Lifestyle and Nutrition Impact

BIO: Lifestyle and Nutrition Impact / Deep Metabotyping

Our interest is to identify the contribution of environmental factors such as diet, drugs and the gut microbiome on the metabolic phenotype. We furthermore metabolically characterize samples from different intervention trials and cohorts in order to elucidate potential biomarkers in cardiovascular disease, chronic kidney disease, Crohn's disease and ulcerative colitis. In nutrition trials, we are interested in corresponding the metabolite profiles with the microbiota information. These are related to resistant starch, iron supplementation, various prebiotics and the importance of probiotics and their corresponding chemistry.

Spatial resolution of the gut for microbiome-metabolome research. The microbiota of the gastrointestinal tract displays compositional differences between mucus and lumen, and longitudinally from cecum to colon and feces. We have reported spatial variation of gut luminal metabolites in mice that directly link to microbial breakdown of carbohydrates and proteins in the cecum and re-absorption processes in the colon. Such metabolic variation is affected by the microbiota but might also directly promote the feedback for growth of selected bacteria along the gut and trigger signaling pathways for the microbiome and the host with effects in health and disease.

We continuously work on the comprehensive chemical characterization of foods and beverages and the elucidation of associated food biomarkers. Further interests include the metabolic phenotyping of human individuals for population stratification using cohort studies and for personalizing human lifestyle interventions.

Selected Publications:

Smirnov, K. S., Maier, T. V., Walker, A., Heinzmann, S. S., Forcisi, S., Martinez, I., ... & Schmitt-Kopplin, P. (2016). Challenges of metabolomics in human gut microbiota research. International Journal of Medical Microbiology, 306(5), 266-279.

Maier, T. V., Lucio, M., Lee, L. H., VerBerkmoes, N. C., Brislawn, C. J., Bernhardt, J., ... & Morton, J. T. (2017). Impact of Dietary Resistant Starch on the Human Gut Microbiome, Metaproteome, and Metabolome. mBio, 8(5), e01343-17.

Kepert, I., Fonseca, J., Müller, C., Milger, K., Hochwind, K., Kostric, M., ... & Bartel, S. (2017). D-tryptophan from probiotic bacteria influences the gut microbiome and allergic airway disease. Journal of Allergy and Clinical Immunology, 139(5), 1525-1535.

Walker, A., Pfitzner, B., Harir, M., Schaubeck, M., Calasan, J., Heinzmann, S. S., ... & Haller, D. (2017). Sulfonolipids as novel metabolite markers of Alistipes and Odoribacter affected by high-fat diets. Scientific reports, 7(1), 11047.

Bazanella, M., Maier, T. V., Clavel, T., Lagkouvardos, I., Lucio, M., Maldonado-Gòmez, M. X., ... & Haller, D. (2017). Randomized controlled trial on the impact of early-life intervention with bifidobacteria on the healthy infant fecal microbiota and metabolome. The American journal of clinical nutrition, 106(5), 1274-1286.

Lee, T., Clavel, T., Smirnov, K., Schmidt, A., Lagkouvardos, I., Walker, A., ... & Haller, D. (2016). Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut, gutjnl-2015.