Research Group Complex Diseases (CD)

Our research objective is the genetic, epigenetic, and functional analysis of complex diseases, such as cardiovascular and metabolic conditions, and their intermediate phenotypes. We use epidemiological methods to study the complex interplay between molecular mechanisms and environmental factors (such as smoking) in relation to the onset and progression of disease. Identified loci are subjected to further functional characterization.

We have particular experience in conducting high-throughput genotyping and genome-wide methylation projects. The group is part of the Genome Analysis Center (GAC), a high-throughput genotyping platform offering several state-of-the-art laboratory technologies (MALDI-TOF MS, Affymetrix, Illumina), techniques enabling the generation of high-dimensional omics data for the investigation of complex diseases. Additionally, we have established a functional pipeline using molecular biology and cell culture-based techniques for functional in vitro and in vivo characterization of SNP and methylation effects.

Team of Research Group "Complex Diseases" at Chiemsee/Bavaria