Workshop Program

The program will cover the following topics and all listed speakers already confirmed their attendance.

A printable version of our program can be downloaded as a pdf-document here!

Sunday,
May 7th, 2017
From 4:00pm
REGISTRATION AND DISTRIBUTION OF MEETING MATERIAL
6:30pm

OPENING
Michele Solimena (Dresden)
for the Beta Cell Workshop
Pierre Maechler (Geneva) for the European Association for the Study of Diabetes

6:45pm

 1st Keynote Lecture - Chair: Pierre Maechler (Geneva)

Phase transition-driven protein assembly: a new view on intra-cellular compartimentalization
Anthony Hyman (Dresden)

7:30pm

WELCOME RECEPTION

Monday, May 8th, 2017
From 8:00amREGISTRATION AND POSTER MOUNTING

8:30h

 

SESSION 1: BETA CELL DEVELOPMENT - Chair: Leif Groop (Malmö)

Nkx2.2 acts downstream of Neurog3 to specify pancreatic endocrine lineages
Lori Sussel (Denver)

Beyond transcription factors in the lineage selection and differentiation of pancreas progenitors
Anthony Gavalas (Dresden)

Myelin transcription factors repress precocious stress responses for the function and survival of pancreatic beta cells
Guoqiang Gu (Nashville)

Phosphoinositide 3Kinase (PI3K) regulates endocrine cell motility and pancreatic islet morphogenesis (Short Talk)
Robin Kimmel (Innsbruck)

Synaptotagmin 13 regulates endocrine cell delamination during pancreas development (Short Talk)
Mostafa Bakhti (Munich)

10:30amCOFFEE BREAK
11:00am

SESSION 2: BETA CELL MATURATION AND REGENERATION - Chair: Christopher Wright (Nashville)

Generating functionally mature beta cells from human stem cells
Matthias Hebrok (San Francisco)

Glucotoxic block of beta cell regeneration
Yuval Dor (Jerusalem)

mTOR signaling regulates the metabolic programing of beta cells leading to functional maturation
Anil Bhushan (San Francisco)

Heterogeneous NFkB activity balances proliferation and function in aging beta cells (Short Talk)
Sharan Janjuha (Dresden)

Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes (Short Talk)
Bernard Peers (Liège)

1:00pmLUNCH
2:00pm

SESSION 3: BETA CELL FUNCTION I - Chair: Shanta Persaud (London)

New and unexpected roles for SNARE proteins in the preservation of functional beta cell mass
Debbie Thurmond (Los Angeles)

Longitudinal in vivo imaging of islets reveals a dominant role of beta cell function in diabetes pathogenesis
Stephan Speier (Dresden)

Regulation of beta-cell function and fate by insulin
James Johnson (Vancouver)

Reversal of human beta cell functional damage induced by lipo-glucotoxic conditions or type 2 diabetes
Piero Marchetti (Pisa)

4:00pmCOFFEE BREAK
4:30pm

SESSION 4: BETA CELL FUNCTION  II - Chair: Hindrik Mulder (Malmö)

Why are large islets unresponsive to incretins?
Susumu Seino (Kobe)

From absence to hyperactivity of glutamate dehydrogenase and the hypo to hyperinsulinsim
Pierre Maechler (Geneva)

Genetic and nutritional control of beta cell connnectivity
Guy Rutter (London)

Glucose dependent granule docking limits insulin secretion and is decreased in human type 2 diabetes (Short Talk)
Nikhil Gandasi (Uppsala)

Primary cilia dysfunction disrupts glucose tolerance and beta cell function (Short Talk)
Francesco Volta (Munich)

6:30pm to 8:30pm

POSTER PRESENTATION SESSION A (ODD NUMBERS) AND REFRESHMENTS

Tuesday, May 9th, 2017
8:30am to 1:00pm CITY TOUR DRESDEN AND EXHIBITION NEW MASTERS OR OLD MASTERS
1:00pmLUNCH
2:00pm

2nd Keynote Lecture - Chair: Stefan Bornstein (Dresden)

From membrane rafts to lipidomics: a life-long journey
Kai Simons (Dresden)

2:45pm

SESSION 5: BETA CELL MASS VERSUS DEDIFFERENTIATION IN TYPE 2 DIABETES - Chair: Gil Leibowitz (Jerusalem)

Beta cell loss in type 2 diabetes is not accounted for by dedifferentiation
Peter Butler (Los Angeles)

When beta cells fail: lessons from dedifferentiation
Domenico Accili (New York)

3:45pm COFFEE BREAK
4:15pm

SESSION 6: GENETICS AND EPIGENETIKS OF BETA CELLS IN TYPE 2 DIABETES -
Chair: Maureen Gannon (Nashville)

Using human genetics and genomics to unravel causal mechanisms for diabetes
Anna Gloyn (Oxford)

Systems biology on organ donor and surgical pancreas specimens defines a transcriptomic signature of type 2 diabetic islets
Anke Schulte (Frankfurt)

Non-coding RNAs and beta cell function
Lena Eliasson (Malmö)

Monogenic diabetes as models of beta cell organelle dysfunction in type 2 diabetes
Miriam Cnop (Brussels)

6:15pm to 8:15pm

POSTER PRESENTATION SESSION B (EVEN NUMBERS) AND REFRESHMENTS

Wednesday, May 10th, 2017
9:00am

SESSION 7: THE SOCIAL EVIRONMENT OF BETA CELLS - Chair: Eduard Montanya (Barcelona)

Sharing is caring: how beta cell function depends on the islet environment
Alejandro Caicedo (Miami)

Molecular and functional interplay between alpha- and beta-cellular clocks in mouse and human models
Charna Dibner (Geneva)

Elucidating the role of pancreatic pericytes in diabetes-associated beta cell dysfunction (Short Talk)
Limor Landsman (Tel Aviv)

PYY modulates pancreatic islet secretory function and acts as a DPP-IV substrate to regulate insulin secretion (Short Talk)
Claudia Guida (Oxford)

10:30amCOFFEE BREAK
11:00am

SESSION 8: BETA CELL THERAPY - Chair: Ole Madsen (Copenhagen)

Reconstructing human pancreatic organogenesis
Raphael Scharfmann (Paris)

Drug design for beta cell protection in diabetes mellitus: NMDA receptor antagonists
Eckhard Lammert (Düsseldorf)

Advances in pharmacologic therapy for human beta cell regeneration
Andrew Stewart (New York)

Current status and future perspectives in diabetes therapy- from cells, pills, and chimera
Barbara Ludwig (Dresden)

1:00pmLUNCH
2:00pm

SESSION 9: BETA CELL IMMUNE INTERACTION - Chair: Ezio Bonifacio (Dresden)

The resident phagocytes of pancreatic islets have a seminal role in islet development and inflammation
Emil Unanue (St. Louis)

Complexities of beta cell failure in type 1 diabetes
Clayton Mathews (Gainsville)

Coordinated analysis using complementary methodologies reveals a viral signature and demonstrates a low level enteroviral infection in the pancreas in type 1 diabetes
Teresa Rodriguez-Calvo (Munich)

A novel, highly proliferative population of islet endocrine cells in adolescent and adult human pancreata (Short Talk)
Jake Kushner (Houston)

Exosome-mediated transfer of microRNAs from lymphocytes to beta cells contributes to type 1 diabetes development (Short Talk)
C
laudiane Guay (Lausanne)

4:00p COFFEE BREAK
4:30pm

SSESSION 10: THE ROLE OF ALPHA CELLS IN ISLET FUNCTION - Chair: Anders Tengholm (Uppsala)

Beta cell reconstitution by modulation of islet cell-type interconversion
Pedro Herrera (Geneva)

Somatostatin mediates glucagonostatic effect of insulin
Patrik Rorsman (Oxford)

5:30pm

3rd Keynote Lecture - Chair: Michele Solimena (Dresden)

Control of pancreatic hormone secretion by brain glucose sensing networks
Bernard Thorens (Lausanne)

6:15pmCLOSING REMARKS
From 8:00pmFAREWELL DINNER AT ALBRECHTSBERG CASTLE