Research Group Therapeutic Antibodies


Li G, Chen TW, Nickel AC, Muhammad S, Steiger HJ, Tzaridis T, Hänggi D, Zeidler R, Zhang W, Kahlert UD. Carbonic Anhydrase XII is a Clinically Significant, Molecular Tumor-Subtype Specific Therapeutic Target in Glioma with the Potential to Combat Invasion of Brain Tumor Cells. OncoTargets and Therapy. In press


Kühne, J. F., Neudörfl, C., Beushausen, K., Keil, J., Malysheva, S., Wandrer, F., Haller, H., Messerle, M., Blume, C., Neuenhahn, M., Schlott, F., Hammerschmidt, W., Zeidler, R., and Falk, C. S. (2020). Differential effects of Belatacept on virus-specific memory versus de novo allo-specific T cell responses of kidney transplant recipients and healthy donors. Transpl Immunol.

Slabik, C., Kalbarczyk, M., Danisch, S., Zeidler, R., Klawonn, F., Volk, V., Krönke, N., Feuerhake, F., Ferreira de Figueiredo, C., Blasczyk, R., Olbrich, H., Theobald, S., Schneider, A., Ganser, A., von Kaiserberg, C., Lienenklaus, S., Bleich, A., Hammerschmidt, W., Stripecke, R. (2020) CAR-T cells targeting Epstein-Barr virus gp350 validated in a humanized mouse model of EBV infection and lymphoproliferative disease. Molecular Therapy: Oncolytics,


Gärtner, K., Luckner, M., Wanner, G., and Zeidler, R. (2019). Engineering extracellular vesicles as novel treatment options: exploiting herpesviral immunity in CLL. Journal of Extracellular Vesicles 8, DOI: 10.1080/20013078.2019.1573051.

Reulen, H. J., Suero Molina, E., Zeidler, R., Gildehaus, F. J., Böning, G., Gosewisch, A., and Stummer, W. (2019). Intracavitary radioimmunotherapy of high-grade gliomas: present status and future developments. Acta Neurochir (Wien) 161, 1109-1124.

Kalbarczyk, M., Slabik, C., Danisch, S., Cornelius, A., Zeidler, R., Kroenke, M., Feuerhake, F., and Stripecke, R. (2019). Cord blood derived CAR-T cells targeting gp350 containing CD28/CD3 zeta or 4-1BB/CD3 zeta signaling domains directly react against cells infected with EBV bypassing the need of HLA-matched memory T cells. Mol Ther 27, 175-176.

Alterio, V., Kellner, M., Esposito, D., Liesche-Starnecker, F., Bua, S., Supuran, C. T., Monti, S. M., Zeidler, R., and De Simone, G. (2019). Biochemical and Structural Insights into Carbonic Anhydrase XII/Fab6A10 Complex. J Mol Biol 431, 4910-4921.

Pan, C., Schoppe, O., Parra-Damas, A., Cai, R., Todorov, M. I., Gondi, G., von Neubeck, B., Böğürcü-Seidel, N., Seidel, S., Sleiman, K., Veltkamp, C., Förstera, B., Mai, H., Rong, Z., Trompak, O., Ghasemigharagoz, A., Reimer, M. A., Cuesta, A. M., Coronel, J., Jeremias, I., Saur, D., Acker-Palmer, A., Acker, T., Garvalov, B. K., Menze, B., Zeidler, R., and Ertürk, A. (2019). Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body. Cell 179, 1661-1676.e19.


von Neubeck, B., Gondi, G., Riganti, C., Pan, C., Parra Damas, A., Scherb, H., Ertürk, A., and Zeidler, R. (2018). An inhibitory antibody targeting carbonic anhydrase XII abrogates chemoresistance and significantly reduces lung metastases in an orthotopic breast cancer model in vivo. Int J Cancer 143, 2065-2075.

Danisch S, Slabik C, Cornelius A, Albanese M, Tagawa T, Chen YA, Krönke N, Eiz-Vesper B, Lienenklaus S, Bleich A, Theobald SJ, Schneider A, Ganser A, von Kaisenberg C, Zeidler R, Hammerschmidt W, Feuerhake F, Stripecke R. Spatiotemporally Skewed Activation of Programmed Cell Death Receptor 1-Positive T Cells after Epstein-Barr Virus Infection and Tumor Development in Long-Term Fully Humanized Mice. Am J Pathol 2018;

Fiedler, L., Kellner, M., Gosewisch, A., Oos, R., Böning, G., Lindner, S., Albert, N., Bartenstein, P., Reulen, H. J., Zeidler, R., and Gildehaus, F. J. (2018). Evaluation of177Lu-CHX-A″-DTPA-6A10 Fab as a radioimmunotherapy agent targeting carbonic anhydrase XII. Nucl Med Biol 60, 55-62.

Fiedler, L., Kellner, M., Oos, R., Böning, G., Ziegler, S., Bartenstein, P., Zeidler, R., Gildehaus, F. J., and Lindner, S. (2018). Fully automated production and characterization of 64Cu and proof-of-principle small animal PET imaging using 64Cu-labelled CA XII targeting 6A10 Fab. ChemMedChem

Kazokaitė, J., Niemans, R., Dudutienė, V., Becker, H. M., Leitāns, J., Zubrienė, A., Baranauskienė, L., Gondi, G., Zeidler, R., Matulienė, J., Tārs, K., Yaromina, A., Lambin, P., Dubois, L. J., and Matulis, D. (2018). Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells. Oncotarget 9, 26800-26816.


Uda, N. R., Seibert, V., Stenner-Liewen, F., Muller, P., Herzig, P., Gondi, G., Zeidler, R., van Dijk, M., Zippelius, A., and Renner, C. (2015). Esterase activity of carbonic anhydrases serves as surrogate for selecting antibodies blocking hydratase activity. J Enzyme Inhib Med Chem 1-6.

Rancan, C., Schirrmann, L., Huls, C., Zeidler, R., and Moosmann, A. (2015). Latent Membrane Protein LMP2A Impairs Recognition of EBV-Infected Cells by CD8+ T Cells. PLoS Pathog 11, e1004906.


Kim, D. K., Lee, J., Kim, S. R., Choi, D. S., Yoon, Y. J., Kim, J. H., Go, G., Nhung, D., Hong, K., Jang, S. C., Kim, S. H., Park, K. S., Kim, O. Y., Park, H. T., Seo, J. H., Aikawa, E., Baj-Krzyworzeka, M., van Balkom, B. W., Belting, M., Blanc, L., Bond, V., Bongiovanni, A., Borras, F. E., Buee, L., Buzas, E. I., Cheng, L., Clayton, A., Cocucci, E., Dela Cruz, C. S., Desiderio, D. M., Di Vizio, D., Ekstrom, K., Falcon-Perez, J. M., Gardiner, C., Giebel, B., Greening, D. W., Gross, J. C., Gupta, D., Hendrix, A., Hill, A. F., Hill, M. M., Nolte-’t Hoen, E., Hwang, D. W., Inal, J., Jagannadham, M. V., Jayachandran, M., Jee, Y. K., Jorgensen, M., Kim, K. P., Kim, Y. K., Kislinger, T., Lasser, C., Lee, D. S., Lee, H., van Leeuwen, J., Lener, T., Liu, M. L., Lotvall, J., Marcilla, A., Mathivanan, S., Moller, A., Morhayim, J., Mullier, F., Nazarenko, I., Nieuwland, R., Nunes, D. N., Pang, K., Park, J., Patel, T., Pocsfalvi, G., Del Portillo, H., Putz, U., Ramirez, M. I., Rodrigues, M. L., Roh, T. Y., Royo, F., Sahoo, S., Schiffelers, R., Sharma, S., Siljander, P., Simpson, R. J., Soekmadji, C., Stahl, P., Stensballe, A., Stepien, E., Tahara, H., Trummer, A., Valadi, H., Vella, L. J., Wai, S. N., Witwer, K., Yanez-Mo, M., Youn, H., Zeidler, R., and Gho, Y. S. (2014). EVpedia: A Community Web Portal for Extracellular Vesicles Research. Bioinformatics

Weller, P., Bankfalvi, A., Gu, X., Lehnerdt, G., Zeidler, R., Brandau, S., Lang, S., and Dumitru, C. (2014). The role of tumor FoxP3 as prognostic marker in different subtypes of head and neck cancer. European Journal of Cancer in press.


Dumitru, C. A., Bankfalvi, A., Gu, X., Zeidler, R., Brandau, S., and Lang, S. (2013). AHNAK and inflammatory markers predict poor survival in laryngeal carcinoma. PLoS One 8, e56420.

Gondi, G., Mysliwietz, J., Hulikova, A., Jen, J. P., Swietach, P., Kremmer, E., and Zeidler, R. (2013). Antitumor efficacy of a monoclonal antibody that inhibits the activity of cancer-associated carbonic anhydrase XII. Cancer Research (in press)

Lee, J. H., Wittki, S., Brau, T., Dreyer, F. S., Kratzel, K., Dindorf, J., Johnston, I. C., Gross, S., Kremmer, E., Zeidler, R., Schlotzer-Schrehardt, U., Lichtenheld, M., Saksela, K., Harrer, T., Schuler, G., Federico, M., and Baur, A. S. (2013). HIV Nef, Paxillin, and Pak1/2 Regulate Activation and Secretion of TACE/ADAM10 Proteases. Mol Cell 49, 668-679.

Dumitru, C. A., Bankfalvi, A., Gu, X., Eberhardt, W. E., Zeidler, R., Lang, S., and Brandau, S. (2013). Neutrophils Activate Tumoral CORTACTIN to Enhance Progression of Orohypopharynx Carcinoma. Front Immunol 4, 33.


Ruiss, R., Ohno, S., Steer, B., Zeidler, R., and Adler, H. (2012). Murine gammaherpesvirus 68 glycoprotein 150 does not contribute to latency establishment in vivo. Virology Journal in press,

Jochum, S., Moosmann, A., Lang, S., Hammerschmidt, W., and Zeidler, R. (2012). The EBV Immunoevasins vIL-10 and BNLF2a Protect Newly Infected B Cells from Immune Recognition and Elimination. PLoS Pathogens 8, e1002704.

Jochum, S., Ruiss, R., Moosmann, A., Hammerschmidt, W., and Zeidler, R. (2012). RNAs in Epstein-Barr virions control early steps of infection. Proc Natl Acad Sci U S A 109, E1396-404.


Dumitru, C. A., Hoffmann, T. K., Lehnerdt, G., Zeidler, R., Lang, S., and Brandau, S. (2011). Innovations in Biomarker Development: a Pathway Towards Individualized Cancer Therapy? Laryngorhinootologie 90, 168-177.

Ruiss, R., Jochum, S., Wanner, G., Reisbach, G., Hammerschmidt, W., and Zeidler, R. (2011). A virus-like particle-based epstein-barr virus vaccine. Journal of Virology 85, 13105-13113.

Battke, C., Kremmer, E., Mysliwietz, J., Gondi, G., Dumitru, C., Brandau, S., Lang, S., Vullo, D., Supuran, C., and Zeidler, R. (2011). Generation and characterization of the first inhibitory antibody targeting tumour-associated carbonic anhydrase XII. Cancer Immunology, Immunotherapy 60, 649-658.

Ruiss, R., Jochum, S., Mocikat, R., Hammerschmidt, W., and Zeidler, R. (2011). EBV-gp350 Confers B-Cell Tropism to Tailored Exosomes and Is a Neo-Antigen in Normal and Malignant B Cells-A New Option for the Treatment of B-CLL. PLoS One 6, e25294.

Andratschke, M., Luebbers, C. W., Johannson, V., Schmitt, B., Mack, B., Zeidler, R., Lang, S., Wollenberg, B., and Gildehaus, F. J. (2011). Biodistribution of 131I-labeled anti-CK8 monoclonal antibody in HNSCC in xenotransplanted SCID mice. Anticancer Res 31, 3315-3321.

Battke, C., Ruiss, R., Welsch, U., Wimberger, P., Lang, S., Jochum, S., and Zeidler, R. (2011). Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC. Cancer Immunology,  Immunotherapy 60, 639-648.


Lehnerdt, G., Hoffmann, T. K., Mattheis, S., Brandau, S., Zeidler, R., and Lang, S. (2010). Diagnostic and prognostic biomarkers in head and neck squamous cell carcinoma. HNO 58, 713-23; 724-5.

Bergmann, C., Strauss, L., Wieckowski, E., Czystowska, M., Albers, A., Wang, Y., Zeidler, R., Lang, S., and Whiteside, T. L. (2009). Tumor-derived microvesicles in sera of patients with head and neck cancer and their role in tumor progression. Head Neck 31, 371-380.

Patents and patent applications

  1. An Epstein-Barr-Virus vaccine (EP 10 00 8835.0)
  2. Novel antibody to a carbonic anhydrase (EP 10 00 4646.5)
  3. Novel CD73 antiboy, preparation and uses thereof (PCT/EP2018/063498
  4. Chimeric antigen receptor and CAR-T cells that bind a herpes virus antigen (EP18168410.1)
  5. Means and methods for treating herpesvirus infection (EP 16000493.3)