Element Speciation

Element Speciation

The group “Elements and Element Speciation” develops methods along our project demands and for future analytical challenges:

  • Elemental mapping: We use LA-ICP-MS for elemental mapping in different kinds of sample types, such as tissue samples, e.g. brain slices, or environmental samples like sediments from Yellowstone gush springs. Special challenges are analytical protocols for quantitative elemental mapping.
  • Element speciation: For speciation analysis several different coupling methods are developed and optimized based on LC-ICP-MS and LC-ICP-OES. The methods are widely applied in our research on neurodegenerative pathologies. A special focus lays on CE-ICP-MS methods in 2D-identification procedures and especially for speciation of nanoparticles.
  • Element determination in low-mass solid samples: We operate and develop element determination methods for solid samples with very low sample mass, unsuitable for digestion. For such samples, we use a modern ETV system hyphenated to ICP-OES with transient signal monitoring.
  • Quality control and reference materials: Aside, methods are developed and validated in the frame of our cooperation with the Institute for Reference Materials and Measurements of the European Joint Research Center“, for certification of a broad range of standard reference materials (CRM), for reference value determination within the German EQUAS system or within the workgroup “Analysis in biological materials” of the Deutsche Forschungsgemeinschaft.
Inductively Coupled Plasma Mass Spectrometer
Source: Helmholtz Zentrum München

 

Selected Publications:

Neth, K. (2015). Manganese: Species Pattern and Mechanisms of Brain Injury. [Dissertation]. Munich: Technical University of Munich, Analytical Food Chemistry

Michalke, B., & Witte, H. (2015). Characterization of a rapid and reliable method for iodide biomonitoring in serum and urine based on ion chromatography–ICP-mass spectrometry. Journal of Trace Elements in Medicine and Biology, 29, 63-68.

Michalke, B. (2017). Biomonitoring of boron: Development and characterization of a simple, reliable and quality controlled biomonitoring method. Journal of Trace Elements in Medicine and Biology, 40, 24-29.

Solovyev, N., Vinceti, M., Grill, P., Mandrioli, J., & Michalke, B. (2017). Redox speciation of iron, manganese, and copper in cerebrospinal fluid by strong cation exchange chromatography–sector field inductively coupled plasma mass spectrometry. Analytica Chimica Acta, 973, 25-33.

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