Team

Source: Helmholtz Zentrum München

Dr. Christian Gieger
Head of Research Unit 'Molecular Epidemiology' (AME)

Phone: +49 89 3187-4106
Fax: +49 89 3187-4567
E-mail
Building/Room: 34/310a

 

Research Biography:

Dr. Christian Gieger received his PhD in Statistics in 1998 from the Institute of Statistics at the University of Munich. His professional career included more than 15 years at leading German research institutions but also several years in IT industry. He is head of the Research Unit of Molecular Epidemiology.  His major research interests are genetic and epigenetic epidemiology of cardiometabolic diseases and other complex diseases as well as bioinformatics and biostatistics. He is developing strategies for the integrated analysis of high-dimensional data generated from various omics-technologies (genomics, epigenomics, transcriptomics, metabolomics). His research unit participated, and had for some phenotypes the lead, in multinational genome-wide meta-analysis consortia (GIANT, ENGAGE, DIAGRAM, MAGIC, CARDIoGRAM, HaemGen, CHARGE, etc.). During the last decade Dr. Gieger was (co-)author of more than 250 peer-reviewed publications in leading international genetic and medical journals, among which more than 10 in Nature and more than 50 in Nature Genetics. These publications have been cited more than 20,000 times (H-index=72). According to a Thomson Reuters analysis of publications from the years 2002 to 2013, Dr. Christian Gieger is among the top one percent most highly cited researchers worldwide.

Previous Academic Appointments:

  • 2011 – 2014: Head of the research group 'Genetic Epidemiology and KORA-gen' and deputy head of the Institute of Genetic Epidemiology, Helmholtz Center Munich.
  • 2004 – 2014: Project leader KORA-gen, a data and biobank infrastructure to provide phenotypes, genotypes and biosamples for genetic-epidemiological research, Helmholtz Center Munich
  • 2009 – 2010: Head of the research group 'Genetic Epidemiology', Institute of Epidemiology, Helmholtz Center Munich
  • 2004 - 2008: Senior scientist, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich
  • 2002 - 2004: Group leader, Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing (SCAI), Sankt Augustin

Currently held Research Grant Funding:

  • 2012 - 2016: Helmholtz-Russia Joint Research Group: The role of genetic interactions in the control of human metabolome. Helmholtz Association Fund (coordinator).
  • 2012 – 2017: MIMOmics -Methods for Integrated analysis of Multiple Omics datasets. EU FP7 program: HEALTH.2012.2.1.1 
  • 2013 - 2018: PAIN-OMICS - Multi-dimensional omics approach to stratification of patients with low back pain, EU FP7 program: HEALTH.2013.2.2.1. 
  • 2013 - 2018: CARTARDIS - Identification and validation of novel pharmaceutical drug targets for cardiovascular disease, EU FP7 program: HEALTH.2013.2.4.2.  
  • 2013 - 2018: e:AtheroSysMed - Systems medicine of myocardial infarction and stroke in BMBF e:Med

Recent and Relevant Publications:

(complete list: PubMed)

  1. Shin SY*, Fauman EB*, Petersen AK*, Krumsiek J*, …, Suhre K*, Brosnan MJ*, Gieger C*, Kastenmüller G*, Spector TD*, Soranzo N*. An atlas of genetic influences on human blood metabolites. Nat Genet. 2014 Jun;46(6):543-50. (* equal contributions)
  2. Ried JS, Shin SY, Krumsiek J, … , Soranzo N, Suhre K, Gieger C. Novel genetic associations with serum level metabolites identified by phenotype set enrichment analyses. Hum Mol Genet. 2014 Nov 1;23(21):5847-57.  
  3. Dick KJ, Nelson CP, … , Gieger C, Tregouet DA, Deloukas P, Samani NJ. DNA methylation and body-mass index: a genome-wide analysis. Lancet. 2014 Jun 7;383(9933):1990-8. 
  4. Shin SY, Petersen AK, … , Gieger C, Soranzo N. Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids. Genome Med. 2014 Mar 28;6(3):25.
  5. Petersen AK, … , Gieger C, Suhre K. Epigenetics meets metabolomics: An epigenome-wide association study with blood serum metabolic traits. Hum Mol Genet. 2014 Jan 15;23(2):534-45.
  6. Albrecht E, Waldenberger M, …, Gieger C, Kastenmülller G, Döring A, Meisinger C. Metabolite profiling reveals new insights into the regulation of serum urate in humans. Metabolomics, 2014,10:141151.
  7. Raffler J, Römisch-Margl W, Petersen AK, … , Gieger C, Kastenmüller G, Suhre K. Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma. Genome Med. 2013 Feb 15;5(2):13.
  8. Köttgen A*, Albrecht E*, Teumer A*, Vitart V*, Krumsiek J*, … , Ciullo M*, Fox CS*, Caulfield M*, Bochud M*, Gieger C*. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet. 2013 Feb;45(2):145-54. (* equal contributions)
  9. van der Harst P*, Zhang W*, Mateo Leach I*, Rendon A*, Verweij N*, Sehmi J*, Paul DS*, Elling U*, … , Hicks AA*, Penninger JM*, Gieger C*, Kooner JS*, Ouwehand WH*, Soranzo N*, Chambers JC*. Seventy-five genetic loci influencing the human red blood cell. Nature. 2012 Dec 20;492(7429):369-75. (* equal contributions)
  10. Ried JS, Döring A, Oexle K, Meisinger C, Winkelmann J, Klopp N, Meitinger T, Peters A, Suhre K, Wichmann HE, Gieger C. PSEA: Phenotype Set Enrichment Analysis - a new method for analysis of multiple phenotypes. Genet Epidemiol. 2012 Apr;36(3):244-52.
  11. Petersen AK, Krumsiek J, Wägele B, Theis FJ, Wichmann HE, Gieger C, Suhre K. On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies. BMC Bioinformatics. 2012 Jun 6;13:120.
  12. Rawal R, Teumer A, Völzke H, Wallaschofski H, Ittermann T, Asvold BO, Bjoro T, Greiser KH, Tiller D, Werdan K, zu Schwabedissen HE, Döring A, Illig T, Gieger C, Meisinger C, Homuth G. Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function. Hum Mol Genet. 2012 Jul 15;21(14):3275-82.
  13. Petersen AK, …, Suhre K, Gieger C, Kastenmüller C. Genetic Associations with Lipoprotein Subfractions Provide Information on their Biological Nature. Hum Mol Genet. 2012 Mar 15;21(6):1433-43. 
  14. Gieger C*, Radhakrishnan A*, Cvejic A*, Tang W*, Porcu E*, Pistis G*, Serbanovic-Canic J*, …, Sanna S*, Hicks AA*, Rendon A*, Ferreira MA*, Ouwehand WH*, Soranzo N*. Sixty-eight genetic loci uncover new gene functions in megakaryopoiesis and platelet formation. Nature. 2011 Nov 30;480(7376):201-208. (* equal contributions)
  15. Suhre K, Gieger C. Genetic variation in metabolic phenotypes: study designs and applications. Nat Rev Genet. 2012 Nov;13(11):759-69.  
  16. Suhre K, Shin SY*, Petersen AK*, … , Soranzo N*, Gieger C*. Human metabolic individuality in biomedical and pharmaceutical research. Nature. 2011 Aug 31;477(7362):54-60. (* equal contributions)
  17. Suhre K, Wallaschofski H, Raffler J, Friedrich N, … , Gieger C, Römisch-Margl W, Nauck M. A genome-wide association study of metabolic traits in human urine. Nat Genet. 2011 Jun;43(6):565-9.
  18. Oexle K*, Ried JS*, Hicks AA*, … , Gieger C*, Winkelmann J*, Meitinger T*. Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels. Hum Mol Genet. 2011 Mar 1;20(5):1042-7. (* equal contributions)
  19. Soranzo N*, Sanna S*, Wheeler E*, Gieger C*, Radke D*, …, Groop L, McCarthy MI, Kao WHL, Florez JC, Uda M, Wareham NJ, Barroso I, Meigs JB. Common variants at ten genomic loci influence hemoglobin A 1C levels via glycemic and non-glycemic pathways. Diabetes. 2010 Dec;59(12):3229-39. (* equal contributions)
  20. Marzi C*, Albrecht E*, …, Koenig W, Illig T*, Gieger C*. Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A. PLoS Genet. 2010 Nov 18;6(11):e1001213. (* equal contributions) 
  21. Illig T*, Gieger C*, … , Spector TD, Adamski J, Suhre K. A genomewide perspective of genetic variation in human metabolism. Nat Genet. 2010 Feb;42(2):137-41. (* equal contributions)
  22. Soranzo N*, Spector TD*, Mangino M*, … , Deloukas P*, Ouwehand WH*, Gieger C*. A meta-analysis of eight hematological parameters identifies 22 associated loci and extensive disease pleiotropy on chromosome 12q24. Nat Genet. 2009 Nov;41(11):1182-90. (* equal contributions)
  23. Kolz M*, Johnson T*, Sanna S, Teumer A, Vitart V, … , Illig T, Gieger C. Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet. 2009 Jun;5(6):e1000504. (* equal contributions)
  24. Soranzo N*, Rendon A*, Gieger C*,…, Ouwehand WH. A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function. Blood. 2009 Apr 16;113(16):3831-7. (* equal contributions)
  25. Meisinger C, Prokisch H, Gieger C, Soranzo N, … , Döring A. A genome-wide association study identifies three loci associated with mean platelet volume. Am J Hum Genet. 2009 Jan;84(1):66-71.
  26. Gieger C, Geistlinger L, Altmaier E, … , Adamski J, Illig T, Suhre K. Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet. 2008 Nov;4(11):e1000282. PLoS Genet
  27. Weidinger S*, Gieger C*, Rodriguez E, Baurecht H, … , Wichmann HE, Illig T. Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. PLoS Genet. 2008 Aug;4(8):e1000166. (* equal contributions)
  28. Lettre G, Jackson AU*, Gieger C*, Schumacher FR*, Berndt SI*, Sanna S*, Hirschhorn JN. Genome-wide association studies identify ten novel loci for height and highlight new biological pathways in human growth. Nat Genet. 2008 May;40(5):584-91. (* equal contributions)
  29. Döring A*, Gieger C*, Mehta D, Gohlke H, Prokisch H, Coassin S, Fischer G, Henke K, Klopp N, Kronenberg F, Paulweber B, Pfeufer A, Rosskopf D, Völzke H, Illig T, Meitinger T, Wichmann H-E, Meisinger C. A genome wide association study reveals SLC2A9 as a major gene for uric acid levels with pronounced gender-specificc effects. Nat Genet 2008 Apr;40(4):430-6. (* equal contributions) 
  30. Wichmann HE, Gieger C, Illig T, MONICA/KORA Study Group. KORA-gen - resource for population genetics, controls and a broad spectrum of disease phenotypes. Gesundheitswesen. 2005 Aug;67 Suppl 1:S26-30.

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