Overview

 

The Assay Development and Screening Platform (ADSP) has been established in 2010 as a Research Group within the Institute of Molecular Toxicology and Pharmacology.

 

Research topics:

  1. Ferroptosis Research: Unraveling mechanisms and cellular regulators that induce or block ferroptosis, a regulated non-apoptotic cell-death pathway.
  2. Ubiquitin Signaling: Identification and characterization of protein interactions and regulators of ubiquitin signaling pathways mainly implicated in immune response, cancer development and DNA repair.

 

Chemical Biology / Drug Discovery:

We collaborate with researchers at the center as well as national and international cooperation partners to custom-designed assays to screen and identify novel bioactive molecules. Here, a major focus is devoted to the development of phenotypic assays for High-Content Screening (HCS) in order to better reflect the biology of the underlying disease state. We use machine learning techniques to analyze high-content images. ADSP provides state-of-the-art equipment and screening techniques as well as oversees the in-house diversity and focussed compound libraries.