C, Rust C, Zischka H
Progressive stages of mitochondrial destruction caused by cell toxic bile salts.
Biochim Biophys Acta. 1828(9):2121-2133, 2013

Sun N, Walch A
Qualitative and quantitative mass spectrometry imaging of drugs and metabolites in tissue at therapeutic levels.
Histochem Cell Biol. 140(2):93-104, 2013

Tapfer A, Braren R, Bech M, Willner M, Zanette I, Weitkamp T, Trajkovic-Arsic M, Siveke JT, Settles M, Aichler M, Walch A, Pfeiffer F
X-Ray Phase-Contrast CT of a Pancreatic Ductal Adenocarcinoma Mouse Model.
PLoS One. 8(3):e58439, 2013

Taruttis A, Wildgruber M, Kosanke K, Beziere N, Licha K, Haag R, Aichler M, Walch A, Rummeny E, Ntziachristos V
Multispectral optoacoustic tomography of myocardial infarction.
Photoacoustics
1(1); 3-8, 2013

Wortmann M, Schneider M, Pircher J, Hellfritsch J, Aichler M, Vegi N, Koelle P, Kuhlencordt P, Walch A, Pohl U, Bornkamm GW, Conrad M, Beck H
Combined Deficiency in Glutathione Peroxidase 4 (Gpx4) and Vitamin E Causes Multi-Organ Thrombus Formation and Early Death in Mice.
Circ Res. 113(4):408-417, 2013

2012

Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, Da Silva-Buttkus P, Bartsch DK, Langer P, Chiblak S, Dürr A, Höfler H, Klöppel G, Müller-Decker K, Brielmeier M, Esposito I
Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues.
J Pathol. 226(5):723-734, 2012

Balluff B, Rauser S, Ebert MP, Siveke JT, Höfler H, Walch A
Direct Molecular Tissue Analysis by MALDI Imaging Mass Spectrometry in the Field of Gastrointestinal Disease.
Gastroenterology. 143(3):544-549, 2012

Berg D, Wolff C, Malinowsky K, Tran K, Walch A, Bronger H, Schuster T, Höfler H, Becker KF
Profiling signalling pathways in formalin-fixed and paraffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, HER3 and uPAR.
J Cell Physiol. 227(1):204-212, 2012

von Brühl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, Khandoga A, Tirniceriu A, Coletti R, Köllnberger M, Byrne RA, Laitinen I, Walch A, Brill A, Pfeiler S, Manukyan D, Braun S, Lange P, Riegger J, Ware J, Eckart A, Haidari S, Rudelius M, Schulz C, Echtler K, Brinkmann V, Schwaiger M, Preissner KT, Wagner DD, Mackman N, Engelmann B, Massberg S
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo.
J Exp Med. 209(4):819-835, 2012

Ebert MP, Tänzer M, Balluff B, Burgermeister E, Kretzschmar AK, Hughes DJ, Tetzner R, Lofton-Day C, Rosenberg R, Reinacher-Schick AC, Schulmann K, Tannapfel A, Hofheinz R, Röcken C, Keller G, Langer R, Specht K, Porschen R, Stöhlmacher-Williams J, Schuster T, Ströbel P, Schmid RM
TFAP2E-DKK4 and chemoresistance in colorectal cancer.
N Engl J Med. 366(1):44-53,2012

Elsner M, Rauser S, Maier S, Schöne C, Balluff B; Meding S, Jung G, Nipp M, Sarioglu H, Maccarrone G, Aichler M, Feuchtinger A, Langer R, Jütting U, Feith M, Küster B, Ueffing M, Zitzelsberger H, Höfler H, Walch A
MALDI Imaging Mass Spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic Markers in Barrett's Adenocarcinoma
J Prot. 75(15):4693-4704, 2012

Feuerecker B, Pirsig S, Seidl C, Aichler M, Feuchtinger A, Bruchelt G, Senekowitsch-Schmidtke R
Lipoic acid inhibits cell proliferation of tumor cells in vitro and in vivo.
Cancer Biol Ther. 13(14):1425-1435, 2012

Gehrmann M, Stangl S, Kirschner A, Foulds GA, Sievert W, Doß BT, Walch A, Pockley AG, Multhoff G
Immunotherapeutic targeting of membrane hsp70-expressing tumors using recombinant human granzyme B.
PLoS One. 7(7):e41341, 2012

Grüner BM, Hahne H, Mazur PK, Trajkovic-Arsic M, Maier S, Esposito I, Kalideris E, Michalski CW, Kleeff J, Rauser S, Schmid RM, Küster B, Walch A, Siveke JT
MALDI Imaging Mass Spectrometry for In Situ Proteomic Analysis of Preneoplastic Lesions in Pancreatic Cancer.
PLoS One. 7(6):e39424, 2012

Grunewald TG, Ranft A, Esposito I, da Silva-Buttkus P, Aichler M, Baumhoer D, Schaefer KL, Ottaviano L, Poremba C, Jundt G, Jürgens H, Dirksen U, Richter GH, Burdach S
High STEAP1 expression is associated with improved outcome of Ewing's sarcoma patients.
Ann Oncol. 23(8):2185-2190, 2012

Hahne H, Neubert P, Kuhn K, Etienne C, Bomgarden R, Rogers JC, Kuster B
Carbonyl-reactive tandem mass tags for the proteome-wide quantification of N-linked glycans.
Anal Chem. 84(8):3716-3724, 2012

Heindl S, Eggenstein E, Keller S, Kneissl J, Keller G, Mutze K, Rauser S, Gasteiger G, Drexler I, Hapfelmeier A, Höfler H, Luber B.
Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell lines.
J Cancer Res Clin Oncol. 138(5):843-858, 2012

Kernt M, Walch A, Neubauer AS, Hirneiss C, Haritoglou C, Ulbig MW, Kampik A
Filtering blue light reduces light-induced oxidative stress, senescence, and accumulation of extracellular matrix proteins in human retinal pigment epithelium cells.
Clin Experiment Ophthalmol. 40(1):e87-97, 2012

Li Z, Graf NA, Herrmann K, Jünger A, Aichler M, Feuchtinger A, Baumgart A, Walch A, Peschel C, Schwaiger M, Buck A, Keller U, Dechow T
FLT-PET Is Superior to FDG-PET for Very Early Response Prediction in NPM-ALK-Positive Lymphoma Treated with Targeted Therapy.
Cancer Res. 72(19):5014-5024, 2012

Malinowsky K, Wolff C, Berg D, Schuster T, Walch A, Bronger H, Mannsperger H, Schmidt C, Korf U, Höfler H, Becker KF
uPA and PAI-1-Related Signaling Pathways Differ between Primary Breast Cancers and Lymph Node Metastases.
Transl Oncol. 5(2):98-104, 2012

Manook A, Yousefi BH, Willuweit A, Platzer S, Reder S, Voss A, Huisman M, Settles M, Neff F, Velden J, Schoor M, von der Kammer H, Wester HJ, Schwaiger M, Henriksen G, Drzezga A
Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease.
PLoS One. 7(3):e31310, 2012

Meding S, Balluff B, Elsner M, Schöne C, Rauser S, Nitsche U, Maak M, Schäfer A, Hauck SM, Ueffing M, Langer R, Höfler H, Friess H, Rosenberg R, Walch A
Tissue Based Proteomics Reveals FXYD3, S100A11 and GSTM3 as Novel Markers for Regional Lymph Node Metastasis in Colon Cancer.
J Pathol. 228(4):459-470, 2012

Meding S, Nitsche U, Balluff B, Elsner M, Rauser S, Schöne C, Nipp M, Maak M, Feith M, Ebert M, Friess H, Langer R, Höfler H, Zitzelsberger H, Rosenberg R, Walch A
Tumor Classification of Six Common Cancer Types Based on Proteomic Profiling by MALDI Imaging.
J Proteome Res. 11(3):1996-2003, 2012

Nipp M, Elsner M, Balluff B, Meding S, Sarioglu H, Ueffing M, Rauser S, Unger K, Höfler H, Walch A, Zitzelsberger H
S100-A10, thioredoxin, and S100-A6 as biomarkers of papillary thyroid carcinoma with lymph node metastasis identified by MALDI Imaging.
J Mol Med (Berl). 90(2):163-174, 2012

Prade E, Tobiasch M, Hitkova I, Schäffer I, Lian F, Xing X, Tänzer M, Rauser S, Walch A, Feith M, Post S, Röcken C, Schmid RM, Ebert MP, Burgermeister E
Bile Acids Down-Regulate Caveolin-1 in Esophageal Epithelial Cells through Sterol Responsive Element-Binding Protein.
Mol Endocrinol. 26(5):819-832, 2012

Saraste A, Laitinen I, Weidl E, Wildgruber M, Weber AW, Nekolla SG, Hölzlwimmer G, Esposito I, Walch A, Leppänen P, Lisinen I, Luppa PB, Ylä-Herttuala S, Wester HJ, Knuuti J, Schwaiger M
Diet intervention reduces uptake of a(v)ß (3) integrin-targeted PET tracer (18)F-galacto-RGD in mouse atherosclerotic plaques.
J Nucl Cardiol. 19(4):775-784, 2012

Seiz L, Dorn J, Kotzsch M, Walch A, Grebenchtchikov NI, Gkazepis A, Schmalfeldt B, Kiechle M, Bayani J, Diamandis EP, Langer R, Sweep FC, Schmitt M, Magdolen V
Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients.
Biol Chem. 393(5):391-401, 2012

Slotta-Huspenina J, Berg D, Bauer K, Wolff C, Malinowsky K, Bauer L, Drecoll E, Bettstetter M, Feith M, Walch A, Höfler H, Becker KF, Langer R
Evidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal adenocarcinomas.
PLoS One. 7(7):e41420, 2012

Stross L, Günther J, Gasteiger G, Asen T, Graf S, Aichler M, Esposito I, Busch DH, Knolle P, Sparwasser T, Protzer U
Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute, experimental hepatitis B virus infection.
Hepatology. 56(3):873-883, 2012

Takenaka S, Möller W, Semmler-Behnke M, Karg E, Wenk A, Schmid O, Stoeger T, Jennen L, Aichler M, Walch A, Pokhrel S, Mädler L, Eickelberg O, Kreyling WG
Efficient internalization and intracellular translocation of inhaled gold nanoparticles in rat alveolar macrophages.
Nanomedicine (Lond). 7(6):855-865, 2012

Trede D, Schiffler S, Becker M, Wirtz S, Steinhorst K, Strehlow J, Aichler M, Kobarg JH, Oetjen J, Dyatlov A, Heldmann S, Walch A, Thiele H, Maass P, Alexandrov T
Exploring 3D MALDI imaging mass spectrometry data: 3D spatial segmentation of mouse kidney.
Anal Chem. 84(14):6079-6087, 2012

Vallon M, Seidl C, Blechert B, Li Z, Gilbertz KP, Baumgart A, Aichler M, Feuchtinger A, Gaertner FC, Bruchertseifer F, Morgenstern A, Walch AK, Senekowitsch-Schmidtke R, Essler M
Enhanced efficacy of combined (213)Bi-DTPA-F3 and paclitaxel therapy of peritoneal carcinomatosis is mediated by enhanced induction of apoptosis and G2/M phase arrest.
Eur J Nucl Med Mol Imaging. 39(12):1886-1897, 2012

Wulfkuhle JD, Berg D, Wolff C, Langer R, Tran K, Illi J, Espina V, Pierobon M, Deng J, Demichele A, Walch A, Bronger H, Becker I, Waldhor C, Höfler H, Esserman LJ, Liotta LA, Becker KF, Petricoin EF 3rd
Molecular analysis of HER2 signaling in human breast cancer by functional protein pathway activation mapping.
Clin Cancer Res. 18(23):6426-6435, 2012

2011

Alexandrov T, Meding S, Trede D, Kobarg JH, Balluff B, Walch A, Thiele H, Maass P
Super-resolution segmentation of imaging mass spectrometry data: Solving the issue of low lateral resolution.
J Proteomics. 75(1):237-245, 2011

Balluff B, Rauser S, Meding S, Elsner M, Schöne C, Feuchtinger A, Schuhmacher C, Novotny A, Jütting U, Maccarrone G, Sarioglu H, Ueffing M, Braselmann H, Zitzelsberger H, Schmid RM, Höfler H, Ebert MP, Walch A
MALDI Imaging Identifies Prognostic Seven-Protein Signature of Novel Tissue Markers in Intestinal-Type Gastric Cancer.
Am J Pathol. 179(6):2720-2729, 2011

Balluff B, Schöne C, Höfler H, Walch A
MALDI imaging mass spectrometry for direct tissue analysis: technological advancements and recent applications.
Histochem Cell Biol. 136(3):227-244, 2011

Baumhoer D, Elsner M, Smida J, Zillmer S, Rauser S, Schoene C, Balluff B, Bielack S, Jundt G, Walch A, Nathrath M
CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients.
Oncotarget. 2(12):970-975, 2012

Berg D, Langer R, Tran K, Walch A, Schuster T, Bronger H, Becker KF
Protein Microarray-based Comparison of HER2, Estrogen Receptor, and Progesterone Receptor Status in Core Biopsies and Surgical Specimens From FFPE Breast Cancer Tissues.
Appl Immunohistochem Mol Morphol. 19(4):300-305, 2011

Deininger SO, Cornett DS, Paape R, Becker M, Pineau C, Rauser S, Walch A, Wolski E
Normalization in MALDI-TOF imaging datasets of proteins: practical considerations.
Anal Bioanal Chem. 401(1):167-181, 2011

Eberhardt C, Amann B, Feuchtinger A, Hauck SM, Deeg CA
Differential expression of inwardly rectifying K+ channels 1 and aquaporins 4 and 5 in autoimmune uveitis indicates misbalance in Müller glial cell-dependent ion and water homeostasis.
Glia. 59(5):697-707, 2011

Lagarrigue M, Becker M, Lavigne R, Deininger SO, Walch A, Aubry F, Suckau D, Pineau C
Revisiting rat spermatogenesis with MALDI imaging at 20 {micro}m resolution.
Mol Cell Proteomics. 10(3):M110.005991, 2011

Langer L, Rauser S, Feith M, Nährig JM, Feuchtinger A, Friess H, Höfler H, Walch A
Assessment of Her2 in esophageal adenocarcinomas – summary of a revised immunohistochemical evaluation system, bright field double in situ hybridisation (BDISH) and fluorescence in situ hybridisation (FISH).
Mod Pathol. 24(7):908-916, 2011

Lian F, Xing X, Yuan G, Schäfer C, Rauser S, Walch A, Röcken Ch, Ebeling M, Wright MB, Schmid RM, Ebert M, Burgermeister E
Farnesoid X receptor protects human and murine gastric epithelial cells against inflammation-induced damage.
Biochem J. 438(2):315-323, 2011

Loos M, Langer R, Schuster T, Gertler R, Walch A, Rauser S, Friess H, Feith M
Clinical significance of the costimulatory molecule B7-H1 in Barrett carcinoma.
Ann Thorac Surg. 91(4):1025-1031, 2011

Luber B, Deplazes J, Keller G, Walch A, Rauser S, Eichmann M, Langer R, Höfler H, Hegewisch-Becker S, Folprecht G, Wöll E, Decker T, Endlicher E, Lorenzen S, Fend F, Peschel C, Lordick F.
Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO).
BMC Cancer. 11:509, 2011

Marjanovic G, Schricker M, Walch A, Zur Hausen A, Hopt UT, Imdahl A, Makowiec F
Detection of Lymph Node Involvement by Cytokeratin Immunohistochemistry is an Independent Prognostic Factor After Curative Resection of Esophageal Cancer.
J Gastrointest Surg. 15(1):29-37, 2011

Pallua JD, Schaefer G, Bittner LK, Pezzei C, Huck-Pezzei V, Schoenbichler SA, Becker M, Schneider S, Meding S, Rauser S, Walch A, Handler M, Netzer M, Osl M, Seger M, Pfeifer B, Baumgartner C, Lindner H, Kremser L, Sarg B, Klocker H, Bartsch G, Bonn GK, Huck CW
Matrix Assisted Laser Desorption/Ionization (MALDI) Imaging Mass Spectrometry (IMS) for Direct Tissue Analysis.
LC*GC Mag Sep Sci. 2011 (accepted 09/2011)

Saarikangas J, Mattila PK, Varjosalo M, Bovellan M, Hakanen J, Calzada-Wack J, Tost M, Jennen L, Rathkolb B, Hans W, Horsch M, Hyvönen ME, Perälä N, Fuchs H, Gailus-Durner V, Esposito I, Wolf E, de Angelis MH, Frilander MJ, Savilahti H, Sariola H, Sainio K, Lehtonen S, Taipale J, Salminen M, Lappalainen P
Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.
J Cell Sci. 124(Pt 8):1245-1255, 2011

Schumann RG, Eibl KH, Zhao F, Scheerbaum M, Scheler R, Schaumberger MM, Wehnes H, Walch AK, Haritoglou C, Kampik A, Gandorfer A
Immunocytochemical and ultrastructural evidence of glial cells and hyalocytes in internal limiting membrane specimens of idiopathic macular holes.
Invest Ophthalmol Vis Sci. 52(11):7822-7834, 2011

Sibbing D, Pfeufer A, Perisic T, Mannes AM, Fritz-Wolf K, Unwin S, Sinner MF, Gieger C, Gloeckner CJ, Wichmann HE, Kremmer E, Schäfer Z, Walch A, Hinterseer M, Näbauer M, Kääb S, Kastrati A, Schömig A, Meitinger T, Bornkamm GW, Conrad M, von Beckerath N
Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy.
Eur Heart J. 32(9):1121-33, 2011

Stangl S, Gehrmann M, Dressel R, Alves F, Dullin C, Themelis G, Ntziachristos V, Staeblein E, Walch A, Winkelmann I, Multhoff G
In vivo imaging of CT26 mouse tumors by using cmHsp70.1 monoclonal antibody.
J Cell Mol Med. 15(4): 874-887, 2011

Timme S, Schmitt E, Stein S, Schwarz-Finsterle J, Wagner J, Walch A, Werner M, Hausmann M, Wiech T
Nuclear position and shape deformation of chromosome 8 territories in pancreatic ductal adenocarcinoma.
Anal Cell Pathol (Amst). 34(1):21-33, 2011

Vela-Chávez T, Adam P, Kremer M, Bink K, Bacon CM, Menon G, Ferry JA, Fend F, Jaffe ES, Quintanilla-Martínez L
Cyclin D1 positive diffuse large B-cell lymphoma is a post-germinal center-type lymphoma without alterations in the CCND1 gene locus.
Leuk Lymphoma. 52(3):458-466, 2011

Walch A, Rauser S, Höfler H
MALDI imaging mass spectrometry on formalin-fixed paraffin-embedded tissues.
In: G. Stanta (ed.), Guidelines for Molecular Analysis in Archive Tissues, Chapter 49. Springer-Verlag Berlin Heidelberg. doi: 10.1007/978-3-642-17890-0_49, 2011

Wolff C, Malinowsky K, Berg D, Schragner K, Schuster T, Walch A, Bronger H, Höfler H, Becker KF
Signalling networks associated with urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in breast cancer tissues: new insights from protein microarray analysis.
J Pathol. 223(1):54-63, 2011

Wu Z, Doondeea JB, Moghaddas Gholami A, Janning MC, Lemeer S, Kramer K, Eccles SA, Gollin SM, Grenman R, Walch A, Feller SM, Kuster B
Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer.
Mol Cell Proteomics. 10(12):M111.011635, 2011

Zischka H, Lichtmannegger J, Schmitt S, Jägemann N, Schulz S, Wartini D, Jennen L, Rust C, Larochette N, Galluzzi L, Chajes V, Bandow N, Gilles VS, Dispirito AA, Esposito I, Goettlicher M, Summer KH, Kroemer G
Liver mitochondrial membrane crosslinking and destruction in a rat model of Wilson disease.
J Clin Invest. 121(4):1508-1518, 2011

2010

Aubele M, Spears M, Ludyga N, Braselmann H, Feuchtinger A, Taylor KJ, Lindner K, Auer G, Stering K, Höfler H, Schmitt M, Bartlett JM
In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissues.
Br J Cancer. 103(5):663-667, 2010

Balluff B, Elsner M, Kowarsch A, Rauser S, Meding S, Schuhmacher C, Feith M, Herrmann K, Röcken C, Schmid RM, Höfler H, Walch A, Ebert MP
Classification of HER2/neu Status in Gastric Cancer using a Breast-Cancer Derived Proteome Classifier.
J Proteome Res. 9(12):6317-6322, 2010

Becker KF, Berg D, Malinowsky K, Wolff C, Ergin B, Meding S, Walch A, Höfler H
[Update on protein analysis of fixed tissues.] Neues zur Proteinanalytik archivierter Gewebeproben
Pathologe. 31 Suppl 2:263-267, 2010

Berg D, Bronger H, Walch A, Höfler H, Becker KF
Analysis of signalling pathways in formalin-fixed breast cancer tissues.
Pathologe. 31 Suppl 2:296-299, 2010

Echtler K, Stark K, Lorenz M, Kerstan S, Walch A, Jennen L, Rudelius M, Seidl S, Kremmer E, Emambokus NR, von Bruehl ML, Frampton J, Isermann B, Genzel-Boroviczény O, Schreiber C, Mehilli J, Kastrati A, Schwaiger M, Shivdasani RA, Massberg S
Platelets contribute to postnatal occlusion of the ductus arteriosus.
Nat Med. 16(1):75-82, 2010

Ergin B, Meding S, Langer R, Kap M, Viertler C, Schott C, Ferch U, Riegman P, Zatloukal K, Walch A, Becker KF.
Proteomic Analysis of PAXgene-Fixed Tissues.
J Proteome Res. 9(10):5188-5196, 2010

Hauck, S, Dietter, J, Kramer R, Hofmaier F, Zipplies J, Amann B, Feuchtinger A, Deeg C, Ueffing M
Deciphering membrane-associated molecular processes in target tissue of autoimmune uveitis by label-free quantitative mass spectrometry .
Mol Cell Proteomics. 9(10):2292-2305, 2010

Herbert Z, Rauser S, Williams L, Kapan N, Güntner M, Walch A, Boyan G
Developmental expression of neuromodulators in the central complex of the grasshopper Schistocerca gregaria.
J Morphology. 271(12):1509-1526, 2010

Hipp S, Berg D, Ergin B, Schuster T, Hapfelmeier A, Walch A, Avril S, Schmalfeldt B, Höfler H, Becker KF
Interaction of Snail and p38 mitogen-activated protein kinase results in shorter overall survival of ovarian cancer patients.
Virchows Arch. 457(6):705-713, 2010

Rauser S, Deininger SO, Suckau D, Höfler H, Walch A
Approaching MALDI Molecular Imaging for Clinical Proteomic Research: Current state and fields of application.
Expert Rev Proteomics. 7(6):927-941, 2010

Rauser S, Langer R, Tschernitz S, Gais P, Jütting U, Feith M, Höfler H, Walch A
High number of CD45RO+ infiltrating lymphocytes is an independent factor in non-metastasized (stage I-IIA) esophageal adenocarcinoma.
BMC Cancer. 10(1):608, 2010

Rauser S, Marquardt C, Balluff B, Deininger SO, Albers C, Belau E, Hartmer R, Suckau D, Specht K, Ebert MP, Schmitt M, Aubele M, Höfler H, Walch A
Classification of HER2 Receptor Status in Breast Cancer Tissues by MALDI Imaging Mass Spectrometry.
J Proteom Res. 9(4)1854-1863, 2010

Rüschoff J, Dietel M, Baretton G, Arbogast S, Walch A, Monges G, Chenard MP, Penault-Llorca F, Nagelmeier I, Schlake W, Höfler H, Kreipe HH
HER2 diagnostics in gastric cancer-guideline validation and development of standardized immunohistochemical testing.
Virchows Arch. 457(3):299-307, 2010

Shyla A, Hölzlwimmer G, Calzada-Wack J, Bink K, Tischenko O, Guilly MN, Chevillard S, Samson E, Graw J, Atkinson MJ, Pellegata NS
Allelic loss of chromosomes 8 and 19 in MENX-associated rat pheochromocytoma.
Int J Cancer. 126(10):2362-2372, 2010

Smida J, Baumhoer D, Rosemann M, Walch A, Bielack S, Poremba C, Remberger K, Korsching E, Scheurlen W, Dierkes C, Burdach S, Jundt G, Atkinson MJ, Nathrath M
Genomic Alterations and Allelic Imbalances are Strong Prognostic Predictors in Osteosarcoma.
Clin Cancer Res. 16(16):4256-4267, 2010

Unger K, Wienberg J, Riches A, Hieber L, Walch A, Brown A, O’Brien P, Briscoe C, Gray L, Rodriguez E, Jackl G, Knijnenburg J, Tallini G, Ferguson-Smith M, Zitzelsberger H
Novel Gene rearragements in breast carcinogenesis identified by array-painting analysis of chromosomal aberrations.
Endocr Relat Cancer. 17(1):87-98, 2010

2009

Aubele M, Vidojkovitch S, Braselmann H, Ritterswürden D, Auer G, Atkinson MJ, Tapio S, Höfler H, Rauser S, Bartlett J
Overexpression of PTK6 (breast tumor kinase) protein--a prognostic factor for long-term breast cancer survival--is not due to gene amplification.
Virchows Arch. 455(2):117-123, 2009

Becker KF, Walch A, Ueffing M.
Protein analysis of tissues-current views and clinical perspectives.
Virchows Arch. 455(2):191-192, 2009

Deplazes J, Fuchs M, Rauser S, Genth H, Lengyel E, Busch R, Luber B
Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation.
Hum Mol Genet. 18(19):3632-3644, 2009

Hermann K, Walch A, Balluff B, Tänzer M, Höfler H, Krause B, Schaiger M, Friess H, Schmid R, Ebeert M
Proteomic and metabolic prediction of response to therapy in gastrointestinal cancers.
Nat Clin Pract Gastro Hepatol. 6(3):170-183, 2009

Hipp S, Walch, A., Schuster T, Losko S, Laux H, Bolton T, Höfler H, Becker KF
Activation of epidermal growth factor receptor results in Snail protein but not mRNA over-expression in endometrial cancer.
J Cell Mol Med. 13(9B):3858-3867, 2009

Khasawneh J, Schulz MD, Walch A, Rozman J, Hrabé de Angelis M, Klingenspor M, Buck A, Schwaiger M, Saur D, Schmid RM, Klöppel G, Sipos B, Greten FR, Arkan MC
Inflammation and mitochondrial fatty acid {beta}-oxidation link obesity to early tumor promotion.
Proc Natl Acad Sci U S A. 106(9):3354-3359, 2009

Laitinen I, Saraste A, Weidl E, Poethko T, Weber AW, Nekolla SG, Leppänen P, Ylä-Herttuala S, Hölzlwimmer G, Walch A, Esposito I, Wester HJ, Knuuti J, Schwaiger M
Evaluation of alphavbeta3 integrin-targeted positron emission tomography tracer 18F-galacto-RGD for imaging of vascular inflammation in atherosclerotic mice.
Circ Cardiovasc Imaging. 2(4):331-338, 2009

Lohmann C, Muschaweckh A, Kirschnek S, Jennen L, Wagner H, Häcker G
Induction of tumor cell apoptosis or necrosis by conditional expression of cell death proteins: analysis of cell death pathways and in vitro immune stimulatory potential.
J Immunol . 182(8):4538-4546, 2009

Peters D, Lepikhov K, Rodenacker K, Marschall S, Boersma A, Hutzler P, Scherb H, Walter J, Hrabé de Angelis M
Effect of IVF and laser zona dissection on DNA methylation pattern of mouse zygotes.
Mamm Genome. 20(9-10):664-673 , 2009

Rauser S, Höfler H, Walch A
[MALDI imaging mass spectrometry for direct tissue analysis.]
Pathologe. 30 Suppl 2:140-145, 2009

Reiter R, Gais P, Steuer-Vogt MK, Boulesteix AL, Deutschle T, Hampel R, Wagenpfeil S, Rauser S, Walch A, Bink K, Jütting U, Neff F, Arnold W, Höfler H, Pickhard A
Centrosome abnormalities in head and neck squamous cell carcinoma (HNSCC).
Acta Otolaryngol. 129(2):205-213, 2009

Rieger S, Senghaas N, Walch A, Köster RW
Cadherin-2 controls directional chain migration of cerebellar granule neurons.
PLoS Biol. 7(11):e1000240, 2009

Roselli F, Hutzler P, Wegerich Y, Livrea P, Almeida OF
Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
PLoS One. 4(6):e6011, 2009

Ruseva Z, Geiger PX, Hutzler P, Kotzsch M, Luber B, Schmitt M, Gross E, Reuning U
Tumor suppressor KAI1 affects integrin alphavbeta3-mediated ovarian cancer cell adhesion, motility, and proliferation.
Exp Cell Res. 315(10):1759-1771, 2009

Saarikangas J, Mattila P, Varjosalo M, Bovellan M, Hakanen J, Calzada-Wack J, Tost, M, Jennen L, Rathkolb B, Hans W, Fuchs H, Gailus-Durner V, Esposito I, Wolf E, Hrabé de Angelis M, Hyvönen M, Perälä N, Savilahti H, Sariola H, Sainio K, Lehtonen S, Taipale J, Salminen M, Lappaleinen P
Missing-in-metastasis is required for kidney epithelia integrity but is dispensable for Sonic hedgehog signalling.
J Exp. Medicine, 2009

Schneider M, Förster H, Boersma A, Seiler A, Wehnes H, Sinowatz F, Neumüller C, Deutsch MJ, Walch A, Hrabé de Angelis M, Wurst W, Ursini F, Roveri A, Maleszewski M, Maiorino M, Conrad M
Mitochondrial glutathione peroxidase 4 disruption causes male infertility.
FASEB J. 23(9):3233-3242, 2009

Sölder E, Kremser C, Rohr I, Hutzler P, Debbage P
Molecular mapping deep within a living human organ: analysis of microvessel function on the timescale of seconds and with sub-micrometre spatial resolution.
Histochem Cell Biol. 131(5):537-551,2009

Sölder E, Rohr I, Kremser C, Hutzler P, Debbage PL
Imaging of placental transport mechanisms: A review.
Eur J Obstet Gynecol Reprod Biol. 144 Suppl 1:S114-120, 2009

Wiech T, Nikolopoulos E, Weis R, Langer R, Bartholomé K, Timmer J, Walch A, Höfler H, Werner M.
Genome-Wide Analysis of Genetic Alterations in Barrett’s Adenocarcinoma Using Single Nucleotide Polymorphism Arrays.
Lab Invest.  89(4):385-397, 2009

Xing X, Burgermeister E, Geisler F, Hiber M, Mages J, Rauser S, Walch A, Röcken C, Ebeling M, Wright MB, Schmid RM, Ebert MP
Hematopoietically expressed homeobox is a target gene of farnesoid X receptor in chenodeoxycholic acid-induced liver hypertrophy.
Hepatology. 49(3):979-988, 2009

2008

Aubele M, Walch A, Ludyga N, Braselmann H, Atkinson MJ, Luber B, Auer G, Tapio S, Cooke T, Bartlett J
Prognostic value of Protein Tyrosine Kinase 6 (PTK6) for long-term survival of Breast Cancer Patients.
British Journal of Cancer. 99(7):1089-1095, 2008

Bauer VL, Braselmann H, Henke M, Mattern D, Walch A, Unger K, Baudis M, Lassmann S, Huber R, Wienberg J, Werner M, Zitzelsberger HF
Chromosomal changes characterize head and neck cancer with poor prognosis.
J Mol Med. 86(12):1353-1365, 2008

Bink K, Haralambieva E, Kremer M, Ott G, Beham-Schmid C, de Leval L, Cheng Peh S, Laeng HR, Jütting U, Hutzler P, Quintanilla-Martinez L, Fend F
Primary extramedullary plasmacytoma: similarities and differences to multiple myeloma revealed by interphase cytogenetics .
Haematologica/The Haematology Journal.  93(4):623-626, 2008

Bremm A, Walch A, Fuchs M, Duyster J, Keller G, Hermannstädter C, Mages J, Becker KF, Rauser S, Langer R, von Weyhern CH, Sarbia M, Höfler H, Luber. B
Enhanced activation of epidermal growth factor receptor caused by tumor-derived E-cadherin mutations.
Cancer Res. 68(3):707-714, 2008

Fend F, Tzankov A, Bink K, Seidl S, Quintanilla-Martinez L, Kremer M, Dirnhofer S
Modern techniques for the diagnostic evaluation of the trephine bone marrow biopsy: methodological aspects and applications.
Prog Histochem Cytochem. 42(4):203-252, 2008

Fuchs, M, Hermannstädter C, Hutzler P, Häcker F, Haller F, Höfler H, Luber, B
Deletion of exon 8 increases cisplatin-induced E-cadherin cleavage.
Exp Cell Res. 314(1):153-163, 2008

Hense B, Gais P, Jütting U, Scherb H, Rodenacker, K
Use of flourescence information for automated phytoplankton investigation by image analysis.
J Plankton Res . 30(5):587-606, 2008

Hipp S, Walch A, Schuster T, Höfler H, Becker KF
Precise measurement of the E-cadherin repressor Snail in formalin-fixed endometrial carcinoma using protein lysate microarrays.
Clin Exp. Metastasis. 25(6):679-683, 2008

Kiermayer, C, Schrewe A, Ludwig C, Schoensiegel F, Bekeredijan F, Walch A, Schmidt J, Ivandic B, Brielmeier M
Mitochondrial degeneration and left ventricular hypertrophy in heart specific mitochondrial thioredoxin reductase (Txnrd2) knockout mice.
Circulation
. 2008

Lisse TS, Thiele F, Fuchs H, Hans W, Przemeck GK, Abe K, Rathkolb B, Quintanilla-Martinez L, Hoelzlwimmer G, Helfrich M, Wolf E, Ralston SH, Hrabé de Angelis M.
ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta.
PLoS Genet. 4(2):e7, 2008

Matiasek K, Gais P, Rodenacker K, Jütting U, Tanck JJ, Schmahl W
Stereological characteristics of the equine accessory nerve.
Anat Histol Embryol. 37(3):205-213, 2008

May F, Matiasek K, Vroemen M, Caspers Ch, Mrva Th, Arndt Ch, Schlenker B, Gais P, Brill Th, Buchner A, Blesch A, Hartung R, Stief C, Gansbacher B, Weidner N
GDNF-Transduced Schwann Cell Grafts Enhance Regeneration of Erectile Nerves.
European Urology. 54(5):1179-1187, 2008

Paschen S, Christian J, Vier J, Schmidt F, Walch A, Ojcius D, Häcker G
Cytopathicity of Chlamydia is largely reproduced by expression of a single chlamydia protease.
J Cell Biol. 182(1):117-127, 2008

Riener MO, Nikolopoulos E, Herr A, Wild PJ, Hausmann M, Wiech T, Orlowska-Volk M, Lassmann S, Walch A, Werner M
Microarray comparative genomic hybridization analysis of tubular breast carcinoma shows recurrent loss of the CDH13 locus on 16q.
Hum Pathol. 39(11):1621-1629, 2008

Schillinger U, Wexel G, Hacker C, Kullmer M, Koch C, Gerg M, Vogt St, Ueblacker P, Tischer T, Hensler D, Willisch J, Aigner J, Walch A, Stemberger A, Plank C
A fibrin glue composition as carrier for nucleic acid vectors.
Pharmaceutic Res. 5(12):2946-2962, 2008

Schmidt R, Bültmann A, Fischel S, Gillitzer A, Cullen P, Walch A, Jost P, Ungerer M, Tollex ND, Lindemann S, Gawaz M, Schömig A, May AE
Extracellular matrix metalloproteinase inducer (CD147) is a novel receptor on pletelets, activates platelets, and augments nuclear factor kappaB-dependent inflammation in monocytes.
Circ Res. 102(3):302-309, 2008

Slotta-Huspenina J, Koch I, Richter M, Bink K, Kremer M, Specht K, Krugmann J, Quintanilla-Martinez L, Fend F
Cyclin D1 positive multiple myeloma: predominance of the short, 3'UTR-deficient transcript is associated with high cyclin D1 mRNA levels in cases with t(11;14) translocation, but does not correlate with proliferation rate or genomic deletions.
Leuk Res. 32(1):79-88, 2008

Unger K, Malisch E, Thomas G, Braselmann H, Walch A, Jackl G, Lewis P, Lengfelder E, Bogdanova T, Wienberg J, Zitzelsberger H
Array CGH demonstrates characteristic aberration signatures in human papillary thyroid carcinomas governed by RET/PTC.
Oncogene. 27(33):4592-4602, 2008

Villmann T, Schleif FM, Kostrzewa M, Walch A, Hammer B
Classification of mass-spectrometric data in clinical proteomics using learning vector quantization methods.
Brief Bioinform. 9(2):129-143, 2008

Walch A, Rauser S, Deininger SO, Höfler H
MALDI Imaging Mass Spectrometry for direct tissue analysis: a new frontier for molecular histology.
Histochemistry and Cell Biology. 130(3):421-434, 2008

Walch A, Seidl S, Hermannstädter Ch, Rauser S, Deplazes J, Langer R, Hann von Weyhern C, Sarbia M, Busch R, Feith M, Gillen S, Höfler H, Luber, B.
Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer.
Modern Pathology. 21(5):544-552, 2008

Wiech T, Nikolopoulos E, Hausmann M, Walch A, Werner M, Fisch P
A case of heterogeneous breast cancer with clonally expanded T-Cells in the HER2+ and metastasis of the HER2- tumor cells.
Breast J. 14(5):487-491, 2008

Winkelheide U, Engelhard K, Kaeppel B, Winkler J, Hutzler P, Werner C, Kochs E
Cerebral Ischemia and Neurogenesis: A Two-time Comparison.
Neurocrit Care. 9(3):387-393, 2008

Ying S, Pettengil M, Latham ER, Walch A, Ojcius DM, Häcker G
Premature Apoptosis of Chlamydia-Infected Cells Disrupts Chalmydial Development.
J Infect Dis. 198(10):1536-1544, 2008

Zischka H, Larochette N, Hoffmann F, Hamöller D, Jägemann N, Lichtmannegger J, Jennen L, Müller-Höcker J, Roggel F, Goettlicher M, Vollmar AM, Kroemer G
Electrophoretic analysis of the mitochondrial outer membrane rupture induced by permeability transition.
Anal Chem. 80(13):5051-5058, 2008

Zischka H, Lichtmannegger J, Jägermann N, Jennen L, Hamöller D, Huber E, Walch A, Summer KH, Göttlicher M
Isolation of highly pure rat liver mitochondria with the aid of zone-electrophoresis in a free flow device (ZE-FFE).
Methods Mol Biol. 424:333-348, 2008