Research Group Signal Transduction


Noncanonical NF-κB Activation by the Oncoprotein Tio Occurs Through a Nonconserved TRAF3-Binding Motif.
de Jong SJ, Albrecht JC, Giehler F, Kieser A, Sticht H, Biesinger B.
Sci Signal. 2013 Apr 23;6(272):ra27.



Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas.
Schrader A, Meyer K, von Bonin F, Vockerodt M, Walther N, Hand E, Ulrich A, Matulewicz K, Lenze D, Hummel M, Kieser A, Engelke M, Trümper L, Kube D.
Cell Commun Signal. 2012 Dec 20;10(1):43.

The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-κB by TRAIL.
Grunert M, Gottschalk K, Kapahnke J, Gündisch S, Kieser A, Jeremias I.
Cell Death Dis. 2012 Oct 25;3:e414.

The Germinal Center Kinase TNIK Is Required for Canonical NF-κB and JNK Signaling in B-Cells by the EBV Oncoprotein LMP1 and the CD40 Receptor.
Shkoda A, Town JA, Griese J, Romio M, Sarioglu H, Knöfel T, Giehler F, Kieser A.
PLoS Biol. 2012 Aug;10(8):e1001376.


Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunology.
Entschladen F, Altschmied J, Baumgrass R, Behrmann I, Giehl K, Hermanns H, Huber O, Kieser A, Klotz LO, Kubatzky KF, Hass R, Janssen O, Friedrich K.
Cell Commun Signal. 2010 Feb 11;8:2.


Signal transduction--receptors, mediators, and genes.
Entschladen F, Lindquist JA, Serfling E, Thiel G, Kieser A, Giehl K, Ehrhardt C, Feller SM, Ullrich O, Schaper F, Janssen O, Hass R, Friedrich K.
Sci Signal. 2009 Mar 24;2(63):mr3.

Signal transduction in the footsteps of goethe and schiller.
Friedrich K, Lindquist JA, Entschladen F, Serfling E, Thiel G, Kieser A, Giehl K, Ehrhardt C, Feller SM, Ullrich O, Schaper F, Janssen O, Hass R.
Cell Commun Signal. 2009 Feb 4;7:2.


Pursuing different 'TRADDes': TRADD signaling induced by TNF-receptor 1 and the Epstein-Barr virus oncoprotein LMP1.
Kieser A.
Biol. Chem. 2008 Oct;389(10):1261-71.

The viral oncoprotein LMP1 exploits TRADD for signaling by masking its apoptotic activity.
Schneider F, Neugebauer J, Griese J, Liefold N, Kutz H, Briseño C, Kieser A.
PLoS Biol. 2008 Jan;6(1):e8.

The c-Jun N-terminal kinase pathway is critical for cell transformation by the latent membrane protein 1 of Epstein-Barr virus.
Kutz H, Reisbach G, Schultheiss U, Kieser A.
Virology. 2008 Feb 20;371(2):246-56.


Proteomic identification of C/EBP-DBD multiprotein complex: JNK1 activates stem cell regulator C/EBPalpha by inhibiting its ubiquitination.
Trivedi AK, Bararia D, Christopeit M, Peerzada AA, Singh SM, Kieser A, Hiddemann W, Behre HM, Behre G.
Oncogene. 2007 Mar 15;26(12):1789-801.

Signal transduction by the Epstein-Barr virus oncogene latent membrane protein 1 (LMP1).
Kieser A.
Signal Transduction. 2007;7:20-33.

Before 2006

Latent membrane protein 1 of Epstein-Barr virus coordinately regulates proliferation with control of apoptosis.
Dirmeier U, Hoffmann R, Kilger E, Schultheiss U, Briseño C, Gires O, Kieser A, Eick D, Sugden B, Hammerschmidt W.
Oncogene. 2005 Mar 3;24(10):1711-7.

EBV latent membrane protein-1 protects B cells from apoptosis by inhibition of BAX.
Grimm T, Schneider S, Naschberger E, Huber J, Guenzi E, Kieser A, Reitmeir P, Schulz TF, Morris CA, Stürzl M.
Blood. 2005 Apr 15;105(8):3263-9. Epub 2004 Dec 21.

A novel assay to quantify cell death after transient expression of apoptotic genes in B- and T-lymphocytes.
Schneider F, Kieser A.
J Immunol Methods. 2004 Sep;292(1-2):165-74.

Activation of mitogen-activated protein kinase and NF-kappaB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein.
Brinkmann MM, Glenn M, Rainbow L, Kieser A, Henke-Gendo C, Schulz TF.
J Virol. 2003 Sep;77(17):9346-58.

Latent membrane protein 1 of Epstein-Barr virus induces CD83 by the NF-kappaB signaling pathway.
Dudziak D, Kieser A, Dirmeier U, Nimmerjahn F, Berchtold S, Steinkasserer A, Marschall G, Hammerschmidt W, Laux G, Bornkamm GW.
J Virol. 2003 Aug;77(15):8290-8.

TRAF6 is a critical mediator of signal transduction by the viral oncogene latent membrane protein 1.
Schultheiss U, Püschner S, Kremmer E, Mak TW, Engelmann H, Hammerschmidt W, Kieser A.
EMBO J. 2001 Oct 15;20(20):5678-91.

Assaying the activity of kinases regulated by LMP1.
Kieser A.
Methods Mol Biol. 2001;174:325-36.

The Raf-1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments.
Janosch P, Kieser A, Eulitz M, Lovric J, Sauer G, Reichert M, Gounari F, Büscher D, Baccarini M, Mischak H, Kolch W.
FASEB J. 2000 Oct;14(13):2008-21.

Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins.
Gires O, Kohlhuber F, Kilger E, Baumann M, Kieser A, Kaiser C, Zeidler R, Scheffer B, Ueffing M, Hammerschmidt W.
EMBO J. 1999 Jun 1;18(11):3064-73.

LMP1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF2.
Kieser A, Kaiser C, Hammerschmidt W.
EMBO J. 1999 May 4;18(9):2511-21.

Activated raf induces the hyperphosphorylation of stathmin and the reorganization of the microtubule network.
Lovrić J, Dammeier S, Kieser A, Mischak H, Kolch W.

J Biol Chem. 1998 Aug 28;273(35):22848-55.

Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor.
Kilger E, Kieser A, Baumann M, Hammerschmidt W.
EMBO J. 1998 Mar 16;17(6):1700-9.

Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade.
Kieser A, Kilger E, Gires O, Ueffing M, Kolch W, Hammerschmidt W.
EMBO J. 1997 Nov 3;16(21):6478-85.

Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells.
Kieser A, Seitz T, Adler HS, Coffer P, Kremmer E, Crespo P, Gutkind JS, Henderson DW, Mushinski JF, Kolch W, Mischak H.
Genes Dev. 1996 Jun 15;10(12):1455-66.

Identification of the primary growth response gene, ST2/T1, as a gene whose expression is differentially regulated by different protein kinase C isozymes.
Kieser A, Goodnight J, Kölch W, Mischak H, Mushinski JF.
FEBS Lett. 1995 Sep 25;372(2-3):189-93.

Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis.
Kolch W, Martiny-Baron G, Kieser A, Marmé D.
Breast Cancer Res Treat. 1995;36(2):139-55.

Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.
Kieser A, Weich HA, Brandner G, Marmé D, Kolch W.
Oncogene. 1994 Mar;9(3):963-9.