Production of Hepatitis B virus proteins

After four decades of research on Hepatits B virus (HBV), and despite the availability of a safe and effective vaccine since the late 80’s of the last century, HBV and hepatocellular carcinoma, the possible outcome of chronic infection, still represent a serious healthcare issue worldwide. Plant molecular farming has become a widely used technique for the production of recombinant protein for industrial as well as pharmaceutical use, yet predominantly for niche markets, where it does not have to compete against the more elaborated systems of protein production.

In collaboration with the Institute of Virology we want to develop a plant-based production system (magnICON® system) for HBV proteins and antibodies, which will be used for scientific and therapeutic issues at a high quality solely and in combination.

Florian Wilsch, Christian Lindermayr

Workflow for production and purification of recombinant Hepatitis B virus proteins using the magnifection system.